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Replication-Dependent Loss of 5-Hydroxymethylcytosine in Mouse Preimplantation Embryos
Open accessAbstract
The oxidation product of methylated cytosine is passively lost from DNA in the zygote as cell division progresses.
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“…5hmC/5fC/5caC in the paternal genome can be passively diluted in the presence of maternal DNMT3A proteins during early preimplantation development (Inoue et al., 2011; Inoue and Zhang, 2011), DNMT3A alone may not be sufficient to effectively methylate hemimodified sites (XG:GC, X = hC, fC, or caC).”
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Metadata
- Authors
- Inoue, A., & Zhang, Y.
- Venue
- Science
- Published
- 2011-10-14
- Volume
- 334
- Issue
- 6053
- Pages
- 194-194
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993981510
- Cited by
- 489
- References
- 1
- FWCI
- 26.45
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
