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Historical perspective: phosphatidylserine and phosphatidylethanolamine from the 1800s to the present

Vance, Jean E.·2018·Journal of Lipid Research

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  • PSS1 and PSS2 use PE as a substrate to produce PS in the endoplasmic reticulum.

    “PSS1 and PSS2 (gene names: Ptdss1 and Ptdss2, respectively) use phosphatidylethanolamine (PE) as a substrate to produce PS in the endoplasmic reticulum (ER) (2, 3).”

    From Molecular insights into human phosphatidylserine synthase 2 and its regulation of SREBP pathways (2025) · cites this paper as [2]

    Our copy says PS synthase-2 uses PE to make PS and places the active sites of both synthases on the cytosolic face of the ER. It does not support the claim that PSS1 also uses PE; the passage describing PSS1 instead distinguishes PC exchange from PSS2’s PE-to-PS activity. The supplied passages are labeled Abstract and have no page numbers. (LLM, conf=0.88)

    Experimental — accuracy not yet measured
  • PSS2 is an endoplasmic reticulum-associated enzyme that utilizes PE as a substrate.

    “As an ER-associated enzyme that utilizes PE as a substrate”

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Cited by

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Metadata

Authors
Vance, J. E.
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2018
Volume
59
Issue
6
Pages
923-944
ISSN
0022-2275
Cited by
113
References
12
Language
en

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