Cited by 1,911Stroke Rehabilitation and RecoveryMotor Control and AdaptationTranscranial Magnetic Stimulation Studies

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Neural Substrates for the Effects of Rehabilitative Training on Motor Recovery After Ischemic Infarct

Nudo, Randolph J., Wise, Birute M., SiFuentes, Frank, Milliken, Garrett W.·1996·Science

Open this paper in CoChat — free account

Abstract

Substantial functional reorganization takes place in the motor cortex of adult primates after a focal ischemic infarct, as might occur in stroke. A subtotal lesion confined to a small portion of the representation of one hand was previously shown to result in a further loss of hand territory in the adjacent, undamaged cortex of adult squirrel monkeys. In the present study, retraining of skilled hand use after similar infarcts resulted in prevention of the loss of hand territory adjacent to the infarct. In some instances, the hand representations expanded into regions formerly occupied by representations of the elbow and shoulder. Functional reorganization in the undamaged motor cortex was accompanied by behavioral recovery of skilled hand function. These results suggest that, after local damage to the motor cortex, rehabilitative training can shape subsequent reorganization in the adjacent intact cortex, and that the undamaged motor cortex may play an important role in motor recovery.

Integrity signals

Registry

Crossref · 10.1126/science.272.5269.1791

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Functional MRI evidence for adult motor cortex plasticity during motor skill learning
Kami, A., Meyer, G., Jezzard, P., Adams, M. M., Turner, R., & Ungerleider, L. G. (1995) · Nature · doi:10.1038/377155a0 · Cited by 1,883
Technique to improve chronic motor deficit after stroke.
Taub, E., Miller, N. E., Novack, T. A., Cook, E. W., Fleming, W. C., Nepomuceno, C., Connell, J., & Crago, J. E. (1993) · PubMed · Cited by 1,557
Use-dependent alterations of movement representations in primary motor cortex of adult squirrel monkeys
Nudo, R. J., Milliken, G. W., Jenkins, W., & Merzenich, M. M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-02-00785.1996 · Cited by 1,416
The functional anatomy of motor recovery after stroke in humans: A study with positron emission tomography
Chollet, F., Piero, V. D., Wise, R. J. S., Brooks, D. J., Dolan, R. J., & Frackowiak, R. S. J. (1991) · Annals of Neurology · doi:10.1002/ana.410290112 · Cited by 1,096
Massive Cortical Reorganization After Sensory Deafferentation in Adult Macaques
Pons, T. P., Garraghty, P. E., Ommaya, A. K., Kaas, J. H., Taub, E., & Mishkin, M. (1991) · Science · doi:10.1126/science.1843843 · Cited by 1,081
THE RESTORATION OF MOTOR FUNCTION FOLLOWING HEMIPLEGIA IN MAN
Twitchell, T. E. (1951) · Brain · doi:10.1093/brain/74.4.443 · Cited by 942
Plasticity of Sensory and Motor Maps in Adult Mammals
Kaas, J. H. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.001033 · Cited by 913
Modulation of Cortical Motor Output Maps During Development of Implicit and Explicit Knowledge
Pascual‐Leone, Á., Grafman, J. H., & Hallett, M. (1994) · Science · doi:10.1126/science.8122113 · Cited by 745
Reorganization of movement representations in primary motor cortex following focal ischemic infarcts in adult squirrel monkeys
Nudo, R. J., & Milliken, G. W. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.75.5.2144 · Cited by 715
Reorganization of Movement Representations in Primary Motor Cortex Following Focal Ischemic Infarcts in Adult Squirrel Monkeys
Simonsen, C. (1998) · Neurology Report · doi:10.1097/01253086-199822020-00019 · Cited by 610

Flagged first, then by citations

Show all 33 references

Research works printed but not linked: 7

BACHYRITA P, RECOVERY FUNCTION TH: 225 (1980).
BLACK P, OUTCOME SEVERE DAMAG: 65 (1975).
BLACK P, T AM NEUROL ASSOC 95, 207 (1970).
BUCY P.C., PRECENTRAL MOTOR COR: 353 (1944).
GOWLAND C, STROKE REHABILITATIO: 217 (1987).
NUDO R.J., SOC NEUR ABSTR 21, 517 (1995).
TRAVIS A.M., AM J PHYS MED 35, 273 (1956).

Sorted by citations

Items 301–400 of 1,000

Predicting the potential of wearable technology
Binkley, P. F., Frontera, W. R., Standaert, D. G., & Stein, J. (2003) · IEEE Engineering in Medicine and Biology Magazine · doi:10.1109/memb.2003.1213623 · Cited by 132
Constraint-induced movement therapy: bridging from the primate laboratory to the stroke rehabilitation laboratory
Taub, E., & Uswatte, G. (2003) · Journal of Rehabilitation Medicine · doi:10.1080/16501960310010124 · Cited by 128
Motor System Reorganization After Stroke: Stimulating and Training Toward Perfection
Jones, T. A., & Adkins, D. L. (2015) · Physiology · doi:10.1152/physiol.00014.2015 · Cited by 142
Effects of Somatosensory Stimulation on Use-Dependent Plasticity in Chronic Stroke
Sawaki, L. A., Wu, C. W. ‐., Kaelin‐Lang, A., & Cohen, L. G. (2005) · Stroke · doi:10.1161/01.str.0000195130.16843.ac · Cited by 129
Pathophysiology of Stroke Rehabilitation: The Natural Course of Clinical Recovery, Use-Dependent Plasticity and Rehabilitative Outcome
Kreisel, S. H., Hennerici, M. G., & Bäzner, H. (2007) · Cerebrovascular Diseases · doi:10.1159/000098323 · Cited by 127
A Review of Transcranial Magnetic Stimulation and Multimodal Neuroimaging to Characterize Post-Stroke Neuroplasticity
Auriat, A. M., Neva, J. L., Peters, S., Ferris, J. K., & Boyd, L. A. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00226 · Cited by 143
Plasticity in the Human Cerebral Cortex: Lessons from the Normal Brain and from Stroke
Bütefisch, C. M. (2004) · The Neuroscientist · doi:10.1177/1073858403262152 · Cited by 127
Disturbance and recovery of language function: correlates in PET activation studies
Wd, H., Thiel, A., Kessler, J., & Herholz, K. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.09.005 · Cited by 128
Effects of Motor Training on the Recovery of Manual Dexterity After Primary Motor Cortex Lesion in Macaque Monkeys
Murata, Y., Higo, N., Oishi, T., Yamashita, A., Matsuda, K., Hayashi, M., & Yamane, S. (2007) · Journal of Neurophysiology · doi:10.1152/jn.01001.2007 · Cited by 135
Effect of sensory discrimination training on structure and function in patients with focal hand dystonia: a case series
Byl, N. N., Nagajaran, S., & McKenzie, A. L. (2003) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/s0003-9993(03)00276-4 · Cited by 124
Enhanced phasic GABA inhibition during the repair phase of stroke: a novel therapeutic target
Hiu, T., Farzampour, Z., Paz, J. T., Wang, E. H.-J., Badgely, C., Olson, A., Micheva, K. D., Wang, G. X., Lemmens, R., Tran, K. C., et al. (2015) · Brain · doi:10.1093/brain/awv360 · Cited by 127
Music supported therapy promotes motor plasticity in individuals with chronic stroke
Ripollés, P., Rojo, N., Grau‐Sánchez, J., Amengual, J. L., Càmara, E., Marco‐Pallarés, J., Juncadella, M., Vaquero, L., Rubio, F. J., Duarte, E., et al. (2015) · Brain Imaging and Behavior · doi:10.1007/s11682-015-9498-x · Cited by 127
Acquisition of anticipatory postural adjustments in a bimanual load-lifting task: normal and pathological aspects
Massion, J., Me, I., Schmitz, C., Viallet, F., & Gantcheva, R. (1999) · Experimental Brain Research · doi:10.1007/s002210050842 · Cited by 128
Motor improvements after focal cortical ischemia in adult rats are mediated by compensatory mechanisms
Metz, G. A. S., Antonow‐Schlorke, I., & Witte, O. W. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.03.002 · Cited by 123
Effects of Postlesion Experience on Behavioral Recovery and Neurophysiologic Reorganization after Cortical Injury in Primates
Friel, K. M., Heddings, A., & Nudo, R. J. (2000) · Neurorehabilitation and neural repair · doi:10.1177/154596830001400304 · Cited by 123
Use-Dependent Exaggeration of Brain Injury: Is Glutamate Involved?
Humm, J. L., Kozlowski, D. A., Bland, S. T., James, D. C., & Schallert, T. J. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7061 · Cited by 121
Structural Plasticity in Adulthood with Motor Learning and Stroke Rehabilitation
Sampaio‐Baptista, C., Sanders, Z., & Johansen‐Berg, H. (2018) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-080317-062015 · Cited by 126
Development and application of virtual reality technology to improve hand use and gait of individuals post-stroke
Deutsch, J. E., Merians, A. S., Adamovich, S. V., Howard Poizner, A., & Burdea, G. (2004) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2004-00280 · Cited by 121
Enriched environment after focal cortical ischemia enhances the generation of astroglia and NG2 positive polydendrocytes in adult rat neocortex
Komitova, M., Perfilieva, E., Mattsson, B., Eriksson, P. S., & Johansson, B. B. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2005.12.007 · Cited by 120
Recovery of function in humans: Cortical stimulation and pharmacological treatments after stroke
Flöel, A., & Cohen, L. G. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.05.027 · Cited by 123
The structural and functional mechanisms of motor recovery: complementary use of diffusion tensor and functional magnetic resonance imaging in a traumatic injury of the internal capsule
Werring, D. J., Clark, C., Barker, G. J., Miller, D., Parker, G. J. M., Brammer, M. J., Bullmore, E. T., Giampietro, V., & Thompson, A. J. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.65.6.863 · Cited by 120
Development and Validation of a Scale for Rating Motor Compensations Used for Reaching in Patients With Hemiparesis: The Reaching Performance Scale
Levin, M. F., Desrosiers, J., Beauchemin, D., Bergeron, N., & Rochette, A. (2004) · Physical Therapy · doi:10.1093/ptj/84.1.8 · Cited by 120
Putting the Brain on the Map: Use of Transcranial Magnetic Stimulation to Assess and Induce Cortical Plasticity of Upper-Extremity Movement
Butler, A. J., & Wolf, S. L. (2007) · Physical Therapy · doi:10.2522/ptj.20060274 · Cited by 125
Neuroimaging experimental studies on brain plasticity in recovery from stroke.
Pm, R., Altamura, C., Ferreri, F., Melgari, J. M., Tecchio, F., Tombini, M., Pasqualetti, P., & Vernieri, F. (2007) · PubMed · Cited by 118
Therapeutic modulation of synaptic connectivity with desynchronizing brain stimulation
Tass, P. A., & Hauptmann, C. (2006) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2006.07.013 · Cited by 117
Harnessing Brain Plasticity through Behavioral Techniques to Produce New Treatments in Neurorehabilitation.
Taub, E. (2004) · American Psychologist · doi:10.1037/0003-066x.59.8.692 · Cited by 119
Improved motor recovery after stroke and massive cortical reorganization following Constraint-Induced Movement therapy
Taub, E., Uswatte, G., & Morris, D. M. (2003) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/s1047-9651(02)00052-9 · Cited by 116
The Effectiveness of Rehabilitation for Cognitive Deficits
(2005) · doi:10.1093/acprof:oso/9780198526544.001.0001 · Cited by 118
Age, plasticity, and homeostasis in childhood brain disorders
Dennis, M., Spiegler, B. J., Juranek, J. J., Bigler, E. D., Snead, O. C., & Fletcher, J. M. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.09.010 · Cited by 133
Physiological studies of the corticomotor projection to the hand after subcortical stroke
Byrnes, M. L., Thickbroom, G. W., Phillips, B. A., Wilson, S. A., & Mastaglia, F. L. (1999) · Clinical Neurophysiology · doi:10.1016/s1388-2457(98)00044-3 · Cited by 117
Improved understanding of cortical injury by incorporating measures of functional anatomy
Crafton, K. R. (2003) · Brain · doi:10.1093/brain/awg159 · Cited by 123
The Role of Timing and Intensity of Rehabilitation Therapies
Teasell, R. W., Bitensky, J., Salter, K. L., & Bayona, N. A. (2005) · Topics in Stroke Rehabilitation · doi:10.1310/etdp-6dr4-d617-vmvf · Cited by 117
Imaging recovery from stroke
Weiller, C. (1998) · Experimental Brain Research · doi:10.1007/s002210050539 · Cited by 117
Motor representation in patients rapidly recovering after stroke: a functional magnetic resonance imaging and transcranial magnetic stimulation study
Foltys, H., Krings, T., Meister, I. G., Sparing, R., Boroojerdi, B., Thron, A. K., & Töpper, R. (2003) · Clinical Neurophysiology · doi:10.1016/s1388-2457(03)00263-3 · Cited by 118
Training-dependent plasticity in patients with multiple sclerosis
Morgen, K. (2004) · Brain · doi:10.1093/brain/awh266 · Cited by 118
The effect of the GENTLE/s robot-mediated therapy system on arm function after stroke
Coote, S. B., Murphy, T. B., Harwin, W., & Stokes, E. (2008) · Clinical Rehabilitation · doi:10.1177/0269215507085060 · Cited by 116
Non-Invasive Brain Stimulation: An Interventional Tool for Enhancing Behavioral Training after Stroke
Wessel, M. J., Zimerman, M., & Hummel, F. C. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00265 · Cited by 118
Treatment effectiveness for patients with a history of repetitive hand use and focal hand dystonia
Byl, N. N., & McKenzie, A. L. (2000) · Journal of Hand Therapy · doi:10.1016/s0894-1130(00)80021-6 · Cited by 115
The promise and perils of causal circuit manipulations
Wolff, S. B. E., & Ölveczky, B. P. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.01.004 · Cited by 121
Functional Electrical Stimulation to Dorsiflexors and Plantar Flexors During Gait to Improve Walking in Adults With Chronic Hemiplegia
Embrey, D. G., Holtz, S. L., Alon, G., Brandsma, B. A., & McCoy, S. W. (2010) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2009.12.024 · Cited by 114
An Overview of Acute Stroke Therapy: Past, Present, and Future
Fisher, M., & Schaebitz, W. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.21.3196 · Cited by 112
Motor learning after stroke: Is skill acquisition a prerequisite for contralesional neuroplastic change?
Boyd, L. A., Vidoni, E. D., & Wessel, B. D. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.06.082 · Cited by 113
Evidenzbasierte Armrehabilitation
Platz, T. (2003) · Der Nervenarzt · doi:10.1007/s00115-003-1549-7 · Cited by 113
Experience-dependent neural plasticity in the adult damaged brain
Kerr, A. L., Cheng, S.-Y., & Jones, T. A. (2011) · Journal of Communication Disorders · doi:10.1016/j.jcomdis.2011.04.011 · Cited by 126
Neuroplasticity and constraint-induced movement therapy.
Mark, V. W., Taub, E., & Morris, D. M. (2006) · PubMed · Cited by 110
Periinfarct and Remote Excitability Changes after Transient Middle Cerebral Artery Occlusion
Neumann‐Haefelin, T., & Witte, O. W. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200001000-00008 · Cited by 112
Different Neural Circuits Subserve Reading before and after Therapy for Acquired Dyslexia
Small, S. L., Flores, D., & Noll, D. C. (1998) · Brain and Language · doi:10.1006/brln.1998.1951 · Cited by 112
The African trypanosome genome
El-Sayed, N. M., Hegde, P. S., Quackenbush, J. F., Melville, S. E., & Donelson, J. E. (2000) · International Journal for Parasitology · doi:10.1016/s0020-7519(00)00015-1 · Cited by 112
Early and late treadmill training after focal brain ischemia in rats
Yang, Y., Wang, R., & Wang, P. S.-G. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00010-7 · Cited by 111
Chronic Deep Cerebellar Stimulation Promotes Long-Term Potentiation, Microstructural Plasticity, and Reorganization of Perilesional Cortical Representation in a Rodent Model
Cooperrider, J., Furmaga, H., Plow, E., Park, H., Chen, Z., Kidd, G. J., Baker, K. B., Gale, J. T., & Machado, A. G. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0953-14.2014 · Cited by 111
Activity-based therapies
Dromerick, A. W., Lum, P. S., & Hidler, J. M. (2006) · NeuroRx · doi:10.1016/j.nurx.2006.07.004 · Cited by 113
A functional magnetic resonance proof of concept pilot trial of cognitive rehabilitation in multiple sclerosis
Sastre‐Garriga, J., Alonso, J., Renom, M., Arévalo, M. J., González, I., Galán, I., Montalbán, X., & Rovira, À. (2010) · Multiple Sclerosis Journal · doi:10.1177/1352458510389219 · Cited by 110
A Functional Threshold for Long-Term Use of Hand and Arm Function Can Be Determined: Predictions From a Computational Model and Supporting Data From the Extremity Constraint-Induced Therapy Evaluation (EXCITE) Trial
Schweighofer, N., Han, C. E., Wolf, S. L., Arbib, M. A., & Winstein, C. J. (2009) · Physical Therapy · doi:10.2522/ptj.20080402 · Cited by 110
Neuroimaging and recovery of language in aphasia
Thompson, C. K., & den Ouden, D. (2008) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-008-0076-0 · Cited by 108
Effects of Small Ischemic Lesions in the Primary Motor Cortex on Neurophysiological Organization in Ventral Premotor Cortex
Dancause, N., Barbay, S., Frost, S. B., Zoubina, E. V., Plautz, E. J., Mahnken, J. D., & Nudo, R. J. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00792.2006 · Cited by 108
A pneumatic muscle hand therapy device
Koeneman, E. J., Schultz, R. S., Wolf, S. L., Herring, D. E., & Koeneman, J. B. (2005) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/iembs.2004.1403777 · Cited by 108
Selective long‐term reorganization of the corticospinal projection from the supplementary motor cortex following recovery from lateral motor cortex injury
McNeal, D. W., Darling, W. G., Ge, J., Stilwell‐Morecraft, K. S., Solon, K., Hynes, S. M., Pizzimenti, M. A., Rotella, D. L., Vanadurongvan, T., & Morecraft, R. J. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22218 · Cited by 115
Neuroplasticity, learning and recovery after stroke: A critical evaluation of constraint-induced therapy
Sunderland, A., & Tuke, A. (2005) · Neuropsychological Rehabilitation · doi:10.1080/09602010443000047 · Cited by 107
Effects of intensive repetition of a new facilitation technique on motor functional recovery of the hemiplegic upper limb and hand
Kawahira, K., Shimodozono, M., Etoh, S., Kamada, K., Noma, T., & Tanaka, N. (2010) · Brain Injury · doi:10.3109/02699052.2010.506855 · Cited by 106
Changes in Brain Size during the Menstrual Cycle
Hagemann, G., Ugur, T., Schleußner, E., Mentzel, H., Fitzek, C., Witte, O. W., & Gaser, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014655 · Cited by 114
Somatotopy and movement representation sites following cortical stroke
Cramer, S. C., & Crafton, K. R. (2005) · Experimental Brain Research · doi:10.1007/s00221-005-0082-2 · Cited by 106
An Integrated Framework for Decision Making in Neurologic Physical Therapist Practice
Schenkman, M. L., Deutsch, J. E., & Gill-Body, K. M. (2006) · Physical Therapy · doi:10.2522/ptj.20050260 · Cited by 105
Effects of Robot-Aided Bilateral Force-Induced Isokinetic Arm Training Combined With Conventional Rehabilitation on Arm Motor Function in Patients With Chronic Stroke
Chang, J., Tung, W., Wu, W., Huang, M., & Su, F. (2007) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2007.07.016 · Cited by 105
Against cortical reorganisation
Makin, T. R., & Krakauer, J. W. (2023) · eLife · doi:10.7554/elife.84716 · Cited by 127
Transcranial Direct Current Stimulation in Stroke Rehabilitation: A Review of Recent Advancements
Gómez-Palacio-Schjetnan, A., Faraji, J., Metz, G. A. S., Tatsuno, M., & Luczak, A. (2013) · Stroke Research and Treatment · doi:10.1155/2013/170256 · Cited by 111
Muscle Activation Patterns and Postural Control Following Stroke
Garland, S. J., Gray, V. L., & Knorr, S. (2009) · Motor Control · doi:10.1123/mcj.13.4.387 · Cited by 104
The effects of virtual reality game exercise on balance and gait of the elderly
Park, E.-C., Kim, S.-G., & Lee, C.-W. (2015) · Journal of Physical Therapy Science · doi:10.1589/jpts.27.1157 · Cited by 103
Breastfeeding Challenges and the Preterm Mother-Infant Dyad: A Conceptual Model
Lau, C. (2017) · Breastfeeding Medicine · doi:10.1089/bfm.2016.0206 · Cited by 108
Cortical Reorganization Following Bimanual Training and Somatosensory Stimulation in Cervical Spinal Cord Injury: A Case Report
Hoffman, L. R., & Field-Fote, E. C. (2007) · Physical Therapy · doi:10.2522/ptj.20050365 · Cited by 103
Rewiring the connectome: Evidence and effects
Bennett, S. H., Kirby, A. J., & Finnerty, G. T. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.03.001 · Cited by 105
The effects of stroke and age on finger interaction in multi-finger force production tasks
Li, S., Latash, M. L., Yue, G. H., Siemionow, V., & Sahgal, V. (2003) · Clinical Neurophysiology · doi:10.1016/s1388-2457(03)00164-0 · Cited by 102
Improving Hand Function in Stroke Survivors: A Pilot Study of Contralaterally Controlled Functional Electric Stimulation in Chronic Hemiplegia
Knutson, J. S., Harley, M. Y., Hisel, T. Z., & Chae, J. (2007) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2007.01.003 · Cited by 102
Addition of intensive repetition of facilitation exercise to multidisciplinary rehabilitation promotes motor functional recovery of the hemiplegic lower limb
Kawahira, K., Shimodozono, M., 緒方, 敦., & Tanaka, N. (2004) · Journal of Rehabilitation Medicine · doi:10.1080/16501970410029753 · Cited by 102
Role of sensory deficits in motor impairments after injury to primary motor cortex
Nudo, R. J., Friel, K. M., & Delia, S. W. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(99)00254-3 · Cited by 102
Paradoxical Motor Recovery From a First Stroke After Induction of a Second Stroke: Reopening a Postischemic Sensitive Period
Zeiler, S. R., Hubbard, R., Gibson, E. M., Zheng, T., Ng, K., O’Brien, R., & Krakauer, J. W. (2016) · Neurorehabilitation and Neural Repair · doi:10.1177/1545968315624783 · Cited by 97
Constraint-Induced Therapy Approach to Restoring Function After Neurological Injury
Morris, D. M., & Taub, E. (2001) · Topics in Stroke Rehabilitation · doi:10.1310/bljx-m89n-ptpy-jdkw · Cited by 97
Brain changes following four weeks of unimanual motor training: Evidence from behavior, neural stimulation, cortical thickness, and functional MRI
Sale, M. V., Reid, L. B., Cocchi, L., Pagnozzi, A. M., Rose, S., & Mattingley, J. B. (2017) · Human Brain Mapping · doi:10.1002/hbm.23710 · Cited by 101
Motor balance and coordination training enhances functional outcome in rat with transient middle cerebral artery occlusion
Ding, Y., Li, J., Lai, Q., Rafols, J. A., Luan, X., Clark, J. C., & Diaz, F. G. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.08.031 · Cited by 100
Neurobiology of Rehabilitation
Dobkin, B. H. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1315.024 · Cited by 97
Constraint-induced movement therapy for recovery of upper-limb function following traumatic brain injury
Shaw, S. E., Morris, D. M., Uswatte, G., McKay, S., Meythaler, J. M., & Taub, E. (2005) · The Journal of Rehabilitation Research and Development · doi:10.1682/jrrd.2005.06.0094 · Cited by 100
Does brain stimulation after stroke have a future?
Talelli, P., & Rothwell, J. C. (2006) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32801080d1 · Cited by 99
Hand Motor Recovery After Stroke: Tuning the Orchestra to Improve Hand Motor Function
Fregni, F., & Pascual‐Leone, Á. (2006) · Cognitive and Behavioral Neurology · doi:10.1097/00146965-200603000-00003 · Cited by 99
Sensorimotor behavioral effects of endothelin-1 induced small cortical infarcts in C57BL/6 mice
Tennant, K. A., & Jones, T. A. (2009) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2009.04.009 · Cited by 100
Adult cortical plasticity following injury: Recapitulation of critical period mechanisms?
Nahmani, M., & Turrigiano, G. G. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.029 · Cited by 97
Temporal Plasticity Involved in Recovery from Manual Dexterity Deficit after Motor Cortex Lesion in Macaque Monkeys
Murata, Y., Higo, N., Hayashi, T., Nishimura, Y., Sugiyama, Y., Oishi, T., Tsukada, H., Isa, T., & Onoe, H. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1737-14.2015 · Cited by 103
Behavioral and neurophysiological effects of delayed training following a small ischemic infarct in primary motor cortex of squirrel monkeys
Barbay, S., Plautz, E. J., Friel, K. M., Frost, S. B., Dancause, N., Stowe, A. M., & Nudo, R. J. (2005) · Experimental Brain Research · doi:10.1007/s00221-005-0129-4 · Cited by 99
Inter-hemispheric coupling changes associate with motor improvements after robotic stroke rehabilitation
Pellegrino, G., Tomasevic, L., Tombini, M., Assenza, G., Bravi, M., Sterzi, S., Giacobbe, V., Zollo, L., Guglielmelli, E., Cavallo, G., et al. (2012) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2012-120227 · Cited by 97
Post-lesional cerebral reorganisation: Evidence from functional neuroimaging and transcranial magnetic stimulation
Bütefisch, C. M., Kleiser, R., & Seitz, R. J. (2006) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2006.03.001 · Cited by 95
HandTutorTM enhanced hand rehabilitation after stroke — a pilot study
Carmeli, E., Peleg, S., Bartur, G., Elbo, E., & Vatine, J. (2010) · Physiotherapy Research International · doi:10.1002/pri.485 · Cited by 95
Translating the science into practice
Winstein, C. J., & Kay, D. B. (2015) · Progress in brain research · doi:10.1016/bs.pbr.2015.01.004 · Cited by 97
Brain plasticity in recovery from stroke: An MEG assessment
Tecchio, F., Zappasodi, F., Tombini, M., Oliviero, A., Pasqualetti, P., Vernieri, F., Ercolani, M., Pizzella, V., & Rossini, P. M. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.05.004 · Cited by 96
Facilitation of Sensory and Motor Recovery by Thermal Intervention for the Hemiplegic Upper Limb in Acute Stroke Patients
Chen, J.-C., Liang, C., & Shaw, F. (2005) · Stroke · doi:10.1161/01.str.0000189992.06654.ab · Cited by 95
Reorganization of Motor Cortex after Controlled Cortical Impact in Rats and Implications for Functional Recovery
Nishibe, M., Barbay, S., Guggenmos, D. J., & Nudo, R. J. (2010) · Journal of Neurotrauma · doi:10.1089/neu.2010.1456 · Cited by 97
Treatment with bone marrow mononuclear cells induces functional recovery and decreases neurodegeneration after sensorimotor cortical ischemia in rats
Giraldi‐Guimarães, A., Rezende-Lima, M., Bruno, F., & Méndez‐Otero, R. (2009) · Brain Research · doi:10.1016/j.brainres.2009.01.062 · Cited by 94
“Learned baduse” limits recovery of skilled reaching for food after forelimb motor cortex stroke in rats: A new analysis of the effect of gestures on success
Alaverdashvili, M. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.11.007 · Cited by 94
Progressive plastic changes in the hand representation of the primary motor cortex parallel incomplete recovery from a unilateral section of the corticospinal tract at cervical level in monkeys
Schmidlin, E., Wannier, T., Bloch, J., & Rouiller, E. M. (2004) · Brain Research · doi:10.1016/j.brainres.2004.05.036 · Cited by 94
Development of a behaviour change intervention to increase upper limb exercise in stroke rehabilitation
Connell, L. A., McMahon, N. E., Redfern, J., Watkins, C. L., & Eng, J. J. (2015) · Implementation Science · doi:10.1186/s13012-015-0223-3 · Cited by 84
The neural consequences of repetition: Clinical implications of a learning hypothesis
Byl, N. N., & Melnick, M. E. (1997) · Journal of Hand Therapy · doi:10.1016/s0894-1130(97)80070-1 · Cited by 93
New Directions in Treatments Targeting Stroke Recovery
Lin, D. J., Finklestein, S. P., & Cramer, S. C. (2018) · Stroke · doi:10.1161/strokeaha.118.021359 · Cited by 90
Comparing a Novel Neuroanimation Experience to Conventional Therapy for High-Dose Intensive Upper-Limb Training in Subacute Stroke: The SMARTS2 Randomized Trial
Krakauer, J. W., Kitago, T., Goldsmith, J., Ahmad, O. M., Roy, P., Stein, J. M., Bishop, L., Casey, K. S., Valladares, B., Harran, M. D., et al. (2021) · Neurorehabilitation and neural repair · doi:10.1177/15459683211000730 · Cited by 93

Authors: Nudo, R. J., Wise, B. M., SiFuentes, F., & Milliken, G. W.
Affiliations: The University of Texas Health Science Center at Houston (US)
Corresponding author: Nudo, Randolph J.
Milliken, Garrett W.
ORCID: Nudo, Randolph J.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1996-06-21
Volume: 272
Issue: 5269
Pages: 1791-1794
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.272.5269.1791
OpenAlex: W2038514344
Cited by: 1,911
References: 33
Citations by year: 2026: 34 · 2025: 38 · 2024: 35 · 2023: 51 · 2022: 61 · 2021: 56 · 2020: 34 · 2019: 59 · 2018: 46 · 2017: 71 · 2016: 71 · 2015: 77 · 2014: 82 · 2013: 79 · 2012: 77
FWCI: 52.86
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r29ns027974-05)
National Institute of Neurological Disorders and Stroke (NS27974, NS30853)
Topics: Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
Keywords: motor cortex, functional reorganization, ischemic infarct, stroke, motor recovery, rehabilitative training, hand representation, squirrel monkey, cortical plasticity
MeSH terms: Animals, Brain Mapping, Cerebral Infarction, Brain Ischemia, Electric Stimulation, Hand, Male, Motor Cortex, Motor Skills, Neuronal Plasticity, Random Allocation, Saimiri

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neural Substrates for the Effects of Rehabilitative Training on Motor Recovery After Ischemic Infarct

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks