Telomere shortening in human diseases

The limited in vitro lifetime of human diploid cell strains

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Shelterin: the protein complex that shapes and safeguards human telomeres

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Mammalian Telomeres End in a Large Duplex Loop

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Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

Blasco, M. A., Lee, H.-W., Hande, M. P., Samper, E., Lansdorp, P. M., DePinho, R. A., & Greider, C. W. (1997) · Cell · doi:10.1016/s0092-8674(01)80006-4 · Cited by 2,108 · see citing works

Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia

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Telomerase Mutations in Families with Idiopathic Pulmonary Fibrosis

Armanios, M. Y., Chen, J. J.-L., Cogan, J. D., Alder, J. K., Ingersoll, R. G., Markin, C., Lawson, W. E., Xie, M., Vulto, I., Phillips, J. A., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa066157 · Cited by 1,357 · see citing works

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

Rudolph, K. L., Chang, S., Lee, H.-W., Blasco, M., Gottlieb, G. J., Greider, C., & DePinho, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80580-2 · Cited by 1,349 · see citing works

The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder

Stewart, G. S., Maser, R. S., Stankovic, T., Bressan, D. A., Kaplan, M. I., Jaspers, N. G. J., Raams, A., Byrd, P. J., Petrini, J. H. J., & Taylor, A. M. R. (1999) · Cell · doi:10.1016/s0092-8674(00)81547-0 · Cited by 1,060 · see citing works

Inhibition of telomerase limits the growth of human cancer cells

Hahn, W. C., Stewart, S. A., Brooks, M. W., York, S. G., Eaton, E. N., Kurachi, A. L., Beijersbergen, R. L., Knoll, J. H. M., Meyerson, M. M., & Weinberg, R. A. (1999) · Nature Medicine · doi:10.1038/13495 · Cited by 1,032 · see citing works

Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging

Blackburn, E. H., Greider, C. W., & Szostak, J. W. (2006) · Nature Medicine · doi:10.1038/nm1006-1133 · Cited by 992 · see citing works

p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis

Chin, L., Artandi, S. E., Shen, Q., Tam, A., Lee, S.-L., Gottlieb, G. J., Greider, C. W., & DePinho, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80762-x · Cited by 979 · see citing works

A Manyfold Increase in Sister Chromatid Exchanges in Bloom's Syndrome Lymphocytes

Chaganti, R. S. K., Schonberg, S. A., & GERMAN, J. L. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.11.4508 · Cited by 947 · see citing works

Protection of mammalian telomeres

de Lange, T. (2002) · Oncogene · doi:10.1038/sj.onc.1205080 · Cited by 942 · see citing works

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma.Preprint

Xu, Y., Ashley, T., Brainerd, E. E., Bronson, R. T., Meyn, M. S., & Baltimore, D. (1996) · Genes & Development · doi:10.1101/gad.10.19.2411 · Cited by 830 · see citing works

Leukocyte Telomere Length and Cardiovascular Disease in the Cardiovascular Health Study

Fitzpatrick, A. L., Kronmal, R. A., Gardner, J. P., Psaty, B. M., Jenny, N. S., Tracy, R. P., Walston, J., Kimura, M., & Aviv, A. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj346 · Cited by 773 · see citing works

Mutations in <i>TERT,</i> the Gene for Telomerase Reverse Transcriptase, in Aplastic Anemia

Yamaguchi, H., Calado, R. T., Ly, H., Kajigaya, S., Baerlocher, G. M., Chanock, S. J., Lansdorp, P. M., & Young, N. S. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042980 · Cited by 723 · see citing works

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

Zhang, X., Mar, V., Zhou, W., Harrington, L., & Robinson, M. O. (1999) · Genes &amp; Development · doi:10.1101/gad.13.18.2388 · Cited by 698 · see citing works

Telomere shortening in atherosclerosis

Samani, N. J., Boultby, R., Butler, R., Thompson, J. R., & Goodall, A. H. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05633-1 · Cited by 609 · see citing works

Defective Telomere Lagging Strand Synthesis in Cells Lacking WRN Helicase Activity

Crabbé, L., Verdún, R. E., Haggblom, C., & Karlseder, J. (2004) · Science · doi:10.1126/science.1103619 · Cited by 604 · see citing works

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

Zhu, X., Küster, B., Mann, M., Petrini, J. H. J., & de Lange, T. (2000) · Nature Genetics · doi:10.1038/77139 · Cited by 602 · see citing works

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

Mohaghegh, P. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.13.2843 · Cited by 599 · see citing works

Bloom Syndrome

GERMAN, J. L. (1993) · Medicine · doi:10.1097/00005792-199311000-00003 · Cited by 593 · see citing works

Telomere Shortening in Familial and Sporadic Pulmonary Fibrosis

Cronkhite, J. T., Xing, C., Raghu, G., Chin, K. M., Torres, F., Rosenblatt, R. L., & Kim Garcia, C. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200804-550oc · Cited by 573 · see citing works

The Bloom’s Syndrome Helicase Unwinds G4 DNA*

Sun, H., Karow, J. K., Hickson, I., & Maizels, N. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.42.27587 · Cited by 552 · see citing works

Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis

WIEMANN, S. U., SATYANARAYANA, A., TSAHURIDU, M., TILLMANN, H. L., ZENDER, L., KLEMPNAUER, J., FLEMMING, P., FRANCO, S., BLASCO, M. A., MANNS, M. P., et al. (2002) · The FASEB Journal · doi:10.1096/fj.01-0977com · Cited by 527 · see citing works

A Box H/ACA Small Nucleolar RNA-Like Domain at the Human Telomerase RNA 3′ End

Mitchell, J. R., Cheng, J., & Collins, K. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.567 · Cited by 510 · see citing works

The Bloom's syndrome gene product promotes branch migration of Holliday junctions

Karow, J., Constantinou, A., Li, J., West, S. C., & Hickson, I. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100448097 · Cited by 502 · see citing works

Essential role of limiting telomeres in the pathogenesis of Werner syndrome

Chang, S., Multani, A. S., Cabrera, N. G., Naylor, M. L., Laud, P., Lombard, D., Pathak, S., Guarente, L., & DePinho, R. A. (2004) · Nature Genetics · doi:10.1038/ng1389 · Cited by 462 · see citing works

Disease anticipation is associated with progressive telomere shortening in families with dyskeratosis congenita due to mutations in TERC

Vulliamy, T., Marrone, A., Szydlo, R., Walne, A., Mason, P. J., & Dokal, I. (2004) · Nature Genetics · doi:10.1038/ng1346 · Cited by 461 · see citing works

Excess of rare cancers in Werner syndrome (adult progeria).

Goto, M., Miller, R. W., Ishikawa, Y., & Sugano, H. (1996) · PubMed · Cited by 434 · see citing works

TINF2, a Component of the Shelterin Telomere Protection Complex, Is Mutated in Dyskeratosis Congenita

Savage, S. A., Giri, N., Baerlocher, G. M., Orr, N., Lansdorp, P. M., & Alter, B. P. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.10.004 · Cited by 414 · see citing works

Telomere shortening in T cells correlates with Alzheimer's disease status

Panossian, L. A. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00043-x · Cited by 409 · see citing works

Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro.

Zaug, A., Podell, E., & Cech, T. (2005) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0504744102 · Cited by 398 · see citing works

The Telomeric Protein TRF2 Binds the ATM Kinase and Can Inhibit the ATM-Dependent DNA Damage Response

Karlseder, J., Hoke, K., Mirzoeva, O. K., Bakkenist, C. J., Kastan, M. B., Petrini, J. H. J., & de Lange, T. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020240 · Cited by 393 · see citing works

Telomere-binding Protein TRF2 Binds to and Stimulates the Werner and Bloom Syndrome Helicases

Opresko, P. L., von Kobbe, C., Lainé, J., Harrigan, J. A., Hickson, I. D., & Bohr, V. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205396200 · Cited by 389 · see citing works

Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice

Zhu, J., Petersen, S., Tessarollo, L., & Nussenzweig, A. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00019-7 · Cited by 374 · see citing works

Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse

Greenberg, R. A., Chin, L., Femino, A., Lee, K.-H., Gottlieb, G. J., Singer, R. H., Greider, C. W., & DePinho, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80761-8 · Cited by 367 · see citing works

Telomere Shortening Is Nearly Universal in Pancreatic Intraepithelial Neoplasia

van Heek, N. T., Meeker, A. K., Kern, S. E., Yeo, C. J., Lillemoe, K. D., Cameron, J. L., Offerhaus, G. J. A., Hicks, J. L., Wilentz, R. E., Goggins, M. G., et al. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64432-x · Cited by 363 · see citing works

In situ analyses of genome instability in breast cancer

Chin, K., de Solorzano, C. O., Knowles, D., Jones, A., Chou, W., Rodriguez, E. G., Kuo, W.-L., Ljung, B.-M., Chew, K., Myambo, K., et al. (2004) · Nature Genetics · doi:10.1038/ng1409 · Cited by 361 · see citing works

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis

González-Suárez, E., Samper, E., Flores, J. M., & Blasco, M. A. (2000) · Nature Genetics · doi:10.1038/79089 · Cited by 347 · see citing works

Chromosomal instability in ulcerative colitis is related to telomere shortening

O'Sullivan, J. N., Bronner, M. P., Brentnall, T. A., Finley, J. C., Shen, W.-T., Emerson, S., Emond, M. J., Gollahon, K. A., Moskovitz, A. H., Crispin, D. A., et al. (2002) · Nature Genetics · doi:10.1038/ng989 · Cited by 346 · see citing works

Monocyte Telomere Shortening and Oxidative DNA Damage in Type 2 Diabetes

Sampson, M., Winterbone, M. S., Hughes, J. C., Dozio, N., & Hughes, D. A. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1715 · Cited by 344 · see citing works

DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?

Passos, J. F., Saretzki, G., & von Zglinicki, T. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm893 · Cited by 344 · see citing works

Mutations in the telomerase component NHP2 cause the premature ageing syndrome dyskeratosis congenita

Vulliamy, T., Beswick, R., Kirwan, M., Marrone, A., Digweed, M., Walne, A., & Dokal, I. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800042105 · Cited by 334 · see citing works

Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts

Wyllie, F. S., Jones, C. J., Skinner, J. W., Haughton, M. F., Wallis, C., Wynford-Thomas, D., Faragher, R. G. A., & Kipling, D. (2000) · Nature Genetics · doi:10.1038/71630 · Cited by 332 · see citing works

Shortened Telomeres in Circulating Leukocytes of Patients with Chronic Obstructive Pulmonary Disease

Savale, L., Chaouat, A., Bastuji‐Garin, S., Marcos, É., Boyer, L., Maître, B., Sarni, M., HOUSSET, B., Weitzenblum, E., Matrat, M., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200809-1398oc · Cited by 322 · see citing works

TINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes

Walne, A. J., Vulliamy, T., Beswick, R., Kirwan, M., & Dokal, I. (2008) · Blood · doi:10.1182/blood-2008-05-153445 · Cited by 317 · see citing works

Genetic heterogeneity in autosomal recessive dyskeratosis congenita with one subtype due to mutations in the telomerase-associated protein NOP10

Walne, A. J., Vulliamy, T., Marrone, A., Beswick, R., Kirwan, M., Masunari, Y., Al-Qurashi, F.-H., Aljurf, M., & Dokal, I. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm111 · Cited by 316 · see citing works

Telomere Length Abnormalities Occur Early in the Initiation of Epithelial Carcinogenesis

Meeker, A. K., Hicks, J. L., Iacobuzio-Donahue, C. A., Montgomery, E. A., Westra, W. H., Chan, T. Y., Ronnett, B. M., & De Marzo, A. M. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-0984-03 · Cited by 306 · see citing works

The Werner Syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2

Opresko, P. L., Otterlei, M., Graakjær, J., Bruheim, P., Dawut, L., Kølvraa, S., May, A., Seidman, M. M., & Bohr, V. A. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.05.023 · Cited by 305 · see citing works

Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome

Yamaguchi, H., Baerlocher, G. M., Lansdorp, P. M., Chanock, S. J., Nunez, O., Sloand, E., & Young, N. S. (2003) · Blood · doi:10.1182/blood-2003-01-0335 · Cited by 301 · see citing works

Progressive Telomere Shortening in Aplastic Anemia

Ball, S. E., Gibson, F. M., Rizzo, S., Tooze, J. A., Marsh, J. C. W., & Gordon‐Smith, E. C. (1998) · Blood · doi:10.1182/blood.v91.10.3582 · Cited by 288 · see citing works

T Cell Telomere Length in HIV-1 Infection: No Evidence for Increased CD4 ⁺ T Cell Turnover

Wolthers, K. C., Bea, G., Wisman, A., Otto, S. A., de Roda Husman, A.-M., Schaft, N., de Wolf, F., Goudsmit, J., Coutinho, R. A., van der Zee, A. G. J., et al. (1996) · Science · doi:10.1126/science.274.5292.1543 · Cited by 286 · see citing works

Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells

Yamaguchi‐Iwai, Y., Sonoda, E., Sasaki, M. S., Morrison, C., Haraguchi, T., Hiraoka, Y., Yamashita, Y. M., Yagi, T., Takata, M., Price, C., et al. (1999) · The EMBO Journal · doi:10.1093/emboj/18.23.6619 · Cited by 282 · see citing works

Leukocyte telomere length and mortality in the Cardiovascular Health Study

Fitzpatrick, A. L., Kronmal, R. A., Kimura, M., Gardner, J. P., Psaty, B. M., Jenny, N. S., Tracy, R. P., Hardikar, S., & Aviv, A. (2011) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glq224 · Cited by 271 · see citing works

The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together

Stracker, T. H., Theunissen, J.-W. F., Morales, M., & Petrini, J. H. J. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.03.014 · Cited by 263 · see citing works

Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita

Zhong, F., Savage, S. A., Shkreli, M., Giri, N., Jessop, L., Myers, T., Chen, R., Alter, B. P., & Artandi, S. E. (2011) · Genes &amp; Development · doi:10.1101/gad.2006411 · Cited by 262 · see citing works

X-Linked Dyskeratosis Congenita Is Predominantly Caused by Missense Mutations in the DKC1 Gene

Knight, S. W., Heiss, N. S., Vulliamy, T., Greschner, S., Stavrides, G., Pai, G. S., Lestringant, G. G., Varma, N., Mason, P. J., Dokal, I. S., et al. (1999) · The American Journal of Human Genetics · doi:10.1086/302446 · Cited by 261 · see citing works

Telomerase and idiopathic pulmonary fibrosis

Armanios, M. (2012) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2011.10.013 · Cited by 245 · see citing works

Telomere dysfunction as a cause of genomic instability in Werner syndrome

Crabbe, L., Jauch, A., Naeger, C. M., Holtgreve-Grez, H., & Karlseder, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609410104 · Cited by 240 · see citing works

Telomere Extension Occurs at Most Chromosome Ends and Is Uncoupled from Fill-In in Human Cancer Cells

Zhao, Y. B., Sfeir, A. J., Zou, Y. S., Buseman, C. M., Chow, T. T., Shay, J. W., & Wright, W. E. (2009) · Cell · doi:10.1016/j.cell.2009.05.026 · Cited by 237 · see citing works

Binding and Melting of D-Loops by the Bloom Syndrome Helicase

van Brabant, A. J., Tian, Y., Sanz, M. M., GERMAN, J. L., Ellis, N. A., & Holloman, W. K. (2000) · Biochemistry · doi:10.1021/bi0018640 · Cited by 223 · see citing works

Telomere Shortening Exposes Functions for the Mouse Werner and Bloom Syndrome Genes

Du, X., Shen, J., Kugan, N., Furth, E. E., Lombard, D. B., Cheung, C., Pak, S., Luo, G., Pignolo, R. J., DePinho, R. A., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.19.8437-8446.2004 · Cited by 213 · see citing works

BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase–double Holliday junction dissolvasomePreprint

Singh, T. R., Ali, A. M., Busygina, V., Raynard, S. J., Fan, Q., Du, C.-H., Andreassen, P. R., Sung, P., & Meetei, A. R. (2008) · Genes & Development · doi:10.1101/gad.1725108 · Cited by 211 · see citing works

NBS1 and TRF1 Colocalize at Promyelocytic Leukemia Bodies during Late S/G2 Phases in Immortalized Telomerase-negative Cells

Wu, G., Lee, W., & Chen, P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000390200 · Cited by 209 · see citing works

A Murine Model of Nijmegen Breakage Syndrome

Williams, B. R., Mirzoeva, O. K., Morgan, W. F., Lin, J., Dunnick, W., & Petrini, J. H. J. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00763-7 · Cited by 208 · see citing works

Mutations in the reverse transcriptase component of telomerase (TERT) in patients with bone marrow failure

Vulliamy, T., Walne, A. J., Baskaradas, A., Mason, P. J., Marrone, A., & Dokal, I. S. (2005) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2004.12.008 · Cited by 207 · see citing works

RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stabilityPreprint

Xu, D., Guo, R., Sobeck, A., Bachrati, C. Z., Yang, J., Enomoto, T., Brown, G. W., Hoatlin, M. E., Hickson, I. D., & Wang, W. (2008) · Genes & Development · doi:10.1101/gad.1708608 · Cited by 206 · see citing works

POT1 Stimulates RecQ Helicases WRN and BLM to Unwind Telomeric DNA Substrates

Opresko, P. L., Mason, P. A., Podell, E. R., Lei, M., Hickson, I. D., Cech, T. R., & Bohr, V. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505211200 · Cited by 202 · see citing works

Short telomere length, myocardial infarction, ischemic heart disease, and early death

Weischer, M., Bojesen, S. E., Cawthon, R. M., Freiberg, J. J., Tybjærg-Hansen, A., & Nordestgaard, B. G. (2012) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.111.237271 · Cited by 197 · see citing works

Telomere attrition and Chk2 activation in human heart failure

Oh, H., Wang, S. C., Prahash, A. J. C., Sano, M., Moravec, C. S., Taffet, G. E., Michael, L. H., Youker, K. A., Entman, M. L., & Schneider, M. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0836098100 · Cited by 197 · see citing works

The Bloom syndrome helicase BLM interacts with TRF2 in ALT cells and promotes telomeric DNA synthesis

Stavropoulos, D. J. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.25.3135 · Cited by 197 · see citing works

Multiple roles for MRE11 at uncapped telomeres

Deng, Y., Guo, X., Ferguson, D. O., & Chang, S. S. (2009) · Nature · doi:10.1038/nature08196 · Cited by 194 · see citing works

Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway

Laud, P. R., Multani, A. S., Bailey, S. M., Wu, L., Ma, J., Kingsley, C., Lebel, M., Pathak, S., DePinho, R. A., & Chang, S. (2005) · Genes &amp; Development · doi:10.1101/gad.1321305 · Cited by 190 · see citing works

DNA damage response at functional and dysfunctional telomeresPreprint

Longhese, M. P. (2008) · Genes & Development · doi:10.1101/gad.1626908 · Cited by 180 · see citing works

Association of Shorter Leukocyte Telomere Repeat Length With Dementia and Mortality

Honig, L. S., Kang, M. S., Schupf, N., Lee, J. H., & Mayeux, R. P. (2012) · Archives of Neurology · doi:10.1001/archneurol.2012.1541 · Cited by 178 · see citing works

Checkpoint Failure and Chromosomal Instability without Lymphomagenesis in Mre11ATLD1/ATLD1 Mice

Theunissen, J.-W. F., Kaplan, M. I., Hunt, P. A., Williams, B. R., Ferguson, D. O., Alt, F. W., & Petrini, J. H. J. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00455-6 · Cited by 170 · see citing works

Chromosome end associations, telomeres and telomerase activity in ataxia telangiectasia cells

Pandita, T. K., Pathak, S., & Geard, C. R. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000134069 · Cited by 166 · see citing works

Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells.

Johnson, F. B., Lombard, D. B., Neff, N. F., et al. (2000) · PubMed · Cited by 163 · see citing works

Disruption of Telomere Maintenance by Depletion of the MRE11/RAD50/NBS1 Complex in Cells That Use Alternative Lengthening of Telomeres

Zhong, Z.-H., Jiang, W.-Q., Cesare, A. J., Neumann, A. A., Wadhwa, R., & Reddel, R. R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701413200 · Cited by 159 · see citing works

Cytomegalovirus Infection Reduces Telomere Length of the Circulating T Cell Pool

van de Berg, P. J. E. J., Griffiths, S. J., Yong, S.-L., Macaulay, R., Bemelman, F. J., Jackson, S., Henson, S. M., ten Berge, I. J. M., Akbar, A. N., & van Lier, R. A. W. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903442 · Cited by 157 · see citing works

Association and regulation of the BLM helicase by the telomere proteins TRF1 and TRF2

Lillard-Wetherell, K., Machwe, A., Langland, G. T., Combs, K. A., Behbehani, G. K., Schonberg, S., GERMAN, J. L., Turchi, J. J., Orren, D. K., & Groden, J. L. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh193 · Cited by 157 · see citing works

The cell cycle of lymphocytes in Fanconi anemia

Dutrillaux, B., Aurias, A., Dutrillaux, A., et al. (1982) · Human Genetics · doi:10.1007/bf00304549 · Cited by 149 · see citing works

Telomere Shortening in Chronic Liver Diseases

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Telomere shortening and inactivation of cell cycle checkpoints characterize human hepatocarcinogenesis†

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