The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Imaginal Discs Secrete Insulin-Like Peptide 8 to Mediate Plasticity of Growth and Maturation
Abstract
Small But Perfectly Formed: The imaginal discs of Drosophila represent defined larval tissues that give rise to the subsequent adult appendages. These tissues regenerate in response to damage. When the imaginal discs are injured or show tumor growth, they signal to the rest of the larval animal to slow down growth and delay morphogenesis. Garelli et al. (p. 579 ) and Colombani et al. (p. 582 ) now show that an insulin-like peptide, termed Dilp8, is secreted into the hemolymph (insect “blood”) and participates in the communication between growing organs and the endocrine system to adjust the growth program and maturation time. This collaboration ensures that adults attain the normal size and maintain appropriate proportions and symmetry.
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Cites
Improved Prediction of Signal Peptides: SignalP 3.0
Dyrløv Bendtsen, J., Nielsen, H., von Heijne, G., & Brunak, S. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.05.028 · Cited by 6,350
FLUCTUATING ASYMMETRY: Measurement, Analysis, Patterns
Palmer, A. R., & Strobeck, C. (1986) · Annual Review of Ecology and Systematics · doi:10.1146/annurev.es.17.110186.002135 · Cited by 1,701
Using FlyAtlas to identify better Drosophila melanogaster models of human disease
Chintapalli, V. R., Wang, J., & Dow, J. A. T. (2007) · Nature Genetics · doi:10.1038/ng2049 · Cited by 1,472
Brogiolo, W., Stocker, H., Ikeya, T., Rintelen, F., Fernandez, R., & Hafen, E. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00068-9 · Cited by 1,255
Episodic radiations in the fly tree of life
Wiegmann, B. M., Trautwein, M. D., Winkler, I. S., Barr, N. B., Kim, J.-W., Lambkin, C., Bertone, M. A., Cassel, B. K., Bayless, K. M., Heimberg, A. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012675108 · Cited by 936
Venken, K. J. T., Schulze, K. L., Haelterman, N. A., Pan, H., He, Y., Evans-Holm, M., Carlson, J. W., Levis, R. W., Spradling, A. C., Hoskins, R. A., et al. (2011) · Nature Methods · doi:10.1038/nmeth.1662 · Cited by 675
Antagonistic Actions of Ecdysone and Insulins Determine Final Size in Drosophila
Colombani, J., Bianchini, L., Layalle, S., Pondeville, E., Dauphin-Villemant, C., Antoniewski, C., Carré, C., Noselli, S., & Léopold, P. (2005) · Science · doi:10.1126/science.1119432 · Cited by 618
Jünger, M. A., Rintelen, F., Stocker, H., Wasserman, J. D., Végh, M., Radimerski, T., Greenberg, M. E., & Hafen, E. (2003) · Journal of Biology · doi:10.1186/1475-4924-2-20 · Cited by 601
The control of body size in insects
Nijhout, H. F. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00276-8 · Cited by 384
Regulation of Tissue Growth through Nutrient Sensing
Hietakangas, V., & Cohen, S. M. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134815 · Cited by 330
Cited by
Secreted Peptide Dilp8 Coordinates Drosophila Tissue Growth with Developmental Timing
Colombani, J., Andersen, D. S., & Léopold, P. (2012) · Science · doi:10.1126/science.1216689 · Cited by 521
Drosophila neuroblasts: a model for stem cell biology
Homem, C. C. F., & Knoblich, J. A. (2012) · Development · doi:10.1242/dev.080515 · Cited by 476
Analyzing Fluctuating Asymmetry with Geometric Morphometrics: Concepts, Methods, and Applications
Klingenberg, C. (2015) · Symmetry · doi:10.3390/sym7020843 · Cited by 433
Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior
Nässel, D. R., & Zandawala, M. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.02.003 · Cited by 355
Eat to reproduce: a key role for the insulin signaling pathway in adult insects
Badisco, L., Van Wielendaele, P., & Vanden Broeck, J. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00202 · Cited by 173
Metadata
- Authors
- Garelli, A., Gontijo, A. M., Miguela, V., Caparros, E., & Dominguez, M.
- Venue
- Science
- Published
- 2012-05-04
- Volume
- 336
- Issue
- 6081
- Pages
- 579-582
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1978433149
- Cited by
- 502
- References
- 24
- FWCI
- 15.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Garelli, A., Gontijo, A. M., Miguela, V., Caparros, E., & Dominguez, M. (2012). Imaginal Discs Secrete Insulin-Like Peptide 8 to Mediate Plasticity of Growth and Maturation. Science. https://doi.org/10.1126/science.1216735
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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