The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
SNARE Proteins: One to Fuse and Three to Keep the Nascent Fusion Pore Open
Open accessAbstract
Facilitating Fusion and Release: For neurotransmitters to be released from a neuron, a synaptic vesicle must fuse with the plasma membrane and form a fusion pore. Soluble N -ethylmaleimide–sensitive factor attachment protein receptor (SNARE) complexes are the core protein machinery involved in fusion; however, there has been debate regarding the mechanism. While in vitro studies have found that a single SNARE can cause fusion of two bilayers, in vivo studies have shown that a minimum of three SNAREs are required for neurotransmitter release. The apparently contradictory results are explained by Shi et al. (p. 1355 ), who monitored fusion of vesicles to membrane nanodiscs. While a single SNARE complex was sufficient to fuse bilayers, a minimum of three SNARE complexes were required to open a pore large enough for neurotransmitter release.
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Südhof, T. C. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131412 · Cited by 2,547
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
Sutton, R. B., Fasshauer, D., Jahn, R., & Brunger, A. T. (1998) · Nature · doi:10.1038/26412 · Cited by 2,417
Molecular anatomy of a trafficking organelle
Takamori, S., Holt, M., Stenius, K., Lemke, E. A., Grønborg, M., Riedel, D., Urlaub, H., Schenck, S., Brügger, B., Ringler, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.10.030 · Cited by 2,373
Cryo-EM structure of the ribosome-SecYE complex in the membrane environment.
Frauenfeld, J., Gumbart, J., Sluis, E. O. V. D., Funes, S., Gartmann, M., Beatrix, B., Mielke, T., Berninghausen, O., Becker, T., Schulten, K., et al. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2026 · Cited by 298
Cited by
Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle
Südhof, T. C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.022 · Cited by 1,197
Single Reconstituted Neuronal SNARE Complexes Zipper in Three Distinct Stages
Gao, Y., Zorman, S., Gundersen, G., Xi, Z., Ma, L., Sirinakis, G., Rothman, J. E., & Zhang, Y. (2012) · Science · doi:10.1126/science.1224492 · Cited by 405
Self-citationThe Synaptic Vesicle Release Machinery
Rizo, J., & Xu, J. (2015) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-060414-034057 · Cited by 339
Synaptic vesicle recycling: steps and principles
Rizzoli, S. O. (2014) · The EMBO Journal · doi:10.1002/embj.201386357 · Cited by 317
The Multifaceted Role of SNARE Proteins in Membrane Fusion
Han, J., Pluhackova, K., & Böckmann, R. A. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00005 · Cited by 285
Metadata
- Authors
- Shi, L., Shen, Q.-T., Kiel, A., Wang, J., Wang, H.-W., Melia, T. J., Rothman, J. E., & Pincet, F.
- Venue
- Science
- Published
- 2012-03-16
- Volume
- 335
- Issue
- 6074
- Pages
- 1355-1359
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2059160047
- Cited by
- 263
- References
- 4
- FWCI
- 12.76
- Type
- journal article
- Language
- en
- Open access
- green
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