Interleukin-13 drives metabolic conditioning of muscle to endurance exercise

Improved vectors and genome-wide libraries for CRISPR screening

Sanjana, N. E., Shalem, O., & Zhang, F. (2014) · Nature Methods · doi:10.1038/nmeth.3047 · Cited by 5,239 · see citing works

Genome-scale CRISPR-Cas9 knockout screening in human cells

Shalem, O., Sanjana, N. E., Hartenian, E., Shi, X., Scott, D. A., Mikkelsen, T. S., Heckl, D., Ebert, B. L., Root, D. E., Doench, J. G., et al. (2014) · Science · doi:10.1126/science.1247005 · Cited by 5,234 · see citing works

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

McCarthy, D. J., Chen, Y., & Smyth, G. K. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks042 · Cited by 5,195 · see citing works

Muscles, exercise and obesity: skeletal muscle as a secretory organ

Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.49 · Cited by 2,909 · see citing works

Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation

Egan, B., & Zierath, J. R. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.012 · Cited by 2,084 · see citing works

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

Neill, D. R., Wong, S. H., Bellosi, A., Flynn, R. J., Daly, M. G., Langford, T. K. A., Bucks, C. M., Kane, C. M., Fallon, P. G., Pannell, R., et al. (2010) · Nature · doi:10.1038/nature08900 · Cited by 2,079 · see citing works

AMPK and PPARδ Agonists Are Exercise Mimetics

Narkar, V. A., Downes, M., Yu, R. T., Embler, E., Wang, Y.-X., Banayo, E., Mihaylova, M. M., Nelson, M. C., Zou, Y., Juguilon, H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.06.051 · Cited by 1,222 · see citing works

Type 2 innate lymphoid cells control eosinophil homeostasis

Nussbaum, J. C., Dyken, S. J. V., von Moltke, J., Cheng, L. E., Mohapatra, A., Molofsky, A. B., Thornton, E. E., Krummel, M. F., Chawla, A., Liang, H.-E., et al. (2013) · Nature · doi:10.1038/nature12526 · Cited by 1,069 · see citing works

Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis

Lee, M.-W., Odegaard, J. I., Mukundan, L., Qiu, Y., Molofsky, A. B., Nussbaum, J. C., Yun, K. M., Locksley, R. M., & Chawla, A. (2014) · Cell · doi:10.1016/j.cell.2014.12.011 · Cited by 680 · see citing works

Correction: Stat3 Activation Is Responsible for IL-6–Dependent T Cell Proliferation through Preventing Apoptosis: Generation and Characterization of T Cell–Specific Stat3-Deficient Mice

Takeda, K., Kaisho, T., Yoshida, N., Takeda, J., Kishimoto, T., & Akira, S. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500168 · Cited by 616 · see citing works

Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice

Takeda, K., Kaisho, T., Yoshida, N., Takeda, J., Kishimoto, T., & Akira, S. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.9.4652 · Cited by 584 · see citing works

Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells

Kuswanto, W. F., Burzyn, D., Panduro, M., Wang, K. K., Jang, Y. C., Wagers, A. J., Benoist, C. O., & Mathis, D. J. (2016) · Immunity · doi:10.1016/j.immuni.2016.01.009 · Cited by 509 · see citing works

Estrogen-Related Receptor α Directs Peroxisome Proliferator-Activated Receptor α Signaling in the Transcriptional Control of Energy Metabolism in Cardiac and Skeletal Muscle

Huss, J. M., Pineda‐Torra, I., Staels, B., Giguère, V., & Kelly, D. P. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.9079-9091.2004 · Cited by 485 · see citing works

Genome-wide Orchestration of Cardiac Functions by the Orphan Nuclear Receptors ERRα and γ

Dufour, C. R., Wilson, B. J., Huss, J. M., Kelly, D. P., Alaynick, W. A., Downes, M., Evans, R. M., Blanchette, M., & Giguère, V. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.03.007 · Cited by 418 · see citing works

Hepatic Bmal1 Regulates Rhythmic Mitochondrial Dynamics and Promotes Metabolic Fitness

Jacobi, D., Liu, S., Burkewitz, K., Kory, N., Knudsen, N. H., Alexander, R., Ünlütürk, U., Li, X., Kong, X., Hyde, A. L., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.08.006 · Cited by 411 · see citing works

Attention to Background Strain Is Essential for Metabolic Research: C57BL/6 and the International Knockout Mouse Consortium

Fontaine, D. A., & Davis, D. B. (2015) · Diabetes · doi:10.2337/db15-0982 · Cited by 233 · see citing works

Distinct immunocyte-promoting and adipocyte-generating stromal components coordinate adipose tissue immune and metabolic tenors

Spallanzani, R. G., Zemmour, D., Xiao, T., Jayewickreme, T., Li, C., Bryce, P. J., Benoist, C. O., & Mathis, D. J. (2019) · Science Immunology · doi:10.1126/sciimmunol.aaw3658 · Cited by 228 · see citing works

Stromal cells maintain immune cell homeostasis in adipose tissue via production of interleukin-33

Mahlakõiv, T., Flamar, A.-L., Johnston, L. K., Moriyama, S., Putzel, G., Bryce, P. J., & Artis, D. (2019) · Science Immunology · doi:10.1126/sciimmunol.aax0416 · Cited by 218 · see citing works

Maximal Oxidative Capacity during Exercise Is Associated with Skeletal Muscle Fuel Selection and Dynamic Changes in Mitochondrial Protein Acetylation

Overmyer, K. A., Evans, C. R., Qi, N., Minogue, C. E., Carson, J. J., Chermside‐Scabbo, C. J., Koch, L. G., Britton, S. L., Pagliarini, D. J., Coon, J. J., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.02.007 · Cited by 196 · see citing works

Estrogen-related Receptor γ Is a Key Regulator of Muscle Mitochondrial Activity and Oxidative Capacity

Rangwala, S. M., Wang, X., Calvo, J. A., Lindsley, L., Zhang, Y., Deyneko, G., Beaulieu, V., Gao, J., Turner, G. M., & Markovits, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.125401 · Cited by 192 · see citing works

Exercise and PGC-1α-Independent Synchronization of Type I Muscle Metabolism and Vasculature by ERRγ

Narkar, V. A., Fan, W., Downes, M., Yu, R. T., Jonker, J. W., Alaynick, W. A., Banayo, E., Karunasiri, M. S., Lorca, S., & Evans, R. M. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.019 · Cited by 185 · see citing works

The multiple universes of estrogen-related receptor α and γ in metabolic control and related diseases

Audet‐Walsh, É., & Giguère, V. (2014) · Acta Pharmacologica Sinica · doi:10.1038/aps.2014.121 · Cited by 175 · see citing works

Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: absence of development of age-related obesity

Gregorio, G. B. D., Hensley, L. L., Lü, T., Ranganathan, G., & Kern, P. A. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00189.2003 · Cited by 160 · see citing works

Assessment of muscle mass and strength in mice

Bonetto, A., Andersson, D. C., & Waning, D. L. (2015) · BoneKEy Reports · doi:10.1038/bonekey.2015.101 · Cited by 152 · see citing works

Direct control of hepatic glucose production by interleukin-13 in mice

Stanya, K. J., Jacobi, D., Liu, S., Bhargava, P., Dai, L., Gangl, M. R., Inouye, K., Barlow, J. L., Ji, Y., Mizgerd, J. P., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64941 · Cited by 140 · see citing works

Estrogen-Related Receptor α (ERRα) and ERRγ Are Essential Coordinators of Cardiac Metabolism and Function

Wang, T., McDonald, C., Petrenko, N. B., Leblanc, M., Wang, T., Giguère, V., Evans, R. M., Patel, V. V., & Pei, L. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.01156-14 · Cited by 131 · see citing works

A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue

Rana, B. M. J., Jou, E., Barlow, J. L., Rodríguez‐Rodríguez, N., Walker, J. A., Knox, C., Jolin, H. E., Hardman, C. S., Sivasubramaniam, M., Szeto, A. C. H., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20190689 · Cited by 125 · see citing works

Humoral Nature of the Hypoglycemic Factor of Muscular Work

Goldstein, M. S. (1961) · Diabetes · doi:10.2337/diab.10.3.232 · Cited by 106 · see citing works

Using Isolated Mitochondria from Minimal Quantities of Mouse Skeletal Muscle for High throughput Microplate Respiratory Measurements

Boutagy, N. E., Rogers, G. W., Pyne, E. S., Ali, M. M., Hulver, M. W., & Frisard, M. I. (2015) · Journal of Visualized Experiments · doi:10.3791/53216 · Cited by 53 · see citing works

Characterization of the Cytoplasmic Domain of Interleukin-13 Receptor-α

Orchansky, P. L., Kwan, R. W.-P., Lee, F., & Schrader, J. W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.30.20818 · Cited by 44 · see citing works

The multiple universes of estrogen-related receptor a and Y in metabolic control and related diseases

Étienne, Audet-Walsh, Vincent, V., & Giguiere (2015) · 中国药理学报：英文版 · Cited by 29 · see citing works

Gene Transfer in Skeletal and Cardiac Muscle Using Recombinant Adeno‐Associated Virus

Gruntman, A. M., Bish, L. T., Mueller, C., Sweeney, H. L., Flotte, T. R., & Gao, G. (2013) · Current Protocols in Microbiology · doi:10.1002/9780471729259.mc14d03s28 · Cited by 25 · see citing works

IL-6 is not essential for exercise-induced increases in glucose uptake

O’Neill, H. M., Palanivel, R., Wright, D. C., MacDonald, T. L., Lally, J., Schertzer, J. D., & Steinberg, G. R. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00946.2012 · Cited by 20 · see citing works

Temporal Changes in Cardiovascular Remodeling Associated with Football Participation

Kim, J. H., Hollowed, C. G., PATEL, K., Hosny, K. M., Aida, H., Gowani, Z., Sher, S., Shoop, J. L., GALANTE, A., Clark, C. B., et al. (2018) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001631 · Cited by 20 · see citing works

Isolation of Mitochondria from Minimal Quantities of Mouse Skeletal Muscle for High Throughput Microplate Respiratory Measurements

Boutagy, N. E., Pyne, E. S., Rogers, G. W., Ali, M. M., Hulver, M. W., & Frisard, M. I. (2015) · Journal of Visualized Experiments · doi:10.3791/53217 · Cited by 20 · see citing works

Patterns of senescence in human cardiovascular fitness: VO2max in subsistence and industrialized populations

Pisor, A. C., Gurven, M., Blackwell, A. D., Kaplan, H. S., & Yetish, G. M. (2013) · American Journal of Human Biology · doi:10.1002/ajhb.22445 · Cited by 15 · see citing works

Echinacea-Based Dietary Supplement Does Not Increase Maximal Aerobic Capacity in Endurance-Trained Men and Women

Stevenson, J. L., Krishnan, S., Iñigo, M. R., Stamatikos, A., Gonzales, J. U., & Cooper, J. A. (2015) · Journal of Dietary Supplements · doi:10.3109/19390211.2015.1036189 · Cited by 11 · see citing works

Exerkines in health, resilience and disease

Chow, L. S., Gerszten, R. E., Taylor, J. M., Pedersen, B. K., van Praag, H., Trappe, S., Febbraio, M. A., Galis, Z. S., Gao, Y., Haus, J. M., et al. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00641-2 · Cited by 927 · see citing works

Tissue homeostasis and inflammation

Meizlish, M. L., Franklin, R. A., Zhou, X., & Medzhitov, R. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-061020-053734 · Cited by 364 · see citing works

Interleukin 6 as an Energy Allocator in Muscle Tissue

Kistner, T. M., Pedersen, B. K., & Lieberman, D. E. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00538-4 · Cited by 295 · see citing works

The effect of exercise on cytokines: implications for musculoskeletal health: a narrative review

Docherty, S., Harley, R., McAuley, J. J., Crowe, L. A. N., Pedret, C., Kirwan, P., Siebert, S., & Millar, N. L. (2022) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-022-00397-2 · Cited by 316 · see citing works

Treatment Options for Motor and Non-Motor Symptoms of Parkinson’s Disease

Church, F. (2021) · Biomolecules · doi:10.3390/biom11040612 · Cited by 303 · see citing works

Molecular Responses to Acute Exercise and Their Relevance for Adaptations in Skeletal Muscle to Exercise Training

Egan, B., & Sharples, A. P. (2023) · Physiological Reviews · doi:10.1152/physrev.00054.2021 · Cited by 278 · see citing works

The molecular athlete: exercise physiology from mechanisms to medals

Furrer, R., Hawley, J. A., & Handschin, C. (2023) · Physiological Reviews · doi:10.1152/physrev.00017.2022 · Cited by 232 · see citing works

Metabolic communication during exercise

Murphy, R. M., Watt, M. J., & Febbraio, M. A. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0258-x · Cited by 158 · see citing works

Naturalizing mouse models for immunology

Graham, A. L. (2021) · Nature Immunology · doi:10.1038/s41590-020-00857-2 · Cited by 121 · see citing works

The Obese Brain: Mechanisms of Systemic and Local Inflammation, and Interventions to Reverse the Cognitive Deficit

Salas-Venegas, V., Flores-Torres, R. P., Rodríguez-Cortés, Y. M., Rodríguez-Retana, D., Carreto, R. J. R., Concepción-Carrillo, L. E., Pérez-Flores, L. J., Alarcón‐Aguilar, A., López‐Díazguerrero, N. E., Gómez‐González, B., et al. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.798995 · Cited by 118 · see citing works

Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging

Zhou, Z., Yao, J., Wu, D., Huang, X., Wang, Y., Li, X., Lu, Q., & Qiu, Y. (2024) · Immunity · doi:10.1016/j.immuni.2024.01.001 · Cited by 120 · see citing works

Organism-wide, cell-type-specific secretome mapping of exercise training in mice

Wei, W., Riley, N. M., Lyu, X., Shen, X., Guo, J., Raun, S. H., Zhao, M., Moya-Garzón, M. D., Basu, H., Tung, A. S.-H., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.04.011 · Cited by 97 · see citing works

The Role of the Skeletal Muscle Secretome in Mediating Endurance and Resistance Training Adaptations

Leuchtmann, A. B., Adak, V., Dilbaz, S., & Handschin, C. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.709807 · Cited by 84 · see citing works

Regulatory T cells shield muscle mitochondria from interferon-γ–mediated damage to promote the beneficial effects of exercise

Langston, P. K., Sun, Y., Ryback, B. A., Mueller, A. L., Spiegelman, B. M., Benoist, C. O., & Mathis, D. J. (2023) · Science Immunology · doi:10.1126/sciimmunol.adi5377 · Cited by 82 · see citing works

The ins and outs of innate and adaptive type 2 immunity

Molofsky, A. B., & Locksley, R. M. (2023) · Immunity · doi:10.1016/j.immuni.2023.03.014 · Cited by 72 · see citing works

Molecular aspects of the exercise response and training adaptation in skeletal muscle

Furrer, R., & Handschin, C. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.07.026 · Cited by 63 · see citing works

Immunological regulation of skeletal muscle adaptation to exercise

Langston, P. K., & Mathis, D. J. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.04.001 · Cited by 52 · see citing works

DHA alleviates diet-induced skeletal muscle fiber remodeling via FTO/m6A/DDIT4/PGC1α signaling

Chen, W., Chen, Y., Wu, R., Guo, G., Liu, Y., Zeng, B., Liao, X., Wang, Y., & Wang, X. (2022) · BMC Biology · doi:10.1186/s12915-022-01239-w · Cited by 46 · see citing works

Immune System Investigation Using Parasitic Helminths

Douglas, B. B., Oyesola, O. O., Cooper, M. M., Posey, A. D., Wojno, E. D. T., Giacomin, P., & Herbert, D. R. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-093019-122827 · Cited by 44 · see citing works

Exercise and Adipose Tissue Immunity: Outrunning Inflammation

Winn, N. C., Cottam, M. A., Wasserman, D. H., & Hasty, A. H. (2021) · Obesity · doi:10.1002/oby.23147 · Cited by 43 · see citing works

Regulatory networks coordinating mitochondrial quality control in skeletal muscle

Slavin, M. B., Memme, J. M., Oliveira, A. N., Moradi, N., & Hood, D. A. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00065.2022 · Cited by 40 · see citing works

Reconciling Mouse and Human Immunology at the Altar of Genetics

Gros, P., & Casanova, J. (2022) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101721-065201 · Cited by 42 · see citing works

Cancer-Related Cachexia: The Vicious Circle between Inflammatory Cytokines, Skeletal Muscle, Lipid Metabolism and the Possible Role of Physical Training

Mangano, G. D., Fouani, M., Damico, D. C. S., Felice, V. D., & Barone, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063004 · Cited by 38 · see citing works

Metabolism in type 2 immune responses

Kabat, A. M., Pearce, E. L., & Pearce, E. J. (2023) · Immunity · doi:10.1016/j.immuni.2023.03.007 · Cited by 37 · see citing works

Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling

Chen, J., Xiang, J., Zhou, M., Huang, R., Zhang, J., Cui, Y., Jiang, X., Yang, L., Zhou, R., Xin, H., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.02.007 · Cited by 33 · see citing works

Differential effects on blood and cerebrospinal fluid immune protein markers and kynurenine pathway metabolites from aerobic physical exercise in healthy subjects

Isung, J., Granqvist, M., Trepci, A., Huang, J., Schwieler, L., Kierkegaard, M., Erhardt, S., Jokinen, J., & Piehl, F. (2021) · Scientific Reports · doi:10.1038/s41598-021-81306-4 · Cited by 32 · see citing works

A Sedentary and Unhealthy Lifestyle Fuels Chronic Disease Progression by Changing Interstitial Cell Behaviour: A Network Analysis

Huston, P. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.904107 · Cited by 34 · see citing works

Sports and Immunity, from the recreational to the elite athlete

Baskerville, R., Castell, L. M., & Bermon, S. (2024) · Infectious Diseases Now · doi:10.1016/j.idnow.2024.104893 · Cited by 38 · see citing works

Macrophages on the run: Exercise balances macrophage polarization for improved health

Voskoboynik, Y., McCulloch, A. D., & Sahoo, D. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.102058 · Cited by 31 · see citing works

Exercise-induced microbial changes in preventing type 2 diabetes

Yao, T., Wang, H., Lin, K., Wang, R., Guo, S., Chen, P., Wu, H., Liu, T., & Wang, R. (2023) · Science China Life Sciences · doi:10.1007/s11427-022-2272-3 · Cited by 31 · see citing works

Gain-of-function mutations of TRPV4 acting in endothelial cells drive blood-CNS barrier breakdown and motor neuron degeneration in mice

Sullivan, J. M., Bagnell, A. M., Alevy, J., Avila, E. M., Mihaljević, L., Saavedra-Rivera, P. C., Kong, L., Huh, J. S., McCray, B. A., Aisenberg, W. H., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adk1358 · Cited by 29 · see citing works

Interleukin‐6 potentiates endurance training adaptation and improves functional capacity in old mice

Leuchtmann, A. B., Furrer, R., Steurer, S. A., Schneider‐Heieck, K., Karrer‐Cardel, B., Sagot, Y., & Handschin, C. (2022) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12949 · Cited by 29 · see citing works

Exercise-induced CLCF1 attenuates age-related muscle and bone decline in mice

Kang, J. S., Kim, J. H., Kim, M. J., Min, B., Lee, S.-M., Go, G.-Y., Kim, J., Kim, S., Kwak, J. Y., Chun, S.-W., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59959-w · Cited by 24 · see citing works

The protein inputs of an ultra-predictive aging clock represent viable anti-aging drug targets

Johnson, A. A., Shokhirev, M. N., & Lehallier, B. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101404 · Cited by 22 · see citing works

Exercise workload: a key determinant of immune health – a narrative review

Shi, X., Hu, L., Nieman, D. C., Li, F., Chen, P., Shi, H., & Shi, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1617261 · Cited by 26 · see citing works

Roles of programmed death‐1 and muscle innate lymphoid cell‐derived interleukin 13 in sepsis‐induced intensive care unit‐acquired weakness

Akama, Y., Park, E. J., Satoh‐Takayama, N., Ito, A., Kawamoto, E., Gaowa, A., Matsuo, E., Oikawa, S., Saito, M., Inoue, S., et al. (2024) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13548 · Cited by 19 · see citing works

Molecular profiling reveals features of clinical immunity and immunosuppression in asymptomatic P. falciparum malaria

Studniberg, S. I., Ioannidis, L. J., Utami, R. A. S., Trianty, L., Liao, Y., Abeysekera, W., Suen, C. S. N. L. W., Pietrzak, H. M., Healer, J., Puspitasari, A. M., et al. (2022) · Molecular Systems Biology · doi:10.15252/msb.202110824 · Cited by 18 · see citing works

Molecular Basis for the Therapeutic Effects of Exercise on Mitochondrial Defects

Memme, J. M., & Hood, D. A. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2020.615038 · Cited by 19 · see citing works

Emerging role of interleukin‐13 in cardiovascular diseases: A ray of hope

Qian, N., Gao, Y., Wang, J., & Wang, Y. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16566 · Cited by 18 · see citing works

Association between physical activity and visceral adiposity index (VAI) in U.S. population with overweight or obesity: a cross-sectional study

Tao, X., Xu, X. M., Xu, Y., Yang, Q., Yang, T., Zhou, X., Xue, H., Ren, X., & Luo, F. (2024) · BMC Public Health · doi:10.1186/s12889-024-19810-1 · Cited by 18 · see citing works

Leveraging metabolic modeling to identify functional metabolic alterations associated with COVID-19 disease severity

Dillard, L. R., Wase, N. V., Ramakrishnan, G., Park, J. J., Sherman, N. E., Carpenter, R. M., Young, M. K., Donlan, A. N., Petri, W. A., & Papin, J. A. (2022) · Metabolomics · doi:10.1007/s11306-022-01904-9 · Cited by 17 · see citing works

Blood Profile of Cytokines, Chemokines, Growth Factors, and Redox Biomarkers in Response to Different Protocols of Treadmill Running in Rats

Supruniuk, E., Maciejczyk, M., Zalewska, A., Górski, J., & Chabowski, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218071 · Cited by 16 · see citing works

Changes in novel anti-infalmmatory cytokine concetration in the bood of endurance and race horses at different levels of training

Plisak, U., Szczepaniak, J., Żmigrodzka, M., Giercuszkiewicz-Hecold, B., & Witkowska‐Piłaszewicz, O. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.12.016 · Cited by 16 · see citing works

The Acute Cytokine Response to 30-Minute Exercise Bouts Before and After 8-Week Endurance Training in Individuals With Obesity

Goj, T., Hoene, M., Fritsche, L., Schneeweiß, P., Machann, J., Petrera, A., Hauck, S. M., Fritsche, A., Birkenfeld, A. L., Peter, A., et al. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac623 · Cited by 14 · see citing works

Immunology of Physical Exercise: Is Equus caballus an Appropriate Animal Model for Human Athletes?

Witkowska‐Piłaszewicz, O., Malin, K., Dąbrowska, I., Grzędzicka‐Agko, J., Ostaszewski, P., & Carter, C. N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105210 · Cited by 15 · see citing works

Perturbations to Homeostasis in Experimental Models Revealed Innate Pathways Driving Food Allergy

Bruton, K. M., Koenig, J. F. E., Phelps, A., & Jordana, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.603272 · Cited by 15 · see citing works

Methylglyoxal reduces molecular responsiveness to 4 weeks of endurance exercise in mouse plantaris muscle

Egawa, T., Ogawa, T., Yokokawa, T., Kido, K., Goto, K., & Hayashi, T. (2022) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00539.2021 · Cited by 14 · see citing works

Effect of physical training on cytokine expression in CD4+ T lymphocytes in subjects with stable COPD

Uzeloto, J. S., de Toledo, A. C., Silva, B. S. D. A., Braz, A. M. M., de Lima, F. F., Grigoletto, I., Ramos, D., Golim, M. D. A., & Ramos, E. M. C. (2022) · Therapeutic Advances in Respiratory Disease · doi:10.1177/17534666221091179 · Cited by 14 · see citing works

The Molecular Mechanisms of Fuel Utilization during Exercise

Pi, A., Villivalam, S. D., & Kang, S. (2023) · Biology · doi:10.3390/biology12111450 · Cited by 14 · see citing works

The Role of Cardiac Troponin and Other Emerging Biomarkers Among Athletes and Beyond: Underlying Mechanisms, Differential Diagnosis, and Guide for Interpretation

Celeski, M., Segreti, A., Crisci, F., Cricco, R., Piscione, M., Gioia, G. D., Nusca, A., FOSSATI, C., Pigozzi, F., Ussia, G. P., et al. (2024) · Biomolecules · doi:10.3390/biom14121630 · Cited by 13 · see citing works

Differential Expression of Innate and Adaptive Immune Genes during Acute Physical Exercise in American Quarter Horses

Wilson, J. A., Donato, M. D., Appelbaum, B., Garcia, C. T., & PETERS, S. O. (2023) · Animals · doi:10.3390/ani13020308 · Cited by 13 · see citing works

Train your T cells: How skeletal muscles and T cells keep each other fit during aging

Slaets, H., Fonteyn, L., Eijnde, B. O., & Hellings, N. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.03.006 · Cited by 12 · see citing works

Eugenol mimics exercise to promote skeletal muscle fiber remodeling and myokine IL-15 expression by activating TRPV1 channel

Huang, T., Chen, X., He, J., Zheng, P., Luo, Y., Wu, A., Yan, H., Yu, B., Chen, D., & Huang, Z. (2023) · eLife · doi:10.7554/elife.90724 · Cited by 12 · see citing works

A feeding-induced myokine modulates glucose homeostasis

Shi, X., Hu, X., Fang, X., Jia, L., Wei, F., Peng, Y. C., Liu, M., Gao, A., Zhao, K., Chen, F., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-024-01175-9 · Cited by 12 · see citing works

Effects of CX3CR1 and CXCR2 antagonists on running-dependent intramuscular neutrophil recruitments and myokine upregulation

Nyasha, M. R., Chen, W., Wang, H., Yaoita, F., Aoki, M., Nagatomi, R., & Kanzaki, M. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00196.2022 · Cited by 11 · see citing works

Exercise and COVID-19: exercise intensity reassures immunological benefits of post-COVID-19 condition

Thirupathi, A., Wang, Y., Oflaz, O., Ağaşçioğlu, E., & Gu, Y. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1036925 · Cited by 11 · see citing works

Tissue adaptation to metabolic stress: insights from SUMOylation

Xie, H., Liu, X., Li, S., Wang, M., Li, Y., Chen, T., Li, L., Wang, F., & Xiao, X. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1434338 · Cited by 11 · see citing works

Inflammation in cancer cachexia: still the central tenet or just another player?

Iaia, N., Noviello, C., Muscaritoli, M., & Costelli, P. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00808.2024 · Cited by 13 · see citing works

IL-13 Alleviates Cardiomyocyte Apoptosis by Improving Fatty Acid Oxidation in Mitochondria

Guo, X., Hong, T., Zhang, S., Wei, Y., Jin, H., Miao, Q., Wang, K., Zhou, M., Wang, C., & He, B. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.736603 · Cited by 11 · see citing works

The circadian clock regulates metabolic responses to physical exercise

Cheng, Q., Lü, C., & Qian, R. (2022) · Chronobiology International · doi:10.1080/07420528.2022.2050384 · Cited by 10 · see citing works

Sodium Butyrate Ameliorates Type 2 Diabetes-Related Sarcopenia Through IL-33-Independent ILC2s/IL-13/STAT3 Signaling Pathway

Cao, Y., Li, Y., Han, W., Xu, J., Zhu, P., Wei, B., Cong, X., & Wang, Z. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s392350 · Cited by 10 · see citing works

Defective BVES-mediated feedback control of cAMP in muscular dystrophy

Li, H., Wang, P., Zhang, C., Zuo, Y., Zhou, Y., & Han, R. (2023) · Nature Communications · doi:10.1038/s41467-023-37496-8 · Cited by 9 · see citing works

Effects of Exhaustive Exercise on Adiponectin and High-Molecular-Weight Oligomer Levels in Male Amateur Athletes

Mallardo, M., Tommasini, E., Missaglia, S., Pecci, C., Rampinini, E., Bosio, A., Morelli, A. M., Daniele, A., Nigro, E., & Tavian, D. (2024) · Biomedicines · doi:10.3390/biomedicines12081743 · Cited by 9 · see citing works

Preadipocyte IL-13/IL-13Rα1 signaling regulates beige adipogenesis through modulation of PPARγ activity

Yesian, A. R., Chalom, M. M., Knudsen, N. H., Hyde, A. L., Personnaz, J., Cho, H., Liou, Y.-H., Starost, K. A., Lee, C., Tsai, D.-Y., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci169152 · Cited by 9 · see citing works

Low‐level light pre‐conditioning promotes C2C12 myoblast differentiation under hypoxic conditions

Yan, M., & Wu, M. X. (2021) · Journal of Biophotonics · doi:10.1002/jbio.202100246 · Cited by 9 · see citing works

Elucidating the interaction between maternal physical activity and circulating myokines throughout gestation: A scoping review

Goudreau, A. D., Everest, C., Nagpal, T. S., Puranda, J. L., Bhattacharjee, J., Vasanthan, T., & Adamo, K. B. (2021) · American Journal of Reproductive Immunology · doi:10.1111/aji.13488 · Cited by 9 · see citing works

Systemic AAV9.BVES delivery ameliorates muscular dystrophy in a mouse model of LGMDR25

Bailin, P. L., Wang, P., Hsu, E., Pinckard, K. M., Stanford, K. I., & Han, R. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.11.012 · Cited by 9 · see citing works

Primate retroelement exonization and sexually dimorphic IL13RA1 transcription tune type 2 immune responses

Plowman, T., Hofland, T., Hall, C., Thompson, R. H., Pape, J., Ng, K. W., Doglio, L. E., & Kassiotis, G. (2025) · Science Immunology · doi:10.1126/sciimmunol.adr1105 · Cited by 8 · see citing works

Piezo1-dependent activation of stromal cells ignites muscle inflammation in exercise and injury and is associated with inflammaging

Langston, P. K., Raghavan, J. V., Benoist, C. O., & Mathis, D. J. (2026) · Nature Immunology · doi:10.1038/s41590-026-02435-4 · Cited by 8 · see citing works

Various diseases and conditions are strongly associated with the next-generation epigenetic aging clock CheekAge

Shokhirev, M. N., & Johnson, A. A. (2025) · GeroScience · doi:10.1007/s11357-025-01579-9 · Cited by 9 · see citing works

Metabolic Flexibility Assists Reprograming of Central and Peripheral Innate Immunity During Neurodevelopment

Cruz-Carrillo, G., & Camacho‐Morales, A. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02154-3 · Cited by 7 · see citing works

Evolutionary Immunology

Bolnick, D. I., Fuess, L. E., Graham, A. L., Khan, I., Steinel, N. C., & Vaziri, G. J. (2025) · Annual Review of Ecology Evolution and Systematics · doi:10.1146/annurev-ecolsys-102723-043048 · Cited by 7 · see citing works

Hydroxysafflor Yellow A Alters Fuel Selection From Glucose to Fat by Activating the PPARδ Pathway in Myocytes

Sun, Y., Wang, Z., Nie, C., Xue, L., Wang, Y., Song, C., Fan, M., Qian, H., Ying, H., Li, Y., et al. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c06034 · Cited by 7 · see citing works

Costly immunometabolic remodelling in disused muscle buildup through physical exercise

Padilha, C. S., Figueiredo, C., Deminice, R., Krüger, K., Seelaender, M. C. L., Neto, J. C. R., & Lira, F. S. (2022) · Acta Physiologica · doi:10.1111/apha.13782 · Cited by 7 · see citing works

Integrative understanding of immune-metabolic interaction

Im, S., Kim, H., Jeong, M., Yang, H., & Hong, J. Y. (2022) · BMB Reports · doi:10.5483/bmbrep.2022.55.6.064 · Cited by 6 · see citing works

Exercising immune cells: The immunomodulatory role of exercise on atrial fibrillation

Miguel‐dos‐Santos, R., Moreira, J. B. N., Loennechen, J. P., Wisløff, U., & Mesquita, T. (2021) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2021.07.008 · Cited by 7 · see citing works

Tumor cells upregulate neurotransmitter GABA in the choroid plexus through STAT6-Bestrophin1 signaling, promoting leptomeningeal dissemination

Das, D., Iyer, M., Nakamura, B. N., Sedighi, S., Hsu, A., Danilov, C. A., LaViolette, P. S., Connelly, J., Chow, F. E., & Neman, J. (2025) · Neuro-Oncology · doi:10.1093/neuonc/noaf027 · Cited by 6 · see citing works

Effect of physical activity on the immune system in the normal state and in various diseases: a review

Vologzhanin, D. A., Голота, А. С., Ignatenko, A.-M. I., Kamilova, Т. A., Kovlen, D. V., Usikova, E., & Shcherbak, S. G. (2025) · Bulletin of Rehabilitation Medicine · doi:10.38025/2078-1962-2025-24-1-91-102 · Cited by 6 · see citing works

Eosinophils Respond to Extracellular Matrix Treated Muscle Injuries but are Not Required for Macrophage Polarization

Lokwani, R., Fertil, D., Hartigan, D. R., Josyula, A., Ngo, T. B., & Sadtler, K. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400134 · Cited by 6 · see citing works

Reducing Systemic Inflammation in IUGR-Born Neonatal Lambs via Daily Oral ω-3 PUFA Supplement Improved Skeletal Muscle Glucose Metabolism, Glucose-Stimulated Insulin Secretion, and Blood Pressure

White, M. R., Gibbs, R. L., Grijalva, P. C. C., Hicks, Z. M., Beer, H. N., Marks-Nelson, E. S., & Yates, D. T. (2025) · Metabolites · doi:10.3390/metabo15060346 · Cited by 5 · see citing works

Mitochondrial Biogenesis in Skeletal Muscle

Hood, D. A., Memme, J. M., Oliveira, A. N., Moradi, N., & Champsi, S. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-88361-3_2 · Cited by 5 · see citing works

Exercise Modulates Exocytosis: Chemical Insights from the Intracellular Vesicle Perspective.

Liu, R., He, X., Liu, J., Sun, Z.-N., Yu, P., Hou, L.-J., & Mao, L.-Q. (2025) · Angewandte Chemie · doi:10.1002/anie.202511277 · Cited by 5 · see citing works

Role of the Th2-like Immune Response in Obesity: IL-4 as a Metabolic Regulator and IL-13 as an Effector of Muscle Energy Metabolism

Méndez-García, L. A., Solleiro-Villavicencio, H., Bueno-Hernández, N., Cérbulo‐Vázquez, A., Escobedo, G., Esquivel‐Velázquez, M., & Fonseca-Sánchez, M. A. (2025) · Biomedicines · doi:10.3390/biomedicines13092208 · Cited by 5 · see citing works

Metabolic Dysfunction-Associated Steatotic Liver Disease and Sarcopenia: Review of Literature

Nishikawa, H., Kim, S. K., Yoshio, S., & ASAI, A. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15041661 · Cited by 5 · see citing works

Power and Endurance: Polar Opposites or Willing Partners?

Ferguson, C., Furrer, R., Murach, K. A., Hepple, R. T., & Rossiter, H. B. (2025) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003793 · Cited by 5 · see citing works

Exercised cytokines promote endurance

Correia, J. C., & Ruas, J. L. (2020) · Science · doi:10.1126/science.abb4116 · Cited by 5 · see citing works

IL13 Promoter (−1055) Polymorphism Associated with Leukocyte Mitochondria DNA Copy Number in Chronic Obstructive Pulmonary Disease

Liu, S., Chang, H.-C., Chang, Y.-P., Kuo, H., & Tsai, Y.-C. (2022) · Cells · doi:10.3390/cells11233787 · Cited by 5 · see citing works

Exercise benefits yourself and your offspring: a mini-review

Wang, K., Zhao, J., Wang, Y., & Liu, M. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1606790 · Cited by 4 · see citing works

Dual mechanisms of salmon skin collagen peptide in alleviating fatigue by enhancing mitochondrial biogenesis and reducing oxidative stress

Ma, X., Xu, Z., Yang, Q., Liu, X., Wang, Y., Wang, Y., Liu, J., Cheng, S., & Du, M. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107526 · Cited by 4 · see citing works

Single‐nucleus RNA sequencing reveals RUNX1 regulation of muscle hypertrophy through PI3K/AKT/mTOR pathway

Wang, C., Ma, J., Wang, Y., Liu, R. R., Zhang, C., Li, Q., Zhang, L., Hou, Q., & Yang, X. (2025) · iMeta · doi:10.1002/imt2.70093 · Cited by 4 · see citing works

STAT Signaling in Metabolic Disorders: From Molecular Mechanisms to Therapeutic Implications

Zhang, K., Sang, J., Kan, C., Sheng, S., Sun, X., & Guo, Z. (2026) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-026-02038-8 · Cited by 4 · see citing works

Redistribution of Intraspinal and Muscular 18F-FDG Uptake after the Epidural Electrical Stimulation Treatment in Spinal Cord Injury Individuals

Yao, Q., Zhang, B., Zhang, F., Zhang, X., Luo, X., & Li, L. (2025) · Clinical Nuclear Medicine · doi:10.1097/rlu.0000000000005894 · Cited by 4 · see citing works

Exercising Immunity: Interleukin-13 Flexes Muscle

Webb, L. M., & Wojno, E. D. T. (2020) · Immunity · doi:10.1016/j.immuni.2020.05.012 · Cited by 4 · see citing works

Salivary Interleukin-13 and Transforming Growth Factor Beta as Potential Biomarkers of Cancer Cachexia

Belev, B., Vičić, I., Sedlić, F., Prtorić, M., Soče, M., Prejac, J., Potočki, S., Silovski, T., Herceg, D., & Kulić, A. (2024) · Cancers · doi:10.3390/cancers16173035 · Cited by 4 · see citing works

Muscle immune cells protect mitochondrial organelles during exercise

Coulis, G., & Villalta, S. A. (2023) · Nature · doi:10.1038/d41586-023-03972-w · Cited by 3 · see citing works

Stabilization Splint Therapy for Patients with Temporomandibular Disorders Improves Opening Movements and Jaw Limitation and Attenuates Pain by Influencing the Levels of IL-7, IL-8, and IL-13 in the Gingival Crevicular Fluid

Sikora, R., Duspara, K., Matić, A., Petrović, A., Kralik, K., Smolić, R., Šikora, M., Šarac, M. Č., Bojanić, K., & Smolić, M. (2025) · Medicina · doi:10.3390/medicina61030375 · Cited by 3 · see citing works

IL-13 priming in precursors drives beige adipogenesis and enhances metabolic homeostasis

Emont, M. P., & Wu, J. (2025) · Journal of Clinical Investigation · doi:10.1172/jci191361 · Cited by 3 · see citing works

Global multi-omics analysis of exerkines in progressive treadmill-exercised rodentsPreprint

Taha, H. B. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.08.627439 · Cited by 3 · see citing works

Recent advances in exercise immunometabolism: Immune cell bioenergetics, muscle-immune cell interactions, and potential dietary adjuvants

Islam, H. (2025) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000001157 · Cited by 2 · see citing works

Muscle–immune metabolic crosstalk: shared pathways in cachexia and exercise

Westermann, S., Bennühr, B., Fumo, A. R., Rohm, M., & Hiller, K. (2026) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2026.103455 · Cited by 2 · see citing works

IL-13 hits the gym

Scanlon, S. T. (2020) · Science · doi:10.1126/science.368.6490.484-k

Exercising Immunity: Interleukin-13 Flexes Muscle

Webb, L. M., & Wojno, E. D. T. (2020) · Immunity · doi:10.1016/j.immuni.2020.05.012 · Cited by 4 · see citing works

Molecular mechanisms of metabolic adaptation to endurance exercise

Knudsen, N. H. (2018) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)

Interleukin-1 signaling contributes to endurance training-induced skeletal muscle adaptations

Naito, A., Sato, T., Tokuda, N., Yamauchi, N., Niibori, A., Okada, K., & Yamada, T. (2026) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00125.2026

IL-15 Overexpression Promotes Endurance, Oxidative Energy Metabolism, and Muscle PPARδ, SIRT1, PGC-1α, and PGC-1β Expression in Male Mice

Quinn, L. S., Anderson, B. G., Conner, J. D., & Wolden-Hanson, T. (2013) · Endocrinology · doi:10.1210/en.2012-1773 · Cited by 102 · see citing works