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Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C
Abstract
Hydrolysis of inositol phospholipids by phospholipase C is initiated by either receptor stimulation or opening of Ca 2+ channels. This was once thought to be the sole mechanism to produce the diacylglycerol that links extracellular signals to intracellular events through activation of protein kinase C. It is becoming clear that agonist-induced hydrolysis of other membrane phospholipids, particularly choline phospholipids, by phospholipase D and phospholipase A 2 may also take part in cell signaling. The products of hydrolysis of these phospholipids may enhance and prolong the activation of protein kinase C. Such prolonged activation of protein kinase C is essential for long-term cellular responses such as cell proliferation and differentiation.
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Metadata
- Authors
- Nishizuka, Y.
- Venue
- Science
- Published
- 1992-10-23
- Volume
- 258
- Issue
- 5082
- Pages
- 607-614
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2086524338
- Cited by
- 4,472
- References
- 0
- FWCI
- 117.45
- Type
- journal article
- Language
- en
- Open access
- closed
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