Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

Cyclophilin: A Specific Cytosolic Binding Protein for Cyclosporin A

Handschumacher, R. E., Harding, M. W., Rice, J. S., Drugge, R. J., & Speicher, D. W. (1984) · Science · doi:10.1126/science.6238408 · Cited by 1,675

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

Fischer, G., Wittmann‐Liebold, B., Lang, K., Kiefhaber, T., & Schmid, F. X. (1989) · Nature · doi:10.1038/337476a0 · Cited by 1,408

A receptor for the immuno-suppressant FK506 is a cis–trans peptidyl-prolyl isomerase

Harding, M. W., Gałat, A., Uehling, D., & Schreiber, S. L. (1989) · Nature · doi:10.1038/341758a0 · Cited by 1,396

Cyclosporine

Oates, J. A., Wood, A. J. J., & Kahan, B. D. (1989) · New England Journal of Medicine · doi:10.1056/nejm198912213212507 · Cited by 1,351

Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin

Takahashi, N., Hayano, T., & Suzuki, M. (1989) · Nature · doi:10.1038/337473a0 · Cited by 1,075

Contingent Genetic Regulatory Events in T Lymphocyte Activation

Crabtree, G. R. (1989) · Science · doi:10.1126/science.2783497 · Cited by 1,071

FK 506 FOR LIVER, KIDNEY, AND PANCREAS TRANSPLANTATION

Starzl, T., Fung, J. J., Venkataraman, R., Todo, S., Demetris, A. J., & Jain, A. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91014-3 · Cited by 1,036

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

Siekierka, J. J., Hung, S. H. Y., Poe, M., Lin, C. S., & SIGAL, N. H. (1989) · Nature · doi:10.1038/341755a0 · Cited by 1,016

Identification of a Putative Regulator of Early T Cell Activation Genes

Shaw, J., Utz, P. J., Durand, D. B., Toole, J. J., Emmel, E. A., & Crabtree, G. R. (1988) · Science · doi:10.1126/science.3260404 · Cited by 946

Polypeptide chain binding proteins: Catalysts of protein folding and related processes in cells

Rothman, J. E. (1989) · Cell · doi:10.1016/0092-8674(89)90005-6 · Cited by 887

The Hsp90 Chaperone Family

Neckers, L., Mimnaugh, E. G., & Schulte, T. W. (1999) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-58259-2_2 · Cited by 25

Fk 506 and Autoimmune Disease: Perspective and Prospects

Thomson, A. W., & Starzl, T. E. (1992) · Autoimmunity · doi:10.3109/08916939209148473 · Cited by 25

Calculation of pathways for the conformational transition between the GTP- and GDP-bound states of the Ha-ras-p21 protein: Calculations with explicit solvent simulations and comparison with calculations in vacuum

Díaz, J. F., Wroblowski, B., Schlitter, J., & Engelborghs, Y. (1997) · Proteins Structure Function and Bioinformatics · doi:10.1002/(sici)1097-0134(199707)28:3 · Cited by 63

Effects of cyclosporin A on erythropoietin production by the human Hep3B hepatoma cell line

Vannucchi, A. M., Grossi, A., Bosi, A., Rafanelli, D., Statello, M., Guidi, S., Saccardi, R., & Rossi-Ferrini, P. (1993) · Blood · doi:10.1182/blood.v82.3.978.978 · Cited by 25

FK506 and cyclosporin A inhibit stem cell factor-dependent cell proliferation/survival, while inducing upregulation of c-kit expression in cells of the mast cell line MC/9

Ito, F., Toyota, N., Sakai, H., Takahashi, H., & Iizuka, H. (1999) · Archives of Dermatological Research · doi:10.1007/s004030050408 · Cited by 25

Podospora anserina target of rapamycin

Pinan‐Lucarré, B., Iraqui, I., & Clavé, C. (2006) · Current Genetics · doi:10.1007/s00294-006-0064-3 · Cited by 24

Pin1: Intimate involvement with the regulatory protein kinase networks in the global phosphorylation landscape

Litchfield, D. W., Shilton, B. H., Brandl, C. J., & Gyenis, L. (2015) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2015.02.018 · Cited by 25

Impacts of Cyclosporin A on clinical pregnancy outcomes of patients with a history of unexplained transfer failure: a retrospective cohort study

Qu, D., Tian, X., Ding, L., Li, Y., & Zhou, W. (2021) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-021-00728-x · Cited by 24

Evidence for a role of nuclear factor-κB in acute hypovolemic hemorrhagic shock

Altavilla, D., Saitta, A., Squadrito, G., Galeano, M., Venuti, S., Guarini, S., Bazzani, C., Bertolini, A., Caputi, A. P., & Squadrito, F. (2002) · Surgery · doi:10.1067/msy.2002.118320 · Cited by 24

Synthesis of Stereochemically and Skeletally Diverse Fused Ring Systems from Functionalized C-Glycosides

Gerard, B., Lee, M. D., Dandapani, S., Duvall, J. R., Fitzgerald, M. E., Kesavan, S., Lowe, J. T., Marié, J., Pandya, B. A., Suh, B., et al. (2013) · The Journal of Organic Chemistry · doi:10.1021/jo4000916 · Cited by 24

Identification of Proteins Modulated in the Date Palm Stem Infested with Red Palm Weevil (Rhynchophorus ferrugineus Oliv.) Using Two Dimensional Differential Gel Electrophoresis and Mass Spectrometry

Rasool, K. G., Khan, M., Aldawood, A. S., Tufail, M., Mukhtār, M., & Takeda, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160819326 · Cited by 24

Cyclophilin and Viruses: Cyclophilin as a Cofactor for Viral Infection and Possible Anti-Viral Target

Watashi, K., & Shimotohno, K. (2007) · Drug Target Insights · doi:10.1177/117739280700200017 · Cited by 24

Specific disruption of renal function and gene transcription by cyclosporin A.

Morris, S. M., Kepka‐Lenhart, D., Mcgill, R., Curthoys, N. P., & Adler, S. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42280-6 · Cited by 24

RECOVERY OF BLOOD MONONUCLEAR CELL CALCINEURIN ACTIVITY SEGREGATES TWO POPULATIONS OF RENAL TRANSPLANT PATIENTS WITH DIFFERENT SENSITIVITIES TO CYCLOSPORINE INHIBITION

Piccinini, G., Gaspari, F., Signorini, O., Remuzzi, G., & Perico, N. (1996) · Transplantation · doi:10.1097/00007890-199605270-00020 · Cited by 24

CsA, FK506, corticosteroids and rapamycin inhibit TNFα production by cultured PTEC

Yard, B. A., Pancham, R. R., Paape, M. E., Daha, M. R., van Es, L. A., & van der Woude, F. J. (1993) · Kidney International · doi:10.1038/ki.1993.251 · Cited by 24

Conformation of the oxalamide group in retro‐bispeptides

Karle, I. L., Ranganathan, D., Shah, K., & Vaish, N. K. (1994) · International journal of peptide & protein research · doi:10.1111/j.1399-3011.1994.tb00517.x · Cited by 24

Chronic inflammatory demyelinating polyneuropathy complicating liver transplantation

Taylor, B. V., Wijdicks, E. F. M., Poterucha, J. J., & Weisner, R. H. (1995) · Annals of Neurology · doi:10.1002/ana.410380519 · Cited by 24

Yin and Yang of Phosphorylation in Cytokine Signaling

Tan, Y. H. (1993) · Science · doi:10.1126/science.7692598 · Cited by 24

A macrolactonization approach to the stevastelins

Sarabia, F., Chammaa, S., & Lopez‐Herrera, F. J. (2002) · Tetrahedron Letters · doi:10.1016/s0040-4039(02)00416-1 · Cited by 24

Chapter 29. Macromolecular X-Ray Crystallography and NMR as Tools for Structure-based Drug Design

Erickson, J. W., & Fesik, S. W. (1992) · Annual reports in medicinal chemistry · doi:10.1016/s0065-7743(08)60427-3 · Cited by 24

Rapamycin Inhibits Protein Kinase C Activity and Stimulates Na+ Transport in A6 Cells

Rokaw, M. D., West, M., & Johnson, J. P. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.50.32468 · Cited by 24

Transplantation Immunology

Krensky, A. M., & Clayberger, C. (1994) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(16)38809-5 · Cited by 24

Calcineurin inhibition blocks within-, but not between-session fear extinction in micePreprint

Almeida-Corrêa, S., Moulin, T. C., Carneiro, C. F. D., Gonçalves, M. M. C., Junqueira, L. S., & Amaral, O. B. (2015) · Learning & Memory · doi:10.1101/lm.037770.114 · Cited by 25

Enantioselective Synthesis and Biological Evaluation of Sanglifehrin A and B and Analogs

Chang, C., Flaxman, H. A., & Woo, C. M. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202103022 · Cited by 22

Bcl-2 and FKBP12 bind to IP3 and ryanodine receptors at overlapping sites: the complexity of protein–protein interactions for channel regulation

Vervliet, T., Parys, J. B., & Bultynck, G. (2015) · Biochemical Society Transactions · doi:10.1042/bst20140298 · Cited by 23

The Fusarium Graminearum virulence factor FGL targets an FKBP12 immunophilin of wheat

Niu, X.-W., Zheng, Z., Feng, Y., Wang-Zhen, G. U. O., & Wang, X. (2013) · Gene · doi:10.1016/j.gene.2013.04.052 · Cited by 23

Effect of a New Immunosuppressant Histon Deacetylase (HDAC) Inhibitor FR276457 in a Rat Cardiac Transplant Model

Kinugasa, F., Yamada, T., Noto, T., Matsuoka, H., Mori, H., Sudo, Y., & Mutoh, S. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.1723 · Cited by 23

Identification of HIV Inhibitors Guided by Free Energy Perturbation Calculations

Acevedo, O., Ambrose, Z., Flaherty, P. T., Aamer, H., Jain, P., & Sambasivarao, S. V. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799436421 · Cited by 23

Wheat Bax Inhibitor-1 interacts with TaFKBP62 and mediates response to heat stress

Lu, P.-P., Zheng, W., Wang, C.-T., Shi, W., Fu, J., Chen, M., Chen, J., Zhou, Y., Xi, Y., & Xu, Z. (2018) · BMC Plant Biology · doi:10.1186/s12870-018-1485-0 · Cited by 23

[33] Purification of Hsp90 partner proteins Hop/p60, p23, and FKBP52

Büchner, J., Weikl, T., Bügl, H., Pirkl, F., & Bose, S. (1998) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(98)90035-0 · Cited by 23

The crystal structure of human WD40 repeat‐containing peptidylprolyl isomerase (PPWD1)

Davis, T. L., Walker, J. R., Ouyang, H., MacKenzie, F., Butler-Cole, C., Newman, E. M., Eisenmesser, E. Z., & Dhe‐Paganon, S. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06381.x · Cited by 23

Engineering the Folding Pathway of Insect Cells: Generation of a Stably Transformed Insect Cell Line Showing Improved Folding of a Recombinant Membrane Protein

Lenhard, T., & Reiländer, H. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7395 · Cited by 23

The effects of cyclosporin A and FK506 on proliferation and IL-8 production of cultured human keratinocytes

Kaplan, A., Matsue, H., Shibaki, A., Kawashima, T., Kobayashi, H., & Ohkawara, A. (1995) · Journal of Dermatological Science · doi:10.1016/0923-1811(95)00395-9 · Cited by 23

Effects of the immunosuppressants cyclosporin A and FK 506 on exocytosis in the rat exocrine pancreas in vitro

Waschulewski, I. H., Hall, D. V., Kern, H. F., & Edwardson, J. M. (1993) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1993.tb13483.x · Cited by 23

Immunosuppressive Drugs in HIV Disease

Argyropoulos, C., & Mouzaki, Α. (2006) · Current Topics in Medicinal Chemistry · doi:10.2174/156802606778194271 · Cited by 23

Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities of FR252921, FR252922 and FR256523.

Fujine, K., Tanaka, M., Ohsumi, K., Hashimoto, M., Takase, S., Ueda, H., Hino, M., & Fujii, T. (2003) · The Journal of Antibiotics · doi:10.7164/antibiotics.56.55 · Cited by 23

Mental retardation and the death penalty: a guide to State Legislative issues.

Ellis, J. W. (2003) · PubMed · Cited by 23

Modeling the interaction between FK506 and FKBP12: A mechanism for formation of the calcineurin inhibitory complex

Ivery, M. T. G., & Weiler, L. (1997) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(96)00229-5 · Cited by 23

Macrophage colony‐stimulating factor‐dependent macrophage proliferation is mediated through a calcineurin‐independent but immunophilin‐dependent mechanism that mediates the activation of external regulated kinases

Comalada, M., Valledor, A. F., Sànchez‐Tilló, E., Umbert, I. J., Xaus, J., & Celada, A. (2003) · European Journal of Immunology · doi:10.1002/eji.200324074 · Cited by 24

Degradation of rapamycin: Synthesis of a rapamycin derived fragment containing the tricarbonyl and triene sectors

Yohannes, D., Myers, C. D., & Danishefsky, S. J. (1993) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)60349-0 · Cited by 23

Overexpression, characterization, and purification of a recombinant mouse immunophilin FKBP-52 and identification of an associated phosphoprotein.

Alnemri, E. S., Fernandes‐Alnemri, T., Nelki, D., Dudley, K., DuBois, G. C., & Litwack, G. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6839 · Cited by 23

The peptidyl-prolyl isomerase, FK506-binding protein, is most likely the 12 kd endogenous inhibitor 2 of protein kinase C

Goebl, M. G. (1991) · Cell · doi:10.1016/0092-8674(91)90258-z · Cited by 23

Novel strategies in Parkinson’s disease treatment: a review

Mitchell, C. L., & Kurouski, D. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1431079 · Cited by 27

Targeted protein degradation in mammalian cells: A promising avenue toward future

Zhang, T., Liu, C., Li, W., Kuang, J., Qiu, X., Lu, M., & Zhu, L. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.09.038 · Cited by 23

Rapamycin impairs endothelial cell function in human internal thoracic arteries

Reineke, D. C., Müller‐Schweinitzer, E., Winkler, B. M., Kunz, D., Konerding, M. A., Grussenmeyer, T., Carrel, T. P., Eckstein, F. S., & Grapow, M. T. R. (2015) · European journal of medical research · doi:10.1186/s40001-015-0150-4 · Cited by 22

Structural comparison of oxidized and reduced FKBP13 from Arabidopsis thaliana

Gopalan, G., He, Z., Battaile, K. P., Luan, S., & Swaminathan, K. (2006) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.21108 · Cited by 22

Resistance to discodermolide, a microtubule-stabilizing agent and senescence inducer, is 4E-BP1–dependent

Chao, S. K., Lin, J., Brouwer‐Visser, J., Smith, A. B., Horwitz, S. B., & McDaid, H. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016962108 · Cited by 22

Recombinant Protein Truncation Strategy for Inducing Bactericidal Antibodies to the Macrophage Infectivity Potentiator Protein of Neisseria meningitidis and Circumventing Potential Cross-Reactivity with Human FK506-Binding Proteins

Bielecka, M. K., Devos, N., Gilbert, M., Hung, M.-C., Weynants, V. E., Heckels, J. E., & Christodoulides, M. (2014) · Infection and Immunity · doi:10.1128/iai.01815-14 · Cited by 22

The Twisted Dwarf's ABC

Bailly, A., Sovero, V., & Geisler, M. M. (2006) · Plant Signaling & Behavior · doi:10.4161/psb.1.6.3531 · Cited by 22

Purification and Characterization of α-Keto Amide Reductase fromSaccharomyces cerevisiae

Ishihara, K., Yamamoto, H., Mitsuhashi, K., Nishikawa, K., Tsuboi, S., Tsuji, H., & Nakajima, N. (2004) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.68.2306 · Cited by 22

Synthesis and evaluation of some lipidic aminoalcohols and diamines as immunomodulators

del Olmo, E., Plaza, Â., Muro, A., Martínez‐Fernández, A. R., Nogal‐Ruiz, J. J., López‐Pérez, J. L., & Feliciano, A. S. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.08.113 · Cited by 22

Octasaccharide is the minimal length unit required for efficient binding of cyclophilin B to heparin and cell surface heparan sulphate

Vanpouille, C., Denys, A., Carpentier, M., Pakula, R., Mazurier, J., & Allain, F. (2004) · Biochemical Journal · doi:10.1042/bj20031453 · Cited by 22

FR177391, A New Anti-hyperlipidemic Agent from Serratia

Yamaoka, M., Sato, K., Kobayashi, M., Nishio, N., Ohkubo, M., Fujii, T., & Nakajima, H. (2005) · The Journal of Antibiotics · doi:10.1038/ja.2005.90 · Cited by 22

High Throughput Scintillation Proximity Assay for the Identification of FKBP-12 Ligands

Graziani, F., Aldegheri, L., & Terstappen, G. C. (1999) · SLAS DISCOVERY · doi:10.1177/108705719900400102 · Cited by 22

The effect of immunosuppressive protocols on spontaneous CNS remyelination following toxin-induced demyelination

Smith, P. M., & Franklin, R. J. M. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00396-4 · Cited by 22

Structure comparison of native and mutant human recombinant FKBP12 complexes with the immunosuppressant drug FK506 (tacrolimus)

Itoh, S., & Navia, M. A. (1995) · Protein Science · doi:10.1002/pro.5560041103 · Cited by 22

Activation of Ca2+ signaling in neutrophils by the mast cell-released immunophilin FKBP12.

Bang, H., Müller, W. S., Hans, M., Brune, K., & Swandulla, D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.8.3435 · Cited by 22

The differentiation of the immune system towards anti-islet autoimmunity. Clinical prospects

Boîtard, C. (1992) · Diabetologia · doi:10.1007/bf00401362 · Cited by 22

Avian scleroderma: Evidence for qualitative and quantitative T cell defects

Wilson, T. J., de Water, J. V., Mohr, F. C., Boyd, R. L., Ansari, A. A., Wick, G., & Gershwin, M. E. (1992) · Journal of Autoimmunity · doi:10.1016/0896-8411(92)90142-d · Cited by 22

Oxidations of Dihydroxyalkanoates to Vicinal Tricarbonyl Compounds with a 4-BzoTEMPO-Sodium Bromite System or by Indirect Electrolysis Using 4-BzoTEMPO and Bromide Ion

Inokuchi, T., Liu, P., & Torii, S. (1994) · Chemistry Letters · doi:10.1246/cl.1994.1411 · Cited by 22

Sequence Polymorphism of dotA and mip Alleles Mediating Invasion and Intracellular Replication of Legionella pneumophila

Bumbaugh, A. C., McGraw, E. A., Page, K. L., Selander, R. K., & Whittam, T. S. (2002) · Current Microbiology · doi:10.1007/s00284-01-0024-6 · Cited by 22

Phototransduction in itDrosophila: a paradigm for the genetic dissection of sensory transduction cascades

Zuker, C. S. (1992) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(92)90029-k · Cited by 22

Cyclosporin and Tacrolimus in Clinical Transplantation

Jain, A., & Fung, J. J. (1996) · BioDrugs · doi:10.1007/bf03259333 · Cited by 22

CD4+CD25+ T regulatory cells in renal transplantation

Cheung, J., Zahorowska, B., SURANYI, M. G., Wong, J. K. W., Diep, J., Spicer, S. T., Verma, N. D., Hodgkinson, S. J., & Hall, B. M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1017683 · Cited by 21

Rapamycin-regulated Control of Antiangiogenic Tumor Therapy Following rAAV-mediated Gene Transfer

Nguyen, M., Huan-Tu, G., Gonzalez-Edick, M., Rivera, V. M., Clackson, T., Jooss, K. U., & Harding, T. C. (2007) · Molecular Therapy · doi:10.1038/mt.sj.6300079 · Cited by 21

A Small‐Molecule–Protein Interaction System with Split‐Ubiquitin as Sensor

Dirnberger, D., Unsin, G., Schlenker, S., & Reichel, C. (2006) · ChemBioChem · doi:10.1002/cbic.200500544 · Cited by 21

Comparative Proteome Analysis of Breast Cancer and Normal Breast

Luo, Y., Zhang, J., Liu, Y., Shaw, A. C., Wang, X., Wu, S., Zeng, X., Chen, J., Gao, Y., & Zheng, D. (2005) · Molecular Biotechnology · doi:10.1385/mb:29:3:233 · Cited by 21

Design and synthesis of a rapamycin-based high affinity binding FKBP12 ligand

Chakraborty, T. K., Weber, H. P., & Nicolaou, K. C. (1995) · Chemistry & Biology · doi:10.1016/1074-5521(95)90070-5 · Cited by 21

Streptomyces chrysomallus FKBP‐33 is a novel immunophilin consisting of two FK506 binding domains; its gene is transcriptionally coupled to the FKBP‐12 gene.

Pahl, A. M., & Keller, U. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06653.x · Cited by 21

Kinetic Analysis of Molecular Interconversion of Immunosuppressant FK506 by High-Performance Liquid Chromatography

Nishikawa, T., Hasumi, H., Suzuki, S., Kubo, H., & Ohtani, H. (1993) · Pharmaceutical Research · doi:10.1023/a:1018938618032 · Cited by 21

Control of IL-5 production by human helper T cells as a treatment for eosinophilic inflammation: Comparison of in vitro and in vivo effects between selective and nonselective cytokine synthesis inhibitors

Mori, A., Kaminuma, O., Ogawa, K., Nakata, A., Egan, R. W., Akiyama, K., & Okudaira, H. (2000) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2000.106775 · Cited by 21

A specific binding site in Nb2 node lymphoma cells mediates the effects of didemnin B, an immunosuppressive cyclic peptide

Shen, G. K., Zukoski, C. F., & Montgomery, D. W. (1992) · International Journal of Immunopharmacology · doi:10.1016/0192-0561(92)90106-u · Cited by 21

Effect of Cyclosporin A on Melanogenesis in Cultured Human Melanocytes

Lee, J. Y., & Kang, W. H. (2003) · Pigment Cell Research · doi:10.1034/j.1600-0749.2003.00081.x · Cited by 21

Intestinal Transplantation

Tzakis, A. G., Todo, S., & Starzl, T. E. (1994) · Annual Review of Medicine · doi:10.1146/annurev.med.45.1.79 · Cited by 21

Structure-based drug design: applications in immunopharmacology and immunosuppression

Navia, M. A., & Peattie, D. A. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90049-q · Cited by 21

Reversal of multidrug resistance in Chinese hamster ovary cells by the immunosuppressive agent rapamycin

Hoof, T., Demmer, A., Christians, U., & Tümmler, B. (1993) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(93)90009-x · Cited by 21

Direct evidence that FK506 inhibition of FcεRI-mediated exocytosis from RBL mast cells involves calcineurin

Hultsch, T., Brand, P., Lohmann, S., Saloga, J., Kincaid, R. L., & KNOP, J. (1998) · Archives of Dermatological Research · doi:10.1007/s004030050301 · Cited by 21

Specific interaction between cyclophilin and cyclic peptides

Gallo, P., Saviano, M., Rossi, F., Pavone, V., Pedone, C., Ragone, R., Stiuso, P., & Colonna, G. (1995) · Biopolymers · doi:10.1002/bip.360360303 · Cited by 21

Molecular mechanisms of the immunosuppressive action of cyclosporin A

Resch, K., & Szamel, M. (1997) · International Journal of Immunopharmacology · doi:10.1016/s0192-0561(98)00004-6 · Cited by 21

RAPAMYCIN BUT NOT FK506 INHIBITS THE PROLIFERATION OF MONONUCLEAR PHAGOCYTES INDUCED BY COLONY-STIMULATING FACTORS

Cooper, M., Gregory, S. H., Starzl, T. E., & Wing, E. J. (1994) · Transplantation · doi:10.1097/00007890-199402150-00021 · Cited by 21

Rapamycin Prolongs Survival of Murine Recipients of Fully Allogeneic Donor Grafts When Administered during the Graft‐versus‐Host Disease Processa

Blazar, B. R., Taylor, P. A., Sehgal, S. N., & Vallera, D. A. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb35854.x · Cited by 21

The cytokine network and regulation of the immune response to organ transplants

Dallman, M. J. (1992) · Transplantation Reviews · doi:10.1016/s0955-470x(10)80006-0 · Cited by 20

The spectrum of action of new immunosuppressive drugs

Thomson, A. W. (1992) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1992.tb06927.x · Cited by 21

The Immunobiology and Clinical Use of Current Immunosuppressive Therapy for Renal Transplantation

Hayes, J. M. (1993) · The Journal of Urology · doi:10.1016/s0022-5347(17)36114-1 · Cited by 21

Purification and Characterization of an Antifungal Protein, C-FKBP, from Chinese Cabbage

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Synthesis, biological evaluation, and molecular docking studies of benzyl, alkyl and glycosyl [2-(arylamino)-4,4-dimethyl-6-oxo-cyclohex-1-ene]carbodithioates, as potential immunomodulatory and immunosuppressive agents

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