The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Regulation of Oligodendrocyte Differentiation and Myelination
Abstract
Despite the importance of myelin for the rapid conduction of action potentials, the molecular bases of oligodendrocyte differentiation and central nervous system (CNS) myelination are still incompletely understood. Recent results have greatly advanced this understanding, identifying new transcriptional regulators of myelin gene expression, elucidating vital roles for microRNAs in controlling myelination, and clarifying the extracellular signaling mechanisms that orchestrate the development of myelin. Studies have also demonstrated an unexpected level of plasticity of myelin in the adult CNS. These recent advances provide new insight into how remyelination may be stimulated in demyelinating disorders such as multiple sclerosis.
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“Myelin formation by oligodendrocytes surrounding axons in the central nervous system regulates conduction velocity (CV), which is a key component of fast and efficient information processing in the brain (Emery, 2010 ; Fields, 2008 ; Nave, 2010 ).”
From Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity (2020) · cites this paper as Emery, 2010
In the citing paper
“Myelin formation by oligodendrocytes surrounding axons in the central nervous system regulates conduction velocity (CV), which is a key component of fast and efficient information processing in the brain (Emery, 2010 ; Fields, 2008 ; Nave, 2010 ).”
From Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity (2020) · cites this paper as Emery, 2010
In the citing paper
“To that end, we have selected a 2.2 kb region upstream of the transcription start site in the human MAG gene and two truncated variants, that harbor an abundance of binding motifs for transcription factors known to regulate gene activity and myelination in oligodendrocytes or Schwann cells (Emery, 2010).”
From Recombinant Human Myelin-Associated Glycoprotein Promoter Drives Selective AAV-Mediated Transgene Expression in Oligodendrocytes (2016) · cites this paper as Emery, 2010
In the citing paper
“This discrepancy could be due to OPCs differentiating into pre-myelinating oligodendrocytes [14] (also see below), which are not myelinating the axons due to continuous cuprizone lesion.”
From Strain differences in cuprizone induced demyelination (2017) · cites this paper as [14]
In the citing paper
“MicroRNAs (miRs) regulate diverse molecular and cellular processes including oligodendrocyte (OL) precursor cell (OPC) proliferation and differentiation in rodents.”
From Regulation of miRNA 219 and miRNA Clusters 338 and 17-92 in Oligodendrocytes (2012) · cites this paper as Emery, 2010
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Cahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4178-07.2008 · Cited by 3,129
Self-citationTraining induces changes in white-matter architecture
Scholz, J., Klein, M. C., Behrens, T. E. J., & Johansen-Berg, H. (2009) · Nature Neuroscience · doi:10.1038/nn.2412 · Cited by 1,508
Structural maturation of neural pathways in children and adolescents: in vivo study
Paus, T., Zijdenbos, A., Worsley, K., Collins, D. L., Blumenthal, J., Giedd, J. N., Rapoport, J. L., & Evans, A. C. (1999) · Science · doi:10.1126/science.283.5409.1908 · Cited by 1,322
Extensive piano practicing has regionally specific effects on white matter development
Bengtsson, S. L., Nagy, Z., Skare, S., Forsman, L., Forssberg, H., & Ullén, F. (2005) · Nature Neuroscience · doi:10.1038/nn1516 · Cited by 1,193
A translational profiling approach for the molecular characterization of CNS cell types
Heiman, M., Schaefer, A., Gong, S., Peterson, J. D., Day, M., Ramsey, K. E., Suárez-Fariñas, M., Schwarz, C., Stephan, D. A., Surmeier, D. J., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.028 · Cited by 1,134
Lu, Q. R., Sun, T., Zhu, Z., Ma, N., Garcia, M., Stiles, C. D., & Rowitch, D. H. (2002) · Cell · doi:10.1016/s0092-8674(02)00678-5 · Cited by 1,087
Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus
Bergles, D. E., Roberts, J. D. B., Somogyi, P., & Jahr, C. E. (2000) · Nature · doi:10.1038/35012083 · Cited by 1,062
PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice
Rivers, L. E., Young, K. M., Rizzi, M., Jamen, F., Psachoulia, K., Wade, A., Kessaris, N., & Richardson, W. D. (2008) · Nature Neuroscience · doi:10.1038/nn.2220 · Cited by 961
Oligodendrocyte dysfunction in schizophrenia and bipolar disorder.
Tkachev, D., Mimmack, M., Ryan, M. M., Wayland, M., Freeman, T., Jones, P., Starkey, M., Webster, M., Yolken, R., & Bahn, S. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14289-4 · Cited by 940
Benes, F. M. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950060041004 · Cited by 744
Notch Receptor Activation Inhibits Oligodendrocyte Differentiation
Wang, S., Sdrulla, A. D., diSibio, G., Bush, G., Nofziger, D., Hicks, C. D., Weinmaster, G., & Barres, B. A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80515-2 · Cited by 706
Astrocytes promote myelination in response to electrical impulses
Ishibashi, T., Dakin, K. A., Stevens, B., Lee, P. R., Kozlov, S. V., Stewart, C. L., & Fields, R. D. (2006) · Neuron · doi:10.1016/j.neuron.2006.02.006 · Cited by 689
Induction of myelination in the central nervous system by electrical activity
Demerens, C., Stankoff, B., Logak, M., Anglade, P., Allinquant, B., Couraud, F., Zalc, B., & Lubetzki, C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9887 · Cited by 678
Proliferation of oligodendrocyte precursor cells depends on electrical activity in axons
Barres, B. A., & Raff, M. C. (1993) · Nature · doi:10.1038/361258a0 · Cited by 673
LINGO-1 negatively regulates myelination by oligodendrocytes
Mi, S., Miller, R. H., Lee, X., Scott, M. L., Shulag-Morskaya, S., Shao, Z., Chang, J., Thill, G., Levesque, M., Zhang, M., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1460 · Cited by 628
Zhou, Q., Choi, G. B., & Anderson, D. J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00414-7 · Cited by 625
Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS
Fancy, S. P. J., Baranzini, S. E., Zhao, C., Yuk, D.-I., Irvine, K.-A., Kaing, S., Sanai, N., Franklin, R. J. M., & Rowitch, D. H. (2009) · Genes & Development · doi:10.1101/gad.1806309 · Cited by 618
Dicer1 and miR-219 Are Required for Normal Oligodendrocyte Differentiation and Myelination
Dugas, J. C., Cuellar, T. L., Scholze, A., Ason, B., Ibrahim, A., Emery, B., Zamanian, J. L., Foo, L. C., McManus, M. T., & Barres, B. A. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.027 · Cited by 577
Self-citationMyelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination
Emery, B., Agalliu, D., Cahoy, J. D., Watkins, T. A., Dugas, J. C., Mulinyawe, S. B., Ibrahim, A., Ligon, K. L., Rowitch, D. H., & Barres, B. A. (2009) · Cell · doi:10.1016/j.cell.2009.04.031 · Cited by 559
Self-citationHDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction
Ye, F., Chen, Y., Hoang, T., Montgomery, R. L., Zhao, X.-H., Bu, H., Hu, T., Taketo, M. M., van Es, J. H., Clevers, H., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2333 · Cited by 559
Stevens (2002) · doi:10.1016/s0896-6273(02)01067-x · Cited by 543
MicroRNA-Mediated Control of Oligodendrocyte Differentiation
Zhao, X., He, X., Han, X., Yu, Y., Ye, F., Chen, Y., Hoang, T., Xu, X., Mi, Q.-S., Xin, M., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.018 · Cited by 508
Mi, S., Hu, B., Hahm, K., Luo, Y., Hui, E. S. K., Yuan, Q., Wong, W. M., Wang, L., Su, H., Chu, T., et al. (2007) · Nature Medicine · doi:10.1038/nm1664 · Cited by 493
Vesicular release of glutamate from unmyelinated axons in white matter
Ziskin, J. L., Nishiyama, A., Rubio, M. E., Fukaya, M., & Bergles, D. E. (2007) · Nature Neuroscience · doi:10.1038/nn1854 · Cited by 488
Temple, S., & RAFF, M. C. (1986) · Cell · doi:10.1016/0092-8674(86)90843-3 · Cited by 455
Brinkmann, B. G., Agarwal, A., Sereda, M. W., Garratt, A. N., Müller, T. H., Wende, H., Stassart, R. M., Nawaz, S., Humml, C., Velanac, V., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.028 · Cited by 440
Gallo, V., Jm, Z., McBain, C. J., Wright, P., Knutson, P., & Armstrong, R. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-08-02659.1996 · Cited by 411
Spiking and nonspiking classes of oligodendrocyte precursor glia in CNS white matter
Káradóttir, R. T., Hamilton, N. B., Bakiri, Y., & Attwell, D. (2008) · Nature Neuroscience · doi:10.1038/nn2060 · Cited by 385
Richardson, W. D., Kessaris, N., & Pringle, N. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1826 · Cited by 385
Chen, Y., Wu, H., Wang, S., Koito, H., Li, J., Ye, F., Hoang, J., Escobar, S. S., Gow, A., Arnett, H. A., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2410 · Cited by 346
Shen, S., Li, J., & Casaccia‐Bonnefil, P. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200412101 · Cited by 336
Watkins, T. A., Emery, B., Mulinyawe, S. B., & Barres, B. A. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.011 · Cited by 329
Self-citationA G Protein–Coupled Receptor Is Essential for Schwann Cells to Initiate Myelination
Monk, K. R., Naylor, S. G., Glenn, T. D., Mercurio, S., Perlin, J. R., Dominguez, C. X., Moens, C. B., & Talbot, W. S. (2009) · Science · doi:10.1126/science.1173474 · Cited by 326
Ion channel expression by white matter glia: The O-2A glial progenitor cell
Barres, B. A., Koroshetz, W. J., Swartz, K. J., Chun, L. L. Y., & Corey, D. P. (1990) · Neuron · doi:10.1016/0896-6273(90)90109-s · Cited by 306
Charles, P., Hernandez, M. P., Stankoff, B., Aigrot, M. S., Colin, C., Rougon, G., Zalc, B., & Lubetzki, C. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100076197 · Cited by 306
Excitability and synaptic communication within the oligodendrocyte lineage
De Biase, L. M., Nishiyama, A., & Bergles, D. E. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.6000-09.2010 · Cited by 286
The Transcription Factor Yin Yang 1 Is Essential for Oligodendrocyte Progenitor Differentiation
He, Y., Dupree, J. L., Wang, J., Sandoval, J., Li, J., Liu, H., Shi, Y., Nave, K. A., & Casaccia‐Bonnefil, P. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.029 · Cited by 272
Myelination: An Overlooked Mechanism of Synaptic Plasticity?
Fields, R. D. (2005) · The Neuroscientist · doi:10.1177/1073858405282304 · Cited by 261
Miesenböck, G. (2009) · Science · doi:10.1126/science.1174520 · Cited by 257
Calcineurin/NFAT Signaling Is Required for Neuregulin-Regulated Schwann Cell Differentiation
Kao, S.-C., Wu, H., Xie, J., Chang, C.-P., Ranish, J. A., Graef, I. A., & Crabtree, G. R. (2009) · Science · doi:10.1126/science.1166562 · Cited by 218
Fu, H. Q., Qi, Y. B., Tan, M., Cai, J., Takebayashi, H., Nakafuku, M., Richardson, W. D., & Qiu, M. S. (2002) · Development · doi:10.1242/dev.129.3.681 · Cited by 216
Dicer ablation in oligodendrocytes provokes neuronal impairment in mice
Shin, D., Shin, J., McManus, M. T., Ptáček, L. J., & Fu, Y. (2009) · Annals of Neurology · doi:10.1002/ana.21927 · Cited by 213
Sex and environmental influences on the size and ultrastructure of the rat corpus callosum
Juraska, J. M., & Kopcik, J. R. (1988) · Brain Research · doi:10.1016/0006-8993(88)91538-7 · Cited by 208
Adult-born SVZ progenitors receive transient synapses during remyelination in corpus callosum
Etxeberría, A., Mangin, J., Aguirre, A. A., & Gallo, V. (2010) · Nature Neuroscience · doi:10.1038/nn.2500 · Cited by 181
OLIGODENDROGLIA AND ITS RELATION TO CLASSICAL NEUROGLIA
Penfield, W. G. (1924) · Brain · doi:10.1093/brain/47.4.430 · Cited by 173
Regulated Expression of the Neural Cell Adhesion Molecule L1 by Specific Patterns of Neural Impulses
Itoh, K., Stevens, B., Schachner, M., & Fields, R. D. (1995) · Science · doi:10.1126/science.270.5240.1369 · Cited by 166
Stidworthy, M. F. (2004) · Brain · doi:10.1093/brain/awh217 · Cited by 164
Control of oligodendroglial cell number by the miR-17-92 cluster
Budde, H., Schmitt, S., Fitzner, D., Opitz, L., Salinas-Riester, G., & Simons, M. (2010) · Development · doi:10.1242/dev.050633 · Cited by 152
Li, Q., Brus-Ramer, M., Martin, J. H., & McDonald, J. W. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.05.043 · Cited by 150
An Integrin–Contactin Complex Regulates CNS Myelination by Differential Fyn Phosphorylation
Laursen, L. S., Chan, C. W., & ffrench‐Constant, C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5942-08.2009 · Cited by 133
A Matter of Identity: Transcriptional Control in Oligodendrocytes
Wegner, M. (2008) · Journal of Molecular Neuroscience · doi:10.1007/s12031-007-9008-8 · Cited by 131
Fu, H. Q., Cai, J., Clevers, H. C., Fast, E. M., Gray, S., Greenberg, R. S., Jain, M. K., Ma, Q., Qiu, M. S., Rowitch, D. H., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0160-09.2009 · Cited by 126
Physiological characteristics of NG2-expressing glial cells
Lin, S.-C., & Bergles, D. (2002) · Journal of Neurocytology · doi:10.1023/a:1025799816285 · Cited by 96
Crang, A. J., Gilson, J. M., & Blakemore, W. F. (1998) · Journal of Neurocytology · doi:10.1023/a:1006960032023 · Cited by 46
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Frühbeis, C., Fröhlich, D., Kuo, W. P., Amphornrat, J., Thilemann, S., Saab, A. S., Kirchhoff, F., Möbius, W., Goebbels, S., Nave, K.-A., et al. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001604 · Cited by 902
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Metadata
- Authors
- Emery, B.
- Affiliations
- The University of Melbourne (AU)
- Corresponding author
- Emery, Ben
- ORCID
- Emery, Ben
- Venue
- Science
- Published
- 2010-11-05
- Volume
- 330
- Issue
- 6005
- Pages
- 779-782
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2001810970
- Cited by
- 653
- References
- 54
- Citations by year
- 2026: 28 · 2025: 23 · 2024: 37 · 2023: 32 · 2022: 50 · 2021: 46 · 2020: 45 · 2019: 50 · 2018: 32 · 2017: 35 · 2016: 40 · 2015: 54 · 2014: 51 · 2013: 50 · 2012: 39
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- oligodendrocyte differentiation, myelination, myelin gene expression, transcription factors, microRNA, extracellular signaling, myelin plasticity, remyelination, demyelinating disease, multiple sclerosis, central nervous system
- MeSH terms
- Animals, Axons, Cell Differentiation, Central Nervous System, Demyelinating Diseases, Gene Expression Regulation, Humans, Myelin Sheath, Oligodendroglia, Transcription, Genetic, Signal Transduction, MicroRNAs, Chromatin Assembly and Disassembly
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