Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

Cyclophilin: A Specific Cytosolic Binding Protein for Cyclosporin A

Handschumacher, R. E., Harding, M. W., Rice, J. S., Drugge, R. J., & Speicher, D. W. (1984) · Science · doi:10.1126/science.6238408 · Cited by 1,675

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

Fischer, G., Wittmann‐Liebold, B., Lang, K., Kiefhaber, T., & Schmid, F. X. (1989) · Nature · doi:10.1038/337476a0 · Cited by 1,408

A receptor for the immuno-suppressant FK506 is a cis–trans peptidyl-prolyl isomerase

Harding, M. W., Gałat, A., Uehling, D., & Schreiber, S. L. (1989) · Nature · doi:10.1038/341758a0 · Cited by 1,396

Cyclosporine

Oates, J. A., Wood, A. J. J., & Kahan, B. D. (1989) · New England Journal of Medicine · doi:10.1056/nejm198912213212507 · Cited by 1,351

Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin

Takahashi, N., Hayano, T., & Suzuki, M. (1989) · Nature · doi:10.1038/337473a0 · Cited by 1,075

Contingent Genetic Regulatory Events in T Lymphocyte Activation

Crabtree, G. R. (1989) · Science · doi:10.1126/science.2783497 · Cited by 1,071

FK 506 FOR LIVER, KIDNEY, AND PANCREAS TRANSPLANTATION

Starzl, T., Fung, J. J., Venkataraman, R., Todo, S., Demetris, A. J., & Jain, A. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91014-3 · Cited by 1,036

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

Siekierka, J. J., Hung, S. H. Y., Poe, M., Lin, C. S., & SIGAL, N. H. (1989) · Nature · doi:10.1038/341755a0 · Cited by 1,016

Identification of a Putative Regulator of Early T Cell Activation Genes

Shaw, J., Utz, P. J., Durand, D. B., Toole, J. J., Emmel, E. A., & Crabtree, G. R. (1988) · Science · doi:10.1126/science.3260404 · Cited by 946

Polypeptide chain binding proteins: Catalysts of protein folding and related processes in cells

Rothman, J. E. (1989) · Cell · doi:10.1016/0092-8674(89)90005-6 · Cited by 887

The nucleotide and deduced amino acid sequences of a peptidyl-prolyl cis-trans isomerase from Arabidopsis thaliana

Hayman, G. T., & Miernyk, J. A. (1994) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(94)90083-3 · Cited by 20

Variation and Selection

Quinkert, G., Bang, H., & Reichert, D. (1996) · Helvetica Chimica Acta · doi:10.1002/hlca.19960790504 · Cited by 22

Rapamycin inhibits IL-1-mediated interferon-gamma production in the YAC-1 T cell lymphoma

Altmeyer, A., & Dumont, F. J. (1993) · Cytokine · doi:10.1016/1043-4666(93)90052-7 · Cited by 20

The effect of cyclosporin A, FK506, and rapamycin on the murine chronic graft-versus-host response—anin vivomodel of Th2-like activity

Bundick, R. V., Craggs, R. I., & Holness, E. (1995) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1995.tb05574.x · Cited by 20

Evaluation of Matrix Metalloproteinase‐1 and Tissue Inhibitor of Metalloproteinase‐1 Levels in Gingival Fibroblasts of Cyclosporin A‐Treated Patients

Tüter, G., Serdar, M. A., Yalım, M., Gurhan, İ. D., & Baloş, K. (2002) · Journal of Periodontology · doi:10.1902/jop.2002.73.11.1273 · Cited by 20

1,4-Remote stereocontrol by asymmetric catalytic carbonyl-ene reaction with chiral homoallylic ethers: An application to the asymmetric synthesis od (11R,14S)-anti- and (31R,34S)-syn-segements of immunosuppressant rapamycin

Mikami, K., & Yoshida, A. (1994) · Tetrahedron Letters · doi:10.1016/0040-4039(94)80120-7 · Cited by 20

Immunopharmacologic Therapy in Renal Transplantation

SHOKER, A. S. (1996) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/j.1875-9114.1996.tb03638.x · Cited by 20

Slow Binding Inhibitors

Copeland, R. A. (2013) · doi:10.1002/9781118540398.ch6 · Cited by 20

Rapamycin synthetic studies. 1. Construction of the C(27)-C(42) subunit

Smith, A. B., Condon, S. M., McCauley, J. A., Leahy, J. W., Leazer, J. L., & Maleczka, R. E. (1994) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)73279-5 · Cited by 20

Presenilin, γ-Secretase, and the Search for Pathogenic Triggers of Alzheimer’s Disease

Wolfe, M. S. (2025) · Biochemistry · doi:10.1021/acs.biochem.4c00830 · Cited by 21

Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs

Gobeil, S., Bobay, B. G., Juvvadi, P. R., Cole, D. C., Heitman, J., Steinbach, W. J., Venters, R. A., & Spicer, L. D. (2021) · mBio · doi:10.1128/mbio.03000-21 · Cited by 18

Synthesis and immunosuppressive activity of new cyclolinopeptide A analogs modified with β‐prolines

Katarzyńska, J., Mazur, A., Bilska, M., Adamek, E., Zimecki, M., Jankowski, S., & Zabrocki, J. (2008) · Journal of Peptide Science · doi:10.1002/psc.1069 · Cited by 20

Analysis of rapamycin induced autophagy in Dictyostelium discoideum.

Swer, P. B., Lohia, R., & Saran, S. (2014) · PubMed · Cited by 19

The study of resistant mechanisms and reversal in an imatinib resistant Ph+ acute lymphoblastic leukemia cell line

Xing, H., Yang, X., Liu, T., Lin, J., Chen, X., & Gong, Y. (2012) · Leukemia Research · doi:10.1016/j.leukres.2011.12.018 · Cited by 19

Label-Free Quantitative Proteomic Analysis of Systemic Responses to Local Wounding and Virus Infection in Arabidopsis thaliana

Niehl, A., Zhang, Z. J., Kuiper, M. T. R., Peck, S. C., & Heinlein, M. (2013) · Journal of Proteome Research · doi:10.1021/pr3010698 · Cited by 19

Towards New Therapies for Parkinson's Disease

Finkelstein, D. I. (2011) · InTech eBooks · doi:10.5772/954 · Cited by 19

A concise synthesis of AG5473/5507 utilizing N-acyliminium ion chemistry

Guo, C., Reich, S., Showalter, R., Villafranca, E., & Dong, L. (2000) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)00846-7 · Cited by 19

Analogs of cyclosporin A modified at the D-Ala8 position.

Patchett, A. A., Taub, D., Hensens, O. D., Goegelman, R. T., Yang, L., Dumont, F. J., Peterson, L., & SIGAL, N. H. (1992) · The Journal of Antibiotics · doi:10.7164/antibiotics.45.94 · Cited by 19

An Internal FK506‐Binding Domain is the Catalytic Core of the Prolyl Isomerase Activity Associated with the Bacillus Subtilis Trigger Factor

Göthel, S. F., Schmid, R., Wipat, A., Carter, N. M., Emmerson, P. T., Harwood, C. R., & Marahiel, M. A. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00059.x · Cited by 19

Genetic relationships among actinomycetes that produce the immunosuppressant macrolides FK506, FK520/FK523 and rapamycin

Garrity, G. M., Heimbuch, B. K., Motamedi, H., & Shafiee, A. R. (1993) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/bf01570127 · Cited by 19

Structure−Activity Studies of Ground- and Transition-State Analogue Inhibitors of Cyclophilin

Wang, H. C., Kim, K., Bakhtiar, R., & Germanas, J. P. (2001) · Journal of Medicinal Chemistry · doi:10.1021/jm010009r · Cited by 19

ENHANCING THE EFFECT OF SECRETED CYCLOPHILIN B ON IMMUNOSUPPRESSIVE ACTIVITY OF CYCLOSPORINE1

Denys, A., Allain, F., Masy, E., Dessaint, J., & Spik, G. ̈. (1998) · Transplantation · doi:10.1097/00007890-199804270-00012 · Cited by 19

The gene encoding the periplasmic cyclophilin homologue, PPlase A, in Escherichia coli, is expressed from four promoters, three of which are activated by the cAMP–CRP complex and negatively regulated by the CytR repressor

Nørregaard‐Madsen, M., Myglnd, B., Pedersen, R., Valentin‐Hansen, P., & Søgaard‐Andersen, L. (1994) · Molecular Microbiology · doi:10.1111/j.1365-2958.1994.tb01333.x · Cited by 19

Effectiveness of FK506 on lipid peroxidation in the spinal cord following experimental traumatic injury

Kaymaz, M., Emmez, H., Bukan, N. C., Dursun, A., Kurt, G., Paşaoğlu, H., & Paşaoğlu, A. (2004) · Spinal Cord · doi:10.1038/sj.sc.3101621 · Cited by 19

Yellow Lupine Cyclophilin Transcripts Are Highly Accumulated in the Nodule Meristem Zone

Nuc, K., Nuc, P., & Słomski, R. (2001) · Molecular Plant-Microbe Interactions · doi:10.1094/mpmi.2001.14.12.1384 · Cited by 19

HEPATOTROPHIC PROPERTIES IN DOGS OF HUMAN FKBP, THE BINDING PROTEIN FOR FK506 AND RAPAMYCIN

&NA; (1991) · Transplantation · doi:10.1097/00007890-199110000-00038 · Cited by 19

Suppressive effects of IPD-1151T (suplatast-tosilate) on induction of mast cells from normal mouse splenocytes

Konno, S.-I., Adachi, M., Asano, K., Gonogami, Y., Ikeda, K., Okamoto, K.-I., & Takahashi, T. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)90151-1 · Cited by 19

A semiempirical AM1, MNDO and PM3 study of the rotational barriers of various ureas, thioureas, amides and thioamides

Feigel, M., & Straßner, T. (1993) · Journal of Molecular Structure THEOCHEM · doi:10.1016/0166-1280(93)87112-q · Cited by 19

Improved therapies for Parkinson's disease: life beyond dopamine D2D3 receptors agonists

Williams, M. J., Wright, S., & Lloyd, G. K. (1997) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(97)90650-7 · Cited by 19

Distribution characteristics of immunosuppressants FK506 and cyclosporin A in the blood compartment

Takada, K., Katayama, N., Kiriyama, A., & Usuda, H. (1993) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.2510140803 · Cited by 19

Metal-dependent nucleotide binding to the Escherichia coli rotamase SlyD

Mitterauer, T., Nanoff, C., Ahorn, H., Freissmuth, M., & HOHENEGGER, M. (1999) · Biochemical Journal · doi:10.1042/0264-6021:3420033 · Cited by 19

Immunopharmacology of new xenobiotic immunosuppressive molecules.

Morris, R. E. (1992) · PubMed · Cited by 19

Cyclosporins: Recent Developments in Biosynthesis, Pharmacology and Biology, and Clinical Applications

Kallen, J., Mikol, V., Quesniaux, V. F. J., Walkinshaw, M. D., Schneider-Scherzer, E., Schörgendorfer, K., Weber, G., & Fliri, H. G. (1997) · Biotechnology · doi:10.1002/9783527620890.ch12 · Cited by 19

Diastereoselective [2,3] Wittig rearrangement of carbohydrate-derived tertiary allylic ethers. 2. Synthesis of an advanced rapamycin intermediate from D-glucose.

Sin, N., & Kallmerten, J. L. (1993) · Tetrahedron Letters · doi:10.1016/0040-4039(93)89003-9 · Cited by 19

STAT3–CyPA signaling pathway in endothelial cell apoptosis

Xie, Y., Li, X., & Ge, J. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.109413 · Cited by 18

FKBP52 in Neuronal Signaling and Neurodegenerative Diseases: A Microtubule Story

Chambraud, B., Byrne, C., Méduri, G., Baulieu, E. E., & Giustiniani, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031738 · Cited by 18

Introducing Immunophilins. From Organ Transplantation to Plant Biology

Romano, P. G. N., He, Z., & Luan, S. (2004) · PLANT PHYSIOLOGY · doi:10.1104/pp.103.900108 · Cited by 18

Borrowing to make ends meet

Clardy, J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.1826 · Cited by 18

Use of parallel-synthesis combinatorial libraries for rapid identification of potent FKBP12 inhibitors

Choi, C., Li, J.-H., Vaal, M. J., Thomas, C., Limburg, D. C., Wu, Y., Chen, Y., Soni, R., Scott, C., Ross, D. T., et al. (2002) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(02)00147-6 · Cited by 18

Trends in Bioprobe Research

Osada, H. (2000) · Springer eBooks · doi:10.1007/978-4-431-65927-3_1 · Cited by 18

An exceptionally mild and efficient route to dehydroalanine peptides

Ranganathan, D., Shah, K., & Vaish, N. K. (1992) · Journal of the Chemical Society Chemical Communications · doi:10.1039/c39920001145 · Cited by 18

Molecular cloning, structure and expression of a novel nuclear RNA-binding cyclophilin-like gene (PPIL4) from human fetal brain

Zeng, L., Zhou, Z. G., Xu, J., Zhao, W., Wang, W., Huang, Y., Cheng, C., Xu, M., Xie, Y., & Mao, Y. (2001) · Cytogenetic and Genome Research · doi:10.1159/000057015 · Cited by 18

Tacrolimus suppresses tumour necrosis factor‐α and protects against splanchnic artery occlusion shock

Squadrito, F., Altavilla, D., Squadrito, G., Ferlito, M., Campo, G. M., Arlotta, M., Grimaldi, S., Quartarone, C., Saitta, A., & Caputi, A. P. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702528 · Cited by 18

Synthesis of secorapamycin esters and amides

Skotnicki, J. S., Kearney, R. M., & Smith, A. L. (1994) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)76509-9 · Cited by 18

Activation-induced apoptosis in Jurkat cells through a myc-independent mechanism

Ruiz-Ruiz, M. D. C., Oliver, F. J., Izquierdo, M., & López‐Rivas, A. (1995) · Molecular Immunology · doi:10.1016/0161-5890(95)00059-n · Cited by 18

The panorama of cyclosporin research

Balakrishnan, K., & Pandey, A. (1996) · Journal of Basic Microbiology · doi:10.1002/jobm.3620360212 · Cited by 18

In Vitro Property and Mode of Action.

Fujine, K., Abe, F., SEKI, N., Ueda, H., Hino, M., & Fujii, T. (2003) · The Journal of Antibiotics · doi:10.7164/antibiotics.56.62 · Cited by 18

An analysis of the expression of cyclophilin C reveals tissue restriction and an intriguing pattern in the mouse kidney.

Friedman, J. S., Weissman, I. L., Friedman, J. S., & Alpert, S. (1994) · PubMed Central · Cited by 18

Comparative effects of FK-506, rapamycin and cyclosporin A, on the in vitro differentiation of dorsal root ganglia explants and septal cholinergic neurons

Carreau, A., Gueugnon, J., Bénavidès, J., & Vigé, X. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00160-3 · Cited by 18

Stereoselective Synthesis of the C1-C7 Segment of (+)-Discodermolide

Miyazawa, M., Oonuma, S., Maruyama, K., & Miyashita, M. (1997) · Chemistry Letters · doi:10.1246/cl.1997.1191 · Cited by 18

Modulation of Nuclear Protein Import

Fujihara, S. M., & Nadler, S. G. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00049-5 · Cited by 18

The “three body solution”: Structural insights into molecular glues

Tomlinson, A. C. A., Knox, J. E., Brunsveld, L., Ottmann, C., & Yano, J. K. (2025) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2025.103007 · Cited by 20

From Drosophila to Humans: Reflections on the Roles of the Prolyl Isomerases and Chaperones, Cyclophilins, in Cell Function and Disease

Ferreira, P. A., & Orry, A. J. W. (2012) · Journal of Neurogenetics · doi:10.3109/01677063.2011.647143 · Cited by 17

A “Clickable” MTX Reagent as a Practical Tool for Profiling Small‐Molecule–Intracellular Target Interactions via MASPIT

Risseeuw, M., Clercq, D. J. H. D., Lievens, S., Hillaert, U., Sinnaeve, D., den Broeck, F. V., Martins, J. C., Tavernier, J. H., & Calenbergh, S. V. (2013) · ChemMedChem · doi:10.1002/cmdc.201200493 · Cited by 17

Cyclophilin B facilitates the replication of Orf virus

Zhao, K., Li, J., He, W., Song, D., XiMu, Z., Zhang, D., Zhou, Y., & Gao, F. (2017) · Virology Journal · doi:10.1186/s12985-017-0781-x · Cited by 17

The ARE-binding protein Tristetraprolin (TTP) is a novel target and mediator of calcineurin tumor suppressing function in the skin

Wu, X., di Vignano, A. T., Zhou, Q., Dziunycz, P., Bai, F., Mi, J., Qin, J., Zu, T., & Hofbauer, G. F. L. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007366 · Cited by 17

Role of aryl hydrocarbon receptor in central nervous system tumors: Biological and therapeutic implications (Review)

Zaragoza‐Ojeda, M., Apatiga‐Vega, E., & Arenas‐Huertero, F. (2021) · Oncology Letters · doi:10.3892/ol.2021.12721 · Cited by 17

Computational Insight into Small Molecule Inhibition of Cyclophilins

Sambasivarao, S. V., & Acevedo, O. (2010) · Journal of Chemical Information and Modeling · doi:10.1021/ci1004114 · Cited by 17

Studies of the interaction of potassium(I), calcium(II), magnesium(II), and copper(II) with cyclosporin A

Cusack, R. M., Grøndahl, L., Fairlie, D. P., Hanson, G. R., & Gahan, L. R. (2003) · Journal of Inorganic Biochemistry · doi:10.1016/s0162-0134(03)00288-5 · Cited by 17

Solid-Phase synthesis of FKBP12 inhibitors: N-Sulfonyl and N-Carbamoylprolyl/pipecolyl amides

Wei, L., Wu, Y., Wilkinson, D. E., Chen, Y., Soni, R., Scott, C., Ross, D. T., Guo, H., Howorth, P., Valentine, H., et al. (2002) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(02)00146-4 · Cited by 17

Mechanism of action of cyclosporin in rheumatoid arthritis

Bentin, J. (1995) · Clinical Rheumatology · doi:10.1007/bf02215854 · Cited by 17

Prolactin Receptor Signal Transduction

Clevenger, C. V., Rycyzyn, M. A., Syed, F., & Kline, J. B. (2001) · Endocrine updates · doi:10.1007/978-1-4615-1683-5_18 · Cited by 17

[15] Regulation of gene expression with synthetic dimerizers

Pollock, R. M., & Rivera, V. M. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)06017-6 · Cited by 17

Analysis of the oxalamide functionality as hydrogen bonding former: geometry, energetics, cooperative effects, NMR chemical characterization and implications in molecular engineering

Alemán, C., & Casanovas, J. (2004) · Journal of Molecular Structure THEOCHEM · doi:10.1016/j.theochem.2003.12.039 · Cited by 17

Anchorage-Independent Activation of Mitogen-Activated Protein Kinase through Phosphatidylinositol-3 Kinase by Insulin-like Growth Factor I

Suzuki, K., & Takahashi, K. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2737 · Cited by 17

Combined cyclosporin-A /prednisone therapy of patients with active uveitis suppresses IFN-γ production and the function of dendritic cells

Frassanito, M. A., Dammacco, R., Fusaro, T., Cusmai, A., Guerriero, S., & Sborgia, C. (2003) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2003.02214.x · Cited by 17

Tacrolimus in Kidney Transplantation

Kliem, V., & Brunkhorst, R. R. (1998) · The Nephron journals/Nephron journals · doi:10.1159/000044985 · Cited by 17

Control of PHAS-I phosphorylation in 3T3-L1 adipocytes: effects of inhibiting protein phosphatases and the p70 S6K signalling pathway

Lin, T. A., & Lawrence, J. C. (1997) · Diabetologia · doi:10.1007/s001250051391 · Cited by 17

Immunosuppressant therapy averts rejection of allogeneic FKBP1A-disrupted CAR-T cells

Maldini, C. R., Messana, A., Bendet, P. B., Camblin, A. J., Musenge, F. M., White, M. L., Rocha, J. J., Coholan, L. J., Karaca, C., Li, F., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.06.022 · Cited by 18

The Formal Total Synthesis of FR252921 – An Immunosuppressant

Yadav, J. S., & Sengupta, S. (2012) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201201097 · Cited by 16

Timcodar (VX-853) Is a Non-FKBP12 Binding Macrolide Derivative That Inhibits PPARγand Suppresses Adipogenesis

Hinds, T. D., John, K., McBeth, L., Trabbic, C. J., & Sánchez, E. R. (2016) · PPAR Research · doi:10.1155/2016/6218637 · Cited by 16

Peptide Conformation: Stability and Dynamics

Marshall, G. R., Beusen, D. D., & Nikiforovich, G. V. (1995) · Elsevier eBooks · doi:10.1016/b978-012310920-0/50006-1 · Cited by 16

Exome sequencing identifies variants in FKBP4 that are associated with recurrent fetal loss in humans

Demetriou, C., Chanudet, E., GOSgene, Joseph, A. P., Topf, M., Thomas, A. C., Bitner-Glindzicz, M. A. K., Regan, L., Stanier, P., & Moore, G. E. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz203 · Cited by 15

The Trypanosoma cruzi PIN1 gene encodes a parvulin peptidyl-prolyl cis/trans isomerase able to replace the essential ESS1 in Saccharomyces cerevisiae☆

Erben, E., Daum, S., & Téllez-Iñón, M. T. (2007) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2007.03.004 · Cited by 16

Marine invertebrates cross phyla comparisons reveal highly conserved immune machinery

Oren, M., Paz, G., Douek, J., Rosner, A., Amar, K.-O., & Rinkevich, B. (2012) · Immunobiology · doi:10.1016/j.imbio.2012.06.004 · Cited by 16

Cymbimicin A and B, Two Novel Cyclophilin-binding Structures Isolated from Actinomycetes.

FEHR, T., Quesniaux, V. F. J., Sanglier, J., Oberer, L., Gschwind, L., Ponelle, M., SCHILLING, W., Wehrli, S., Enz, A., Zenke, G., et al. (1997) · The Journal of Antibiotics · doi:10.7164/antibiotics.50.893 · Cited by 16

Beneficial effects of FK506 for experimental temporal lobe epilepsy

Nishimura, T., Imai, H., Minabe, Y., Sawa, A., & Kato, N. (2006) · Neuroscience Research · doi:10.1016/j.neures.2006.08.006 · Cited by 16

1 alpha,25-dihydroxyvitamin D3-induced upregulation of calcineurin during leukemic HL-60 cell differentiation

Omay, S. B., Nakai, K., Kuno, T., Shiku, H., & Nishikawa, M. (1996) · Blood · doi:10.1182/blood.v87.7.2947.bloodjournal8772947 · Cited by 16

Cancer Cell‐Based Genomic and Small Molecule Screens

Caldwell, J. S. (2006) · Advances in cancer research · doi:10.1016/s0065-230x(06)96006-0 · Cited by 16

Stereochemical Course of the Oxidation of l -Pipecolic Acid by the Flavoenzyme l -Pipecolate Oxidase

Zabriskie, T. M., Kelly, W. L., & Liang, X. (1997) · Journal of the American Chemical Society · doi:10.1021/ja970825h · Cited by 16

Use of immunosuppressive agents in ocular diseases

Mochizuki, M., & de Smet, M. D. (1994) · Progress in Retinal and Eye Research · doi:10.1016/1350-9462(94)90020-5 · Cited by 16

A gene of Acinetobacter calcoaceticus BD413 encodes a periplasmic peptidyl-prolyl cis-trans isomerase of the cyclophilin sub-class that is not essential for growth

Kok, R. G., Christoffels, V. M., Vosman, B., & Hellingwerf, K. J. (1994) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(94)90218-6 · Cited by 16

An FKBP‐Rapamycin‐Sensitive, Cyclin‐Dependent Kinase Activity that Correlates with the FKBP‐Rapamycin‐Induced G1 Arrest Point in MG‐63 Cellsa

Albers, M. W., Brown, E. J., Tanaka, A., Williams, R. T., Hall, F. L., & Schreiber, S. L. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb17142.x · Cited by 16

Deoxyspergualin

Tepper, M. A. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb17147.x · Cited by 16

Molecular characterization of cyclophilin A-like protein from Piriformospora indica for its potential role to abiotic stress tolerance in E. coli

Trivedi, D. K., Ansari, M. W., Dutta, T., Singh, P., & Tuteja, N. K. (2013) · BMC Research Notes · doi:10.1186/1756-0500-6-555 · Cited by 15

Overcoming resistance to rapalogs in gliomas by combinatory therapies

Grzmil, M., & Hemmings, B. A. (2013) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2013.01.041 · Cited by 15

A Rice Immunophilin Gene, OsFKBP16-3, Confers Tolerance to Environmental Stress in Arabidopsis and Rice

Park, H., Lee, S. Y., You, Y., Yoon, D. S., Kim, B., Ahn, J. C., & Cho, H. S. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14035899 · Cited by 15

Autocrine pathways involving S100A8 and/or S100A9 that are postulated to regulate the immunological functions of macrophages in rats

Okada, K., Arai, S., Nakase, H., Kohno, H., Nakamura, F., Takeda, M., Toda, Y., Itoh, H., Adachi, S., & Ikemoto, M. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.11.099 · Cited by 15

Targeted Mass Spectrometry-Based Approach for Protein–Ligand Binding Analyses in Complex Biological Mixtures Using a Phenacyl Bromide Modification Strategy

Jin, L., Wang, D., Gooden, D. M., Ball, C. H., & Fitzgerald, M. C. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b02658 · Cited by 15

Targeting the Cyclophilin Domain of Ran-binding Protein 2 (Ranbp2) with Novel Small Molecules to Control the Proteostasis of STAT3, hnRNPA2B1 and M-Opsin

Cho, K., Orry, A. J. W., Park, S. E., & Ferreira, P. A. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00134 · Cited by 15

Cyclosporin A and FK506 prevent the derepression of the IL-2 gene in mitogen-induced primary T lymphocytes

Mouzaki, Α., Dai, Y., Weil, R., & Rungger, D. (1992) · Cytokine · doi:10.1016/1043-4666(92)90050-2 · Cited by 15

Molecular mode of action of cyclosporin and FK506in human thymocytes

Reem, G. H. (1992) · Journal of Autoimmunity · doi:10.1016/0896-8411(92)90030-t · Cited by 15

Establishment of ex vivo systems to identify compounds acting on innate immune responses and to determine their target molecules using transgenic Drosophila

Sekiya, M., Ueda, K., Fujita, T., Kitayama, M., Kikuchi, H., Oshima, Y., & Kurata, S. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.08.026 · Cited by 15

Mammalian FKBP-25 and Its Associated Proteins

Leclercq, M., Vinci, F., & Gałat, A. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1883 · Cited by 15

Photo‐Cross‐Linked Small‐Molecule Affinity Matrix for Facilitating Forward and Reverse Chemical Genetics

Kanoh, N., Honda, K., Simizu, S., Muroi, M., & Osada, H. (2005) · Angewandte Chemie · doi:10.1002/ange.200462370 · Cited by 15

Localization of cyclophilin A and cyclophilin C mRNA in murine kidney using RT-PCR

Otsuka, M., Terada, Y., Yang, T., Nonoguchi, H., Tomita, K., & Marumo, F. (1994) · Kidney International · doi:10.1038/ki.1994.175 · Cited by 15

Cloning, characterization and functional expression of a cyclophilin of Entamoeba histolytica☆

Ostoa‐Saloma, P., Carrero, J. C., Petrossian, P., Hérion, P., Landa, A., & Laclette, J. P. (2000) · Molecular and Biochemical Parasitology · doi:10.1016/s0166-6851(00)00190-0 · Cited by 15

Covalent binding of cyclosporine inhibits irreversibly T-lymphocyte activation

Ryffel, B., Woerly, G., Quesniaux, V. F. J., Husi, H., & Foxwell, B. M. J. (1992) · Biochemical Pharmacology · doi:10.1016/0006-2952(92)90598-d · Cited by 15

Interleukin-2 receptor (CD25) upregulation on human T-lymphocytes: sensitivity to immunosuppressants is defined by the mode of T-lymphocyte activation

Ryffel, B., Willcocks, J. L., Brooks, N., & Woerly, G. (1995) · Immunopharmacology · doi:10.1016/0162-3109(95)00023-m · Cited by 15

Structural organization of the genes encoding human and murine FK506-binding protein (FKBP) 13 and comparison to FKBP1

Hendrickson, B. A., Zhang, W., Craig, R. J., Yong-Jiu, J., Bierer, B. E., Burakoff, S. J., & DiLella, A. G. (1993) · Gene · doi:10.1016/0378-1119(93)90106-d · Cited by 15

Immunophilins in protein folding and immunosuppression 1

Fruman, D. A., Burakoff, S. J., & Bierer, B. E. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.6.7513288 · Cited by 249

REVIEWS Immunophilins in protein folding and immunosuppression1

Vruman, D. A., Burakoff, S. J., & Bierer*tll, B. E. (2013)

Immunophilin Receptors for Immunosuppressive Drugs

Soldin, S. J., Murthy, J. N., Donnelly, J. G., Chen, Y., & Goodyear, N. (1993) · Therapeutic Drug Monitoring · doi:10.1097/00007691-199312000-00002 · Cited by 10

Chapter 22. Immunophilins and Immunosuppressive Drug Action

Armistead, D. M., & Harding, M. W. (1993) · Annual reports in medicinal chemistry · doi:10.1016/s0065-7743(08)60892-1 · Cited by 10

The molecular mechanism of immunophilin binding immunosuppressant

Zhang, W. (2002) · Zhongguo yaolixue yu dulixue zazhi