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IRAK: A Kinase Associated with the Interleukin-1 Receptor
Abstract
The pleiotropic biological activities of interleukin-1 (IL-1) are mediated by its type I receptor (IL-1RI). When the ligand binds, IL-1RI initiates a signaling cascade that results in the activation of the transcription regulator nuclear factor kappa B (NF-κB). A protein kinase designated IRAK (IL-1 receptor-associated kinase) was purified, and its complementary DNA was molecularly cloned. When human embryonic kidney cells (cell line 293) overexpressing IL-1RI or HeLa cells were exposed to IL-1, IRAK rapidly associated with the IL-1RI complex and was phosphorylated. The primary amino acid sequence of IRAK shares similarity with that of Pelle, a protein kinase that is essential for the activation of a NF-κB homolog in Drosophila .
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Metadata
- Authors
- Cao, Z., Henzel, W. J., & Gao, X.
- Venue
- Science
- Published
- 1996-02-23
- Volume
- 271
- Issue
- 5252
- Pages
- 1128-1131
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2089938437
- Cited by
- 899
- References
- 3
- FWCI
- 25.39
- Type
- journal article
- Language
- en
- Open access
- closed
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