Cited by 1,911Stroke Rehabilitation and RecoveryMotor Control and AdaptationTranscranial Magnetic Stimulation Studies

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Neural Substrates for the Effects of Rehabilitative Training on Motor Recovery After Ischemic Infarct

Nudo, Randolph J., Wise, Birute M., SiFuentes, Frank, Milliken, Garrett W.·1996·Science

Open this paper in CoChat — free account

Abstract

Substantial functional reorganization takes place in the motor cortex of adult primates after a focal ischemic infarct, as might occur in stroke. A subtotal lesion confined to a small portion of the representation of one hand was previously shown to result in a further loss of hand territory in the adjacent, undamaged cortex of adult squirrel monkeys. In the present study, retraining of skilled hand use after similar infarcts resulted in prevention of the loss of hand territory adjacent to the infarct. In some instances, the hand representations expanded into regions formerly occupied by representations of the elbow and shoulder. Functional reorganization in the undamaged motor cortex was accompanied by behavioral recovery of skilled hand function. These results suggest that, after local damage to the motor cortex, rehabilitative training can shape subsequent reorganization in the adjacent intact cortex, and that the undamaged motor cortex may play an important role in motor recovery.

Integrity signals

Registry

Crossref · 10.1126/science.272.5269.1791

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Functional MRI evidence for adult motor cortex plasticity during motor skill learning
Kami, A., Meyer, G., Jezzard, P., Adams, M. M., Turner, R., & Ungerleider, L. G. (1995) · Nature · doi:10.1038/377155a0 · Cited by 1,883
Technique to improve chronic motor deficit after stroke.
Taub, E., Miller, N. E., Novack, T. A., Cook, E. W., Fleming, W. C., Nepomuceno, C., Connell, J., & Crago, J. E. (1993) · PubMed · Cited by 1,557
Use-dependent alterations of movement representations in primary motor cortex of adult squirrel monkeys
Nudo, R. J., Milliken, G. W., Jenkins, W., & Merzenich, M. M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-02-00785.1996 · Cited by 1,416
The functional anatomy of motor recovery after stroke in humans: A study with positron emission tomography
Chollet, F., Piero, V. D., Wise, R. J. S., Brooks, D. J., Dolan, R. J., & Frackowiak, R. S. J. (1991) · Annals of Neurology · doi:10.1002/ana.410290112 · Cited by 1,096
Massive Cortical Reorganization After Sensory Deafferentation in Adult Macaques
Pons, T. P., Garraghty, P. E., Ommaya, A. K., Kaas, J. H., Taub, E., & Mishkin, M. (1991) · Science · doi:10.1126/science.1843843 · Cited by 1,081
THE RESTORATION OF MOTOR FUNCTION FOLLOWING HEMIPLEGIA IN MAN
Twitchell, T. E. (1951) · Brain · doi:10.1093/brain/74.4.443 · Cited by 942
Plasticity of Sensory and Motor Maps in Adult Mammals
Kaas, J. H. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.001033 · Cited by 913
Modulation of Cortical Motor Output Maps During Development of Implicit and Explicit Knowledge
Pascual‐Leone, Á., Grafman, J. H., & Hallett, M. (1994) · Science · doi:10.1126/science.8122113 · Cited by 745
Reorganization of movement representations in primary motor cortex following focal ischemic infarcts in adult squirrel monkeys
Nudo, R. J., & Milliken, G. W. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.75.5.2144 · Cited by 715
Reorganization of Movement Representations in Primary Motor Cortex Following Focal Ischemic Infarcts in Adult Squirrel Monkeys
Simonsen, C. (1998) · Neurology Report · doi:10.1097/01253086-199822020-00019 · Cited by 610

Show all 33 references

Research works printed but not linked: 7

BACHYRITA P, RECOVERY FUNCTION TH: 225 (1980).
BLACK P, OUTCOME SEVERE DAMAG: 65 (1975).
BLACK P, T AM NEUROL ASSOC 95, 207 (1970).
BUCY P.C., PRECENTRAL MOTOR COR: 353 (1944).
GOWLAND C, STROKE REHABILITATIO: 217 (1987).
NUDO R.J., SOC NEUR ABSTR 21, 517 (1995).
TRAVIS A.M., AM J PHYS MED 35, 273 (1956).

Sorted by citations

Items 501–600 of 1,000

Transcranial magnetic stimulation combined with upper-limb training for improving function after stroke: A systematic review and meta-analysis
Graef, P., Dadalt, M. L. R., Rodrigués, D. A. M. D. S., Stein, C., & Pagnussat, A. S. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.08.016 · Cited by 75
Time window of intracisternal osteogenic protein-1 in enhancing functional recovery after stroke
Ren, J., Kaplan, P. L., Charette, M., Speller, H., & Finklestein, S. P. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(99)00261-0 · Cited by 72
Sprouting of Brainstem–Spinal Tracts in Response to Unilateral Motor Cortex Stroke in Mice
Bachmann, L. C., Lindau, N. T., Felder, P., & Schwab, M. E. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4384-13.2014 · Cited by 74
Constraint‐induced movement therapy (CIMT): Pediatric applications
Brady, K. T., & Garcia, T. (2009) · Developmental Disabilities Research Reviews · doi:10.1002/ddrr.59 · Cited by 72
Reduced intracortical inhibition and facilitation of corticospinal neurons in musicians
Nordstrom, M. A., & Butler, S. L. (2002) · Experimental Brain Research · doi:10.1007/s00221-002-1051-7 · Cited by 73
A Novel Functional Electrical Stimulation Treatment for Recovery of Hand Function in Hemiplegia: 12-Week Pilot Study
Knutson, J. S., Hisel, T. Z., Harley, M. Y., & Chae, J. (2008) · Neurorehabilitation and neural repair · doi:10.1177/1545968308317577 · Cited by 71
Therapeutic applications of BCI technologies
McFarland, D. J., Daly, J. J., Boulay, C., & Parvaz, M. A. (2017) · Brain-Computer Interfaces · doi:10.1080/2326263x.2017.1307625 · Cited by 71
Topographically Divergent and Convergent Connectivity between Premotor and Primary Motor Cortex
Dancause, N., Barbay, S., Frost, S. B., Plautz, E. J., Popescu, M., Dixon, P. M., Stowe, A. M., Friel, K. M., & Nudo, R. J. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhj049 · Cited by 71
Noninvasive brain stimulation in neurorehabilitation
Sandrini, M., & Cohen, L. (2013) · Handbook of Clinical Neurology · doi:10.1016/b978-0-444-53497-2.00040-1 · Cited by 66
Sleep Disruption Aggravates Focal Cerebral Ischemia in the Rat
Gao, B., Cam, E., Jaeger, H., Zunzunegui, C., Sarnthein, J., & Bassetti, C. L. (2010) · SLEEP · doi:10.1093/sleep/33.7.879 · Cited by 70
Outcome prediction in acute monohemispheric stroke via magnetoencephalography
Tecchio, F., Pasqualetti, P., Zappasodi, F., Tombini, M., Lupoi, D., Vernieri, F., & Rossini, P. M. (2007) · Journal of Neurology · doi:10.1007/s00415-006-0355-0 · Cited by 70
Magneto-Optic Spectroscopy of a Protein Tetramer Binding Two Exciton-Coupled Chlorophylls
Hughes, J. L., Razeghifard, R., Logue, M., Oakley, A. J., Wydrzynski, T., & Krausz, E. (2006) · Journal of the American Chemical Society · doi:10.1021/ja056576b · Cited by 70
Lesions to Primary Sensory and Posterior Parietal Cortices Impair Recovery from Hand Paresis after Stroke
Abela, E., Missimer, J. H., Wiest, R., Federspiel, A., Hess, C. W., Sturzenegger, M., & Weder, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031275 · Cited by 70
Effects of muscimol inactivations of functional domains in motor, premotor, and posterior parietal cortex on complex movements evoked by electrical stimulation
Stepniewska, I., Gharbawie, O. A., Burish, M. J., & Kaas, J. H. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00491.2013 · Cited by 72
Cognitive rehabilitation: attention and neglect
Robertson, I. H. (1999) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(99)01378-9 · Cited by 70
Metabolic and electrophysiological validation of functional MRI
Krings, T. (2001) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.71.6.762 · Cited by 70
Rehabilitation of executive deficits
Worthington, A. D. (2005) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198526544.003.0021 · Cited by 69
The effects of intracortical endothelin-1 injections on skilled forelimb use: implications for modelling recovery of function after stroke
Gilmour, G., Iversen, S. D., O‘Neill, M. F., & Bannerman, D. M. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.07.006 · Cited by 69
Innovative approaches to the rehabilitation of upper extremity hemiparesis using virtual environments.
Merians, A. S., Tunik, E., Fluet, G. G., Qiu, Q., & Adamovich, S. V. (2009) · PubMed · Cited by 69
Finding the Intersection of Neuroplasticity, Stroke Recovery, and Learning: Scope and Contributions to Stroke Rehabilitation
Carey, L., Walsh, A., Adikari, A., Goodin, P., Alahakoon, D., De Silva, D., Ong, K.-L., Nilsson, M., & Boyd, L. (2019) · Neural Plasticity · doi:10.1155/2019/5232374 · Cited by 68
Longitudinal Structural and Functional Differences Between Proportional and Poor Motor Recovery After Stroke
Guggisberg, A. G., Nicolo, P., Cohen, L. G., Schnider, A., & Buch, E. R. (2017) · Neurorehabilitation and neural repair · doi:10.1177/1545968317740634 · Cited by 68
Behavioral recovery from unilateral photothrombotic infarcts of the forelimb sensorimotor cortex in rats: Role of the contralateral cortex
Shanina, E., Schallert, T. J., Witte, O. W., & Redecker, C. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.01.016 · Cited by 68
A study of constraint-induced movement therapy in subacute stroke patients in Hong Kong
Myint, J., Yuen, G., Yu, T. K. K., Kng, C., Wong, A. M. Y., Chow, K. K. C., Li, H. C. K., & Wong, C. P. (2008) · Clinical Rehabilitation · doi:10.1177/0269215507080141 · Cited by 68
The Effect of Lesion Size on the Organization of the Ipsilesional and Contralesional Motor Cortex
Touvykine, B., Mansoori, B. K., Jean-Charles, L., Deffeyes, J. E., Quessy, S., & Dancause, N. (2015) · Neurorehabilitation and neural repair · doi:10.1177/1545968315585356 · Cited by 74
Inflammation and neural repair after ischemic brain injury
Sakai, S., & Shichita, T. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.10.013 · Cited by 67
Recovery from aphasia following brain injury: the role of reorganization
Marsh, E. B., & Hillis, A. E. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)57009-8 · Cited by 67
Robust Neuroprosthetic Control from the Stroke Perilesional Cortex
Gulati, T., Won, S. J., Ramanathan, D., Wong, C. C., Bodepudi, A., Swanson, R. A., & Ganguly, K. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.5007-14.2015 · Cited by 70
Deterioration of pre-existing hemiparesis brought about by subsequent ipsilateral lacunar infarction
Ago, T. (2003) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.74.8.1152 · Cited by 67
Dynamically Controlled Ankle-Foot Orthosis (DCO) with Regenerative Kinetics: Incrementally Attaining User Portability
Hitt, J. K., Oymagil, A. M., Sugar, T. G., Hollander, K. W., Boehler, A., & Fleeger, J. (2007) · Proceedings - IEEE International Conference on Robotics and Automation/Proceedings · doi:10.1109/robot.2007.363543 · Cited by 67
ALK5 signaling pathway mediates neurogenesis and functional recovery after cerebral ischemia/reperfusion in rats via Gadd45b
Zhang, K., Zhang, Q., Deng, J., Li, J., Li, J., Wen, L., Ma, J., & Li, C. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1596-z · Cited by 67
Stroke Rehabilitation Research: Time to Answer more Specific Questions?
Whitall, J. (2004) · Neurorehabilitation and neural repair · doi:10.1177/0888439003262876 · Cited by 70
Cerebral plasticity in multiple sclerosis: insights from fMRI
Cifelli, A., & Matthews, P. M. (2002) · Multiple Sclerosis Journal · doi:10.1191/1352458502ms820oa · Cited by 68
Synergistic Effects of Enriched Environment and Task-Specific Reach Training on Poststroke Recovery of Motor Function
Jeffers, M. S., & Corbett, D. (2018) · Stroke · doi:10.1161/strokeaha.118.020814 · Cited by 66
NEUROANATOMY OF MEMORY
Markowitsch, H. J., & CALABRESE, P. (1999) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198526544.003.0010 · Cited by 65
Modulation of motor learning and memory formation by non-invasive cortical stimulation of the primary motor cortex
Tanaka, S., Sandrini, M., & Cohen, L. G. (2011) · Neuropsychological Rehabilitation · doi:10.1080/09602011.2011.605589 · Cited by 68
Imaging rapid redistribution of sensory-evoked depolarization through existing cortical pathways after targeted stroke in mice
Sigler, A., Mohajerani, M. H., & Murphy, T. H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812695106 · Cited by 62
Differences in somatosensory hand organization in a healthy flutist and a flutist with focal hand dystonia
Byl, N. N., McKenzie, A. L., & Nagarajan, S. S. (2000) · Journal of Hand Therapy · doi:10.1016/s0894-1130(00)80022-8 · Cited by 65
Rehabilitation and Functional Neuroimaging Dose-Response Trajectories for Clinical Trials
Dobkin, B. H. (2005) · Neurorehabilitation and neural repair · doi:10.1177/1545968305281892 · Cited by 64
Adaptability and Flexibility of the Human Motor System:Implications for Neurological Rehabilitation
Mulder, T. W., & Hochstenbach, J. B. H. (2001) · Neural Plasticity · doi:10.1155/np.2001.131 · Cited by 65
Cortical plasticity and rehabilitation
Moucha, R., & Kilgard, M. P. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)57007-4 · Cited by 62
Anatomical correlates of recovery in single pellet reaching in spinal cord injured rats
Hurd, C., Weishaupt, N., & Fouad, K. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.02.013 · Cited by 64
The functional anatomy of cerebral reorganisation after focal brain injury
Ward, N., & Frackowiak, R. S. J. (2006) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2006.03.002 · Cited by 65
Sensory loss and cortical reorganization in mature primates
Kaas, J. H. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)38077-4 · Cited by 64
Motor control and learning principles for rehabilitation of upper limb movements after brain injury
Winstein, C. J., Wing, A. M., & Whitall, J. (2003) · Cited by 62
Treatment-Induced Plasticity in Cerebral Palsy: A Diffusion Tensor Imaging Study
Trivedi, R., Gupta, R. K., Shah, V., Tripathi, M., Rathore, R. K. S., Kumar, M., Pandey, C. M., & Narayana, P. A. (2008) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2008.07.012 · Cited by 63
A Novel Phosphodiesterase Type 4 Inhibitor, HT-0712, Enhances Rehabilitation-Dependent Motor Recovery and Cortical Reorganization After Focal Cortical Ischemia
MacDonald, E., der Lee, H. V., Pocock, D., Cole, C. J., Thomas, N. J., VandenBerg, P. M., Bourtchouladze, R., & Kleim, J. A. (2007) · Neurorehabilitation and neural repair · doi:10.1177/1545968307305521 · Cited by 63
Review of the effects of soft robotic gloves for activity-based rehabilitation in individuals with reduced hand function and manual dexterity following a neurological event
Proulx, C. E., Beaulac, M., David, M., Deguire, C., Haché, C., Klug, F., Kupnik, M., Higgins, J., & Gagnon, D. H. (2020) · Journal of Rehabilitation and Assistive Technologies Engineering · doi:10.1177/2055668320918130 · Cited by 63
Noradrenergic modulation of human cortex excitability by the presynaptic α2-antagonist yohimbine
Plewnia, C., Bartels, M., Cohen, L. G., & Gerloff, C. P. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01921-8 · Cited by 63
Environmental influence on brain-derived neurotrophic factor messenger RNA expression after middle cerebral artery occlusion in spontaneously hypertensive rats
Zhao, L. R., Mattsson, B., & Johansson, B. B. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00023-3 · Cited by 63
Brain Plasticity and Genetic Factors
Pearson‐Fuhrhop, K. M., Kleim, J. A., & Cramer, S. C. (2009) · Topics in Stroke Rehabilitation · doi:10.1310/tsr1604-282 · Cited by 65
Recrudescence of Deficits After Stroke
Topçuoğlu, M. A., Saka, E., Silverman, S. B., Schwamm, L. H., & Singhal, A. B. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2017.1668 · Cited by 62
Performance-Based Adaptive Schedules Enhance Motor Learning
Choi, Y., Qi, F., Gordon, J., & Schweighofer, N. (2008) · Journal of Motor Behavior · doi:10.3200/jmbr.40.4.273-280 · Cited by 62
Neuroimaging in cerebrovascular disorders: Measurement of cerebral physiology after stroke and assessment of stroke recovery
Mountz, J. M., Liu, H.-G., & DEUTSCH, G. (2003) · Seminars in Nuclear Medicine · doi:10.1053/snuc.2003.127293 · Cited by 61
Tracking Motor Improvement at the Subtask Level During Robot-Aided Neurorehabilitation of Stroke Patients
Panarese, A., Colombo, R., Sterpi, I., Pisano, F., & Micera, S. (2012) · Neurorehabilitation and neural repair · doi:10.1177/1545968311431966 · Cited by 63
Models to Tailor Brain Stimulation Therapies in Stroke
Plow, E. B., Sankarasubramanian, V., Cunningham, D. A., Potter–Baker, K. A., Varnerin, N. M., Cohen, L. G., Sterr, A., Conforto, A. B., & Machado, A. G. (2016) · Neural Plasticity · doi:10.1155/2016/4071620 · Cited by 65
Rehabilitative therapies differentially alter proliferation and survival of glial cell populations in the perilesional zone of cortical infarcts
Keiner, S., Wurm, F., Kunze, A., Witte, O. W., & Redecker, C. (2008) · Glia · doi:10.1002/glia.20632 · Cited by 61
Neuromuscular Electrical Stimulation Improves Severe Hand Dysfunction for Individuals With Chronic Stroke
dos Santos, M. J., Zahner, L. H., McKiernan, B. J., Mahnken, J. D., & Quaney, B. M. (2006) · Neurology Report · doi:10.1097/01.npt.0000281254.33045.e4 · Cited by 60
Setting goals for cognitive rehabilitation
Robertson, I. H. (1999) · Current Opinion in Neurology · doi:10.1097/00019052-199912000-00008 · Cited by 60
Dosing of a Cued Picture-Naming Treatment for Anomia
Harnish, S. M., Morgan, J., Lundine, J. P., Bauer, A., Singletary, F., Benjamin, M. L., Gonzalez Rothi, L. J., & Crosson, B. (2014) · American Journal of Speech-Language Pathology · doi:10.1044/2014_ajslp-13-0081 · Cited by 60
Cortical Stimulation for Upper Limb Recovery Following Ischemic Stroke: A Small Phase II Pilot Study of a Fully Implanted Stimulator
Huang, M. E., Harvey, R. L., Stoykov, M. E., Ruland, S. D., Weinand, M. E., Lowry, D. W., & Levy, R. M. (2008) · Topics in Stroke Rehabilitation · doi:10.1310/tsr1502-160 · Cited by 60
Multisensory Stimulation to Improve Low- and Higher-Level Sensory Deficits after Stroke: A Systematic Review
Tinga, A. M., Visser‐Meily, J. M. A., van der Smagt, M. J., der Stigchel, S. V., van Ee, R., & Nijboer, T. C. W. (2015) · Neuropsychology Review · doi:10.1007/s11065-015-9301-1 · Cited by 66
The Treatment of cerebral palsy: what we know, what we don't know
Goldstein, M. (2004) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2004.05.022 · Cited by 60
Environmental Enrichment Provides a Cognitive Reserve to be Spent in the Case of Brain Lesion
Mandolesi, L., Bartolo, P. D., Foti, F., Gelfo, F., Federico, F., Leggio, M. G., & Petrosini, L. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-15102 · Cited by 60
Middle cerebral artery (MCA) stroke produces dysfunction in adjacent motor cortex as detected by intracortical microstimulation in rats
Gharbawie, O. A., Gonzalez, C. L. R., Williams, P. T. J. A., Kleim, J. A., & Whishaw, I. Q. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.10.010 · Cited by 59
Kinematics of Reaching Movements in a 2-D Virtual Environment in Adults With and Without Stroke
Liebermann, D. G., Berman, S., Weiss, P. L., & Levin, M. F. (2012) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2012.2206117 · Cited by 59
A virtual reality-based exercise program for stroke rehabilitation
Jack, D., Boian, R., Merians, A. S., Adamovich, S., Tremaine, M. M., Recce, M. L., Burdea, G., & Howard Poizner, A. (2000) · International ACM SIGACCESS Conference on Computers and Accessibility (ASSETS) · doi:10.1145/354324.354340 · Cited by 59
Designing Rehabilitation Programs for Neglect: Could 2 Be More Than 1+1?
Sævarsson, S., Halsband, U., & Kristjansson, A. K. (2011) · Applied Neuropsychology · doi:10.1080/09084282.2010.547774 · Cited by 59
Functional reorganization of upper-body movement after spinal cord injury
Casadio, M., Pressman, A., Fishbach, A., Danziger, Z. C., Acosta, S., Chen, D., Tseng, H.-Y., & Mussa-Ivaldi, F. A. (2010) · Experimental Brain Research · doi:10.1007/s00221-010-2427-8 · Cited by 59
Functional testing in animal models of spinal cord injury: not as straight forward as one would think
Fouad, K., Hurd, C., & Magnuson, D. S. K. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00085 · Cited by 59
Dopaminergic neurons degenerate by apoptosis in Parkinson's disease
Hirsch, É. C., Hunot, S., Faucheux, B. A., Agid, Y., Mizuno, Y., Mochizuki, H., Tatton, W. G., Tatton, N. A., & Olanow, W. C. (1999) · Movement Disorders · doi:10.1002/1531-8257(199903)14:2 · Cited by 152
Force Myography for Monitoring Grasping in Individuals with Stroke with Mild to Moderate Upper-Extremity Impairments: A Preliminary Investigation in a Controlled Environment
Sadarangani, G. P., Jiang, X., Simpson, L. A., Eng, J. J., & Menon, C. (2017) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2017.00042 · Cited by 59
On the Reporting of Experimental and Control Therapies in Stroke Rehabilitation Trials: A Systematic Review
Lohse, K. R., Pathania, A., Wegman, R., Boyd, L. A., & Lang, C. E. (2018) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2017.12.024 · Cited by 60
Training-induced Recovery of Visual Motion Perception after Extrastriate Cortical Damage in the Adult Cat
Huxlin, K. R. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg106 · Cited by 59
Cortical Reorganization of Sensorimotor Systems and the Role of Intracortical Circuits After Spinal Cord Injury
Mohammed, H., & Hollis, E. R., II (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0638-z · Cited by 60
Impact of the robotic-assistance level on upper extremity function in stroke patients receiving adjunct robotic rehabilitation: sub-analysis of a randomized clinical trial
Takebayashi, T., Takahashi, K., Okita, Y., Kubo, H., Hachisuka, K., & Domen, K. (2022) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/s12984-022-00986-9 · Cited by 61
Memory Formation in the Motor Cortex Ipsilateral to a Training Hand
Duqué, J., Mazzocchio, R., Stefan, K., Hummel, F. C., Olivier, E., & Cohen, L. G. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm173 · Cited by 58
Progressive enhancement of alpha activity and visual function in patients with optic neuropathy: A two-week repeated session alternating current stimulation study
Schmidt, S. H., Mante, A., Rönnefarth, M., Fleischmann, R., Gall, C., & Brandt, S. A. (2012) · Brain stimulation · doi:10.1016/j.brs.2012.03.008 · Cited by 62
Therapeutic Interventions to Improve Upper Extremity Recovery and Function
Richards, L. G., & Pohl, P. S. (1999) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(18)30033-8 · Cited by 58
Reducing the Energy Cost of Hemiparetic Gait Using Center of Mass Feedback: A Pilot Study
Massaad, F., Lejeune, T. M., & Detrembleur, C. (2009) · Neurorehabilitation and neural repair · doi:10.1177/1545968309349927 · Cited by 56
Post-stroke hemiplegia rehabilitation: Evolution of the concepts
Marqué, P., Gasq, D., Castel-Lacanal, E., Boissezon, X. D., & Loubinoux, I. (2014) · Annals of Physical and Rehabilitation Medicine · doi:10.1016/j.rehab.2014.08.004 · Cited by 58
Exercise Paradigms to Study Brain Injury Recovery in Rodents
Arida, R. M., Scorza, F. A., da Silva, S. G., Cysneiros, R. M., & Cavalheiro, É. A. (2011) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0b013e3182063a9c · Cited by 57
Running wheel activity restores MPTP-induced functional deficits
Fredriksson, A., Stigsdotter, I. M., Hurtig, A., Ewalds‐Kvist, B. M., & Archer, T. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0474-8 · Cited by 57
In Vivo 2-Photon Imaging of Fine Structure in the Rodent Brain
Sigler, A., & Murphy, T. H. (2010) · Stroke · doi:10.1161/strokeaha.110.594648 · Cited by 57
Recovery Potential After Acute Stroke
Seitz, R. J., & Donnan, G. A. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00238 · Cited by 56
Neural network remodeling underlying motor map reorganization induced by rehabilitative training after ischemic stroke
Okabe, N., Shiromoto, T., Himi, N., Feng, L., Nakamura‐Maruyama, E., Narita, K., Iwachidou, N., Yagita, Y., & Miyamoto, O. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.10.008 · Cited by 57
Comparative analysis of mRNA levels in the frontal cortex and the hippocampus in the basal state and in response to experimental brain injury
Rall, J., Matzilevich, D., & Dash, P. K. (2003) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2003.00439.x · Cited by 56
Motor recovery after stroke: Lessons from functional brain imaging
Thirumala, P. D., Hier, D. B., & Patel, P. (2002) · Neurological Research · doi:10.1179/016164102101200320 · Cited by 57
Neuroplasticity
Thompson, C. K. (2000) · Journal of Communication Disorders · doi:10.1016/s0021-9924(00)00031-9 · Cited by 58
Does training improve writer's cramp?
Schenk, T., Bauer, B., Steidle, B., & Marquardt, C. (2004) · Journal of Hand Therapy · doi:10.1197/j.jht.2004.04.005 · Cited by 56
Poststroke Aphasia Recovery Assessed With Functional Magnetic Resonance Imaging and a Picture Identification Task
Szaflarski, J. P., Eaton, K. P., Ball, A. L., Banks, C., Vannest, J. J., Allendorfer, J. B., Page, S. J., & Holland, S. K. (2010) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2010.02.003 · Cited by 56
Effect of task-related continuous auditory feedback during learning of tracking motion exercises
Rosati, G., Oscari, F., Spagnol, S., Avanzini, F., & Masiero, S. (2012) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/1743-0003-9-79 · Cited by 56
Genetic Influences on Neural Plasticity
Pearson‐Fuhrhop, K. M., & Cramer, S. C. (2010) · PM&R · doi:10.1016/j.pmrj.2010.09.011 · Cited by 59
Evaluating the Effectiveness of Semantic-Based Treatment for Naming Deficits in Aphasia: What Works?
Kiran, S., & Bassetto, G. M. (2008) · Seminars in Speech and Language · doi:10.1055/s-2008-1061626 · Cited by 59
Practical constraints on estimation of source extent with MEG beamformers
Hillebrand, A., & Barnes, G. R. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.10.036 · Cited by 56
Different Patterns of Cortical Inputs to Subregions of the Primary Motor Cortex Hand Representation inCebus apella
Dea, M. K., Hamadjida, A., Elgbeili, G., Quessy, S., & Dancause, N. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhv324 · Cited by 54
A Critical Review of Neuromuscular Electrical Stimulation for Treatment of Motor Dysfunction in Hemiplegia
Chae, J., & Yu, D. (2000) · Assistive Technology · doi:10.1080/10400435.2000.10132008 · Cited by 56
Correlation of Clinical Neuromusculoskeletal and CentralSomatosensory Performance: Variability in Controls and PatientsWith Severe and Mild Focal Hand Dystonia
Byl, N. N., Nagarajan, S. S., Merzenich, M. M., Roberts, T. P. L., & McKenzie, A. L. (2002) · Neural Plasticity · doi:10.1155/np.2002.177 · Cited by 56
Functional Imaging Correlates of Recovery after Stroke in Humans
Herholz, K., & Heiss, W. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200012000-00001 · Cited by 56
Design of a Robotic Upper Extremity Repetitive Therapy Device
He, J., Koeneman, E. J., Schultz, R. S., Huang, H., Wanberg, J., Herring, D. E., Sugar, T. G., Herman, R. M., & Koeneman, J. B. (2005) · International Conference on Rehabilitation Robotics · doi:10.1109/icorr.2005.1501060 · Cited by 56
Dance for Parkinson’s—The effects on whole body co-ordination during turning around
Hulbert, S., Ashburn, A., Roberts, L. C., & Verheyden, G. (2017) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2017.03.012 · Cited by 55

Authors: Nudo, R. J., Wise, B. M., SiFuentes, F., & Milliken, G. W.
Affiliations: The University of Texas Health Science Center at Houston (US)
Corresponding author: Nudo, Randolph J.
Milliken, Garrett W.
ORCID: Nudo, Randolph J.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1996-06-21
Volume: 272
Issue: 5269
Pages: 1791-1794
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.272.5269.1791
OpenAlex: W2038514344
Cited by: 1,911
References: 33
Citations by year: 2026: 34 · 2025: 38 · 2024: 35 · 2023: 51 · 2022: 61 · 2021: 56 · 2020: 34 · 2019: 59 · 2018: 46 · 2017: 71 · 2016: 71 · 2015: 77 · 2014: 82 · 2013: 79 · 2012: 77
FWCI: 52.86
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r29ns027974-05)
National Institute of Neurological Disorders and Stroke (NS27974, NS30853)
Topics: Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
Keywords: motor cortex, functional reorganization, ischemic infarct, stroke, motor recovery, rehabilitative training, hand representation, squirrel monkey, cortical plasticity
MeSH terms: Animals, Brain Mapping, Cerebral Infarction, Brain Ischemia, Electric Stimulation, Hand, Male, Motor Cortex, Motor Skills, Neuronal Plasticity, Random Allocation, Saimiri

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neural Substrates for the Effects of Rehabilitative Training on Motor Recovery After Ischemic Infarct

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks