Cited by 1,911Stroke Rehabilitation and RecoveryMotor Control and AdaptationTranscranial Magnetic Stimulation Studies

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Neural Substrates for the Effects of Rehabilitative Training on Motor Recovery After Ischemic Infarct

Nudo, Randolph J., Wise, Birute M., SiFuentes, Frank, Milliken, Garrett W.·1996·Science

Open this paper in CoChat — free account

Abstract

Substantial functional reorganization takes place in the motor cortex of adult primates after a focal ischemic infarct, as might occur in stroke. A subtotal lesion confined to a small portion of the representation of one hand was previously shown to result in a further loss of hand territory in the adjacent, undamaged cortex of adult squirrel monkeys. In the present study, retraining of skilled hand use after similar infarcts resulted in prevention of the loss of hand territory adjacent to the infarct. In some instances, the hand representations expanded into regions formerly occupied by representations of the elbow and shoulder. Functional reorganization in the undamaged motor cortex was accompanied by behavioral recovery of skilled hand function. These results suggest that, after local damage to the motor cortex, rehabilitative training can shape subsequent reorganization in the adjacent intact cortex, and that the undamaged motor cortex may play an important role in motor recovery.

Integrity signals

Registry

Crossref · 10.1126/science.272.5269.1791

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Functional MRI evidence for adult motor cortex plasticity during motor skill learning
Kami, A., Meyer, G., Jezzard, P., Adams, M. M., Turner, R., & Ungerleider, L. G. (1995) · Nature · doi:10.1038/377155a0 · Cited by 1,883
Technique to improve chronic motor deficit after stroke.
Taub, E., Miller, N. E., Novack, T. A., Cook, E. W., Fleming, W. C., Nepomuceno, C., Connell, J., & Crago, J. E. (1993) · PubMed · Cited by 1,557
Use-dependent alterations of movement representations in primary motor cortex of adult squirrel monkeys
Nudo, R. J., Milliken, G. W., Jenkins, W., & Merzenich, M. M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-02-00785.1996 · Cited by 1,416
The functional anatomy of motor recovery after stroke in humans: A study with positron emission tomography
Chollet, F., Piero, V. D., Wise, R. J. S., Brooks, D. J., Dolan, R. J., & Frackowiak, R. S. J. (1991) · Annals of Neurology · doi:10.1002/ana.410290112 · Cited by 1,096
Massive Cortical Reorganization After Sensory Deafferentation in Adult Macaques
Pons, T. P., Garraghty, P. E., Ommaya, A. K., Kaas, J. H., Taub, E., & Mishkin, M. (1991) · Science · doi:10.1126/science.1843843 · Cited by 1,081
THE RESTORATION OF MOTOR FUNCTION FOLLOWING HEMIPLEGIA IN MAN
Twitchell, T. E. (1951) · Brain · doi:10.1093/brain/74.4.443 · Cited by 942
Plasticity of Sensory and Motor Maps in Adult Mammals
Kaas, J. H. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.001033 · Cited by 913
Modulation of Cortical Motor Output Maps During Development of Implicit and Explicit Knowledge
Pascual‐Leone, Á., Grafman, J. H., & Hallett, M. (1994) · Science · doi:10.1126/science.8122113 · Cited by 745
Reorganization of movement representations in primary motor cortex following focal ischemic infarcts in adult squirrel monkeys
Nudo, R. J., & Milliken, G. W. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.75.5.2144 · Cited by 715
Reorganization of Movement Representations in Primary Motor Cortex Following Focal Ischemic Infarcts in Adult Squirrel Monkeys
Simonsen, C. (1998) · Neurology Report · doi:10.1097/01253086-199822020-00019 · Cited by 610

Flagged first, then by citations

Show all 33 references

Research works printed but not linked: 7

BACHYRITA P, RECOVERY FUNCTION TH: 225 (1980).
BLACK P, OUTCOME SEVERE DAMAG: 65 (1975).
BLACK P, T AM NEUROL ASSOC 95, 207 (1970).
BUCY P.C., PRECENTRAL MOTOR COR: 353 (1944).
GOWLAND C, STROKE REHABILITATIO: 217 (1987).
NUDO R.J., SOC NEUR ABSTR 21, 517 (1995).
TRAVIS A.M., AM J PHYS MED 35, 273 (1956).

Sorted by citations

Items 101–200 of 1,000

A randomized controlled comparison of upper-extremity rehabilitation strategies in acute stroke: a pilot study of immediate and long-term outcomes
Winstein, C. J., Rose, D. K., Tan, S., Lewthwaite, R., Chui, H. C., & Azen, S. P. (2004) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2003.06.027 · Cited by 339
Spasticity, Motor Recovery, and Neural Plasticity after Stroke
Li, S. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00120 · Cited by 339
In Vivo Voltage-Sensitive Dye Imaging in Adult Mice Reveals That Somatosensory Maps Lost to Stroke Are Replaced over Weeks by New Structural and Functional Circuits with Prolonged Modes of Activation within Both the Peri-Infarct Zone and Distant Sites
Brown, C. E., Aminoltejari, K., Erb, H., Winship, I. R., & Murphy, T. H. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4249-08.2009 · Cited by 319
Mechanisms for recovery of motor function following cortical damage
Nudo, R. J. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.10.004 · Cited by 332
Neural Changes following Remediation in Adult Developmental Dyslexia
Eden, G. F., Jones, K. M., Cappell, K. A., Gareau, L., Wood, F., Zeffiro, T. A., Dietz, N. A. E., Agnew, J., & Flowers, D. L. (2004) · Neuron · doi:10.1016/j.neuron.2004.10.019 · Cited by 341
It’s More Than a Black Box; It’s a Russian Doll: Defining Rehabilitation Treatments
Whyte, J., & Hart, T. (2003) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/01.phm.0000078200.61840.2d · Cited by 297
Recovery recapitulates ontogeny
Cramer, S. C., & Chopp, M. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01562-9 · Cited by 326
Virtual reality for the rehabilitation of the upper limb motor function after stroke: a prospective controlled trial
Turolla, A., Dam, M., Ventura, L., Tonin, P., Agostini, M., Zucconi, C. S., Kiper, P., Cagnin, A., & Piron, L. (2013) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/1743-0003-10-85 · Cited by 322
Mental practice with motor imagery in stroke recovery: randomized controlled trial of efficacy
Ietswaart, M., Johnston, M., Dijkerman, H. C., Joice, S., Scott, C. L., MacWalter, R. S., & Hamilton, S. (2011) · Brain · doi:10.1093/brain/awr077 · Cited by 331
Electrical stimulation driving functional improvements and cortical changes in subjects with stroke
Kimberley, T. J., Lewis, S. M., Auerbach, E. J., Dorsey, L. L., Lojovich, J. M., & Carey, J. R. (2004) · Experimental Brain Research · doi:10.1007/s00221-003-1695-y · Cited by 318
In Search of the Motor Engram: Motor Map Plasticity as a Mechanism for Encoding Motor Experience
Monfils, M., Plautz, E. J., & Kleim, J. A. (2005) · The Neuroscientist · doi:10.1177/1073858405278015 · Cited by 331
Neuromuscular Stimulation for Upper Extremity Motor and Functional Recovery in Acute Hemiplegia
Chae, J., Béthoux, F., Bohinc, T., Dobos, L., Davis, T., & Friedl, A. S. (1998) · Stroke · doi:10.1161/01.str.29.5.975 · Cited by 310
Mechanisms of Cortical Reorganization in Lower-Limb Amputees
Chen, R., Corwell, B., Yaseen, Z., Hallett, M., & Cohen, L. G. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-09-03443.1998 · Cited by 309
Motor Enrichment and the Induction of Plasticity Before or After Brain Injury
Kleim, J. A., Jones, T. A., & Schallert, T. J. (2003) · Neurochemical Research · doi:10.1023/a:1026025408742 · Cited by 309
Design and Control of RUPERT: A Device for Robotic Upper Extremity Repetitive Therapy
Sugar, T. G., He, J., Koeneman, E. J., Koeneman, J. B., Herman, R. M., Huang, H., Schultz, R. S., Herring, D. E., Wanberg, J., Balasubramanian, S., et al. (2007) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2007.903903 · Cited by 304
New Patterns of Intracortical Projections after Focal Cortical Stroke
Carmichael, S. T., Wei, L., Rovainen, C. M., & Woolsey, T. A. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0425 · Cited by 302
Collateral Growth and Angiogenesis Around Cortical Stroke
Wei, L., Erinjeri, J. P., Rovainen, C. M., & Woolsey, T. A. (2001) · Stroke · doi:10.1161/hs0901.094282 · Cited by 300
Disability, atrophy and cortical reorganization following spinal cord injury
Freund, P., Weiskopf, N., Ward, N., Hutton, C., Gall, A., Ciccarelli, O., Craggs, M. D., Friston, K. J., & Thompson, A. J. (2011) · Brain · doi:10.1093/brain/awr093 · Cited by 296
Intracisternal basic fibroblast growth factor enhances functional recovery and up-regulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction
Kawamata, T., Dietrich, W. D., Schallert, T. J., Gotts, J. E., Cocke, R. R., Benowitz, L. I., & Finklestein, S. P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.8179 · Cited by 296
Factors influencing the magnitude and reproducibility of corticomotor excitability changes induced by paired associative stimulation
Sale, M. V., Ridding, M. C., & Nordstrom, M. A. (2007) · Experimental Brain Research · doi:10.1007/s00221-007-0960-x · Cited by 303
Inhibitory control of acquired motor programmes in the human brain
Hummel, F. C., Andres, F. G., ALTENMÜLLER, E. O., DICHGANS, J., & Gerloff, C. P. (2002) · Brain · doi:10.1093/brain/awf030 · Cited by 297
Synaptic circuit remodelling by matrix metalloproteinases in health and disease
Huntley, G. W. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3320 · Cited by 267
Simple, Efficient, and Modular Syntheses of Polyene Natural Products via Iterative Cross-Coupling
Lee, S. J., Gray, K. C., Paek, J. S., & Burke, M. D. (2007) · Journal of the American Chemical Society · doi:10.1021/ja078129x · Cited by 284
Post-infarct cortical plasticity and behavioral recovery using concurrent cortical stimulation and rehabilitative training: A feasibility study in primates
Plautz, E. J., Barbay, S., Frost, S. B., Friel, K. M., Dancause, N., Zoubina, E. V., Stowe, A. M., Quaney, B. M., & Nudo, R. J. (2003) · Neurological Research · doi:10.1179/016164103771953880 · Cited by 285
Motor compensation and recovery for reaching in stroke patients
Roby-Brami, A., Feydy, A., Combeaud, M., Biryukova, Е. V., Bussel, B., & Levin, M. F. (2003) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2003.00021.x · Cited by 297
Loss of the innate cortical engram for action patterns used in skilled reaching and the development of behavioral compensation following motor cortex lesions in the rat
Whishaw, I. Q. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(99)00259-2 · Cited by 281
Treadmill Exercise Activates Subcortical Neural Networks and Improves Walking After Stroke
Luft, A. R., Macko, R. F., Forrester, L. W., Villagra, F., Ivey, F. M., Sorkin, J. D., Whitall, J., McCombe-Waller, S., Katzel, L. I., Goldberg, A. P., et al. (2008) · Stroke · doi:10.1161/strokeaha.108.527531 · Cited by 279
RELATION BETWEEN STIMULATION CHARACTERISTICS AND CLINICAL OUTCOME IN STUDIES USING ELECTRICAL STIMULATION TO IMPROVE MOTOR CONTROL OF THE UPPER EXTREMITY IN STROKE
de Kroon, J. R., IJzerman, M. J., Chae, J., Lankhorst, G. J., & Zilvold, G. (2005) · Journal of Rehabilitation Medicine · doi:10.1080/16501970410024190 · Cited by 275
A longitudinal fMRI study: in recovering and then in clinically stable sub-cortical stroke patients
Tombari, D., Loubinoux, I., Pariente, J., Gerdelat, A., Albucher, J., Tardy, J., Cassol, E., & Chollet, F. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.058 · Cited by 272
Cerebellar hemispheric activation ipsilateral to the paretic hand correlates with functional recovery after stroke
Small, S. L. (2002) · Brain · doi:10.1093/brain/awf148 · Cited by 274
Arm function after stroke: Neurophysiological correlates and recovery mechanisms assessed by transcranial magnetic stimulation
Talelli, P., Greenwood, R., & Rothwell, J. C. (2006) · Clinical Neurophysiology · doi:10.1016/j.clinph.2006.01.016 · Cited by 278
Does anodal transcranial direct current stimulation enhance excitability of the motor cortex and motor function in healthy individuals and subjects with stroke: A systematic review and meta-analysis
Bastani, A., & Jaberzadeh, S. (2011) · Clinical Neurophysiology · doi:10.1016/j.clinph.2011.08.029 · Cited by 275
Contribution of the ipsilateral motor cortex to recovery after chronic stroke
Werhahn, K. J., Conforto, A. B., Kadom, N., Hallett, M., & Cohen, L. G. (2003) · Annals of Neurology · doi:10.1002/ana.10686 · Cited by 274
Counting Repetitions: An Observational Study of Outpatient Therapy for People with Hemiparesis Post-Stroke
Lang, C. E., MacDonald, J. R., & Gnip, C. (2007) · Neurology Report · doi:10.1097/01.npt.0000260568.31746.34 · Cited by 265
Effectiveness of Virtual Reality in Children With Cerebral Palsy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Chen, Y., Fanchiang, H. D., & Howard, A. (2018) · Physical Therapy · doi:10.1093/ptj/pzx107 · Cited by 257
Inosine induces axonal rewiring and improves behavioral outcome after stroke
Chen, P., Goldberg, D. E., Kolb, B. E., Lanser, M. E., & Benowitz, L. I. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132076299 · Cited by 265
Electrocorticographic control of a prosthetic arm in paralyzed patients
Yanagisawa, T., Hirata, M., Saitoh, Y., Kishima, H., Matsushita, K., Goto, T., Fukuma, R., Yokoi, H., Kamitani, Y., & Yoshimine, T. (2012) · Annals of Neurology · doi:10.1002/ana.22613 · Cited by 256
Dynamics of Motor Network Overactivation After Striatocapsular Stroke: A Longitudinal PET Study Using a Fixed-Performance Paradigm
Calautti, C., Leroy, F., Guincestre, J.-Y., & Baron, J. (2001) · Stroke · doi:10.1161/hs1101.097401 · Cited by 260
Use-dependent exacerbation of brain damage occurs during an early post-lesion vulnerable period
Humm, J. L., Kozlowski, D. A., James, D. C., Gotts, J. E., & Schallert, T. J. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01356-5 · Cited by 256
Motor learning after unilateral brain damage
Winstein, C. J. (1999) · Neuropsychologia · doi:10.1016/s0028-3932(98)00145-6 · Cited by 257
Intensive Sensorimotor Arm Training Mediated by Therapist or Robot Improves Hemiparesis in Patients With Chronic Stroke
Volpe, B. T., Lynch, D., Rykman, A., Ferraro, M., Galgano, M. A., Hogan, N., & Krebs, H. I. (2008) · Neurorehabilitation and neural repair · doi:10.1177/1545968307311102 · Cited by 259
Arm Training Induced Brain Plasticity in Stroke Studied with Serial Positron Emission Tomography
Nelles, G., Jentzen, W., Jueptner, M., Müller, S., & Diener, H. (2001) · NeuroImage · doi:10.1006/nimg.2001.0757 · Cited by 255
Rapidly induced auditory plasticity: The ventriloquism aftereffect
Recanzone, G. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.869 · Cited by 255
Brain Plasticity and Rehabilitation in Stroke Patients
Hara, Y. (2015) · Journal of Nippon Medical School · doi:10.1272/jnms.82.4 · Cited by 253
Swallowing and Dysphagia Rehabilitation: Translating Principles of Neural Plasticity Into Clinically Oriented Evidence
Robbins, J., Butler, S. G., Daniels, S. K., Gross, R. D., Langmore, S. E., Lazarus, C. L., Martin‐Harris, B., McCabe, D., Musson, N. D., & Rosenbek, J. C. (2008) · Journal of Speech Language and Hearing Research · doi:10.1044/1092-4388(2008/021 · Cited by 266
Functional Differentiation of Multiple Perilesional Zones after Focal Cerebral Ischemia
Witte, O., Bidmon, H.-J., Schiene, K., Redecker, C., & Hagemann, G. (2000) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1097/00004647-200008000-00001 · Cited by 260
Neural Adaptation in the Generation of Rhythmic Behavior
Pearson, K. G. (2000) · Annual Review of Physiology · doi:10.1146/annurev.physiol.62.1.723 · Cited by 251
Mechanisms of recovery of dexterity following unilateral lesion of the sensorimotor cortex in adult monkeys
Liu, Y., & Rouiller, E. M. (1999) · Experimental Brain Research · doi:10.1007/s002210050830 · Cited by 249
Learning perceptual skills: behavioral probes into adult cortical plasticity
Karni, A., & Bertini, G. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80033-5 · Cited by 252
Brain networks and their relevance for stroke rehabilitation
Guggisberg, A. G., Koch, P., Hummel, F. C., & Buetefisch, C. M. (2019) · Clinical Neurophysiology · doi:10.1016/j.clinph.2019.04.004 · Cited by 266
Computational Maps in the Visual Cortex
Miikkulainen, R., Sirosh, J., Choe, Y., & Bednar, J. A. (2005) · Springer eBooks · doi:10.1007/0-387-28806-6 · Cited by 247
Motor disinhibition in affected and unaffected hemisphere in the early period of recovery after stroke
Manganotti, P., Patuzzo, S., Cortese, F., Palermo, A., Smania, N., & Fiaschi, A. (2002) · Clinical Neurophysiology · doi:10.1016/s1388-2457(02)00062-7 · Cited by 243
Robot-aided sensorimotor arm training improves outcome in patients with chronic stroke
Ferraro, M., Palazzolo, J. J., Krol, J., Krebs, H. I., Hogan, N., & Volpe, B. T. (2003) · Neurology · doi:10.1212/01.wnl.0000095963.00970.68 · Cited by 242
Brain Imaging of Attentional Networks in Normal and Pathological States
Fernandez‐Duque, D., & Posner, M. I. (2001) · Journal of Clinical and Experimental Neuropsychology · doi:10.1076/jcen.23.1.74.1217 · Cited by 254
Motor cortex stimulation enhances motor recovery and reduces peri-infarct dysfunction following ischemic insult
Kleim, J. A., Hines, R. M., VandenBerg, P. M., MacDonald, E., Mulrooney, R., & Pocock, D. (2003) · Neurological Research · doi:10.1179/016164103771953862 · Cited by 238
Vicarious function within the human primary motor cortex?
Jaillard, A. S., Delon‐Martin, C., Garambois, K., Bas, J. F. L., & Hommel, M. (2005) · Brain · doi:10.1093/brain/awh456 · Cited by 236
Cortical electrical stimulation combined with rehabilitative training: Enhanced functional recovery and dendritic plasticity following focal cortical ischemia in rats
Adkins, D. L., & Jones, T. A. (2003) · Neurological Research · doi:10.1179/016164103771953853 · Cited by 235
On whether the environmental enrichment may provide cognitive and brain reserves
Petrosini, L., Bartolo, P. D., Foti, F., Gelfo, F., Cutuli, D., Leggio, M. G., & Mandolesi, L. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.07.002 · Cited by 255
Somatosensory Stimulation Enhances the Effects of Training Functional Hand Tasks in Patients With Chronic Stroke
Celnik, P. A., Hummel, F. C., Harris-Love, M. L., Wolk, R., & Cohen, L. G. (2007) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2007.08.001 · Cited by 234
Early Training May Exacerbate Brain Damage after Focal Brain Ischemia in the Rat
Risedal, A., Zeng, R., & Johansson, B. B. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199909000-00007 · Cited by 230
Functional MRI Detects Posterior Shifts in Primary Sensorimotor Cortex Activation After Stroke
Pineiro, R., Pendlebury, S. T., Johansen‐Berg, H., & Matthews, P. M. (2001) · Stroke · doi:10.1161/01.str.32.5.1134 · Cited by 228
Neural Plasticity: The Biological Substrate For Neurorehabilitation
Warraich, Z., & Kleim, J. A. (2010) · PM&R · doi:10.1016/j.pmrj.2010.10.016 · Cited by 238
The Role of Diaschisis in Stroke Recovery
Seitz, R. J., Azari, N. P., Knorr, U., Binkofski, F., Herzog, H. R., & Freund, H. (1999) · Stroke · doi:10.1161/01.str.30.9.1844 · Cited by 227
Reorganization of Human Cerebral Cortex: The Range of Changes Following Use and Injury
Elbert, T. R., & Rockstroh, B. S. (2004) · The Neuroscientist · doi:10.1177/1073858403262111 · Cited by 227
The Basal Forebrain Cholinergic System Is Essential for Cortical Plasticity and Functional Recovery following Brain Injury
Conner, J. M., Chiba, A. A., & Tuszynski, M. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.03.003 · Cited by 223
Comparison of Robotics, Functional Electrical Stimulation, and Motor Learning Methods for Treatment of Persistent Upper Extremity Dysfunction After Stroke: A Randomized Controlled Trial
McCabe, J., Monkiewicz, M., Holcomb, J. P., Pundik, S., & Daly, J. J. (2014) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2014.10.022 · Cited by 227
Virtual reality for stroke rehabilitation
Laver, K., George, S., Thomas, S., Deutsch, J. E., & Crotty, M. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008349.pub2 · Cited by 226
Randomized, Controlled Trial to Evaluate Increased Intensity of Physiotherapy Treatment of Arm Function After Stroke
Lincoln, N. B., Parry, R. H., & Vass, C. (1999) · Stroke · doi:10.1161/01.str.30.3.573 · Cited by 220
Movement-dependent stroke recovery: a systematic review and meta-analysis of TMS and fMRI evidence.
Richards, L., Stewart, K. C., Woodbury, M., Senesac, C., & Cauraugh, J. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.08.013 · Cited by 211
Repetitive Task Practice: A Critical Review of Constraint-Induced Movement Therapy in Stroke
Wolf, S. L., Blanton, S., Baer, H., Breshears, J., & Butler, A. J. (2002) · The Neurologist · doi:10.1097/01.nrl.0000031014.85777.76 · Cited by 218
Robotic Devices for Movement Therapy After Stroke: Current Status and Challenges to Clinical Acceptance
Lum, P. S., Reinkensmeyer, D. J., Mahoney, R. M., Rymer, W. Z., & Burgar, C. G. (2002) · Topics in Stroke Rehabilitation · doi:10.1310/9kfm-kf81-p9a4-5ww0 · Cited by 218
Increased long‐term potentiation in the surround of experimentally induced focal cortical infarction
Hagemann, G., Redecker, C., Neumann‐Haefelin, T., Freund, H., & Witte, O. W. (1998) · Annals of Neurology · doi:10.1002/ana.410440217 · Cited by 217
Doing It with Mirrors: A Case Study of a Novel Approach to Neurorehabilitation
Sathian, K., Greenspan, A. I., & Wolf, S. L. (2000) · Neurorehabilitation and neural repair · doi:10.1177/154596830001400109 · Cited by 217
Reorganization of Sensory and Motor Systems in Hemiplegic Stroke Patients
Nelles, G., Spiekermann, G., Jueptner, M., Leonhardt, G., Müller, S. P., Gerhard, H., & Diener, H. (1999) · Stroke · doi:10.1161/01.str.30.8.1510 · Cited by 217
Reliability of motor cortex transcranial magnetic stimulation in four muscle representations.
Malcolm, M., Triggs, W., Light, K., Shechtman, O., Khandekar, G., & Rothi, L. G. G. (2006) · Clinical Neurophysiology · doi:10.1016/j.clinph.2006.02.005 · Cited by 228
Irradiation attenuates neurogenesis and exacerbates ischemia‐induced deficits
Raber, J., Fan, Y., Matsumori, Y., Liu, Z., Weinstein, P. R., Fike, J. R., & Liu, J. (2004) · Annals of Neurology · doi:10.1002/ana.10853 · Cited by 220
Functional reorganisation of the corticomotor projection to the hand in skilled racquet players
Pearce, A. J., Thickbroom, G. W., Byrnes, M. L., & Mastaglia, F. L. (2000) · Experimental Brain Research · doi:10.1007/s002219900236 · Cited by 215
Corticofugal modulation of the midbrain frequency map in the bat auditory system
Yan, W., & Suga, N. (1998) · Nature Neuroscience · doi:10.1038/255 · Cited by 214
Electromyogram-triggered neuromuscular stimulation for improving the arm function of acute stroke survivors: A randomized pilot study
Francisco, G. E., Chae, J., Chawla, H., Kirshblum, S., Zorowitz, R. D., Lewis, G., & Pang, S. (1998) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/s0003-9993(98)90074-0 · Cited by 213
Functional MRI of Language in Aphasia: A Review of the Literature and the Methodological Challenges
Crosson, B., McGregor, K., Gopinath, K., Conway, T. W., Benjamin, M., Chang, Y., MOORE, A. B., Raymer, A. M., Briggs, R. W., Sherod, M., et al. (2007) · Neuropsychology Review · doi:10.1007/s11065-007-9024-z · Cited by 214
Enhancing Encoding of a Motor Memory in the Primary Motor Cortex By Cortical Stimulation
Bütefisch, C. M., Khurana, V., Kopylev, L., & Cohen, L. G. (2004) · Journal of Neurophysiology · doi:10.1152/jn.01038.2003 · Cited by 211
Effects of virtual reality-based rehabilitation on distal upper extremity function and health-related quality of life: a single-blinded, randomized controlled trial
Shin, J., Kim, M., Lee, J.-Y., Jeon, Y.-J., Kim, S. Y., Lee, S., Seo, B., & Choi, Y. (2016) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/s12984-016-0125-x · Cited by 211
Are We Ready for a Natural History of Motor Learning?
Shmuelof, L., & Krakauer, J. W. (2011) · Neuron · doi:10.1016/j.neuron.2011.10.017 · Cited by 209
Disparity Between Functional Recovery and Daily Use of the Upper and Lower Extremities During Subacute Stroke Rehabilitation
Rand, D., & Eng, J. J. (2011) · Neurorehabilitation and neural repair · doi:10.1177/1545968311408918 · Cited by 211
Is robot-aided sensorimotor training in stroke rehabilitation a realistic option?
Volpe, B. T., Krebs, H. I., & Hogan, N. (2001) · Current Opinion in Neurology · doi:10.1097/00019052-200112000-00011 · Cited by 209
Targeting interhemispheric inhibition with neuromodulation to enhance stroke rehabilitation
Boddington, L. J., & Reynolds, J. N. J. (2017) · Brain stimulation · doi:10.1016/j.brs.2017.01.006 · Cited by 206
Recovery after damage to motor cortical areas
Nudo, R. J. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)00027-6 · Cited by 202
Virtual reality games for movement rehabilitation in neurological conditions: how do we meet the needs and expectations of the users?
Lewis, G. N., & Rosie, J. A. (2012) · Disability and Rehabilitation · doi:10.3109/09638288.2012.670036 · Cited by 205
Activity-dependent neural plasticity from bench to bedside
Ganguly, K., & Poo, M.-M. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.028 · Cited by 202
Shaping plasticity to enhance recovery after injury
Dancause, N., & Nudo, R. J. (2011) · Progress in brain research · doi:10.1016/b978-0-444-53355-5.00015-4 · Cited by 209
Human Neural Stem Cell Grafts Modify Microglial Response and Enhance Axonal Sprouting in Neonatal Hypoxic–Ischemic Brain Injury
Daadi, M. M., Davis, A. S., Arac, A., Li, Z., Maag Anne-Lise, D., Bhatnagar, R., Jiang, K., Sun, G.-H., Wu, J. C., & Steinberg, G. K. (2010) · Stroke · doi:10.1161/strokeaha.109.573691 · Cited by 199
Hydrogel-delivered brain-derived neurotrophic factor promotes tissue repair and recovery after stroke
Cook, D. J., Nguyen, C., Chun, H. N., Llorente, I. L., Chiu, A. S., Machnicki, M., Zarembinski, T. I., & Carmichael, S. T. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16649964 · Cited by 204
Mental Practice With Motor Imagery: Evidence for Motor Recovery and Cortical Reorganization After Stroke
Butler, A. J., & Page, S. J. (2006) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2006.08.326 · Cited by 198
Arm Function after Stroke: From Physiology to Recovery
Krakauer, J. W. (2005) · Seminars in Neurology · doi:10.1055/s-2005-923533 · Cited by 202
Mapping clinically relevant plasticity after stroke
Cramer, S. C., & Bastings, E. P. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(99)00258-0 · Cited by 194
Bi‐hemispheric contribution to functional motor recovery of the affected forelimb following focal ischemic brain injury in rats
Biernaskie, J. A., Szymanska, A., Windle, V., & Corbett, D. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03899.x · Cited by 204
Sprouting, regeneration and circuit formation in the injured spinal cord: factors and activity
Maier, I. C., & Schwab, M. E. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1890 · Cited by 197
Hand Rehabilitation Following Stroke: A Pilot Study of Assisted Finger Extension Training in a Virtual Environment
Fischer, H. C., Stubblefield, K. A., Kline, T., Luo, X., Kenyon, R. V., & Kamper, D. G. (2007) · Topics in Stroke Rehabilitation · doi:10.1310/tsr1401-1 · Cited by 194
Differential Impairment of Individuated Finger Movements in Humans After Damage to the Motor Cortex or the Corticospinal Tract
Lang, C. E., & Schieber, M. H. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00130.2003 · Cited by 194
Changes in Dynamic Trunk/Head Stability and Functional Reach After Hippotherapy
Shurtleff, T. L., Standeven, J. W., & Engsberg, J. R. (2009) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2009.01.026 · Cited by 192

Authors: Nudo, R. J., Wise, B. M., SiFuentes, F., & Milliken, G. W.
Affiliations: The University of Texas Health Science Center at Houston (US)
Corresponding author: Nudo, Randolph J.
Milliken, Garrett W.
ORCID: Nudo, Randolph J.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1996-06-21
Volume: 272
Issue: 5269
Pages: 1791-1794
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.272.5269.1791
OpenAlex: W2038514344
Cited by: 1,911
References: 33
Citations by year: 2026: 34 · 2025: 38 · 2024: 35 · 2023: 51 · 2022: 61 · 2021: 56 · 2020: 34 · 2019: 59 · 2018: 46 · 2017: 71 · 2016: 71 · 2015: 77 · 2014: 82 · 2013: 79 · 2012: 77
FWCI: 52.86
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r29ns027974-05)
National Institute of Neurological Disorders and Stroke (NS27974, NS30853)
Topics: Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
Keywords: motor cortex, functional reorganization, ischemic infarct, stroke, motor recovery, rehabilitative training, hand representation, squirrel monkey, cortical plasticity
MeSH terms: Animals, Brain Mapping, Cerebral Infarction, Brain Ischemia, Electric Stimulation, Hand, Male, Motor Cortex, Motor Skills, Neuronal Plasticity, Random Allocation, Saimiri

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neural Substrates for the Effects of Rehabilitative Training on Motor Recovery After Ischemic Infarct

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks