Cited by 1,911Stroke Rehabilitation and RecoveryMotor Control and AdaptationTranscranial Magnetic Stimulation Studies

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Neural Substrates for the Effects of Rehabilitative Training on Motor Recovery After Ischemic Infarct

Nudo, Randolph J., Wise, Birute M., SiFuentes, Frank, Milliken, Garrett W.·1996·Science

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Abstract

Substantial functional reorganization takes place in the motor cortex of adult primates after a focal ischemic infarct, as might occur in stroke. A subtotal lesion confined to a small portion of the representation of one hand was previously shown to result in a further loss of hand territory in the adjacent, undamaged cortex of adult squirrel monkeys. In the present study, retraining of skilled hand use after similar infarcts resulted in prevention of the loss of hand territory adjacent to the infarct. In some instances, the hand representations expanded into regions formerly occupied by representations of the elbow and shoulder. Functional reorganization in the undamaged motor cortex was accompanied by behavioral recovery of skilled hand function. These results suggest that, after local damage to the motor cortex, rehabilitative training can shape subsequent reorganization in the adjacent intact cortex, and that the undamaged motor cortex may play an important role in motor recovery.

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Authors: Nudo, R. J., Wise, B. M., SiFuentes, F., & Milliken, G. W.
Affiliations: The University of Texas Health Science Center at Houston (US)
Corresponding author: Nudo, Randolph J.
Milliken, Garrett W.
ORCID: Nudo, Randolph J.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1996-06-21
Volume: 272
Issue: 5269
Pages: 1791-1794
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.272.5269.1791
OpenAlex: W2038514344
Cited by: 1,911
References: 33
Citations by year: 2026: 34 · 2025: 38 · 2024: 35 · 2023: 51 · 2022: 61 · 2021: 56 · 2020: 34 · 2019: 59 · 2018: 46 · 2017: 71 · 2016: 71 · 2015: 77 · 2014: 82 · 2013: 79 · 2012: 77
FWCI: 52.86
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r29ns027974-05)
National Institute of Neurological Disorders and Stroke (NS27974, NS30853)
Topics: Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
Keywords: motor cortex, functional reorganization, ischemic infarct, stroke, motor recovery, rehabilitative training, hand representation, squirrel monkey, cortical plasticity
MeSH terms: Animals, Brain Mapping, Cerebral Infarction, Brain Ischemia, Electric Stimulation, Hand, Male, Motor Cortex, Motor Skills, Neuronal Plasticity, Random Allocation, Saimiri

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Neural Substrates for the Effects of Rehabilitative Training on Motor Recovery After Ischemic Infarct

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