Cited by 1,073Gut microbiota and healthInflammatory Bowel DiseaseImmune Response and Inflammation

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Interactions Between Commensal Fungi and the C-Type Lectin Receptor Dectin-1 Influence Colitis

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Iliev, Iliyan D., Funari, Vincent A., Taylor, Kent D., Nguyen, Quoclinh, Reyes, Christopher N., Strom, Samuel P., Brown, Jordan, Becker, Courtney A., Fleshner, Phillip R., Dubinsky, Marla, Rotter, Jerome I., Wang, Hanlin L., McGovern, Dermot P. B., Brown, Gordon D., Underhill, David M.·2012·Science

DOI 10.1126/science.1221789PMC PMC3432565

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Abstract

The intestinal microflora, typically equated with bacteria, influences diseases such as obesity and inflammatory bowel disease. Here, we show that the mammalian gut contains a rich fungal community that interacts with the immune system through the innate immune receptor Dectin-1. Mice lacking Dectin-1 exhibited increased susceptibility to chemically induced colitis, which was the result of altered responses to indigenous fungi. In humans, we identified a polymorphism in the gene for Dectin-1 (CLEC7A) that is strongly linked to a severe form of ulcerative colitis. Together, our findings reveal a eukaryotic fungal community in the gut (the "mycobiome") that coexists with bacteria and substantially expands the repertoire of organisms interacting with the intestinal immune system to influence health and disease.

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Authors: Iliev, I. D., Funari, V. A., Taylor, K. D., Nguyen, Q., Reyes, C. N., Strom, S. P., Brown, J., Becker, C. A., Fleshner, P. R., Dubinsky, M., Rotter, J. I., Wang, H. L., McGovern, D. P. B., Brown, G. D., & Underhill, D. M.
Affiliations: Cedars-Sinai Medical Center (US)
University of California, Los Angeles (US)
University of Aberdeen (GB)
Corresponding author: Underhill, David M.
ORCID: Iliev, Iliyan D.
Funari, Vincent A.
Taylor, Kent D.
Strom, Samuel P.
Brown, Jordan
Becker, Courtney A.
Fleshner, Phillip R.
Dubinsky, Marla
Rotter, Jerome I.
Wang, Hanlin L.
McGovern, Dermot P. B.
Brown, Gordon D.
Underhill, David M.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2012-06-08
Volume: 336
Issue: 6086
Pages: 1314-1317
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1221789
PMC: PMC3432565
OpenAlex: W2036743290
Cited by: 1,073
References: 40
Citations by year: 2026: 36 · 2025: 64 · 2024: 54 · 2023: 74 · 2022: 75 · 2021: 111 · 2020: 79 · 2019: 98 · 2018: 70 · 2017: 84 · 2016: 67 · 2015: 67 · 2014: 84 · 2013: 88 · 2012: 22
FWCI: 33.53
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: Wellcome Trust (086558)
Crohn's and Colitis Foundation
National Institutes of Health (1ul1rr033176-01, UL1TR000124)
National Institute of Allergy and Infectious Diseases (AI071116, R01AI071116)
National Institute of Diabetes and Digestive and Kidney Diseases (P01DK046763, R01DK093426)
National Center for Research Resources (UL1-RR-033176)
National Center for Advancing Translational Sciences
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: Dectin-1, commensal fungi, fungal communities, colitis, ulcerative colitis, innate immunity, intestinal immunity, chemically induced colitis, genetic polymorphism, inflammatory bowel disease
MeSH terms: Dectin-1, Animals, Antibodies, Fungal, Colitis, Ulcerative, Colon, Disease Susceptibility, Female, Fungi, Haplotypes, Humans, Immunity, Innate, Intestinal Mucosa, Intestines, Mice, Inbred C57BL, Colony Count, Microbial, Dextran Sulfate, Immunity, Mucosal, Polymorphism, Single Nucleotide, Lectins, C-Type, Candida tropicalis, Mice, Metagenome

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Interactions Between Commensal Fungi and the C-Type Lectin Receptor Dectin-1 Influence Colitis

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