Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

Cited by (1,002)

Items 201–300 of 1,002

1. Sanglifehrins A, B, C and D, Novel Cyclophilin-binding Compounds Isolated from Streptomyces sp. A92-308110. I. Taxonomy, Fermentation, Isolation and Biological Activity.
   Jean‐Jacques Sanglier, Valerie F. J. Quesniaux, THEODOR FEHR, HANS HOFMANN, Marion Mahnke, Klaus Memmert, W. Schüler, Gerhard Zenke, Liliane Gschwind, Claudine Maurer et al. · 1999 · The Journal of Antibiotics
2. Three-part inventions: intracellular signaling and induced proximity.
   G. Crabtree, Stuart L. Schreiber · 1996 · TIBS -Trends in Biochemical Sciences. Regular ed
3. The design and development of an immunosuppressive drug, mycophenolate mofetil
   ANTHONY C. ALLISON, Elsie M. Eugui · 1993 · Springer Seminars in Immunopathology
4. Solution structure of the major binding protein for the immunosuppressant FK506
   Jonathan M. Moore, Debra A. Peattie, Matthew J. Fitzgibbon, John A Thomson · 1991 · Nature
5. Natural Products as Probes of Cellular Function: Studies of Immunophilins
   Michael K. Rosen, Stuart L. Schreiber · 1992 · Angewandte Chemie International Edition in English
6. Oral activity of a nature-derived cyclic peptide for the treatment of multiple sclerosis
   Kathrin Thell, Roland Hellinger, Emine Sahin, Paul Michenthaler, Markus Gold-Binder, Thomas T. Haider, Mario Kuttke, Zita Liutkevičiūtė, Ulf Göransson, Carsten Gründemann et al. · 2016 · Proceedings of the National Academy of Sciences
7. Mammalian Target of Rapamycin: A New Molecular Target for Breast Cancer
   Monica M Mita, Alain C. Mita, Eric Keith Rowinsky · 2003 · Clinical Breast Cancer
8. Interaction between FKBP12-rapamycin and TOR involves a conserved serine residue.
   Rodica Stan, Megan M. McLaughlin, Robert Cafferkey, Randall K. Johnson, Martin J. Rosenberg, George P. Livi · 1994 · Journal of Biological Chemistry
9. Regulation of Sensing, Transportation, and Catabolism of Nitrogen Sources in Saccharomyces cerevisiae
   Weiping Zhang, Guocheng Du, Jingwen Zhou, Jian Chen · 2018 · Microbiology and Molecular Biology Reviews
10. Destabilization of the complete protein secondary structure on binding to the chaperone GroEL
    Ralph Zahn, Claus E. Spitzfaden, Marcel Ottiger, Kurt Wüthrich A, Andreas Plückthun · 1994 · Nature
11. The Alpha Keto Amide Moiety as a Privileged Motif in Medicinal Chemistry: Current Insights and Emerging Opportunities
    Marco Robello, Elisabetta Barresi, Emma Baglini, Silvia Salerno, Sabrina Taliani, Federico Da Settimo · 2021 · Journal of Medicinal Chemistry
12. Immunosuppressants FK506 and rapamycin function as reversal agents of the multidrug resistance phenotype
    R.J. Arceci, Kimberly A. Stieglitz, Barbara E. Bierer · 1992 · Blood
13. A role for FKBP52 in tau protein function
    Chambraud, Béatrice, Sardin, Elodie, Giustiniani, Julien, Dounane, Omar, Schumacher, Michael, Goedert, Michel, Baulieu, Etienne-Emile · 2010 · Proceedings of the National Academy of Sciences
14. Leben am Ende der Chromosomen: Telomere und Telomerase
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15. Phosphorylation-dependent prolyl isomerization: a novel signaling regulatory mechanism
    Xiao Zhen Zhou, Pei‐Jung Lu, Gerburg M. Wulf, Kun Ping Lu · 1999 · Cellular and Molecular Life Sciences
16. A MULTICENTER TRIAL OF FK506 (TACROLIMUS) THERAPY IN REFRACTORY ACUTE RENAL ALLOGRAFT REJECTION
    E. Steve Woodle, J. Richard Thistlethwaite, John H. Gordon, David A. Laskow, Mark H. Deierhoi, James F. Burdick, John D. Pirsch, Hans W. Sollinger, Flavio G. Vincenti, Lewis Burrows et al. · 1996 · Transplantation
17. Quantitative Characterization of the Binding and Unbinding of Millimolar Drug Fragments with Molecular Dynamics Simulations
    Albert C. Pan, Huafeng Xu, Timothy Palpant, David Elliot Shaw · 2017 · Journal of Chemical Theory and Computation
18. Characterization of the cyclophilin gene family of Arabidopsis thaliana and phylogenetic analysis of known cyclophilin proteins
    Irene T. Chou, Charles S. Gasser · 1997 · Plant Molecular Biology
19. The immunophilins, FK506 binding protein and cyclophilin, are discretely localized in the brain: relationship to calcineurin
    Ted M. Dawson, J.P. Steiner, W. Ernest Lyons, Majid Fotuhi, Mary E. Blue, Solomon H. Snyder · 1994 · Neuroscience
20. Mechanisms of resistance to rapamycins
    Shile Huang, Peter J. Houghton · 2001 · Drug Resistance Updates
21. Neuronal regeneration enhances the expression of the immunophilin FKBP- 12
    W. Ernest Lyons, J.P. Steiner, Solomon H. Snyder, TM Dawson · 1995 · Journal of Neuroscience
22. Genetic Basis for Activity Differences Between Vancomycin and Glycolipid Derivatives of Vancomycin
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23. Display cloning: functional identification of natural product receptors using cDNA-phage display
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24. TRPV5 and TRPV6 in Ca2+ (re)absorption: regulating Ca2+ entry at the gate
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25. Potent Immunosuppressants, 2-Alkyl-2-aminopropane-1,3-diols
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26. Interaction with glycosaminoglycans is required for cyclophilin B to trigger integrin-mediated adhesion of peripheral blood T lymphocytes to extracellular matrix
    Fabrice Allain, Christophe Vanpouille, Mathieu Carpentier, Marie‐Christine Slomianny, Sandrine Durieux, Geneviève Spik · 2002 · Proceedings of the National Academy of Sciences
27. mTOR inhibitors in the treatment of cancer
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28. The X‐ray structure of a tetrapeptide bound to the active site of human cyclophilin A
    Joerg A. Kallen, Malcolm D. Walkinshaw · 1992 · FEBS Letters
29. Immunophilins: Switched on protein binding domains?
    Michael T. G. Ivery · 2000 · Medicinal Research Reviews
30. Inhibition of human immunodeficiency virus and growth of infected T cells by the immunosuppressive drugs cyclosporin A and FK 506.
    Abraham Karpas, Mark W. Lowdell, Susan Kim Jacobson, F. Hill · 1992 · Proceedings of the National Academy of Sciences
31. A yeast genetic system for selecting small molecule inhibitors of protein–protein interactions in nanodroplets
    Jing Huang, Stuart L. Schreiber · 1997 · Proceedings of the National Academy of Sciences
32. A rapamycin-selective 25-kDa immunophilin
    Andrzej Gałat, William S. Lane, Robert F. Standaert, Stuart L. Schreiber · 1992 · Biochemistry
33. Calcineurin Is a Key Signaling Enzyme in T Lymphocyte Activation and the Target of the Immunosuppressive Drugs Cyclosporin A and FK506a
    Neil A. Clipstone, Gerald R. Crabtree · 1993 · Annals of the New York Academy of Sciences
34. Proteomics of buccal squamous cell carcinoma: The involvement of multiple pathways in tumorigenesis
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35. Proline isomerases function during heat shock.
    Kathryn Sykes, Mary-Jane H. Gething, Joseph Sambrook · 1993 · Proceedings of the National Academy of Sciences
36. Charged surface residues of FKBP12 participate in formation of the FKBP12-FK506-calcineurin complex.
    Robert A. Aldape, Olga Futer, Maureen T. DeCenzo, Beth P. Jarrett, Mark A. Murcko, David J. Livingston · 1992 · Journal of Biological Chemistry
37. Signal‐Transduction Therapy
    Alexander Levitzki · 1994 · European Journal of Biochemistry
38. A redox-active FKBP-type immunophilin functions in accumulation of the photosystem II supercomplex in Arabidopsis thaliana
    Amparo Lima, Santiago Lima, Joshua H. H. Wong, Robert S. Phillips, Bob B. Buchanan, Sheng Luan · 2006 · Proceedings of the National Academy of Sciences
39. Efomycine M, a new specific inhibitor of selectin, impairs leukocyte adhesion and alleviates cutaneous inflammation
    Michael Peter Schön, Thomas Krahn, Margarete Schön, Maria-L. Rodriguez, Horst Antonicek, Jeanette E. Schultz, Ralf Joachim Ludwig, Thomas Matthias Zollner, Erwin Bischoff, K. D. Bremm et al. · 2002 · Nature Medicine
40. Calcineurin-mediated protein dephosphorylation in brain nerve terminals regulates the release of glutamate.
    Robert A. Nichols, G. Suplick, J.M. Brown · 1994 · Journal of Biological Chemistry
41. Prevention of Cardiac Hypertrophy by Calcineurin Inhibition
    Eric N. Olson, Jeffery D. Molkentin · 1999 · Circulation Research
42. Megavesicles Implicated in the Rapid Transport of Intracisternal Aggregates across the Golgi Stack
    Allen Volchuk, MYLENE AMHERDT, Mariella Ravazzola, Britta Brügger, Victor M. Rivera, Tim Clackson, Alain Perrelet, Thomas H. Söllner, James E. Rothman, Lelio Orci · 2000 · Cell
43. The Effects of FK506 on Dorsal Column Axons Following Spinal Cord Injury in Adult Rats: Neuroprotection and Local Regeneration
    Seb Bavetta, Peter J. Hamlyn, Geoffrey Burnstock, A. Robert Lieberman, Patrick Norval Anderson · 1999 · Experimental Neurology
44. Augmenter of Liver Regeneration: Its Place in the Universe of Hepatic Growth Factors
    A. Francavilla, Michio Hagiya, Kendrick A. Porter, Lorenzo Polimeno, Izumi Ihara, Thomas E. Starzl · 1994 · Hepatology
45. Parameterization of OPLS–AA force field for the conformational analysis of macrocyclic polyketides
    Kalju Kahn, Thomas C. Bruice · 2002 · Journal of Computational Chemistry
46. Hsp47 and Cyclophilin B Traverse the Endoplasmic Reticulum with Procollagen into Pre-Golgi Intermediate Vesicles
    Timothy Smith, Luciano Resende Ferreira, CARLA A. HEBERT, Kathleen Norris, John J. Sauk · 1995 · Journal of Biological Chemistry
47. CYCLOSPORINE A INHIBITS THE EXPRESSION OF COSTIMULATORY MOLECULES ON IN VITRO-GENERATED DENDRITIC CELLS
    Jang-Ik Lee, Raymond W. Ganster, David A. Geller, Gilbert J. Burckart, Angus W. Thomson, Lina Lü · 1999 · Transplantation
48. Manumycin polyketides act as molecular glues between UBR7 and P53
    Isobe, Yosuke, Okumura, Mikiko, McGregor, Lynn M., Brittain, Scott M., Jones, Michael D., Liang, Xiaoyou, White, Ross, Forrester, William, McKenna, Jeffrey M., Tallarico, John A. et al. · 2020 · Nature Chemical Biology
49. A critical review on fungi mediated plant responses with special emphasis to Piriformospora indica on improved production and protection of crops
    Mohammad Wahid Ansari, Dipesh Kumar Trivedi, Ranjan Kumar Sahoo, Sarvajeet Singh Gill, Narendra Tuteja · 2013 · Plant Physiology and Biochemistry
50. Tissue Distribution and Abundance of Human FKBP51, an FK506-Binding Protein That Can Mediate Calcineurin Inhibition
    Gail Baughman, Greg Wiederrecht, Fon Chang, Mary M. Martin, Suzanne Bourgeois · 1997 · Biochemical and Biophysical Research Communications
51. The 25-kDa FK506-binding protein is localized in the nucleus and associates with casein kinase II and nucleolin.
    Y J Jin, Steven J. Burakoff · 1993 · Proceedings of the National Academy of Sciences
52. Influence of site specifically altered Mip proteins on intracellular survival of Legionella pneumophila in eukaryotic cells
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53. Prolactin receptor signal transduction
    Charles V. Clevenger, James Bradford Kline · 2001 · Lupus
54. Photo‐Cross‐Linked Small‐Molecule Affinity Matrix for Facilitating Forward and Reverse Chemical Genetics
    Naoki Kanoh, Kaori Honda, Siro Simizu, Makoto Muroi, Hiroyuki Osada · 2005 · Angewandte Chemie International Edition
55. Immunophilin ligands demonstrate common features of signal transduction leading to exocytosis or transcription.
    Thomas Hultsch, M W Albers, Stuart L. Schreiber, Robert J. Hohman · 1991 · Proceedings of the National Academy of Sciences
56. Sirolimus, a New, Potent Immunosuppressive Agent
    Patrick A. Kelly, Scott A. Gruber, Fariba Behbod, Barry D. Kahan · 1997 · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy
57. FKBPs: at the crossroads of folding and transduction.
    Yaël Harrar, Catherine Bellini, J. Faure · 2001 · Trends in Plant Science
58. Molecular analysis of the interaction of calcineurin with drug-immunophilin complexes
    Neil A. Clipstone, David Franklin Fiorentino, Gerald R. Crabtree · 1994 · Journal of Biological Chemistry
59. T Lymphocytes Are Direct, Aryl Hydrocarbon Receptor (AhR)-Dependent Targets of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD): AhR Expression in Both CD4+ and CD8+ T Cells Is Necessary for Full Suppression of a Cytotoxic T Lymphocyte Response by TCDD
    Nancy Isaacson Kerkvliet · 2002 · Toxicology and Applied Pharmacology
60. Sensorimotor neuropathy resembling CIDP in patients receiving FK506
    John R. Wilson, ROBIN A. CONWIT, Benjamin H. Eidelman, Thomas E. Starzl, Kareem M Abu-Elmagd · 1994 · Muscle & Nerve
61. Sympathetic Neural Mechanisms of Cyclosporine-Induced Hypertension*
    Mikael Sander, Teresa Lyson, Gail D. Thomas, Ronald G. Victor · 1996 · American Journal of Hypertension
62. FKBP12‐rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol‐4 kinase activity.
    Maria Elena Cardenas, Joseph Heitman · 1995 · The EMBO Journal
63. Inducible gene expression in mammalian cells and transgenic mice.
    Enrique Saez, David No, Andrew B. West, R. Evans · 1997 · Current Opinion in Biotechnology
64. Ng‐MIP, a surface‐exposed lipoprotein of Neisseria gonorrhoeae, has a peptidyl‐prolyl cis/trans isomerase (PPIase) activity and is involved in persistence in macrophages
    Rosanna Leuzzi, Laura Serino, Maria Scarselli, Silvana Savino, Maria Rita Fontana, Elisabetta Monaci, Annarita Taddei, Gunter S. Fischer, Rino Rappuoli, Mariagrazia Pizza · 2005 · Molecular Microbiology
65. Pharmacologic circumvention of multidrug resistance
    James M. Ford, William N. Hait · 1993 · Cytotechnology
66. Decanolides, 10-membered lactones of natural origin
    Gerald Dräger, Andreas Kirschning, Ralf Thiericke, Marion Zerlin · 1996 · Natural Product Reports
67. Sensitive and specific quantification of sirolimus (rapamycin) and its metabolites in blood of kidney graft recipients by HPLC/electrospray-mass spectrometry
    Frank Streit, Uwe Christians, Hans‐Martin Schiebel, Kimberly L. Napoli, Ludger Ernst, A Linck, Barry D. Kahan, K.‐Fr. Sewing · 1996 · Clinical Chemistry
68. VASCULAR ENDOTHELIAL GROWTH FACTOR INDUCES PROTEIN KINASE C (PKC)-DEPENDENT Akt/PKB ACTIVATION AND PHOSPHATIDYLINOSITOL 3′-KINASE-MEDIATED PKCδ PHOSPHORYLATION: ROLE OF PKC IN ANGIOGENESIS
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69. The ascomycin macrolactam pimecrolimus (Elidel, SDZ ASM 981) is a potent inhibitor of mediator release from human dermal mast cells and peripheral blood basophils
    Torsten Zuberbier, Sie-Uen Chong, Karl Grunow, Sven Guhl, Pia Welker, Maximilian A. Grassberger, Beate Maria Henz · 2001 · Journal of Allergy and Clinical Immunology
70. The Common Tetratricopeptide Repeat Acceptor Site for Steroid Receptor-associated Immunophilins and Hop Is Located in the Dimerization Domain of Hsp90
    Amerigo Carrello, Evan Ingley, Rodney F. Minchin, Schickwann Tsai, Thomas Ratajczak · 1999 · Journal of Biological Chemistry
71. Mammalian Target of Rapamycin Inhibition
    Janice P. Dutcher · 2004 · Clinical Cancer Research
72. Curcumin inhibits mitogen stimulated lymphocyte proliferation, NFκB activation, and IL-2 signaling
    Dinesh Ranjan, Changguo Chen, Thomas D. Johnston, Hoonbae Jeon, Moolky Nagabhushan · 2004 · Journal of Surgical Research
73. Bacterial expression and photoaffinity labeling of a pheromone binding protein
    Glenn D. Prestwich · 1993 · Protein Science
74. Cyclosporine: mechanisms of action and toxicity
    B. H. Brouhard, R. M. Graham · 1994 · Cleveland Clinic Journal of Medicine
75. PPIase catalysis by human FK506-binding protein proceeds through a conformational twist mechanism.
    S.T. Park, Robert A. Aldape, Olga Futer, Maureen T. DeCenzo, David J. Livingston · 1992 · Journal of Biological Chemistry
76. In vivomonitoring of amine neurotransmitters using microdialysis with on-line capillary electrophoresis
    Michael T. Bowser, Robert T. Kennedy · 2001 · Electrophoresis
77. Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506?
    Matthias W. Sieber, Ria Baumgrass · 2009 · Cell Communication and Signaling
78. The calcium release channel of sarcoplasmic reticulum is modulated by FK-506 binding protein: Effect of FKBP-12 on single channel activity of the skeletal muscle ryanodine receptor
    Martin Mayrleitner, Anthony P. Timerman, Greg Wiederrecht, Sidney Fleischer · 1994 · Cell Calcium
79. Adeno-Associated Virus Type 2-Mediated Gene Transfer: Role of Cellular FKBP52 Protein in Transgene Expression
    Qing, Keyun, Hansen, Jonathan, Weigel-Kelley, Kirsten A., Tan, Mengqun, Zhou, Shangzhen, Srivastava, Arun · 2001 · Journal of Virology
80. Driving GDNF expression: The green and the red traffic lights
    Ana Saavedra, Graça Baltazar, Emı́lia P. Duarte · 2008 · Progress in Neurobiology
81. Tacrolimus and Cyclosporine a Inhibit Allostimulatory Capacity and Cytokine Production of Human Myeloid Dendritic Cells
    Gyöngyi Szabó, Cristina Gavala, Pranoti Mandrekar · 2001 · Journal of Investigative Medicine
82. Secretion by Trypanosoma cruzi of a peptidyl‐prolyl cis‐trans isomerase involved in cell infection.
    A. Moro, Francisco Ruiz‐Cabello, A. Fernández-Cano, Roberto Pablo Stock, Antonio Gustavo González · 1995 · The EMBO Journal
83. New Immunosuppressive Drugs: Mechanistic Insights and Potential Therapeutic Advances
    Angus W. Thomson, Thomas E. Starzl · 1993 · Immunological Reviews
84. 2-Aryl-2,2-difluoroacetamide FKBP12 Ligands: Synthesis and X-ray Structural Studies
    Gene M. Dubowchik, Vivekananda M. Vrudhula, Bireshwar Dasgupta, Jonathan L. Ditta, Ti Chen, S. Sheriff, Karin Sipman, Mark R. Witmer, Jeffrey A. Tredup, Dolatrai M. Vyas et al. · 2001 · Organic Letters
85. Plant organelles contain distinct peptidylprolyl cis,trans-isomerases.
    A Breiman, T.W. Fawcett, Maria Lucia Ghirardi, Autar K. Mattoo · 1992 · Journal of Biological Chemistry
86. Total Synthesis of Rapamycin
    Kyriacos Costa Nicolaou, Anthony D. Piscopio, Peter Bertinato, Tushar Kanti Chakraborty, Nobuto Minowa, Kazunori Koide · 1995 · Chemistry - A European Journal
87. FTY720 Story. Its Discovery and the following Accelerated Development of Sphingosine 1-Phosphate Receptor Agonists as Immunomodulators Based on Reverse Pharmacology
    Kunitomo Adachi, Kenji Chiba · 2007 · Perspectives in Medicinal Chemistry
88. Rapamycin: FK506's fraternal twin or distant cousin?
    Randall Ellis Morris · 1991 · Immunology Today
89. Sanglifehrin A, a Novel Cyclophilin-Binding Compound Showing Immunosuppressive Activity with a New Mechanism of Action
    Gerhard Zenke, Ulrike Strittmatter, Serge Fuchs, Valerie F. J. Quesniaux, Volker Brinkmann, W. Schüler, Mauro G. M. Zurini, Albert Enz, Andreas Billich, Jean‐Jacques Sanglier et al. · 2001 · The Journal of Immunology
90. Injection of LPS Causes Transient Suppression of Biological Clock Genes in Rats
    Kazuyuki Okada, Masahiko Yano, Yuichiro� Doki, Takashi Azama, Hiroshi Iwanaga, Hirofumi Miki, Mitsuo Nakayama, Hiroshi Miyata, Shuji Takiguchi, Yoshiyuki Fujiwara et al. · 2008 · Journal of Surgical Research
91. A Conformation of Cyclosporin A in Aqueous Environment Revealed by the X-Ray Structure of a Cyclosporin-Fab Complex
    Danièle Altschuh, Olivier Vix, B. Rees, Jean‐Claude Thierry · 1992 · Science
92. Nitroso Diels–Alder (NDA) reaction as an efficient tool for the functionalization of diene-containing natural products
    Serena Carosso, Marvin J. Miller · 2014 · Organic & Biomolecular Chemistry
93. Immunosuppressant-Induced Nephropathy
    Ali J. Olyaei, Angelo M. de Mattos, William M. Bennett · 1999 · Drug Safety
94. Multidomain Peptidyl Prolyl cis/trans Isomerases
    Cordelia Schiene‐Fischer · 2014 · Biochimica et Biophysica Acta (BBA) - General Subjects
95. Structural analysis uncovers a role for redox in regulating FKBP13, an immunophilin of the chloroplast thylakoid lumen
    Gayathri Gopalan, Zengyong He, Yves Balmer, Patrick G.N. Romano, Rajeev Gupta, Annie Heroux, Bob B. Buchanan, Kunchithapadam Swaminathan, Sheng Luan · 2004 · Proceedings of the National Academy of Sciences
96. Cyclophilins: a new family of proteins involved in intracellular folding
    Mark A. Stamnes, Suzanne L. Rutherford, Charles S. Zuker · 1992 · Trends in Cell Biology
97. Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation
    Meaghan Wall, Gretchen Poortinga, Katherine M. Hannan, Richard B. Pearson, Ross D. Hannan, Grant A. McArthur · 2008 · Blood
98. Two FKBP-related proteins are associated with progesterone receptor complexes.
    David F. Smith, Bruce A. Baggenstoss, Tony N. Marion, Ronald A. Rimerman · 1993 · Journal of Biological Chemistry
99. Role of p70 S6 Protein Kinase in Angiotensin II-induced Protein Synthesis in Vascular Smooth Muscle Cells
    Edith Giasson, Sylvain Meloche · 1995 · Journal of Biological Chemistry
100. Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs
     Gao, Jinxu, Mfuh, Adelphe, Amako, Yuka, Woo, Christina M. · 2018 · Journal of the American Chemical Society