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Luteinizing Hormone Deficiency and Female Infertility in Mice Lacking the Transcription Factor NGFI-A (Egr-1)
Abstract
The immediate-early transcription factor NGFI-A (also called Egr-1, zif/268, or Krox-24) is thought to couple extracellular signals to changes in gene expression. Although activins and inhibins regulate follicle-stimulating hormone (FSH) synthesis, no factor has been identified that exclusively regulates luteinizing hormone (LH) synthesis. An analysis of NGFI-A-deficient mice derived from embryonic stem cells demonstrated female infertility that was secondary to LH-β deficiency. Ovariectomy led to increased amounts of FSH-β but not LH-β messenger RNA, which suggested a pituitary defect. A conserved, canonical NGFI-A site in the LH-β promoter was required for synergistic activation by NGFI-A and steroidogenic factor-1 (SF-1). NGFI-A apparently influences female reproductive capacity through its regulation of LH-β transcription.
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Metadata
- Authors
- Lee, S. L., Sadovsky, Y., Swirnoff, A. H., Polish, J. A., Goda, P., Gavrilina, G., & Milbrandt, J.
- Venue
- Science
- Published
- 1996-08-30
- Volume
- 273
- Issue
- 5279
- Pages
- 1219-1221
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2059671369
- Cited by
- 480
- References
- 0
- FWCI
- 31.32
- Type
- journal article
- Language
- en
- Open access
- closed
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