The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans

Surfing the p53 network

Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607 · see citing works

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649 · see citing works

Mdm2 promotes the rapid degradation of p53

Haupt, Y., Maya, R., Kazaz, A., & Oren, M. (1997) · Nature · doi:10.1038/387296a0 · Cited by 4,506 · see citing works

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

Malkin, D., Li, F. P., Strong, L. C., Fraumeni, J. F., Nelson, C. E., Kim, D. H., Kassel, J., Gryka, M. A., Bischoff, F. Z., Tainsky, M. A., et al. (1990) · Science · doi:10.1126/science.1978757 · Cited by 3,765 · see citing works

Regulation of p53 stability by Mdm2

Kubbutat, M. H. G., Jones, S. N., & Vousden, K. H. (1997) · Nature · doi:10.1038/387299a0 · Cited by 3,312 · see citing works

Live or let die: the cell's response to p53

Vousden, K. H., & Lü, X. (2002) · Nature reviews. Cancer · doi:10.1038/nrc864 · Cited by 3,177 · see citing works

SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells

Kiel, M. J., Yilmaz, Ö. H., Iwashita, T., Yilmaz, O. H., Terhorst, C., & Morrison, S. J. (2005) · Cell · doi:10.1016/j.cell.2005.05.026 · Cited by 3,168 · see citing works

Blinded by the Light: The Growing Complexity of p53

Vousden, K. H., & Prives, C. (2009) · Cell · doi:10.1016/j.cell.2009.04.037 · Cited by 3,163 · see citing works

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Momand, J., Zambetti, G. P., Olson, D. C., George, D., & Levine, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90644-r · Cited by 3,113 · see citing works

p53 is required for radiation-induced apoptosis in mouse thymocytes

Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., & Jacks, T. (1993) · Nature · doi:10.1038/362847a0 · Cited by 2,864 · see citing works

A model for p53-induced apoptosis

Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/38525 · Cited by 2,500 · see citing works

Thymocyte apoptosis induced by p53-dependent and independent pathways

Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L., & Wyllie, A. H. (1993) · Nature · doi:10.1038/362849a0 · Cited by 2,271 · see citing works

Long-Term Lymphohematopoietic Reconstitution by a Single CD34-Low/Negative Hematopoietic Stem Cell

Osawa, M., Hanada, K., Hamada, H., & Nakauchi, H. (1996) · Science · doi:10.1126/science.273.5272.242 · Cited by 2,141 · see citing works

Tumor spectrum analysis in p53-mutant mice

Jacks, T., Remington, L., Williams, B. O., Schmitt, E. M., Halachmi, S., Bronson, R. T., & Weinberg, R. A. (1994) · Current Biology · doi:10.1016/s0960-9822(00)00002-6 · Cited by 2,051 · see citing works

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

Canman, C. E., Lim, D.-S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., & Siliciano, J. D. (1998) · Science · doi:10.1126/science.281.5383.1677 · Cited by 2,042 · see citing works

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

Honda, R., Tanaka, H., & Yasuda, H. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01480-4 · Cited by 1,951 · see citing works

Amplification of a gene encoding a p53-associated protein in human sarcomas

Oliner, J. D., Kinzler, K. W., Meltzer, P. S., George, D. L., & Vogelstein, B. (1992) · Nature · doi:10.1038/358080a0 · Cited by 1,949 · see citing works

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

Banin, S., Moyal, L., Shieh, S.-Y., Taya, Y., Anderson, C. W., Chessa, L., Smorodinsky, N. I., Prives, C., Reiss, Y., Shiloh, Y., et al. (1998) · Science · doi:10.1126/science.281.5383.1674 · Cited by 1,797 · see citing works

Senescence in premalignant tumours

Collado, M., Gil, J., Efeyan, A., Guerra, C., Schuhmacher, A. J., Barradas, M., Benguría, A., Zaballos, A., Flores, J. M., Barbacid, M., et al. (2005) · Nature · doi:10.1038/436642a · Cited by 1,482 · see citing works

p53 mutant mice that display early ageing-associated phenotypes

Tyner, S. D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C., et al. (2002) · Nature · doi:10.1038/415045a · Cited by 1,459 · see citing works

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

de Oca Luna, R. M., Wagner, D. S., & Lozano, G. (1995) · Nature · doi:10.1038/378203a0 · Cited by 1,420 · see citing works

Hematopoietic Stem Cell Quiescence Maintained by p21 ^cip1/waf1

Cheng, T., Rodrigues, N., Shen, H., Yang, Y.-G., Dombkowski, D., Sykes, M., & Scadden, D. T. (2000) · Science · doi:10.1126/science.287.5459.1804 · Cited by 1,339 · see citing works

p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

Villunger, A., Michalak, E. M., Coultas, L., Müllauer, F., Böck, G., Ausserlechner, M. J., Adams, J. M., & Strasser, A. (2003) · Science · doi:10.1126/science.1090072 · Cited by 1,327 · see citing works

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

Olive, K. P., Tuveson, D. A., Ruhe, Z. C., Yin, B., Willis, N. A., Bronson, R. T., Crowley, D., & Jacks, T. (2004) · Cell · doi:10.1016/j.cell.2004.11.004 · Cited by 1,308 · see citing works

Suppression of induced pluripotent stem cell generation by the p53–p21 pathway

Hong, H., Takahashi, K., Ichisaka, T., Aoi, T., Kanagawa, O., Nakagawa, M., Okita, K., & Yamanaka, S. (2009) · Nature · doi:10.1038/nature08235 · Cited by 1,301 · see citing works

DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2

Hirao, A., Kong, Y., Matsuoka, S., Wakeham, A. C., Ruland, J., Yoshida, H., Liu, D., Elledge, S. J., & Mak, T. W. (2000) · Science · doi:10.1126/science.287.5459.1824 · Cited by 1,288 · see citing works

Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

Toledo, F., & Wahl, G. M. (2006) · Nature reviews. Cancer · doi:10.1038/nrc2012 · Cited by 1,286 · see citing works

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

Jones, S. N., Roe, A. E., Donehower, L. A., & Bradley, A. (1995) · Nature · doi:10.1038/378206a0 · Cited by 1,280 · see citing works

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome

Srivastava, S. K., Zou, Z., Pirollo, K. F., Blattner, W. A., & Chang, E. H. (1990) · Nature · doi:10.1038/348747a0 · Cited by 1,210 · see citing works

Linking the p53 tumour suppressor pathway to somatic cell reprogramming

Kawamura, T., Suzuki, J., Wang, Y. V., Menendez, S., Morera, L. B., Raya, A., Wahl, G. M., & Belmonte, J. C. I. (2009) · Nature · doi:10.1038/nature08311 · Cited by 1,115 · see citing works

The antioxidant function of the p53 tumor suppressor

Sablina, A. A., Budanov, A. V., Ilyinskaya, G. V., Agapova, L. S., Kravchenko, J. E., & Chumakov, P. M. (2005) · Nature Medicine · doi:10.1038/nm1320 · Cited by 1,110 · see citing works

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome

Lang, G. A., Iwakuma, T., Suh, Y.-A., Liu, G., Rao, V. A., Parant, J. M., Valentin-Vega, Y. A., Terzian, T., Caldwell, L. C., Strong, L. C., et al. (2004) · Cell · doi:10.1016/j.cell.2004.11.006 · Cited by 1,069 · see citing works

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

Ebert, B. L., Pretz, J. L., Bosco, J., Chang, C. Y., Tamayo, P., Galili, N., Raza, A., Root, D. E., Attar, E. C., Ellis, S. R., et al. (2008) · Nature · doi:10.1038/nature06494 · Cited by 925 · see citing works

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

Jeffers, J. R., Parganas, E., Lee, Y., Yang, C., Wang, J., Brennan, J. A., Maclean, K. H., Han, J., Chittenden, T., Ihle, J. N., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00244-7 · Cited by 880 · see citing works

Ribosomopathies: human disorders of ribosome dysfunction

Narla, A., & Ebert, B. L. (2010) · Blood · doi:10.1182/blood-2009-10-178129 · Cited by 806 · see citing works

The gene encoding ribosomal protein S19 is mutated in Diamond-Blackfan anaemia

Draptchinskaia, N., Gustavsson, P., Andersson, B., Pettersson, M., Willig, T.-N., Dianzani, I., Ball, S., Tchernia, G., Klar, J., Matsson, H., et al. (1999) · Nature Genetics · doi:10.1038/5951 · Cited by 795 · see citing works

Association of Spindle Assembly Checkpoint Component XMAD2 with Unattached Kinetochores

Chen, R., Waters, J. C., Salmon, E. D., & Murray, A. W. (1996) · Science · doi:10.1126/science.274.5285.242 · Cited by 783 · see citing works

The Biology of Hematopoietic Stem Cells

Morrison, S. J., Uchida, N., & Weissman, I. L. (1995) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cb.11.110195.000343 · Cited by 774 · see citing works

The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells

Cicalese, A., Bonizzi, G., Pasi, C. E., Faretta, M., Ronzoni, S., Giulini, B., Brisken, C., Minucci, S., Fiore, P. P. D., & Pelicci, P. G. (2009) · Cell · doi:10.1016/j.cell.2009.06.048 · Cited by 695 · see citing works

MDMX: a novel p53‐binding protein with some functional properties of MDM2.

Shvarts, A., Steegenga, W. T., Riteco, N., van Laar, T., Dekker, P., Bazuine, M., van Ham, R. C., van der Houven van Oordt, W., Hateboer, G., van der Eb, A. J., et al. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00919.x · Cited by 648 · see citing works

Inactivation of the p53 pathway in retinoblastoma

Laurie, N. A., Donovan, S. L., Shih, C.-S., Zhang, J., Mills, N., Fuller, C., Teunisse, A., Lam, S., Ramos, Y., Mohan, A., et al. (2006) · Nature · doi:10.1038/nature05194 · Cited by 595 · see citing works

The role of p53 in determining sensitivity to radiotherapy

Gudkov, A. V., & Komarova, E. A. (2003) · Nature reviews. Cancer · doi:10.1038/nrc992 · Cited by 569 · see citing works

p53 Regulates Hematopoietic Stem Cell Quiescence

Liu, Y., Elf, S. E., Miyata, Y., Sashida, G., Liu, Y., Huang, G., Di Giandomenico, S., Lee, J. M., Deblasio, A., Menendez, S., et al. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2008.11.006 · Cited by 547 · see citing works

Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells

Hock, H., Hamblen, M. J., Rooke, H. M., Schindler, J. W., Saleque, S., Fujiwara, Y., & Orkin, S. H. (2004) · Nature · doi:10.1038/nature02994 · Cited by 541 · see citing works

'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally

García‐Cao, I., García‐Cao, M., Martín‐Caballero, J., Criado, L. M., Klatt, P., Flores, J. M., Weill, J., Blasco, M. A., & Serrano, M. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf595 · Cited by 529 · see citing works

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

Parant, J., Chavez-Reyes, A., Little, N. A., Yan, W., Reinke, V., Jochemsen, A. G., & Lozano, G. (2001) · Nature Genetics · doi:10.1038/ng714 · Cited by 517 · see citing works

P53 and radiation responses

Fei, P., & El‐Deiry, W. S. (2003) · Oncogene · doi:10.1038/sj.onc.1206677 · Cited by 497 · see citing works

IARC Database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools

Hainaut, P. L. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.1.205 · Cited by 446 · see citing works

Distinct haematological disorder with deletion of long arm of No. 5 chromosome

BERGHE, H. V. D., Cassiman, J., David, G., Fryns, J., Michaux, J., & SOKAL, G. (1974) · Nature · doi:10.1038/251437a0 · Cited by 442 · see citing works

p53 suppresses the self-renewal of adult neural stem cells

Meletis, K., Wirta, V., Hede, S., Nistér, M., Lundeberg, J., & Frisén, J. (2005) · Development · doi:10.1242/dev.02208 · Cited by 414 · see citing works

Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells

Dutt, S., Narla, A., Lin, K. I., Mullally, A., Abayasekara, N., Megerdichian, C., Wilson, F. H., Currie, T., Khanna‐Gupta, A., Berliner, N., et al. (2010) · Blood · doi:10.1182/blood-2010-07-295238 · Cited by 410 · see citing works

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis

Jones, S. N., Hancock, A. R., Vogel, H., Donehower, L. A., & Bradley, A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15608 · Cited by 386 · see citing works

The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

Christophorou, M. A., Ringshausen, I., Finch, A. J., Swigart, L. B., & Evan, G. I. (2006) · Nature · doi:10.1038/nature05077 · Cited by 382 · see citing works

p53 at a glance

Brady, C. A., & Attardi, L. D. (2010) · Journal of Cell Science · doi:10.1242/jcs.064501 · Cited by 374 · see citing works

p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis

Kemp, C. J., Wheldon, T. E., & Balmain, A. (1994) · Nature Genetics · doi:10.1038/ng0994-66 · Cited by 366 · see citing works

p53-Mediated Hematopoietic Stem and Progenitor Cell Competition

Bondar, T., & Medzhitov, R. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.03.002 · Cited by 342 · see citing works

A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q– syndrome

Barlow, J. L., Drynan, L. F., Hewett, D. R., Holmes, L. R., Lorenzo-Abalde, S., Lane, A. L., Jolin, H. E., Pannell, R., Middleton, A. J., Wong, S. H., et al. (2009) · Nature Medicine · doi:10.1038/nm.2063 · Cited by 337 · see citing works

Transcription factor Gfi1 regulates self‐renewal and engraftment of hematopoietic stem cells

Zeng, H., Yücel, R., Kosan, C., Klein‐Hitpaß, L., & Möröy, T. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600419 · Cited by 328 · see citing works

Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice

Liu, G., Parant, J. M., Lang, G., Chau, P., Chavez-Reyes, A., El-Naggar, A. K., Multani, A., Chang, S., & Lozano, G. (2004) · Nature Genetics · doi:10.1038/ng1282 · Cited by 325 · see citing works

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development

Migliorini, D., Denchi, E. L., Danovi, D., Jochemsen, A., Capillo, M., Gobbi, A., Helin, K., Pelicci, P. G., & Marine, J.-C. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.15.5527-5538.2002 · Cited by 313 · see citing works

Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents

Lotem, J., & Sachs, L. (1993) · Blood · doi:10.1182/blood.v82.4.1092.1092 · Cited by 300 · see citing works

Differential Expression of Novel Potential Regulators in Hematopoietic Stem Cells

Forsberg, E. C., Prohaska, S. S., Katzman, S. J., Heffner, G. C., Stuart, J. M., & Weissman, I. L. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010028 · Cited by 284 · see citing works

Ribosomal Protein S24 Gene Is Mutated in Diamond-Blackfan Anemia

Gazda, H. T., Grabowska, A. K., de Long, L. M., Latawiec, E., Schneider, H. E., Lipton, J. M. M., Vlachos, A., Atsidaftos, E., Ball, S. E., Orfali, K. A., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/510020 · Cited by 276 · see citing works

The promises and perils of p53

Krizhanovsky, V., & Lowe, S. W. (2009) · Nature · doi:10.1038/4601085a · Cited by 274 · see citing works

Transgenic mice with p53‐responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo

Komarova, E. A., Chernov, M. V., Franks, R., Wang, K., Armin, G., Zelnick, C. R., Chin, D. M., Bacus, S. S., Stark, G. R., & Gudkov, A. V. (1997) · The EMBO Journal · doi:10.1093/emboj/16.6.1391 · Cited by 272 · see citing works

Mouse hematopoietic stem-cell antigen Sca-1 is a member of the Ly-6 antigen family.

van de Rijn, M., Heimfeld, S., Spangrude, G. J., & Weissman, I. L. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.12.4634 · Cited by 265 · see citing works

Declining p53 function in the aging process: A possible mechanism for the increased tumor incidence in older populations

Feng, Z., Hu, W., Teresky, A. K., Hernando, E., Cordon-Cardo, C., & Levine, A. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708043104 · Cited by 264 · see citing works

Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo

Ringshausen, I., O'Shea, C. C., Finch, A. J., Swigart, L. B., & Evan, G. I. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.10.010 · Cited by 256 · see citing works

Do reactive oxygen species play a role in myeloid leukemias?

Hole, P. S., Darley, R. L., & Tonks, A. (2011) · Blood · doi:10.1182/blood-2011-01-326025 · Cited by 252 · see citing works

The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging

Dumble, M. L., Moore, L. M., Chambers, S. M., Geiger, H., Zant, G. E. V., Goodell, M. A., & Donehower, L. A. (2006) · Blood · doi:10.1182/blood-2006-03-010413 · Cited by 241 · see citing works

Mdm2 Regulates p53 mRNA Translation through Inhibitory Interactions with Ribosomal Protein L26

Ofir-Rosenfeld, Y., Boggs, K., Michael, D., Kastan, M. B., & Oren, M. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.08.031 · Cited by 240 · see citing works

Abnormalities of the large ribosomal subunit protein, Rpl35a, in Diamond-Blackfan anemia

Farrar, J. E., Nater, M., Caywood, E., McDevitt, M. A., Kowalski, J., Takemoto, C. M., Talbot, C. C., Meltzer, P. S., Esposito, D., Beggs, A. H., et al. (2008) · Blood · doi:10.1182/blood-2008-02-140012 · Cited by 239 · see citing works

p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis

Kirsch, D. G., Santiago, P. M., di Tomaso, E., Sullivan, J. M., Hou, W.-S., Dayton, T. L., Jeffords, L. B., Sodha, P., Mercer, K. L., Cohen, R., et al. (2009) · Science · doi:10.1126/science.1166202 · Cited by 238 · see citing works

<i>mdm2</i> Is Critical for Inhibition of p53 during Lymphopoiesis and the Response to Ionizing Irradiation

Mendrysa, S. M., McElwee, M. K., Michalowski, J., O'Leary, K. A., Young, K. M., & Perry, M. E. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.2.462-473.2003 · Cited by 234 · see citing works

Tumor suppressor genes in normal and malignant hematopoiesis

Krug, U. O., Ganser, A., & Koeffler, H. P. (2002) · Oncogene · doi:10.1038/sj.onc.1205322 · Cited by 229 · see citing works

Ribosomal protein S17 gene (RPS17) is mutated in Diamond-Blackfan anemia

Čmejla, R., Čmejlová, J., Handrková, H., Petrák, J., & Pospı́šilová, D. (2007) · Human Mutation · doi:10.1002/humu.20608 · Cited by 220 · see citing works

p53-family proteins and their regulators: hubs and spokes in tumor suppression

Collavin, L., Lunardi, A., & Sal, G. D. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.35 · Cited by 219 · see citing works

p53 Lesions in Leukemic Transformation

Harutyunyan, A. S., Klampfl, T., Cazzola, M., & Královics, R. (2011) · New England Journal of Medicine · doi:10.1056/nejmc1012718 · Cited by 211 · see citing works

Tumor suppression and normal aging in mice with constitutively high p53 activity

Mendrysa, S. M., O'Leary, K. A., McElwee, M. K., Michalowski, J., Eisenman, R. N., Powell, D. A., & Perry, M. E. (2006) · Genes &amp; Development · doi:10.1101/gad.1378506 · Cited by 210 · see citing works

Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein.

Gilks, C. B., Bear, S. E., Grimes, H. L., & Tsichlis, P. N. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.3.1759 · Cited by 207 · see citing works

Ribosomal Protein S7 Is Both a Regulator and a Substrate of MDM2

Zhu, Y. Y., Poyurovsky, M. V., Li, Y., Biderman, L., Stahl, J., Jacq, X., & Prives, C. L. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.07.014 · Cited by 206 · see citing works

Human RPS19, the gene mutated in Diamond-Blackfan anemia, encodes a ribosomal protein required for the maturation of 40S ribosomal subunits

Flygare, J., Aspesi, A., Bailey, J. C., Miyake, K., Caffrey, J. M., Karlsson, S., & Ellis, S. R. (2006) · Blood · doi:10.1182/blood-2006-07-038232 · Cited by 194 · see citing works

Single Adult Human CD34+/Lin−/CD38− Progenitors Give Rise to Natural Killer Cells, B-Lineage Cells, Dendritic Cells, and Myeloid Cells

Miller, J. S., McCullar, V., Punzel, M., Lemischka, I. R., & Moore, K. A. (1999) · Blood · doi:10.1182/blood.v93.1.96.401k13_96_106 · Cited by 186 · see citing works

Dysfunction of the TP53 tumor suppressor gene in lymphoid malignancies

Xu-Monette, Z. Y., Medeiros, L. J., Li, Y., Orlowski, R. Z., Andreeff, M., Bueso-Ramos, C., Greiner, T. C., McDonnell, T. J., & Young, K. H. (2012) · Blood · doi:10.1182/blood-2011-11-366062 · Cited by 181 · see citing works

Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors

Akala, O. O., Park, I.-K., Qian, D., Pihalja, M., Becker, M. W., & Clarke, M. F. (2008) · Nature · doi:10.1038/nature06869 · Cited by 168 · see citing works

Low Doses of Radiation Increase the Latency of Spontaneous Lymphomas and Spinal Osteosarcomas in Cancer-Prone, Radiation-SensitiveTrp53Heterozygous Mice

Mitchel, R. E. J., Jackson, J. S., Morrison, D. P., & Carlisle, S. M. (2003) · Radiation Research · doi:10.1667/0033-7587(2003)159[0320:ldorit]2.0.co;2 · Cited by 163 · see citing works

The prognostic impact of 17p (p53) deletion in 2272 adults with acute myeloid leukemia

Seifert, H., Mohr, B., Thiede, C., Oelschlägel, U., Schäkel, U., Illmer, T., Soucek, S., Ehninger, G., Schaich, M. A., & on behalf of the Study Alliance Leukemia (SAL) (2009) · Leukemia · doi:10.1038/leu.2008.375 · Cited by 158 · see citing works

Ser18 and 23 phosphorylation is required for p53‐dependent apoptosis and tumor suppression

Chao, C., Herr, D., Chun, J., & Xu, Y. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601167 · Cited by 158 · see citing works

Targeted Disruption of the Ribosomal Protein S19 Gene Is Lethal Prior to Implantation

Matsson, H., Davey, E. J., Draptchinskaia, N., Hamaguchi, I., Ooka, A., Levéen, P., Forsberg, E., Karlsson, S., & Dahl, N. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.9.4032-4037.2004 · Cited by 156 · see citing works

Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain

Yadavilli, S., Mayo, L. D., Higgins, M., Laı́n, S., Hegde, V. K., & Deutsch, W. A. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.07.003 · Cited by 155 · see citing works

Phosphorylation of Serine 18 Regulates Distinct p53 Functions in Mice

Sluss, H. K., Armata, H., Gallant, J., & Jones, S. N. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.3.976-984.2004 · Cited by 152 · see citing works

Irradiation selects for p53-deficient hematopoietic progenitors.

Marusyk, A., Porter, C. C., Zaberezhnyy, V., & DeGregori, J. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000324 · Cited by 151 · see citing works

Mdm2 Is Required for Survival of Hematopoietic Stem Cells/Progenitors via Dampening of ROS-Induced p53 Activity

Abbas, H. A., Macció, D. R., Coşkun, S., Jackson, J. G., Hazen, A. L., Sills, T., You, M. J., Hirschi, K. K., & Lozano, G. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.09.013 · Cited by 141 · see citing works

Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose γ-irradiation

Yu, H. M., Shen, H., Yuan, Y., XuFeng, R., Hu, X., Garrison, S. P., Zhang, L., Yu, J., Zambetti, G. P., & Cheng, T. (2010) · Blood · doi:10.1182/blood-2009-10-248278 · Cited by 141 · see citing works

Establishment of a Normal Hematopoietic and Leukemia Stem Cell HierarchyPreprint

Chao, M. P., Seita, J., & Weissman, I. L. (2008) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2008.73.031 · Cited by 135 · see citing works

Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability

Pant, V., Xiong, S., Iwakuma, T., Quintás-Cardama, A., & Lozano, G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102241108 · Cited by 134 · see citing works

Mdm2 haplo‐insufficiency profoundly inhibits Myc‐induced lymphomagenesis

Alt, J. R., Greiner, T. C., Cleveland, J. L., & Eischen, C. M. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg133 · Cited by 129 · see citing works

A High-Frequency Regulatory Polymorphism in the p53 Pathway Accelerates Tumor Development

Post, S. M., Quintás-Cardama, A., Pant, V., Iwakuma, T., Hamir, A., Jackson, J. G., Maccio, D. R., Bond, G. L., Johnson, D. G., Levine, A. J., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.07.010 · Cited by 127 · see citing works

Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice

TeKippe, M., Harrison, D. E., & Chen, J. (2003) · Experimental Hematology · doi:10.1016/s0301-472x(03)00072-9 · Cited by 126 · see citing works

Mutation of ribosomal protein RPS24 in Diamond-Blackfan anemia results in a ribosome biogenesis disorder

Choesmel, V., Fribourg, S., Aguissa-Touré, A.-H., Pinaud, N., Legrand, P., Gazda, H. T., & Gleizes, P. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn015 · Cited by 126 · see citing works

Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23

MacPherson, D., Kim, J., Kim, T., Rhee, B. K., van Oostrom, C. T., DiTullio, R. A., Venere, M., Halazonetis, T. D., Bronson, R., de Vries, A., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600363 · Cited by 124 · see citing works

Prognostic factors identified three risk groups in the LRF CLL4 trial, independent of treatment allocation

Oscier, D. G., Wade, R. L., Davis, Z. A., Morilla, A. M., Best, G., Richards, S. M., Else, M., Matutes, E., & Catovsky, D. (2010) · Haematologica · doi:10.3324/haematol.2010.025338 · Cited by 122 · see citing works

Flow cytometry analysis of murine hematopoietic stem cells

Mayle, A., Luo, M., Jeong, M., & Goodell, M. A. (2012) · Cytometry Part A · doi:10.1002/cyto.a.22093 · Cited by 118 · see citing works

A Limited Role for p21Cip1/Waf1 in Maintaining Normal Hematopoietic Stem Cell Functioning

van Os, R. P., Kamminga, L. M., Ausema, A., Bystrykh, L. V., Draijer, D. P., van Pelt, K., Dontje, B., & de Haan, G. (2006) · Stem Cells · doi:10.1634/stemcells.2006-0631 · Cited by 118 · see citing works

Haploinsufficiency of <i>Mdm2</i> and <i>Mdm4</i> in Tumorigenesis and Development

Terzian, T., Wang, Y., Van Pelt, C. S., Box, N. F., Travis, E. L., & Lozano, G. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00555-06 · Cited by 116 · see citing works

Pathologies Associated with the p53 ResponsePreprint

Gudkov, A. V., & Komarova, E. A. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001180 · Cited by 116 · see citing works

Puma is required for p53-induced depletion of adult stem cells

Liu, D., Ou, L. Y., Clemenson, G. D., Chao, C., Lutske, M. E., Zambetti, G. P., Gage, F. H., & Xu, Y. (2010) · Nature Cell Biology · doi:10.1038/ncb2100 · Cited by 114 · see citing works

Mechanisms controlling hematopoietic stem cell functions during normal hematopoiesis and hematological malignancies

Warr, M. R., Pietras, E. M., & Passegué, E. (2011) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.145 · Cited by 112 · see citing works

Development and aging of primitive hematopoietic stem cells in BALB/cBy mice

Chen, J., Astle, C. M., & Harrison, D. E. (1999) · Experimental Hematology · doi:10.1016/s0301-472x(99)00018-1 · Cited by 109 · see citing works

THE CLINICAL SIGNIFICANCE OF MUTATIONS OF THE P52 TUMOUR SUPPRESSOR GENE IN HAEMATOLOGICAL MALIGNANCIES

Preudhomme, C., & Fenaux, P. (1997) · British Journal of Haematology · doi:10.1046/j.1365-2141.1997.2403057.x · Cited by 106 · see citing works

Enrichment of hematopoietic stem cells with SLAM and LSK markers for the detection of hematopoietic stem cell function in normal and Trp53 null mice

Chen, J., Ellison, F. M., Keyvanfar, K., Omokaro, S. O., Desierto, M. J., Eckhaus, M., & Young, N. S. (2008) · Experimental Hematology · doi:10.1016/j.exphem.2008.04.012 · Cited by 102 · see citing works

Pluripotent hematopoietic stem cell development during embryogenesis

Cumano, A., & Godin, I. (2001) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00200-4 · Cited by 98 · see citing works

Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation

Shao, L., Sun, Y., Zhang, Z., Feng, W., Gao, Y., Cai, Z., Wang, Z., Look, A. T., & Wu, W. (2010) · Blood · doi:10.1182/blood-2009-10-248872 · Cited by 97 · see citing works

A transgenic mouse model demonstrates a dominant negative effect of a point mutation in the RPS19 gene associated with Diamond-Blackfan anemia

Devlin, E. E., DaCosta, L., Mohandas, N., Elliott, G., & Bodine, D. M. (2010) · Blood · doi:10.1182/blood-2010-03-275776 · Cited by 97 · see citing works

Ribosomal protein L11 mutation in zebrafish leads to haematopoietic and metabolic defects

Danilova, N., Sakamoto, K. M., & Lin, S. (2010) · British Journal of Haematology · doi:10.1111/j.1365-2141.2010.08396.x · Cited by 96 · see citing works

Regulation of hematopoietic stem cell growth

Attar, E. C., & Scadden, D. T. (2004) · Leukemia · doi:10.1038/sj.leu.2403515 · Cited by 92 · see citing works

The Regulation of the p53-mediated Stress Response by MDM2 and MDM4Preprint

Perry, M. E. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000968 · Cited by 92 · see citing works

The p53 Tumor Suppressor Protein Does Not Regulate Expression of Its Own Inhibitor, MDM2, Except under Conditions of Stress

Mendrysa, S. M., & Perry, M. E. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.6.2023-2030.2000 · Cited by 87 · see citing works

P53 Gene Mutations in Lymphoid Diseases and Their Possible Relevance to Drug Resistance

Newcomb, E. W. (1995) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428199509056825 · Cited by 85 · see citing works

Validation of MdmX as a therapeutic target for reactivating p53 in tumors

Garcia, D., Warr, M. R., Martins, C. P., Brown Swigart, L., Passegué, E., & Evan, G. I. (2011) · Genes &amp; Development · doi:10.1101/gad.16722111 · Cited by 83 · see citing works

Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4

Xiong, S., Pant, V., Suh, Y.-A., Van Pelt, C. S., Wang, Y., Valentin-Vega, Y. A., Post, S. M., & Lozano, G. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1457 · Cited by 82 · see citing works

Increased Radioresistance and Accelerated B Cell Lymphomas in Mice with Mdmx Mutations that Prevent Modifications by DNA-Damage-Activated Kinases

Wang, Y. V., Leblanc, M., Wade, M., Jochemsen, A. G., & Wahl, G. M. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.05.008 · Cited by 79 · see citing works

Murine hematopoietic stem cell characterization and its regulation in BM transplantation

Zhao, Y., Lin, Y., Zhan, Y., Yang, G., Louie, J. P., Harrison, D. E., & Anderson, W. F. (2000) · Blood · doi:10.1182/blood.v96.9.3016 · Cited by 77 · see citing works

Diamond Blackfan Anemia

Ball, S. E. (2011) · Hematology · doi:10.1182/asheducation-2011.1.487 · Cited by 69 · see citing works

Timed Somatic Deletion of p53 in Mice Reveals Age-Associated Differences in Tumor Progression

Hinkal, G. W., Parikh, N., & Donehower, L. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006654 · Cited by 68 · see citing works

Chapter 8 Diamond Blackfan Anemia: A Disorder of Red Blood Cell Development

Ellis, S. R., & Lipton, J. M. M. (2008) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(07)00008-7 · Cited by 66 · see citing works

Necdin, a p53 target gene, regulates the quiescence and response to genotoxic stress of hematopoietic stem/progenitor cells

Asai, T., Liu, Y., Giandomenico, S. D., Bae, N., Ndiaye‐Lobry, D., DeBlasio, A., Menéndez, S., Antipin, Y., Reva, B. A., Wevrick, R., et al. (2012) · Blood · doi:10.1182/blood-2011-11-393983 · Cited by 65 · see citing works

Distinct roles of Mdm2 and Mdm4 in red cell production

Maetens, M., Doumont, G., Clercq, S. D., Francoz, S., Froment, P., Bellefroid, E., Klingmuller, U., Lozano, G., & Marine, J.-C. (2007) · Blood · doi:10.1182/blood-2006-03-013656 · Cited by 64 · see citing works

The p53–Mdm2 network in progenitor cell expansion during mouse postnatal development

Liu, G., Terzian, T., Xiong, S., Pelt, C. S. V., Audiffred, A., Box, N. F., & Lozano, G. (2007) · The Journal of Pathology · doi:10.1002/path.2238 · Cited by 60 · see citing works

Loss of heterozygosity frequency at the Trp53 locus in p53-deficient (+/-) mouse tumors is carcinogen-and tissue-dependent

French, J. E. (2001) · Carcinogenesis · doi:10.1093/carcin/22.1.99 · Cited by 58 · see citing works

Diamond Blackfan anemia 2008–2009: broadening the scope of ribosome biogenesis disorders

Lipton, J. M. M., & Ellis, S. R. (2010) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e328334573b · Cited by 57 · see citing works

Mutated and non‐mutated TP53 as targets in the treatment of leukaemia

Nahi, H., Selivanova, G., Lehmann, S., Möllgård, L., Bengtzén, S., Concha, H., Svensson, A., Wiman, K. G., Merup, M., & Paul, C. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07046.x · Cited by 56 · see citing works

Role of p53 in Hematopoietic Recovery After Cytotoxic Treatment

Wlodarski, P. K., Wasik, M. A., Ratajczak, M. Z., Sevignani, C., Hoser, G., Kawiak, J., Gewirtz, A. M., Calabretta, B., & Skórski, T. (1998) · Blood · doi:10.1182/blood.v91.8.2998.2998_2998_3006 · Cited by 53 · see citing works

Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity

Wang, Y. V., Leblanc, M., Fox, N., Mao, J.-H., Tinkum, K. L., Krummel, K., Engle, D., Piwnica-Worms, D., Piwnica-Worms, H., Balmain, A., et al. (2011) · Genes &amp; Development · doi:10.1101/gad.2024411 · Cited by 53 · see citing works

Pathogenesis of the erythroid failure in Diamond Blackfan anaemia

Sieff, C. A., Yang, J. C., de Long, L. M., & Lodish, H. F. (2009) · British Journal of Haematology · doi:10.1111/j.1365-2141.2009.07993.x · Cited by 50 · see citing works

Animal Models of Diamond Blackfan Anemia

McGowan, K. A., & Mason, P. J. (2011) · Seminars in Hematology · doi:10.1053/j.seminhematol.2011.02.001 · Cited by 44 · see citing works

A small molecule inhibitor of p53 stimulates amplification of hematopoietic stem cells but does not promote tumor development in mice

Leonova, K. I., Shneyder, J., Antoch, M. P., Toshkov, I. A., Novototskaya, L. R., Komarov, P. G., Komarova, E. A., & Gudkov, A. V. (2010) · Cell Cycle · doi:10.4161/cc.9.7.11508 · Cited by 40 · see citing works

Erythropoiesis in the Rps19 disrupted mouse: Analysis of erythropoietin response and biochemical markers for Diamond-Blackfan anemia

Matsson, H., Davey, E. J., Fröjmark, A.-S., Miyake, K., Utsugisawa, T., Flygare, J., Zahou, E., Byman, I., Landin, B., Ronquist, G. K., et al. (2006) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.12.002 · Cited by 40 · see citing works

High-Resolution Array-Based Comparative Genomic Hybridization of Bladder Cancers Identifies Mouse Double Minute 4 ( MDM4 ) as an Amplification Target Exclusive of MDM2 and TP53

Veerakumarasivam, A., Scott, H. E., Chin, S., Warren, A. Y., Wallard, M. J., Grimmer, D., Ichimura, K., Caldas, C., Collins, V. P., Neal, D. E., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4129 · Cited by 37 · see citing works

Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models

Terzian, T., Dumble, M. L., Arbab, F., Christina Thaller, B., Donehower, L. A., Lozano, G., Justice, M. J., Roop, D. R., & Box, N. F. (2011) · The Journal of Pathology · doi:10.1002/path.2891 · Cited by 29 · see citing works

MDM4 (MDMX) is overexpressed in chronic lymphocytic leukaemia (CLL) and marks a subset of p53wild‐type CLL with a poor cytotoxic response to Nutlin‐3

Bo, M. D., Secchiero, P., Degan, M., Marconi, D., Bomben, R., Pozzato, G., Gaïdano, G., Poeta, G. D., Forconi, F., Zauli, G., et al. (2010) · British Journal of Haematology · doi:10.1111/j.1365-2141.2010.08185.x · Cited by 26 · see citing works

Apoptosis in bone marrow cells of mice with different p53 genotypes after gamma-rays irradiation in vitro.

Cui, Y., Zhou, P., Woolford, L. B., Lord, B. I., Hendry, J. H., & Wang, D. W. (1995) · PubMed · Cited by 25 · see citing works

Prognostic Impact of the MDM2SNP309 Allele in Leukemia and Lymphoma

Post, S. M., Pant, V., Abbas, H. A., & Quintás‐Cardama, A. (2010) · Oncotarget · doi:10.18632/oncotarget.123 · Cited by 11 · see citing works

Cellular senescence and cancer

(1999) · doi:10.1002/(sici)1096-9896(199901)187:1

Unravelling mechanisms of p53-mediated tumour suppression

Bieging-Rolett, K. T., Mello, S. S., & Attardi, L. D. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3711 · Cited by 1,389 · see citing works

Uncovering the role of p53 splice variants in human malignancy: a clinical perspective

Bourdon, J., Surget, S., & Khoury, M. P. (2013) · OncoTargets and Therapy · doi:10.2147/ott.s53876 · Cited by 380 · see citing works

MDM2 inhibition: an important step forward in cancer therapy

Konopleva, M. Y., Martinelli, G., Daver, N. G., Papayannidis, C., Wei, A. H., Higgins, B., Ott, M., Mascarenhas, J. O., & Andreeff, M. (2020) · Leukemia · doi:10.1038/s41375-020-0949-z · Cited by 376 · see citing works

Deconstructing networks of p53-mediated tumor suppression in vivo

Kaiser, A. M., & Attardi, L. D. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.171 · Cited by 227 · see citing works

Natural course and biology of CML

Chereda, B., & Melo, J. V. (2015) · Annals of Hematology · doi:10.1007/s00277-015-2325-z · Cited by 222 · see citing works

USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis.

Fan, Y.-H., Cheng, J., Vasudevan, S. A., Dou, J., Zhang, H., Patel, R. H., Ma, I. T., Rojas, Y., Zhao, Y., Yu, Y., et al. (2013) · Cell Death &amp; Disease · doi:10.1038/cddis.2013.400 · Cited by 199 · see citing works

Poly(A)-specific ribonuclease deficiency impacts telomere biology and causes dyskeratosis congenita

Tummala, H., Walne, A. J., Collopy, L. C., Cardoso, S. R., de la Fuente, J., Lawson, S., Powell, J., Cooper, N. S., Foster, A. C., Mohammed, S. N., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78963 · Cited by 198 · see citing works

RCAD/Ufl1, a Ufm1 E3 ligase, is essential for hematopoietic stem cell function and murine hematopoiesis

Zhang, M., Zhu, X., Zhang, Y., Cai, Y., Chen, J., Sivaprakasam, S., Gurav, A., Pi, W., Makala, L., Wu, J., et al. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.51 · Cited by 186 · see citing works

Dysfunctional diversity of p53 proteins in adult acute myeloid leukemia: projections on diagnostic workup and therapy

Prokocimer, M., Molchadsky, A., & Rotter, V. (2017) · Blood · doi:10.1182/blood-2017-02-763086 · Cited by 165 · see citing works

Cold atmospheric plasma conveys selectivity on triple negative breast cancer cells both in vitro and in vivo

Xiang, L., Xu, X., Zhang, S., Cai, D., & Dai, X. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.06.001 · Cited by 136 · see citing works

Li‐Fraumeni syndrome: a paradigm for the understanding of hereditary cancer predisposition

Valdez, J. M., Nichols, K. E., & Kesserwan, C. A. (2016) · British Journal of Haematology · doi:10.1111/bjh.14461 · Cited by 121 · see citing works

The role of TP53 in acute myeloid leukemia: Challenges and opportunities

Barbosa, K., Li, S., Adams, P. D., & Deshpande, A. J. (2019) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22796 · Cited by 115 · see citing works

Abnormal erythropoiesis and the pathophysiology of chronic anemia

Koury, M. J. (2014) · Blood Reviews · doi:10.1016/j.blre.2014.01.002 · Cited by 96 · see citing works

Biosensors in Clinical Practice: Focus on Oncohematology

Fracchiolla, N., Artuso, S., & Cortelezzi, A. (2013) · Italian National Conference on Sensors · doi:10.3390/s130506423 · Cited by 72 · see citing works

p53 mediates loss of hematopoietic stem cell function and lymphopenia in Mysm1 deficiency

Belle, J. I., Langlais, D., Petrov, J. C., Pardo, M., Jones, R. G., Gros, P., & Nijnik, A. (2015) · Blood · doi:10.1182/blood-2014-05-574111 · Cited by 77 · see citing works

Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis.

Lee, C., Blum, J. M., & Kirsch, D. G. (2013) · PubMed · Cited by 72 · see citing works

Haploinsufficient tumor suppressor genes.

Inoue, K., & Fry, E. A. (2017) · PubMed · Cited by 63 · see citing works

Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways

Chen, Z., Yi, W., Morita, Y., Wang, H., Cong, Y., Liu, J., Xiao, Z., Rudolph, K. L., Cheng, T., & Ju, Z. (2015) · Nature Communications · doi:10.1038/ncomms7808 · Cited by 61 · see citing works

Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma

Lee, C., Castle, K. D., Moding, E. J., Blum, J. M., Williams, N. T., Luo, L., Ma, Y., Borst, L. B., Kim, Y., & Kirsch, D. G. (2015) · Nature Communications · doi:10.1038/ncomms9477 · Cited by 58 · see citing works

Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance

Belle, J. I., Petrov, J. C., Langlais, D., Robert, F., Cencic, R., Shen, S., Pelletier, J., Gros, P., & Nijnik, A. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2015.140 · Cited by 58 · see citing works

Ferroptosis regulates hemolysis in stored murine and human red blood cells

D’Alessandro, A., Keele, G. R., Hay, A. M., Nemkov, T. G., Earley, E. J., Stephenson, D., Vincent, M. J., Deng, X., Stone, M., Dzieciątkowska, M., et al. (2024) · Blood · doi:10.1182/blood.2024026109 · Cited by 57 · see citing works

Li–Fraumeni Syndrome Disease Model: A Platform to Develop Precision Cancer Therapy Targeting Oncogenic p53

Zhou, R., Xu, A., Gingold, J. A., Strong, L. C., Zhao, R., & Lee, D. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.07.004 · Cited by 52 · see citing works

Basal p53 expression is indispensable for mesenchymal stem cell integrity

Boregowda, S. V., Krishnappa, V., Strivelli, J., Haga, C. L., Booker, C. N., & Phinney, D. G. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-017-0004-4 · Cited by 53 · see citing works

MicroRNA 155 Control of p53 Activity Is Context Dependent and Mediated by Aicda and Socs1

Bouamar, H., Jiang, D., Wang, L., Lin, A., Ortega, M. M., & Aguiar, R. C. T. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.01446-14 · Cited by 49 · see citing works

The Inhibitory Effect of Ginger Extract on Ovarian Cancer Cell Line; Application of Systems Biology

Pashaei‐Asl, R., Pashaei-Asl, F., Gharabaghi, P. M., Khodadadi, K., Ebrahimi, M., Ebrahimie, E., & Pashaiasl, M. (2017) · Advanced Pharmaceutical Bulletin · doi:10.15171/apb.2017.029 · Cited by 49 · see citing works

TP53 in Acute Myeloid Leukemia: Molecular Aspects and Patterns of Mutation

George, B., Kantarjian, H. M., Baran, N., Krocker, J. D., & Rios, A. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910782 · Cited by 50 · see citing works

DNA Damage Responses and Oxidative Stress in Dyskeratosis Congenita

Pereboeva, L., Westin, E. R., Patel, T., Flaniken, I. Z., Lamb, L. S., Klingelhutz, A. J., & Goldman, F. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076473 · Cited by 48 · see citing works

Ufl1/RCAD, a Ufm1 E3 ligase, has an intricate connection with ER stress.

Xie, Z.-Y., Fang, Z., & Pan, Z.-Z. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.05.170 · Cited by 38 · see citing works

Loss of p53 induces leukemic transformation in a murine model of Jak2 V617F-driven polycythemia vera

Tsuruta-Kishino, T., Koya, J., Kataoka, K., Narukawa, K., Sumitomo, Y., Kobayashi, H., Sato, T., & Kurokawa, M. (2017) · Oncogene · doi:10.1038/onc.2016.478 · Cited by 41 · see citing works

Ex vivo HSC expansion challenges the paradigm of unidirectional human hematopoiesis

Papa, L., Djedaini, M., & Hoffman, R. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14133 · Cited by 44 · see citing works

Ex vivo human HSC expansion requires coordination of cellular reprogramming with mitochondrial remodeling and p53 activation

Papa, L., Zimran, E., Djedaini, M., Ge, Y., Özbek, U., Sebra, R., Sealfon, S. C., & Hoffman, R. (2018) · Blood Advances · doi:10.1182/bloodadvances.2018024273 · Cited by 42 · see citing works

TP53 in MDS and AML: Biological and clinical advances

Zhao, Y., Chen, W., Yu, J., Pei, S., Zhang, Q., Shi, J., Huang, H., & Zhao, Y. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216767 · Cited by 44 · see citing works

p53-/- synergizes with enhanced NrasG12D signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia.

Zhang, J.-F., Kong, G., Rajagopalan, A., Lu, L., Song, J., Hussaini, M., Zhang, X., Ranheim, E., Liu, Y., Wang, J.-Y., et al. (2017) · Blood · doi:10.1182/blood-2016-06-719237 · Cited by 35 · see citing works

Restoring p53 in cancer: the promises and the challenges

Lozano, G. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjz063 · Cited by 40 · see citing works

Blocking ETV6/RUNX1-induced MDM2 overexpression by Nutlin-3 reactivates p53 signaling in childhood leukemia

Kaindl, U., Morak, M., Portsmouth, C., Mecklenbräuker, A., Kauer, M., Zeginigg, M., Attarbaschi, A., Haas, O. A., & Panzer‐Grümayer, R. (2013) · Leukemia · doi:10.1038/leu.2013.345 · Cited by 39 · see citing works

A first-in-human phase I study of a novel MDM2/p53 inhibitor alrizomadlin in advanced solid tumors

Zhang, X., Wen, X., Peng, R., Pan, Q., Weng, D., Ma, Y., Zhang, Y., Yang, J., Men, L., Wang, H., et al. (2024) · ESMO Open · doi:10.1016/j.esmoop.2024.103636 · Cited by 35 · see citing works

Advancements in MDM2 inhibition: Clinical and pre-clinical investigations of combination therapeutic regimens

Alaseem, A. M. (2023) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2023.101790 · Cited by 36 · see citing works

Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis

Carr, M. I., Roderick, J. E., Gannon, H., Kelliher, M. A., & Jones, S. N. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.014 · Cited by 34 · see citing works

The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger

Keightley, M.-C., Carradice, D., Layton, J. E., Pase, L. B., Bertrand, J. Y., Wittig, J. G., Dakic, A., Badrock, A. P., Cole, N. J., Traver, D. J., et al. (2017) · Nature Communications · doi:10.1038/ncomms14911 · Cited by 30 · see citing works

p53 balances between tissue hierarchy and anarchy

Koifman, G., Aloni-Grinstein, R., & Rotter, V. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjz022 · Cited by 33 · see citing works

Asrij/OCIAD1 suppresses CSN5-mediated p53 degradation and maintains mouse hematopoietic stem cell quiescence

Sinha, S., Dwivedi, T. R., Yengkhom, R., Bheemsetty, V. A., Abe, T., Kiyonari, H., VijayRaghavan, K., & Inamdar, M. S. (2019) · Blood · doi:10.1182/blood.2019000530 · Cited by 32 · see citing works

Genetically engineered mouse models for studying radiation biology

Castle, K. D., Chen, M., Wisdom, A. J., & Kirsch, D. G. (2017) · Translational Cancer Research · doi:10.21037/tcr.2017.06.19 · Cited by 30 · see citing works

Gamma-Tocotrienol Modulates Radiation-Induced MicroRNA Expression in Mouse Spleen

Ghosh, S. P., Pathak, R., Kumar, P., Biswas, S., Bhattacharyya, S., Kumar, V. P., Hauer‐Jensen, M., & Biswas, R. (2016) · Radiation Research · doi:10.1667/rr14248.1 · Cited by 30 · see citing works

Ppm1d truncating mutations promote the development of genotoxic stress-induced AML

Burócziová, M., Daněk, P., Oravetzova, A., Chalupova, Z., Alberich-Jordà, M., & Macůrek, L. (2023) · Leukemia · doi:10.1038/s41375-023-02030-8 · Cited by 29 · see citing works

Cell-Cycle-Specific Function of p53 in Fanconi Anemia Hematopoietic Stem and Progenitor Cell Proliferation

Li, X., Wilson, A. F., Du, W., & Pang, Q. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.12.006 · Cited by 28 · see citing works

Awakening the HSC: Dynamic Modeling of HSC Maintenance Unravels Regulation of the TP53 Pathway and Quiescence

Ikonomi, N., Werle, S. D., Schwab, J. D., & Kestler, H. A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00848 · Cited by 27 · see citing works

Alpha-Enolase Is Upregulated on the Cell Surface and Responds to Plasminogen Activation in Mice Expressing a ∆133p53α Mimic

Sawhney, S., Hood, K. A., Shaw, A., Braithwaite, A. W., Stubbs, R., Hung, N. A., Royds, J. A., & Slatter, T. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116270 · Cited by 27 · see citing works

ANP32B-mediated repression of p53 contributes to maintenance of normal and CML stem cells

Yang, S., Zhu, X., Zhang, H., Yang, Q., Wei, Y.-S., Zhu, D., Liu, M.-D., Shen, S.-M., Li, X., He, P., et al. (2021) · Blood · doi:10.1182/blood.2020010400 · Cited by 26 · see citing works

The autism-related protein CHD8 contributes to the stemness and differentiation of mouse hematopoietic stem cells

Nita, A., Muto, Y., Katayama, Y., Matsumoto, A., Nishiyama, M., & Nakayama, K. I. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108688 · Cited by 24 · see citing works

<i>Txnip</i> Enhances Fitness of <i>Dnmt3a</i> -Mutant Hematopoietic Stem Cells via <i>p21</i>

Zhang, C. R., Ostrander, E. L., Kukhar, O., Mallaney, C., Sun, J., Haussler, E., Celik, H., Koh, W. K., King, K. Y., Gontarz, P., et al. (2022) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-21-0132 · Cited by 23 · see citing works

A p53-JAK-STAT connection involved in myeloproliferative neoplasm pathogenesis and progression to secondary acute myeloid leukemia

Goyal, H., Chachoua, I., Pecquet, C., Vainchenker, W., & Constantinescu, S. N. (2020) · Blood Reviews · doi:10.1016/j.blre.2020.100712 · Cited by 23 · see citing works

Altered Expression of Genes in Signaling Pathways Regulating Proliferation of Hematopoietic Stem and Progenitor Cells in Mice with Subchronic Benzene Exposure

Sun, R., Zhang, J., Xiong, M., Wei, H., Tan, K., Yin, L., & Pu, Y. (2015) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph120809298 · Cited by 22 · see citing works

Network Pharmacology‐Based Investigation of the System‐Level Molecular Mechanisms of the Hematopoietic Activity of Samul‐Tang, a Traditional Korean Herbal Formula

Lee, H.-S., Lee, I.-H., Park, S., & Lee, D.-Y. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/9048089 · Cited by 21 · see citing works

MSC-Derived Extracellular Vesicles: New Emergency Treatment to Limit the Development of Radiation-Induced Hematopoietic Syndrome?

Cavallero, S., Riccobono, D., Drouet, M., & François, S. (2020) · Health Physics · doi:10.1097/hp.0000000000001264 · Cited by 21 · see citing works

Tissue specificity and spatio-temporal dynamics of the p53 transcriptional program

Pant, V., Sun, C., & Lozano, G. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01123-2 · Cited by 21 · see citing works

Direct regulation of p53 by miR-142a-3p mediates the survival of hematopoietic stem and progenitor cells in zebrafish

Lu, X., Wei, Y., & Liu, F. (2015) · Cell Discovery · doi:10.1038/celldisc.2015.27 · Cited by 20 · see citing works

DNA damage response, redox status and hematopoiesis

Weiss, C. N., & Ito, K. (2013) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2013.08.002 · Cited by 19 · see citing works

p53 regulates diverse tissue-specific outcomes to endogenous DNA damage in mice

Hill, R. J., Bona, N., Smink, J., Webb, H. K., Crisp, A., Garaycoechea, J. I., & Crossan, G. P. (2024) · Nature Communications · doi:10.1038/s41467-024-46844-1 · Cited by 18 · see citing works

Disease‐specific mutations in mature lymphoid neoplasms: Recent advances

Sakata‐Yanagimoto, M., Enami, T., Yokoyama, Y., & Chiba, S. (2014) · Cancer Science · doi:10.1111/cas.12408 · Cited by 17 · see citing works

Increased Risk for Lymphoma Following Hemorrhagic Fever With Renal Syndrome

Klingström, J., Granath, F. N., Ekbom, A., Björkström, N. K., & Ljunggren, H. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu488 · Cited by 17 · see citing works

UBA1 dysfunction in VEXAS and cancer

Sakuma, M., Haferlach, T., & Walter, W. (2024) · Oncotarget · doi:10.18632/oncotarget.28646 · Cited by 16 · see citing works

p57 regulates T-cell development and prevents lymphomagenesis by balancing p53 activity and pre-TCR signaling

Matsumoto, A., Takeishi, S., & Nakayama, K. I. (2014) · Blood · doi:10.1182/blood-2013-10-532390 · Cited by 16 · see citing works

Synthesis and biological evaluation of naphthalimide-polyamine conjugates modified by alkylation as anticancer agents through p53 pathway

Dai, F., He, H., Xu, X., Chen, S., Wang, C., Feng, C., Tian, Z., Dong, H., & Xie, S. (2018) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2017.12.036 · Cited by 16 · see citing works

Guilu Erxian Glue (龟鹿二仙胶) Inhibits Chemotherapy-Induced Bone Marrow Hematopoietic Stem Cell Senescence in Mice May via p16INK4a-Rb Signaling Pathway

Wang, J., Ying, Y., Chen, Z., Shao, K., Zhang, W., & Lin, S. (2020) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-020-3098-3 · Cited by 15 · see citing works

The Biology and Pathogenesis of Chronic Myeloid Leukemia

Chereda, B., & Melo, J. V. (2016) · Hematologic malignancies · doi:10.1007/978-3-319-33198-0_2 · Cited by 15 · see citing works

Decreased p53 is associated with a decline in asymmetric stem cell self‐renewal in aged human epidermis

Charruyer, A., Weisenberger, T., Li, H., Khalifa, A., Schroeder, A., Belzer, A., & Ghadially, R. (2021) · Aging Cell · doi:10.1111/acel.13310 · Cited by 16 · see citing works

Cellular stress pathways in pediatric bone marrow failure syndromes: many roads lead to neutropenia

Glaubach, T., Minella, A. C., & Corey, S. J. (2013) · Pediatric Research · doi:10.1038/pr.2013.197 · Cited by 14 · see citing works

An expert overview of emerging therapies for acute myeloid leukemia: novel small molecules targeting apoptosis, p53, transcriptional regulation and metabolism

Saxena, K., & Konopleva, M. Y. (2020) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2020.1804856 · Cited by 13 · see citing works

RNA polymerase III component Rpc9 regulates hematopoietic stem and progenitor cell maintenance in zebrafish

Wei, Y., Xu, J., Zhang, W., Wen, Z., & Liu, F. (2016) · Development · doi:10.1242/dev.126797 · Cited by 13 · see citing works

Impairment of fetal hematopoietic stem cell function in the absence of Fancd2

Suzuki, S., Racine, R. R., Manalo, N. A., Cantor, S. B., & Raffel, G. D. (2016) · Experimental Hematology · doi:10.1016/j.exphem.2016.11.006 · Cited by 13 · see citing works

p53 immunohistochemistry discriminates between pure erythroid leukemia and reactive erythroid hyperplasia

Alexandres, C. A., Basha, B. M., King, R. L., Howard, M. T., & Reichard, K. K. (2021) · Journal of Hematopathology · doi:10.1007/s12308-020-00431-7 · Cited by 12 · see citing works

Role of long non-coding RNAs in normal and malignant hematopoiesis

Wei, P., Han, B., & Chen, Y. (2013) · Science China Life Sciences · doi:10.1007/s11427-013-4550-9 · Cited by 11 · see citing works

Proteomic analysis of JAK2V617F-induced changes identifies potential new combinatorial therapeutic approaches

Pearson, S., Williamson, A. J. K., Blance, R., Somervaille, T. C. P., Taylor, S. S., Azadbakht, N., Whetton, A. D., & Pierce, A. (2017) · Leukemia · doi:10.1038/leu.2017.143 · Cited by 11 · see citing works

New Treatment Options for Older Patients with Acute Myeloid Leukemia

Saxena, K., & Konopleva, M. Y. (2021) · Current Treatment Options in Oncology · doi:10.1007/s11864-021-00841-4 · Cited by 11 · see citing works

New monogenic disorders identify more pathways to neutropenia: from the clinic to next-generation sequencing

Corey, S. J., & Oyarbide, U. (2017) · Hematology · doi:10.1182/asheducation-2017.1.172 · Cited by 10 · see citing works

The proto‐oncogene function of Mdm2 in bone

Olivos, D. J., Perrien, D. S., Hooker, R. A., Cheng, Y., Fuchs, R. K., Hong, J. M., Bruzzaniti, A., Chun, K. T., Eischen, C. M., Kacena, M. A., et al. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27133 · Cited by 10 · see citing works

The spliceosome factor sart3 regulates hematopoietic stem/progenitor cell development in zebrafish through the p53 pathway

Zhao, Y., Wu, M., Li, J., Meng, P., Chen, J., Huang, Z., Xu, J., Wen, Z., Zhang, W., & Zhang, Y. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04215-4 · Cited by 10 · see citing works

STAT3 protects hematopoietic stem cells by preventing activation of a deleterious autocrine type-I interferon response

Patel, B., Zhou, Y., Babcock, R. L., Ma, F., Zal, M. A., Kumar, D., Medik, Y. B., Kahn, L. M., Pineda, J. E., Park, E. M., et al. (2024) · Leukemia · doi:10.1038/s41375-024-02218-6 · Cited by 9 · see citing works

Differentiating erythroblasts adapt to mechanical stimulation by upregulation of cholesterol biosynthesis via S1P/SREBP-induced HMGCR expression

Iacono, G., Abay, A., Gallego‐Murillo, J. S., Aglialoro, F., Yağcı, N., Varga, E., Bijlsma, T., Sohler, J., Fu, K., Reisz, J. A., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-81746-8 · Cited by 9 · see citing works

Latexin and hematopoiesis

Zhang, C., & Liang, Y. (2018) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000428 · Cited by 10 · see citing works

Nbs1‐mediated DNA damage repair pathway regulates haematopoietic stem cell development and embryonic haematopoiesis

Chen, Y., Sun, J., Ju, Z., Wang, Z., & Li, T. (2021) · Cell Proliferation · doi:10.1111/cpr.12972 · Cited by 9 · see citing works

TP53 Alterations in Myelodysplastic Syndromes and Acute Myeloid Leukemia

Rahmé, R., Braun, T., Manfredi, J. J., & Fenaux, P. (2023) · Biomedicines · doi:10.3390/biomedicines11041152 · Cited by 9 · see citing works

Genetic deficiency of the tumor suppressor protein p53 influences erythrocyte survival

Bissinger, R., Lang, E., González-Menéndez, I., Quintanilla‐Martínez, L., Ghashghaeinia, M., Pelzl, L., Sukkar, B., Bhuyan, A. A. M., Salker, M. S., Singh, Y., et al. (2018) · APOPTOSIS · doi:10.1007/s10495-018-1481-8 · Cited by 9 · see citing works

TP53 ‐Mutated Acute Myeloid Leukemia: Unanswered Questions

Bruzzese, A., Vigna, E., Martino, E. A., Labanca, C., Caridà, G., Mendicino, F., Lucia, E., Olivito, V., Puccio, N., Neri, A., et al. (2025) · Hematological Oncology · doi:10.1002/hon.70106 · Cited by 10 · see citing works

DDX41 resolves G-quadruplexes to maintain erythroid genome integrity and prevent cGAS-mediated cell death

Bi, H., Ren, K., Wang, P., Li, E., Han, X., Wang, W., Yang, J., Aydemir, I., Tao, K., Ma, R., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62307-7 · Cited by 8 · see citing works

Proteasome inhibitor bortezomib stabilizes and activates p53 in hematopoietic stem/progenitors and double-negative T cells in vivo

Xue, Y., Luis, B. S., Dress, R. J., Murad, K. B. A., Ginhoux, F., Barker, N., & Lane, D. P. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2219978120 · Cited by 8 · see citing works

Increased p53 protein expression as a potential predictor of early relapse after hematopoietic stem cell transplantation in children with acute myelogenous leukemia

Mattsson, K., Honkaniemi, E., Barbany, G., & Gustafsson, B. M. (2015) · Pediatric Transplantation · doi:10.1111/petr.12585 · Cited by 8 · see citing works

Discrete Logic Modeling of Cell Signaling Pathways

Ikonomi, N., Werle, S. D., Schwab, J. D., & Kestler, H. A. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2277-3_12 · Cited by 8 · see citing works

The Relationship Between Leukemia and TP53 Gene Codon Arg72Pro Polymorphism: Analysis in a Multi-Ethnic Population

Drokow, E. K., Chen, Y., Ahmed, H. A. W., Oppong, T. B., Akpabla, G. S., Pei, Y., Kumah, M. A., Neku, E. A., & Sun, K. (2020) · Future Oncology · doi:10.2217/fon-2019-0792 · Cited by 8 · see citing works

Pharmacological mechanism of mylabris in the treatment of leukemia based on bioinformatics and systematic pharmacology

Zhan, H., Bai, Y., Lv, Y., Zhang, X., Zhang, L., & Deng, S. (2021) · Bioengineered · doi:10.1080/21655979.2021.1943110 · Cited by 7 · see citing works

Cancer spectrum in TP53-deficient golden Syrian hamsters: A new model for li-fraumeni syndrome

Wang, Y., Wang, Z., Cormier, R., Miao, J., Li, R., Wettere, A. V., Guo, H., Tăbăran, F., O'Sullivan, M., Carlson, T., et al. (2021) · Journal of Carcinogenesis · doi:10.4103/jcar.jcar_18_21 · Cited by 7 · see citing works

Phosphorylated ATM and H2AX in T and B lymphocytes from rats with moderate and severe malnutrition

Gutiérrez, A. M. G., Ortiz, R., García‐Rodríguez, M. D. C., & Barberena, E. C. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.102640 · Cited by 7 · see citing works

Elevated p53 Protein Expression; A Predictor of Relapse in Rare Chronic Myeloid Malignancies in Children?

Honkaniemi, E., Mattsson, K., Barbany, G., Sander, B., & Gustafsson, B. M. (2014) · Pediatric Hematology and Oncology · doi:10.3109/08880018.2014.898723 · Cited by 6 · see citing works

The histone methyltransferase inhibitor A-366 enhances hemoglobin expression in erythroleukemia cells upon co‐exposure with chemical inducers in culture

Papagiannopoulos, C. I., Theodoroula, N. F., Kyritsis, K., Akrivou, M. G., Kosmidou, M. S., Tsouderou, K., Grigoriadis, N., & Vizirianakis, I. S. (2021) · Journal of Biological Research - Thessaloniki · doi:10.1186/s40709-020-00132-3 · Cited by 6 · see citing works

Mouse Models of Frequently Mutated Genes in Acute Myeloid Leukemia

Mohanty, S., & Heuser, M. (2021) · Cancers · doi:10.3390/cancers13246192 · Cited by 6 · see citing works

Mouse Models of Myeloid MalignanciesPreprint

Basheer, F., & Vassiliou, G. S. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a035535 · Cited by 6 · see citing works

Airway epithelial cell‐derived insulin‐like growth factor‐1 triggers skewed CD8+ T cell polarization

Zou, J., Huang, S., Li, Y., Chen, H., Rong, J., & Ye, S. (2014) · Cell Biology International · doi:10.1002/cbin.10313 · Cited by 5 · see citing works

DDR1 regulates RUNX1-CBFβ to control breast stem cell differentiation

Trepicchio, C. J., Rauner, G., Traugh, N. C., Wang, R., Parrish, M. E., Fein, D. E. C., Mal, Y., Gupta, P. B., Monti, S., & Kuperwasser, C. (2025) · Stem Cell Reports · doi:10.1016/j.stemcr.2025.102576 · Cited by 4 · see citing works

Eulophia Gracilis Orchid Profers Mitigative Influence on Benzene-Initiated Onco-Hematologic Toxicities in Male Wistar Rats

Ola, O. S. (2023) · Journal on oncology · doi:10.52768/2692-563x/1086 · Cited by 4 · see citing works

APEX1 Nuclease and Redox Functions are Both Essential for Adult Mouse Hematopoietic Stem and Progenitor Cells

Zaunz, S., Smedt, J. D., Lauwereins, L., Cleuren, L., Laffeber, C., Bajaj, M. S., Lebbink, J. H. G., Marteijn, J. A. F., Keersmaecker, K. D., & Verfaillie, C. M. (2023) · Stem Cell Reviews and Reports · doi:10.1007/s12015-023-10550-0 · Cited by 5 · see citing works

The ups and downs of p53 regulation in hematopoietic stem cells

Abbas, H. A., Pant, V., & Lozano, G. (2011) · Cell Cycle · doi:10.4161/cc.10.19.17721 · Cited by 31 · see citing works

The p53 tumor suppressor protein is a critical regulator of hematopoietic stem cell behavior

Liu, Y., Elf, S., Asai, T., Miyata, Y., Liu, Y., Sashida, G., Huang, G., Giandomenico, S. D., Koff, A., & Nimer, S. D. (2009) · Cell Cycle · doi:10.4161/cc.8.19.9627 · Cited by 65 · see citing works

A new role of P53 in preventing early leukemic transformation of HSCS

Brown, A., Eiwen, K., Pospiech, J., Saçma, M., Moehrle, B., & Geiger, H. (2016) · Experimental Hematology · doi:10.1016/j.exphem.2016.06.099

p53 mediates loss of hematopoietic stem cell function and lymphopenia in Mysm1 deficiency

Belle, J. I., Langlais, D., Petrov, J. C., Pardo, M., Jones, R. G., Gros, P., & Nijnik, A. (2015) · Blood · doi:10.1182/blood-2014-05-574111 · Cited by 77 · see citing works

Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance

Belle, J. I., Petrov, J. C., Langlais, D., Robert, F., Cencic, R., Shen, S., Pelletier, J., Gros, P., & Nijnik, A. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2015.140 · Cited by 58 · see citing works