Cited by 1,494Signaling Pathways in DiseaseS100 Proteins and AnnexinsProtein Interaction Studies and Fluorescence Analysis

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Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

Schreiber, Stuart L.·1991·Science

DOI 10.1126/science.1702904

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Abstract

Cyclosporin A, FK506, and rapamycin are inhibitors of specific signal transduction pathways that lead to T lymphocyte activation. These immunosuppressive agents bind with high affinity to cytoplasmic receptors termed immunophilins (immunosuppressant binding proteins). Studies in this area have focused on the structural basis for the molecular recognition of immunosuppressants by immunophilins and the biological consequences of their interactions. Defining the biological roles of this emerging family of receptors and their ligands may illuminate the process of protein trafficking in cells and the mechanisms of signal transmission through the cytoplasm.

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Authors: Schreiber, S. L.
Affiliations: Harvard University (US)
Corresponding author: Schreiber, Stuart L.
ORCID: Schreiber, Stuart L.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1991-01-18
Volume: 251
Issue: 4991
Pages: 283-287
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1702904
OpenAlex: W2024842574
Cited by: 1,494
References: 56
Citations by year: 2026: 7 · 2025: 21 · 2024: 13 · 2023: 18 · 2022: 17 · 2021: 21 · 2020: 13 · 2019: 15 · 2018: 12 · 2017: 19 · 2016: 23 · 2015: 27 · 2014: 28 · 2013: 34 · 2012: 23
FWCI: 15.51
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (GM38627)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
Keywords: immunophilins, cyclosporine, FK506, rapamycin, T cell activation, signal transduction inhibition, protein trafficking, molecular recognition, protein-ligand binding
MeSH terms: Amino Acid Isomerases, Animals, Anti-Bacterial Agents, Carrier Proteins, Cyclosporins, Humans, Immunosuppressive Agents, Isomerases, Ligands, Lymphocyte Activation, Polyenes, Receptors, Immunologic, T-Lymphocytes, Tacrolimus, Peptidylprolyl Isomerase, Sirolimus, Tacrolimus Binding Proteins

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Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

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