The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Interactions Between Commensal Fungi and the C-Type Lectin Receptor Dectin-1 Influence Colitis
Open accessAbstract
The intestinal microflora, typically equated with bacteria, influences diseases such as obesity and inflammatory bowel disease. Here, we show that the mammalian gut contains a rich fungal community that interacts with the immune system through the innate immune receptor Dectin-1. Mice lacking Dectin-1 exhibited increased susceptibility to chemically induced colitis, which was the result of altered responses to indigenous fungi. In humans, we identified a polymorphism in the gene for Dectin-1 (CLEC7A) that is strongly linked to a severe form of ulcerative colitis. Together, our findings reveal a eukaryotic fungal community in the gut (the "mycobiome") that coexists with bacteria and substantially expands the repertoire of organisms interacting with the intestinal immune system to influence health and disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A recent study49 demonstrated that mice lacking Dectin1 had increased susceptibility to chemically induced colitis, due to their altered responses to indigenous fungi.”
From Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease (2014) · cites this paper as [49]
In the citing paper
“diet might also affect intestinal fungal communities, which have been associated with pathogenesis of inflammatory bowel diseases (IBD)49.”
From Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease (2014) · cites this paper as [49]
In the citing paper
“a polymorphism in the gene encoding Dectin1 (CLEC7A) was associated with a severe form of ulcerative colitis in humans49.”
From Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease (2014) · cites this paper as [49]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
<tt>BLAT</tt> —The <tt>BLAST</tt> -Like Alignment Tool
Kent, W. J. (2002) · Genome Research · doi:10.1101/gr.229202 · Cited by 8,480
Enterotypes of the human gut microbiome
MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548
A New Statistical Method for Haplotype Reconstruction from Population Data
Stephens, M., Smith, N. J. C., & Donnelly, P. (2001) · The American Journal of Human Genetics · doi:10.1086/319501 · Cited by 7,512
Multiple sequence alignment with the Clustal series of programs
Chenna, R. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg500 · Cited by 4,905
The Cardiovascular Health Study: design and rationale.
Fried, L. P., Borhani, N. O., Enright, P., Furberg, C. D., Gardin, J. M., Kronmal, R. A., Kuller, L. H., Manolio, T. A., Mittelmark, M. B., Newman, A., et al. (1991) · Annals of Epidemiology · doi:10.1016/1047-2797(91)90005-w · Cited by 3,652
A Comparison of Bayesian Methods for Haplotype Reconstruction from Population Genotype Data
Stephens, M., & Donnelly, P. (2003) · The American Journal of Human Genetics · doi:10.1086/379378 · Cited by 3,516
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
Henao-Mejia, J., Elinav, E., Jin, C., Hao, L., Mehal, W. Z., Strowig, T., Thaiss, C. A., Kau, A. L., Eisenbarth, S. C., Jurczak, M. J., et al. (2012) · Nature · doi:10.1038/nature10809 · Cited by 2,435
Cited by
Sorted by citations
Role of the microbiota in immunity and inflammation.
Belkaid, Y., & Hand, T. W. (2014) · Cell · doi:10.1016/j.cell.2014.03.011 · Cited by 5,385
Hidden Killers: Human Fungal Infections
Brown, G. D., Denning, D. W., Gow, N. A. R., Levitz, S. M., Netea, M. G., & White, T. C. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004404 · Cited by 4,284
Self-citationZelante, T., Iannitti, R. G., Cunha, C., De Luca, A., Giovannini, G., Pieraccini, G., Zecchi, R., D’Angelo, C., Massi-Benedetti, C., Fallarino, F., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.003 · Cited by 2,614
The microbiome and innate immunity
Thaiss, C. A., Zmora, N., Levy, M., & Elinav, E. (2016) · Nature · doi:10.1038/nature18847 · Cited by 2,012
Gut microbiota and IBD: causation or correlation?
Ni, J., Wu, G. D., Albenberg, L., & Tomov, V. T. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.88 · Cited by 1,778
Epidemiology and risk factors for IBD
Ananthakrishnan, A. N. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.34 · Cited by 1,741
Lamas, B., Richard, M. L., Leducq, V., Pham, H.-P., Michel, M.-L., Da Costa, G., Bridonneau, C., Jegou, S., Hoffmann, T. W., Natividad, J. M., et al. (2016) · Nature Medicine · doi:10.1038/nm.4102 · Cited by 1,482
Fungal microbiota dysbiosis in IBD
Sokol, H., Leducq, V., Aschard, H., Pham, H., Jégou, S., Landman, C., Cohen, D., Liguori, G., Bourrier, A., Nion–Larmurier, I., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-310746 · Cited by 1,382
Homeostatic Immunity and the Microbiota
Belkaid, Y., & Harrison, O. J. (2017) · Immunity · doi:10.1016/j.immuni.2017.04.008 · Cited by 1,261
Topographic diversity of fungal and bacterial communities in human skin
NIH Intramural Sequencing Center Comparative Sequencing Program, Findley, K., Oh, J., Yang, J., Conlan, S., Deming, C., Meyer, J. A., Schoenfeld, D., Nomicos, E., Park, M., et al. (2013) · Nature · doi:10.1038/nature12171 · Cited by 1,206
Defining dysbiosis and its influence on host immunity and disease
Petersen, C., & Round, J. L. (2014) · Cellular Microbiology · doi:10.1111/cmi.12308 · Cited by 1,249
New evidences on the altered gut microbiota in autism spectrum disorders
Strati, F., Cavalieri, D., Albanese, D., De Felice, C., Donati, C., Hayek, J., Jousson, O., Leoncini, S., Renzi, D., Calabrò, A., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0242-1 · Cited by 1,040
The gut mycobiome of the Human Microbiome Project healthy cohort
Nash, A. K., Auchtung, T. A., Wong, M. C., Smith, D. P., Gesell, J. R., Ross, M. C., Stewart, C. J., Metcalf, G., Muzny, D. M., Gibbs, R. A., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0373-4 · Cited by 1,039
The microbiome and inflammatory bowel disease
Glassner, K. L., Abraham, B. P., & Quigley, E. M. M. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.11.003 · Cited by 875
Lewis, J. D., Chen, E. Z., Baldassano, R. N., Otley, A. R., Griffiths, A. M., Lee, D., Bittinger, K., Bailey, A., Friedman, E. S., Hoffmann, C., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.09.008 · Cited by 823
The effect of host genetics on the gut microbiome
Bonder, M. J., Kurilshikov, A., Tigchelaar, E. F., Mujagic, Z., Imhann, F., Vila, A. V., Deelen, P., Vatanen, T., Schirmer, M., Smeekens, S. P., et al. (2016) · Nature Genetics · doi:10.1038/ng.3663 · Cited by 819
Archaea and fungi of the human gut microbiome: correlations with diet and bacterial residents
Hoffmann, C., Dollive, S., Grunberg, S., Chen, J., Li, H., Wu, G. D., Lewis, J. D., & Bushman, F. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066019 · Cited by 808
“Recent work using a murine model has suggested that normally mutualistic or commensal fungi species may exacerbate intestinal inflammation in mice with sensitized genotypes [33].”
BackgroundSartor, R. B., & Wu, G. D. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.10.012 · Cited by 808
Host–microbiota interactions in inflammatory bowel disease
Caruso, R., Lo, B. C., & Núñez, G. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-019-0268-7 · Cited by 808
C-type lectins in immunity and homeostasis
Brown, G. D., Willment, J. A., & Whitehead, L. (2018) · Nature reviews. Immunology · doi:10.1038/s41577-018-0004-8 · Cited by 772
Self-citationExperimental Models of Inflammatory Bowel Diseases
Kiesler, P., Fuss, I. J., & Strober, W. (2015) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2015.01.006 · Cited by 743
Dyken, S. J. V., & Locksley, R. M. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095906 · Cited by 743
Goodrich, J. K., Di Rienzi, S. C., Poole, A. C., Koren, O., Walters, W. A., Caporaso, J. G., Knight, R., & Ley, R. E. (2014) · Cell · doi:10.1016/j.cell.2014.06.037 · Cited by 714
The mycobiota: interactions between commensal fungi and the host immune system
Underhill, D. M., & Iliev, I. D. (2014) · Nature reviews. Immunology · doi:10.1038/nri3684 · Cited by 721
Self-citationThe gut microbiome: connecting spatial organization to function
Tropini, C., Earle, K. A., Huang, K. C., & Sonnenburg, J. L. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.03.010 · Cited by 685
Regulation of inflammation by microbiota interactions with the host
Blander, J. M., Longman, R., Iliev, I. D., Sonnenberg, G. F., & Artis, D. (2017) · Nature Immunology · doi:10.1038/ni.3780 · Cited by 654
Self-citationInflammatory bowel diseases (IBD) and the microbiome-searching the crime scene for clues
Lee, M., & Chang, E. B. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.09.056 · Cited by 645
Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals
Shan, M., Gentile, M., Yeiser, J. R., Walland, A. C., Bornstein, V. U., Chen, K., He, B., Cassis, L., Bigas, A., Cols, M., et al. (2013) · Science · doi:10.1126/science.1237910 · Cited by 642
Immune defence against Candida fungal infections
Netea, M. G., Joosten, L. A. B., van der Meer, J. W. M., Kullberg, B.-J., & van de Veerdonk, F. L. (2015) · Nature Reviews Immunology · doi:10.1038/nri3897 · Cited by 642
Chen, J., Peng, H., Wang, X., Shao, F., Yuan, Z., & Han, H. (2013) · Nanoscale · doi:10.1039/c3nr04941h · Cited by 614
Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease
Albenberg, L. G., & Wu, G. D. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.058 · Cited by 606
The Virome in Mammalian Physiology and Disease
Virgin, H. W. (2014) · Cell · doi:10.1016/j.cell.2014.02.032 · Cited by 603
The Gut Microbiota in the Pathogenesis and Therapeutics of Inflammatory Bowel Disease
Zuo, T., & Ng, S. C. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02247 · Cited by 605
Immunopathology of inflammatory bowel disease
Wallace, K. L. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i1.6 · Cited by 593
Microbial Ecology along the Gastrointestinal Tract
Hillman, E. T., Lu, H., Yao, T., & Nakatsu, C. H. (2017) · Microbes and Environments · doi:10.1264/jsme2.me17017 · Cited by 614
The emerging world of the fungal microbiome
Huffnagle, G. B., & Noverr, M. C. (2013) · Trends in Microbiology · doi:10.1016/j.tim.2013.04.002 · Cited by 582
Inflammation and colorectal cancer: colitis-associated neoplasia
Grivennikov, S. I. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-012-0352-6 · Cited by 574
Structure and function of the human skin microbiome
Schommer, N. N., & Gallo, R. L. (2013) · Trends in Microbiology · doi:10.1016/j.tim.2013.10.001 · Cited by 561
Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions
Narunsky-Haziza, L., Sepich-Poore, G. D., Livyatan, I., Asraf, O., Martino, C., Nejman, D., Gavert, N., Stajich, J. E., Amit, G., González, A., et al. (2022) · Cell · doi:10.1016/j.cell.2022.09.005 · Cited by 538
“(G) Principal coordinate analysis (PCoA) of Jaccard dissimilarities between comp Since fungi and bacteria elicit unique host immune responses (Aykut et al., 2019; Iliev et al., 2012; Jain et al., 2021; Ost et al., 2021; Sepich-Poore et al., 2021; Shiao et al., 2021; Underhill and Iliev, 2014; Wolf and Underhill, 2018)…”
BackgroundHuman genetic variation and the gut microbiome in disease
Hall, A. B., Tolonen, A. C., & Xavier, R. J. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.63 · Cited by 517
Enteric fungal microbiota dysbiosis and ecological alterations in colorectal cancer
Coker, O. O., Nakatsu, G., Dai, R. Z., Wu, W. K. K., Wong, S. H., Ng, S. C., Chan, F. K. L., Sung, J. J. Y., & Yu, J. (2019) · Gut · doi:10.1136/gutjnl-2018-317178 · Cited by 511
Host–microbiota interactions in immune-mediated diseases
Ruff, W. E., Greiling, T. M., & Kriegel, M. A. (2020) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0367-2 · Cited by 503
C-type lectins in immunity: recent developments
Dambuza, I. M., & Brown, G. D. (2015) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.12.002 · Cited by 482
Self-citationBacteriome and Mycobiome Interactions Underscore Microbial Dysbiosis in Familial Crohn’s Disease
Hoarau, G., Mukherjee, P. K., Gower‐Rousseau, C., Hager, C. L., Chandra, J., Retuerto, M. A., Neut, C., Vermeire, S., Clemente, J. C., Colombel, J., et al. (2016) · mBio · doi:10.1128/mbio.01250-16 · Cited by 499
IL-12, IL-23 and IL-17 in IBD: immunobiology and therapeutic targeting
Moschen, A. R., Tilg, H., & Raine, T. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0084-8 · Cited by 488
Intestinal fungi contribute to development of alcoholic liver disease
Yang, A., Inamine, T., Hochrath, K., Chen, P., Wang, L., Llorente, C., Bluemel, S., Hartmann, P., Xu, J., Koyama, Y., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90562 · Cited by 470
Self-citationMalassezia Is Associated with Crohn’s Disease and Exacerbates Colitis in Mouse Models
Limon, J. J., Tang, J., Li, D., Wolf, A. J., Michelsen, K. S., Funari, V., Gargus, M. D., Nguyen, C., Sharma, P., Maymí, V. I., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.01.007 · Cited by 463
Self-citationLung microbiome: new insights into the pathogenesis of respiratory diseases
Li, R., Li, J., & Zhou, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01722-y · Cited by 483
Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization
Fan, D., Coughlin, L. A., Neubauer, M. M., Kim, J., Kim, M. S., Zhan, X., Simms-Waldrip, T. R., Xie, Y., Hooper, L. V., & Koh, A. Y. (2015) · Nature Medicine · doi:10.1038/nm.3871 · Cited by 426
Intestinal Commensal Microbes as Immune Modulators
Ivanov, I. I., & Honda, K. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.09.009 · Cited by 437
Immunological Consequences of Intestinal Fungal Dysbiosis
Wheeler, M. L., Limon, J. J., Bar, A. S., Leal, C. A., Gargus, M. D., Tang, J., Brown, J. S., Funari, V. A., Wang, H. L., Crother, T. R., et al. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.05.003 · Cited by 427
Self-citationThe Gut Microbiome and Inflammatory Bowel Diseases
Shan, Y., Lee, M., & Chang, E. B. (2021) · Annual Review of Medicine · doi:10.1146/annurev-med-042320-021020 · Cited by 447
N-Acetylglucosamine Functions in Cell Signaling
Konopka, J. B. (2012) · Scientifica · doi:10.6064/2012/489208 · Cited by 422
Commensal microbes and interferon-λ determine persistence of enteric murine norovirus infection
Baldridge, M. T., Nice, T. J., McCune, B. T., Yokoyama, C. C., Kambal, A., Wheadon, M. J., Diamond, M., Ivanova, Y., Artyomov, M. N., & Virgin, H. W. (2014) · Science · doi:10.1126/science.1258025 · Cited by 419
Richard, M. L., & Sokol, H. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0121-2 · Cited by 428
Zhang, F., Aschenbrenner, D., Yoo, J. Y., & Zuo, T. (2022) · The Lancet Microbe · doi:10.1016/s2666-5247(22)00203-8 · Cited by 424
Fungal dysbiosis: immunity and interactions at mucosal barriers
Iliev, I. D., & Leonardi, I. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.55 · Cited by 400
Self-citationIntestinal flora and disease mutually shape the regional immune system in the intestinal tract
Zhou, B., Yuan, Y., Zhang, S., Guo, C., Li, X., Li, G., Xiong, W., & Zeng, Z. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00575 · Cited by 396
Compartmentalized and systemic control of tissue immunity by commensals
Belkaid, Y., & Naik, S. (2013) · Nature Immunology · doi:10.1038/ni.2604 · Cited by 382
The human mycobiome in health and disease
Cui, L., Morris, A., & Ghedin, E. (2013) · Genome Medicine · doi:10.1186/gm467 · Cited by 394
Immune responses to human fungal pathogens and therapeutic prospects
Lionakis, M. S., Drummond, R. A., & Hohl, T. M. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-022-00826-w · Cited by 379
Kim, Y.-G., Udayanga, K. G. S., Totsuka, N., Weinberg, J. B., Núñez, G., & Shibuya, A. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2013.12.010 · Cited by 366
Trained Immunity: Reprogramming Innate Immunity in Health and Disease
Bekkering, S., Domínguez‐Andrés, J., Joosten, L. A. B., Riksen, N. P., & Netea, M. G. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-102119-073855 · Cited by 360
Zhu, L., Zhao, X.-Q., Jiang, C., You, Y., Chen, X., Jiang, Y.-Y., Jia, X., & Lin, X. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.017 · Cited by 347
Mukherjee, P. K., Chandra, J., Retuerto, M., Sikaroodi, M., Brown, R. E., Jurevic, R., Salata, R. A., Lederman, M. M., Gillevet, P. M., & Ghannoum, M. A. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1003996 · Cited by 337
Commensal Fungi in Health and Disease
Limon, J. J., Skalski, J. H., & Underhill, D. M. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.07.002 · Cited by 336
Self-citationFungal Dysbiosis in Mucosa-associated Microbiota of Crohn’s Disease Patients
Liguori, G., Lamas, B., Richard, M. L., Brandi, G., Costa, G. D., Hoffmann, T. W., Simone, M. P. D., Calabrese, C., Poggioli, G., Langella, P., et al. (2015) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjv209 · Cited by 344
Hu, J., Ma, L., Nie, Y., Chen, J., Zheng, W., Wang, X., Xie, C., Zheng, Z., Wang, Z., Yang, T., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.11.006 · Cited by 339
Antimicrobial Defense of the Intestine
Mukherjee, S., & Hooper, L. V. (2015) · Immunity · doi:10.1016/j.immuni.2014.12.028 · Cited by 334
Modulation of immune development and function by intestinal microbiota
Kabat, A. M., Srinivasan, N., & Maloy, K. J. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.07.010 · Cited by 320
Host Genetics and Gut Microbiome: Challenges and Perspectives
Kurilshikov, A., Wijmenga, C., Fu, J., & Zhernakova, A. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.06.003 · Cited by 309
Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity
Leonardi, I., Gao, I. H., Lin, W.-Y., Allen, M., Li, X. V., Fiers, W. D., De Celie, M. B., Putzel, G. G., Yantiss, R. K., Johncilla, M., et al. (2022) · Cell · doi:10.1016/j.cell.2022.01.017 · Cited by 307
Self-citationLiu, N.-N., Jiao, N., Tan, J.-C., Wang, Z., Wu, D., Wang, A.-J., Chen, J., Tao, L., Zhou, C., Fang, W., et al. (2022) · Nature Microbiology · doi:10.1038/s41564-021-01030-7 · Cited by 306
Self-citationIL-17–Mediated Immunity to the Opportunistic Fungal Pathogen Candida albicans
Conti, H. R., & Gaffen, S. L. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500909 · Cited by 301
Commensal Fungi Recapitulate the Protective Benefits of Intestinal Bacteria
Jiang, T. T., Shao, T., Ang, W. X. G., Kinder, J. M., Turner, L. H., Pham, G. H., Whitt, J., Alenghat, T., & Way, S. S. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.10.013 · Cited by 301
Control of Immunity by the Microbiota
Ansaldo, E., Farley, T. K., & Belkaid, Y. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-093019-112348 · Cited by 312
Pathogenesis of Inflammatory Bowel Disease and Recent Advances in Biologic Therapies
Kim, D. H., & Cheon, J. H. (2017) · Immune Network · doi:10.4110/in.2017.17.1.25 · Cited by 295
Urbanization and the gut microbiota in health and inflammatory bowel disease
Zuo, T., Kamm, M. A., Colombel, J., & Ng, S. C. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0003-z · Cited by 298
Investigating Colonization of the Healthy Adult Gastrointestinal Tract by Fungi
Auchtung, T. A., Fofanova, T. Y., Stewart, C. J., Nash, A. K., Wong, M. C., Gesell, J. R., Auchtung, J. M., Ajami, N. J., & Petrosino, J. F. (2018) · mSphere · doi:10.1128/msphere.00092-18 · Cited by 296
CX3CR1 + mononuclear phagocytes control immunity to intestinal fungi
Leonardi, I., Li, X., Semon, A., Li, D., Doron, I., Putzel, G., Bar, A., Prieto, D., Rescigno, M., McGovern, D. P. B., et al. (2018) · Science · doi:10.1126/science.aao1503 · Cited by 289
Self-citationAn integrative view of microbiome-host interactions in inflammatory bowel diseases
Wlodarska, M., Kostic, A. D., & Xavier, R. J. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.008 · Cited by 287
Tang, C., Kamiya, T., Liu, Y., Kadoki, M., Kakuta, S., Oshima, K., Hattori, M., Takeshita, K., Kanai, T., Saijo, S., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.07.003 · Cited by 285
Monk, B. C., Tomasiak, T. M., Keniya, M. V., Huschmann, F. U., Tyndall, J. D. A., O’Connell, J. D., Cannon, R. D., McDonald, J. G., Rodriguez, A. I., Finer-Moore, J. S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1324245111 · Cited by 295
Gut Microbiota beyond Bacteria—Mycobiome, Virome, Archaeome, and Eukaryotic Parasites in IBD
Matijašić, M., Meštrović, T., Paljetak, H. Č., Perić, M., Barešić, A., & Verbanac, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082668 · Cited by 315
Handley, S. A., Thackray, L. B., Zhao, G., Presti, R. M., Miller, A. D., Droit, L., Abbink, P., Maxfield, L. F., Kambal, A., Duan, E., et al. (2012) · Cell · doi:10.1016/j.cell.2012.09.024 · Cited by 280
Forgotten fungi—the gut mycobiome in human health and disease
Huseyin, C. E., O’Toole, P. W., Cotter, P. D., & Scanlan, P. D. (2017) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuw047 · Cited by 284
Commensal bacteria and fungi differentially regulate tumor responses to radiation therapy
Shiao, S. L., Kershaw, K. M., Limon, J. J., You, S., Yoon, J., Ko, E. Y., Guarnerio, J., Potdar, A. A., McGovern, D. P. B., Bose, S., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.07.002 · Cited by 285
Self-citationMetagenomics for pathogen detection in public health
Miller, R. R., Montoya, V., Gardy, J. L., Patrick, D. M., & Tang, P. (2013) · Genome Medicine · doi:10.1186/gm485 · Cited by 274
Obesity changes the human gut mycobiome
Rodríguez, M. M., Pérez, D., Chaves, F. J., Esteve, E., Marín-García, P., Xifra, G., Vendrell, J. J., Jové, M., Pamplona, R., Ricart, W., et al. (2015) · Scientific Reports · doi:10.1038/srep14600 · Cited by 276
Lactate signalling regulates fungal β-glucan masking and immune evasion
Ballou, E. R., Avelar, G. M., Childers, D. S., Mackie, J., Bain, J. M., Wagener, J., Kastora, S. L., Panea, M. D., Hardison, S. E., Walker, L. A., et al. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.238 · Cited by 269
Self-citationFungal Signature in the Gut Microbiota of Pediatric Patients With Inflammatory Bowel Disease
Chehoud, C., Albenberg, L. G., Judge-Golden, C. P., Hoffmann, C., Grunberg, S., Bittinger, K. L., Baldassano, R. N., Lewis, J. D., Bushman, F. D., & Wu, G. D. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000454 · Cited by 265
The microbiome in inflammatory bowel diseases: from pathogenesis to therapy
Liu, S., Zhao, W., Lan, P., & Mou, X. (2020) · Protein & Cell · doi:10.1007/s13238-020-00745-3 · Cited by 279
Signalling C ‐Type lectin receptors, microbial recognition and immunity
Hoving, J. C., Wilson, G. J., & Brown, G. D. (2013) · Cellular Microbiology · doi:10.1111/cmi.12249 · Cited by 262
Self-citationScanlan, P. D., Stensvold, C. R., Rajilić-Stojanović, M. D., Heilig, H. G. H. J., de Vos, W. M., O’Toole, P. W., & Cotter, P. D. (2014) · FEMS Microbiology Ecology · doi:10.1111/1574-6941.12396 · Cited by 261
The lung mycobiome: an emerging field of the human respiratory microbiome
Nguyen, L. D. N., Viscogliosi, E., & Delhaes, L. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00089 · Cited by 260
C-type lectins: their network and roles in pathogen recognition and immunity
Mayer, S., Raulf, M., & Lepenies, B. (2016) · Histochemistry and Cell Biology · doi:10.1007/s00418-016-1523-7 · Cited by 263
Zuo, T., Wong, S. H., Cheung, C. P., Lam, K., Lui, R. N.-S., Cheung, K., Zhang, F., Tang, W., Ching, J. Y. L., Wu, J. C. Y., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06103-6 · Cited by 262
Oral-resident natural Th17 cells and γδ T cells control opportunistic Candida albicans infections
Conti, H. R., Peterson, A. C., Brane, L., Huppler, A. R., Hernández-Santos, N., Whibley, N., Garg, A. V., Simpson-Abelson, M. R., Gibson, G. A., Mamo, A. J., et al. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20130877 · Cited by 254
Intestinal fungi are causally implicated in microbiome assembly and immune development in mice
Bernardes, E. V. T., Pettersen, V. K., Gutierrez, M. W., Laforest‐Lapointe, I., Jendzjowsky, N. G., Cavin, J., Vicentini, F., Keenan, C. M., Ramay, H. R., Samara, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16431-1 · Cited by 254
Gut Mycobiota in Immunity and Inflammatory Disease
Li, X. V., Leonardi, I., & Iliev, I. D. (2019) · Immunity · doi:10.1016/j.immuni.2019.05.023 · Cited by 246
Self-citation
Metadata
- Authors
- Iliev, I. D., Funari, V. A., Taylor, K. D., Nguyen, Q., Reyes, C. N., Strom, S. P., Brown, J., Becker, C. A., Fleshner, P. R., Dubinsky, M., Rotter, J. I., Wang, H. L., McGovern, D. P. B., Brown, G. D., & Underhill, D. M.
- Affiliations
- Cedars-Sinai Medical Center (US)
- University of California, Los Angeles (US)
- University of Aberdeen (GB)
- Corresponding author
- Underhill, David M.
- ORCID
- Venue
- Science
- Published
- 2012-06-08
- Volume
- 336
- Issue
- 6086
- Pages
- 1314-1317
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3432565
- OpenAlex
- W2036743290
- Cited by
- 1,073
- References
- 40
- Citations by year
- 2026: 36 · 2025: 64 · 2024: 54 · 2023: 74 · 2022: 75 · 2021: 111 · 2020: 79 · 2019: 98 · 2018: 70 · 2017: 84 · 2016: 67 · 2015: 67 · 2014: 84 · 2013: 88 · 2012: 22
- FWCI
- 33.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust (086558)
- Crohn's and Colitis Foundation
- National Institutes of Health (1ul1rr033176-01, UL1TR000124)
- National Institute of Allergy and Infectious Diseases (AI071116, R01AI071116)
- National Institute of Diabetes and Digestive and Kidney Diseases (P01DK046763, R01DK093426)
- National Center for Research Resources (UL1-RR-033176)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- Dectin-1, commensal fungi, fungal communities, colitis, ulcerative colitis, innate immunity, intestinal immunity, chemically induced colitis, genetic polymorphism, inflammatory bowel disease
- MeSH terms
- Dectin-1, Animals, Antibodies, Fungal, Colitis, Ulcerative, Colon, Disease Susceptibility, Female, Fungi, Haplotypes, Humans, Immunity, Innate, Intestinal Mucosa, Intestines, Mice, Inbred C57BL, Colony Count, Microbial, Dextran Sulfate, Immunity, Mucosal, Polymorphism, Single Nucleotide, Lectins, C-Type, Candida tropicalis, Mice, Metagenome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
