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Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI
Abstract
Complementary DNA clones encoding mouse cytokine synthesis inhibitory factor (CSIF; interleukin-10), which inhibits cytokine synthesis by T H 1 helper T cells, were isolated and expressed. The predicted protein sequence shows extensive homology with an uncharacterized open reading frame, BCRFI, in the Epstein-Barr virus genome, suggesting the possibility that this herpes virus exploits the biological activity of a captured cytokine gene to enhance its survival in the host.
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Citations
Cited by
Interleukin-10 and the Interleukin-10 Receptor
Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737
Self-citationde Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C. G., & de Vries, J. E. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.5.1209 · Cited by 3,762
“In murine systems, I1-10 was produced by the CD4 + Th2 subset and inhibits the cytokine production, particularly IFN-3', by Thl clones (1, 2).”
Opal, S. M., & DePalo, V. A. (2000) · Chest · doi:10.1378/chest.117.4.1162 · Cited by 1,752
T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
Fossiez, F., Djossou, O., Chomarat, P., Flores-Romo, L., Ait-Yahia, S., Maat, C., Pin, J. J., Garrone, P., Garcia, E., Saeland, S., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2593 · Cited by 1,526
“Finally, mCTLA8 showed 57% homology with the predicted amino acid sequence of the open reading frame 13 (ORF13) o f Herpesvims saimiri (HVS) (3), a situation analogous to the presence of an IL-10 homolog in Epstein-Barr virus (7).”
Interleukin‐10: new perspectives on an old cytokine
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Contextual Regulation of Inflammation: A Duet by Transforming Growth Factor-β and Interleukin-10
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T cell responses: naïve to memory and everything in between
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VIALLARD, J. F., PELLEGRIN, J. L., RANCHIN, V, SCHAEVERBEKE, T., DEHAIS, J., LONGY-BOURSIER, M., RAGNAUD, J. M., LENG, B., & MOREAU, J. F. (2001) · Clinical and Experimental Immunology · doi:10.1046/j.1365-2249.1999.00766.x · Cited by 247
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The chemokine CCL18 causes maturation of cultured monocytes to macrophages in the M2 spectrum
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Opal, S. M., Wherry, J. C., & Grint, P. (1998) · Clinical Infectious Diseases · doi:10.1086/515032 · Cited by 114
van der Sluijs, K. F., Nijhuis, M., Levels, J. H. M., Florquin, S., Mellor, A. L., Jansen, H. M., der Poll, T. V., & Lutter, R. (2006) · The Journal of Infectious Diseases · doi:10.1086/498911 · Cited by 111
IL‐10 Production by CD5 B Cells
O'GARRA, A., & HOWARD, M. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb24615.x · Cited by 74
Volkening, J. D., Spatz, S. J., Garcia, M., Ross, T. A., Maekawa, D. A., Rosenthal, K. S., Zamora, A. C., Skipper, A., Blakey, J. R., & Paudel, R. (2025) · PLOS Pathogens · doi:10.1371/journal.ppat.1013219 · Cited by 1
Metadata
- Authors
- Moore, K. W., Vieira, P., Fiorentino, D. F., Trounstine, M. L., Khan, T. A., & Mosmann, T. R.
- Venue
- Science
- Published
- 1990-06-08
- Volume
- 248
- Issue
- 4960
- Pages
- 1230-1234
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2060546545
- Cited by
- 1,143
- References
- 0
- FWCI
- 33.11
- Type
- journal article
- Language
- en
- Open access
- closed
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