Cited by 1,494Signaling Pathways in DiseaseS100 Proteins and AnnexinsProtein Interaction Studies and Fluorescence Analysis

The DOI matches its Crossref record; 55 of the 56 references it cites were found in a registry or an index.

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

Schreiber, Stuart L.·1991·Science

DOI 10.1126/science.1702904

Open this paper in CoChat — free account

Abstract

Cyclosporin A, FK506, and rapamycin are inhibitors of specific signal transduction pathways that lead to T lymphocyte activation. These immunosuppressive agents bind with high affinity to cytoplasmic receptors termed immunophilins (immunosuppressant binding proteins). Studies in this area have focused on the structural basis for the molecular recognition of immunosuppressants by immunophilins and the biological consequences of their interactions. Defining the biological roles of this emerging family of receptors and their ligands may illuminate the process of protein trafficking in cells and the mechanisms of signal transmission through the cytoplasm.

Integrity signals

Registry

Crossref · 10.1126/science.1702904

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cyclophilin: A Specific Cytosolic Binding Protein for Cyclosporin A
Handschumacher, R. E., Harding, M. W., Rice, J. S., Drugge, R. J., & Speicher, D. W. (1984) · Science · doi:10.1126/science.6238408 · Cited by 1,675
Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins
Fischer, G., Wittmann‐Liebold, B., Lang, K., Kiefhaber, T., & Schmid, F. X. (1989) · Nature · doi:10.1038/337476a0 · Cited by 1,408
A receptor for the immuno-suppressant FK506 is a cis–trans peptidyl-prolyl isomerase
Harding, M. W., Gałat, A., Uehling, D., & Schreiber, S. L. (1989) · Nature · doi:10.1038/341758a0 · Cited by 1,396
Self-citation
Cyclosporine
Oates, J. A., Wood, A. J. J., & Kahan, B. D. (1989) · New England Journal of Medicine · doi:10.1056/nejm198912213212507 · Cited by 1,351
Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin
Takahashi, N., Hayano, T., & Suzuki, M. (1989) · Nature · doi:10.1038/337473a0 · Cited by 1,075
Contingent Genetic Regulatory Events in T Lymphocyte Activation
Crabtree, G. R. (1989) · Science · doi:10.1126/science.2783497 · Cited by 1,071
FK 506 FOR LIVER, KIDNEY, AND PANCREAS TRANSPLANTATION
Starzl, T., Fung, J. J., Venkataraman, R., Todo, S., Demetris, A. J., & Jain, A. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91014-3 · Cited by 1,036
A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin
Siekierka, J. J., Hung, S. H. Y., Poe, M., Lin, C. S., & SIGAL, N. H. (1989) · Nature · doi:10.1038/341755a0 · Cited by 1,016
Identification of a Putative Regulator of Early T Cell Activation Genes
Shaw, J., Utz, P. J., Durand, D. B., Toole, J. J., Emmel, E. A., & Crabtree, G. R. (1988) · Science · doi:10.1126/science.3260404 · Cited by 946
Polypeptide chain binding proteins: Catalysts of protein folding and related processes in cells
Rothman, J. E. (1989) · Cell · doi:10.1016/0092-8674(89)90005-6 · Cited by 887

Flagged first, then by citations

Show all 56 references

1 of the 56 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

Bierer, B. E., Proceedings of the National Academy of Sciences of the United States of America 87: 9231 (1990).
Matila P. S. EMBO Journal in press.

Sorted by citations

Items 101–200 of 1,002

Structure of human cyclophilin and its binding site for cyclosporin A determined by X-ray crystallography and NMR spectroscopy
Kallen, J., Spitzfaden, C. E., Zurini, M. G. M., Wider, G., Widmer, H., Kurt Wüthrich, A., & Walkinshaw, M. D. (1991) · Nature · doi:10.1038/353276a0 · Cited by 271
Prolyl Isomerases: Role in Protein Folding
Schmid, F. X., Mayr, L. M., Mücke, M., & Schönbrunner, E. R. (1993) · Advances in protein chemistry · doi:10.1016/s0065-3233(08)60563-x · Cited by 267
Effects of glucocorticoids on the trabecular meshwork: towards a better understanding of glaucoma
Wordinger, R. J., & Clark, A. F. (1999) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(98)00035-4 · Cited by 257
Cyclosporin A, FK506 and rapamycin: more than just immunosuppression
Kunz, J., & Hall, M. N. (1993) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(93)90069-y · Cited by 258
Industrial natural product chemistry for drug discovery and development
Bauer, A., & Brönstrup, M. (2013) · Natural Product Reports · doi:10.1039/c3np70058e · Cited by 262
Rapamycins: Antifungal, antitumor, antiproliferative, and immunosuppressive macrolides
Morris, R. E. (1992) · Transplantation Reviews · doi:10.1016/s0955-470x(10)80014-x · Cited by 253
Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes.
Peattie, D. A., Harding, M. W., Fleming, M. A., DeCenzo, M. T., Lippke, J. A., Livingston, D. J., & Benasutti, M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.10974 · Cited by 251
TGFβ1 Inhibits NF-κB/Rel Activity Inducing Apoptosis of B Cells: Transcriptional Activation of IκBα
Arsura, M., Wu, M., & Sonenshein, G. E. (1996) · Immunity · doi:10.1016/s1074-7613(00)80307-6 · Cited by 246
Pharmacokinetics of tacrolimus in liver transplant patients*
Jusko, W. J., Piekoszewski, W., Klintmalm, G. B. G., Shaefer, M. S., Hébert, M. F., Piergies, A. A., Lee, C. C., Schechter, P. J., & Mekki, Q. A. (1995) · Clinical Pharmacology & Therapeutics · doi:10.1016/0009-9236(95)90153-1 · Cited by 250
Immunophilins in protein folding and immunosuppression 1
Fruman, D. A., Burakoff, S. J., & Bierer, B. E. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.6.7513288 · Cited by 249
Immunosuppressants implicate protein phosphatase regulation of K+ channels in guard cells.
Luan, S., Li, W., Rusnak, F. M., Assmann, S. M., & Schreiber, S. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.6.2202 · Cited by 248
Self-citation
Newer Immunosuppressive Drugs
Gummert, J. F., Ikonen, T. S., & Morris, R. E. (1999) · Journal of the American Society of Nephrology · doi:10.1681/asn.v1061366 · Cited by 245
Peptidylproline cis/trans isomerases
Gałat, A., & Metcalfe, S. M. (1995) · Progress in Biophysics and Molecular Biology · doi:10.1016/0079-6107(94)00009-x · Cited by 240
Control of PHAS-I by Insulin in 3T3-L1 Adipocytes
Lin, T.-A., Kong, X., Saltiel, A. R., Blackshear, P. J., & Lawrence, J. C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.31.18531 · Cited by 237
Immunophilin FK506-Binding Protein 52 (Not FK506-Binding Protein 12) Mediates the Neurotrophic Action of FK506
Gold, B. G., Densmore, V. S., Shou, W., Matzuk, M. M., & Gordon, H. S. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38260-6 · Cited by 236
Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins
Shamji, A. F., Kuruvilla, F. G., & Schreiber, S. L. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00866-6 · Cited by 234
Self-citation
Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition.
Dudkin, L., Dilling, M. B., Cheshire, P. J., Harwood, F. C., Hollingshead, M. G., Arbuck, S. G., Travis, R., Sausville, E. A., & Houghton, P. J. (2001) · PubMed · Cited by 232
Interaction of the Immunosuppressant Deoxyspergualin with a Member of the Hsp70 Family of Heat Shock Proteins
Nadler, S. G., Tepper, M. A., Schacter, B., & Mazzucco, C. E. (1992) · Science · doi:10.1126/science.1411548 · Cited by 231
A novel chaperone complex for steroid receptors involving heat shock proteins, immunophilins, and p23.
Johnson, J. L., & Toft, D. O. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31487-4 · Cited by 229
The architecture of the interleukin-2 promoter: a reflection of T lymphocyte activation
Serfling, E., Avots, A., & Neumann, M. (1995) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(95)00112-t · Cited by 229
Medicinal Chemistry in the Golden Age of Biology: Lessons from Steroid and Peptide Research
Hirschmann, R. F. (1991) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199112781 · Cited by 227
Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells.
Yeh, W., Bierer, B. E., & McKnight, S. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.11086 · Cited by 226
Regulation of Cell Proliferation, Apoptosis, and Carcinogenesis by Activin
Chen, Y., Lui, H. M., Lin, S.-L., Lee, J. M., & Ying, S. (2002) · Experimental Biology and Medicine · doi:10.1177/153537020222700201 · Cited by 225
Infection in the Organ Transplant Recipient
Rubin, R. H. (1994) · Springer eBooks · doi:10.1007/978-1-4615-2490-8_24 · Cited by 223
The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin.
Dumont, F. J., Staruch, M. J., Koprak, S. L., Siekierka, J. J., Lin, C. S., Harrison, R., Sewell, T., Kindt, V. M., Beattie, T. R., & Wyvratt, M. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.3.751 · Cited by 250
Synthesis and Immunosuppressive Activity of 2-Substituted 2-Aminopropane-1,3-diols and 2-Aminoethanols
Kiuchi, M., Adachi, K., Kohara, T., Minoguchi, M., Hanano, T., Aoki, Y., Mishina, T., Arita, M., Nakao, N., Ohtsuki, M., et al. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm000173z · Cited by 218
Neuroprotective Actions of FK506 in Experimental Stroke:In VivoEvidence against an Antiexcitotoxic Mechanism
Butcher, S. P., Henshall, D. C., TERAMURA, Y., Iwasaki, K., & Sharkey, J. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-18-06939.1997 · Cited by 215
Immunophilins and Parvulins. Superfamily of Peptidyl Prolyl Isomerases in Arabidopsis
He, Z., Li, L., & Luan, S. (2004) · PLANT PHYSIOLOGY · doi:10.1104/pp.103.031005 · Cited by 214
X-ray structure of a decameric cyclophilin-cyclosporin crystal complex
Pflügl, G., Kallen, J., Schirmer, T., Jansonius, J. N., Zurini, M. G. M., & Walkinshaw, M. D. (1993) · Nature · doi:10.1038/361091a0 · Cited by 216
FKBP12 Binds the Inositol 1,4,5-Trisphosphate Receptor at Leucine-Proline (1400–1401) and Anchors Calcineurin to this FK506-like Domain
Cameron, A. M., Nucifora, F. C., Fung, E. T., Livingston, D. J., Aldape, R. A., Ross, C. A., & Snyder, S. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.44.27582 · Cited by 212
Heat stress proteins and transcription factors
Nover, L., & Scharf, K. (1997) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000583 · Cited by 210
Rapamycin Resistance Tied to Defective Regulation of p27 Kip1
Luo, Y., Marx, S. O., Kiyokawa, H., Koff, A., Massagué, J., & Marks, A. R. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.12.6744 · Cited by 210
Diversity in GeneticIn VivoMethods for Protein-Protein Interaction Studies: from the Yeast Two-Hybrid System to the Mammalian Split-Luciferase System
Stynen, B., Tournu, H., Tavernier, J. H., & Dijck, P. V. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05021-11 · Cited by 218
Protein Kinase A Phosphorylation of the Cardiac Calcium Release Channel (Ryanodine Receptor) in Normal and Failing Hearts
Reiken, S. R., Gaburjáková, M., Guatimosim, S., Gomez, A. M., D'Armiento, J. M., Burkhoff, D., Wang, J., Vassort, G., Lederer, W. J., & Marks, A. R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207028200 · Cited by 205
Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells.
Redmon, J. B., Olson, L. K., Armstrong, M. B., Greene, M. J., & Robertson, R. P. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119105 · Cited by 204
Downregulation of Ca2+ and Mg2+ Transport Proteins in the Kidney Explains Tacrolimus (FK506)-Induced Hypercalciuria and Hypomagnesemia
Nijenhuis, T., Hoenderop, J. G. J., & Bindels, R. J. M. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000113318.56023.b6 · Cited by 203
Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor alpha gene promoter.
Goldfeld, A. E., McCaffrey, P. G., Strominger, J. L., & Rao, A. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.4.1365 · Cited by 197
Neural actions of immunophilin ligands
Snyder, S. H., Sabatini, D. M., Lai, M. M.-S., Steiner, J. P., Hamilton, G. S., & Suzdak, P. D. (1998) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(97)01146-2 · Cited by 198
Polyene natural products
Thirsk, C., & Whiting, A. (2002) · Journal of the Chemical Society Perkin Transactions 1 · doi:10.1039/b109741p · Cited by 192
Natural products as immunosuppressive agents
Mann, J. (2001) · Natural Product Reports · doi:10.1039/b001720p · Cited by 192
Quantitative proteomics approach for identifying protein–drug interactions in complex mixtures using protein stability measurements
West, G. M., Tucker, C. L., Xu, T., Park, S. K., Han, X., Yates, J. R., & Fitzgerald, M. C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000148107 · Cited by 189
Purification and N-terminal sequencing of peptidyl-prolyl cis-trans-isomerase from rat liver mitochondrial matrix reveals the existence of a distinct mitochondrial cyclophilin
Connern, C. P., & Halestrap, A. P. (1992) · Biochemical Journal · doi:10.1042/bj2840381 · Cited by 191
FK506 and the role of immunophilins in nerve regeneration
Gold, B. G. (1997) · Molecular Neurobiology · doi:10.1007/bf02740664 · Cited by 191
A ligand-reversible dimerization system for controlling protein–protein interactions
Rollins, C. T., Rivera, V. M., Woolfson, D. N., Keenan, T. P., Hatada, M. H., Adams, S. E., Andrade, L. J., Yaeger, D., van Schravendijk, M. R., Holt, D. A., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100101997 · Cited by 189
Immunophilins and nervous system
Snyder, S. H., & Sabatini, D. M. (1995) · Nature Medicine · doi:10.1038/nm0195-32 · Cited by 186
The IL-2/IL-2 receptor system: a target for rational immune intervention
Waldmann, T. A. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90043-k · Cited by 188
Everolimus and sirolimus in transplantation-related but different
Klawitter, J., Nashan, B., & Christians, U. (2015) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2015.1040388 · Cited by 187
The cyclophilin component of the unactivated estrogen receptor contains a tetratricopeptide repeat domain and shares identity with p59 (FKBP59)
Ratajczak, T., Carrello, A., Mark, P. J., Warner, B., Simpson, R. J., Moritz, R. L., & House, A. K. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38636-3 · Cited by 187
Ligand-Binding Proteins: Their Potential for Application in Systems for Controlled Delivery and Uptake of Ligands
de Wolf, F. A., & Brett, G. M. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01447-9 · Cited by 186
Signal-Transduction Therapy. A Novel Approach to Disease Management
Levitzki, A. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.tb20020.x · Cited by 184
Immunophilins in the Nervous System
Snyder, S. H., Lai, M. M.-S., & Burnett, P. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)80538-3 · Cited by 181
Effects of Rapamycin on Ryanodine Receptor/Ca 2+ -Release Channels From Cardiac Muscle
Kaftan, E. J., Marks, A. R., & Ehrlich, B. E. (1996) · Circulation Research · doi:10.1161/01.res.78.6.990 · Cited by 182
Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tail.
Jones, B. G., Thomas, L., Molloy, S. S., Thulin, C. D., Fry, M. D., Walsh, K. A., & Thomas, G. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00275.x · Cited by 183
Comparative Dose-Dependence Study of FK506 and Cyclosporin A on the Rate of Axonal Regeneration in the Rat Sciatic Nerve
Wang, M.-S., Zeleny-Pooley, M., & Gold, B. G. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36886-7 · Cited by 180
Role for p27 Kip1 in Vascular Smooth Muscle Cell Migration
Sun, J., Marx, S. O., Chen, H., Poon, M., Marks, A. R., & Rabbani, L. E. (2001) · Circulation · doi:10.1161/01.cir.103.24.2967 · Cited by 179
Ryanodine Receptors/Calcium Release channels in Heart Failure and Sudden Cardiac Death
Marks, A. R. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1343 · Cited by 178
Immunophilins: Beyond Immunosuppression
Hamilton, G. S., & Steiner, J. P. (1998) · Journal of Medicinal Chemistry · doi:10.1021/jm980307x · Cited by 178
Mip protein of Legionella pneumophila exhibits peptidyl‐prolyl‐cis/trans isomerase (PPIase) activity
Fischer, G., Bang, H., Ludwig, B., Mann, K., & Hacker, J. (1992) · Molecular Microbiology · doi:10.1111/j.1365-2958.1992.tb00858.x · Cited by 176
FKBP51, a novel T-cell-specific immunophilin capable of calcineurin inhibition
Baughman, G., Wiederrecht, G. J., Campbell, N. F., Martin, M. M., & Bourgeois, S. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.8.4395 · Cited by 173
Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones*
Pratt, W. B., & Toft, D. O. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.3.0303 · Cited by 1,791
The p70 S6 Kinase Integrates Nutrient and Growth Signals to Control Translational Capacity
Avruch, J., BELHAM, C. M., Weng, Q. P., Hara, K., & Yonezawa, K. (2001) · Progress in molecular and subcellular biology · doi:10.1007/978-3-642-56688-2_5 · Cited by 181
Prolyl isomerase Pin1: a catalyst for oncogenesis and a potential therapeutic target in cancer
Ryo, A., Liou, Y., Lu, K. P., & Wulf, G. M. (2003) · Journal of Cell Science · doi:10.1242/jcs.00276 · Cited by 172
Protein-peptide interactions
Stanfield, R. L., & Wilson, I. A. (1995) · Current Opinion in Structural Biology · doi:10.1016/0959-440x(95)80015-s · Cited by 173
Multiple Components of the HSP90 Chaperone Complex Function in Regulation of Heat Shock Factor 1 In Vivo
Bharadwaj, S., Ali, A. H., & Ovsenek, N. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.12.8033 · Cited by 173
Studies on the Mechanism of Resistance to Rapamycin in Human Cancer Cells
Hosoi, H., Dilling, M. B., Liu, L. N., Danks, M. K., Shikata, T., Sekulic, A., Abraham, R. T., Lawrence, J. C., & Houghton, P. J. (1998) · Molecular Pharmacology · doi:10.1124/mol.54.5.815 · Cited by 173
Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13.
Jin, Y. J., Albers, M. W., Lane, W. S., Bierer, B. E., Schreiber, S. L., & Burakoff, S. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.15.6677 · Cited by 173
Self-citation
Cyclosporin A inhibits an initial step in folding of transferrin within the endoplasmic reticulum
Lodish, H. F., & Kong, N. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98546-7 · Cited by 171
Abiotic stress responses in plants: roles of calmodulin-regulated proteins
Virdi, A. S., Singh, S. N., & Singh, P. (2015) · Frontiers in Plant Science · doi:10.3389/fpls.2015.00809 · Cited by 167
Rapamycin Inhibits α 1 -Adrenergic Receptor–Stimulated Cardiac Myocyte Hypertrophy but Not Activation of Hypertrophy-Associated Genes
Boluyt, M. O., Zheng, J.-S., Younès, A., Long, X., O’Neill, L., Silverman, H. S., Lakatta, E. G., & Crow, M. T. (1997) · Circulation Research · doi:10.1161/01.res.81.2.176 · Cited by 167
Hepatitis C Virus NS5A Protein Is a Substrate for the Peptidyl-prolyl cis/trans Isomerase Activity of Cyclophilins A and B
Hanoulle, X., Badillo, A., Wieruszeski, J., Verdegem, D., Landrieu, I., Bartenschlager, R. F. W., Pénin, F., & Lippens, G. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809244200 · Cited by 168
The NFAT-Related Protein NFATL1 (TonEBP/NFAT5) Is Induced Upon T Cell Activation in a Calcineurin-Dependent Manner
Trama, J. P., Lu, Q., Hawley, R. G., & Ho, S. N. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.9.4884 · Cited by 170
A chloroplast cyclophilin functions in the assembly and maintenance of photosystem II in Arabidopsis thaliana
Fu, A., He, Z., Cho, H. S., Lima, A., Buchanan, B. B., & Luan, S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707851104 · Cited by 167
An immunophilin that binds M(r) 90,000 heat shock protein: main structural features of a mammalian p59 protein.
Callebaut, I., Renoir, J., Lebeau, M., Massol, N., Burny, A., Baulieu, E. E., & Mornon, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.14.6270 · Cited by 167
The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13.
Yem, A. W., Tomasselli, A. G., Heinrikson, R. L., Zürcher-Neely, H. A., Ruff, V. A., Johnson, R. A., & Deibel, M. R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50664-0 · Cited by 167
The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL
Teachey, D. T., Obzut, D. A., Cooperman, J., Fang, J., Carroll, M. P., Choi, J. K., Houghton, P. J., Brown, V. I., & Grupp, S. A. (2005) · Blood · doi:10.1182/blood-2005-05-1935 · Cited by 166
Rapamycin: A novel immunosuppressive macrolide
Sehgal, S. N., Molnar-Kimber, K. L., Ocain, T. D., & Weichman, B. M. (1994) · Medicinal Research Reviews · doi:10.1002/med.2610140102 · Cited by 166
Automated, fast and sensitive quantification of drugs in blood by liquid chromatography–mass spectrometry with on-line extraction: immunosuppressants
Christians, U., Jacobsen, W., Serkova, N. J., Benet, L. Z., Vidal, C., Sewing, K.-F., Manns, M. P., & Kirchner, G. I. (2000) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)00380-7 · Cited by 166
Tacrolimus (FK 506)--a new therapeutic agent for severe recalcitrant psoriasis
Jegasothy, B. V. (1992) · Archives of Dermatology · doi:10.1001/archderm.128.6.781 · Cited by 166
Mechanism of action of rapamycin: New insights into the regulation of G1-phase progression in eukaryotic cells
Wiederrecht, G., Sabers, C. J., Brunn, G. J., Martin, M. M., Dumont, F. J., & Abraham, R. T. (1995) · Springer eBooks · doi:10.1007/978-1-4615-1809-9_5 · Cited by 164
Activation of pp70/85 S6 Kinases in Interleukin-2-Responsive Lymphoid Cells Is Mediated by Phosphatidylinositol 3-Kinase and Inhibited by Cyclic AMP
Monfar, M., Lemon, K. P., Grammer, T. C., Cheatham, L. A., Chung, J., Vlahos, C. J., & Blenis, J. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.1.326 · Cited by 161
Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin.
Calvo, V., Crews, C. M., Vik, T. A., & Bierer, B. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7571 · Cited by 163
Inhibition of Target of Rapamycin Signaling by Rapamycin in the Unicellular Green Alga Chlamydomonas reinhardtii
Crespo, J. L., Díaz‐Troya, S., & Florencio, F. J. (2005) · PLANT PHYSIOLOGY · doi:10.1104/pp.105.070847 · Cited by 161
Two FK506 resistance-conferring genes in Saccharomyces cerevisiae, TAT1 and TAT2, encode amino acid permeases mediating tyrosine and tryptophan uptake.
Schmidt, A., Hall, M. N., & Koller, A. A. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.10.6597 · Cited by 161
Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands.
Cardenas, M. E., Hemenway, C. S., Muir, R. S., Ye, R., Fiorentino, D. F., & Heitman, J. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06940.x · Cited by 160
Peptidyl‐prolyl isomerases: a new twist to transcription
Shaw, P. E. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf118 · Cited by 158
Cyclosporin metabolism in transplant patients
Christians, U., & Sewing, K. ‐. (1993) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(93)90059-m · Cited by 158
A cyclophilin links redox and light signals to cysteine biosynthesis and stress responses in chloroplasts
Domínguez‐Solís, J. R., He, Z., Lima, A., Ting, J. T. L., Buchanan, B. B., & Luan, S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808204105 · Cited by 157
Regulation of Both Glycogen Synthase and PHAS-I by Insulin in Rat Skeletal Muscle Involves Mitogen-activated Protein Kinase-independent and Rapamycin-sensitive Pathways
Azpiazu, I., Saltiel, A. R., DePaoli-Roach, A. A., & Lawrence, J. C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.9.5033 · Cited by 152
Rapamycin blocks cell cycle progression of activated T cells prior to events characteristic of the middle to late G1 phase of the cycle
Terada, N., Lucas, J. J., Szepesi, Á., Franklin, R. A., Domenico, J. M., & Gelfand, E. W. (1993) · Journal of Cellular Physiology · doi:10.1002/jcp.1041540103 · Cited by 156
Protein expression profiling identifies macrophage migration inhibitory factor and cyclophilin a as potential molecular targets in non-small cell lung cancer.
Campa, M. J., Wang, M. Z., Howard, B. A., Fitzgerald, M. C., & Patz, E. F. (2003) · PubMed · Cited by 155
Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling
Brown, V. I., Fang, J.-J., Alcorn, K., Barr, R., Kim, J. M., Wasserman, R., & Grupp, S. (2003) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.2436348100 · Cited by 168
Natural products as probes of cell biology: 20 years of didemnin research
Vera, M. D., & Joullié, M. M. (2002) · Medicinal Research Reviews · doi:10.1002/med.10003 · Cited by 153
A novel peptidyl‐prolyl cisltrans isomerase from Escherichia coli
Rahfeld, J., Schierhorn, A., Mann, K., & Fischer, G. S. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)80608-x · Cited by 154
Cross talk among calcineurin, Sp1/Sp3, and NFAT in control of p21 WAF1/CIP1 expression in keratinocyte differentiation
Santini, M. P., Talora, C., Seki, T., Bolgan, L., & Dotto, G. P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161299698 · Cited by 153
Total Synthesis and Immunosuppressive Activity of (−)-Pateamine A and Related Compounds: Implementation of a β-Lactam-Based Macrocyclization
Romo, D., Rzasa, R. M., Shea, H. A., Park, K., Langenhan, J. M., Sun, L., Akhiezer, A., & Liu, J. O. (1998) · Journal of the American Chemical Society · doi:10.1021/ja981846u · Cited by 151
Structure−Activity Relationships of the Didemnins
Sakai, R., Rinehart, K. L., Kishore, V., Kundu, B. K., Faircloth, G. T., Gloer, J. B., Carney, J. R., Namikoshi, M., Sun, F.-R., Hughes, R. G., et al. (1996) · Journal of Medicinal Chemistry · doi:10.1021/jm960048g · Cited by 150
T cell responses in calcineurin A alpha-deficient mice.
Zhang, B. W., Zimmer, G., Chen, J., Ladd, D., Li, E., Alt, F. W., Wiederrecht, G., Cryan, J. G., O’Neill, E. A., Seidman, C. E., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.2.413 · Cited by 150
A mechanism for rotamase catalysis by the FK506 binding protein (FKBP)
Fischer, S., Michnick, S. W., & Karplus, M. (1993) · Biochemistry · doi:10.1021/bi00213a011 · Cited by 149
A novel multi‐functional chloroplast protein: identification of a 40 kDa immunophilin‐like protein located in the thylakoid lumen
Fulgosi, H., Vener, A. V., Altschmied, L., Herrmann, R. G., & Andersson, B. (1998) · The EMBO Journal · doi:10.1093/emboj/17.6.1577 · Cited by 150
Refined structure of the FKBP12–rapamycin–FRB ternary complex at 2.2 Å resolution
Liang, J., Choi, J., & Clardy, J. (1999) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444998014747 · Cited by 148

Authors: Schreiber, S. L.
Affiliations: Harvard University (US)
Corresponding author: Schreiber, Stuart L.
ORCID: Schreiber, Stuart L.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1991-01-18
Volume: 251
Issue: 4991
Pages: 283-287
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1702904
OpenAlex: W2024842574
Cited by: 1,494
References: 56
Citations by year: 2026: 7 · 2025: 21 · 2024: 13 · 2023: 18 · 2022: 17 · 2021: 21 · 2020: 13 · 2019: 15 · 2018: 12 · 2017: 19 · 2016: 23 · 2015: 27 · 2014: 28 · 2013: 34 · 2012: 23
FWCI: 15.51
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (GM38627)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
Keywords: immunophilins, cyclosporine, FK506, rapamycin, T cell activation, signal transduction inhibition, protein trafficking, molecular recognition, protein-ligand binding
MeSH terms: Amino Acid Isomerases, Animals, Anti-Bacterial Agents, Carrier Proteins, Cyclosporins, Humans, Immunosuppressive Agents, Isomerases, Ligands, Lymphocyte Activation, Polyenes, Receptors, Immunologic, T-Lymphocytes, Tacrolimus, Peptidylprolyl Isomerase, Sirolimus, Tacrolimus Binding Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks