Specific Inhibition of Stat3 Signal Transduction by PIAS3

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080

Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6

Zhong, Z., Wen, Z., & Darnell, J. E. (1994) · Science · doi:10.1126/science.8140422 · Cited by 2,070

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

Wen, Z., Zhong, Z., & Darnell, J. E. (1995) · Cell · doi:10.1016/0092-8674(95)90311-9 · Cited by 1,974

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

Schindler, C., & Darnell, J. E. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.003201 · Cited by 1,808

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

Takeda, K., Noguchi, K., Shi, W., Tanaka, T., Matsumoto, M., Yoshida, N., Kishimoto, T., & Akira, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.3801 · Cited by 1,323

Cytokine receptor signalling

Ihle, J. N. (1995) · Nature · doi:10.1038/377591a0 · Cited by 1,201

Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice.

Vaisse, C., Halaas, J. L., Horvath, C. M., Darnell, J. E., Stoffel, M., & Friedman, J. M. (1996) · Nature Genetics · doi:10.1038/ng0996-95 · Cited by 1,086

Structure and function of a new STAT-induced STAT inhibitor

Naka, T., Narazaki, M., Hirata, M., Matsumoto, T., Minamoto, S., Aono, A., Nishimoto, N., Kajita, T., Taga, T., Yoshizaki, K., et al. (1997) · Nature · doi:10.1038/43219 · Cited by 1,040

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

Akira, S., Nishio, Y., Inoue, M., Wang, X.-J., We, S., Matsusaka, T., Yoshida, K., Sudo, T., Naruto, M., & Kishimoto, T. (1994) · Cell · doi:10.1016/0092-8674(94)90235-6 · Cited by 1,019

The JAK/STAT pathway in Drosophila hematopoiesis: function and regulatory mechanisms

Shen, Y. (2007) · Europe PMC (PubMed Central)

Small molecule compounds targeting DNA binding domain of STAT3 for inhibition of tumor growth and metastasis

Huang, W. (2014) · IUScholarWorks (Indiana University) · doi:10.7912/c2/310

Facteurs prédictifs de réponse et données de tolérance du tocilizumab au cours de la polyarthrite rhumatoïde

Dick, L. (2013) · OpenGrey (Institut de l'Information Scientifique et Technique)

STAT Signaling by Erythropoietin

Constantinescu, S. N., & Moucadel, V. (2003) · Springer eBooks · doi:10.1007/978-94-017-3000-6_36

The role of parallel signaling pathways in maintaining lymphoid cell survival

Nagy, Z. S., & Kirken, R. A. (2002)

Prevention and Treatment of Head and Neck Cancer with Natural Compound Inhibitors of STAT3

Leeman‐Neill, R. J. (2008) · D-Scholarship@Pitt (University of Pittsburgh)

Molecular Understanding of RET/PTC-Mediated Thyroid Carcinogenesis

Jo, Y. S., Kim, D. W., Lee, M. H., Kim, S. J., Hwang, J. H., & Shong, M. (2009) · Springer eBooks · doi:10.1007/978-4-431-88659-4_21

Generierung zweier knock in Mausmutanten zur funktionellen Charakterisierung einzelner Domänen des Gfi1-Zinkfingerproteins

Fiolka, K. (2006) · DuEPublico (University of Duisburg-Essen)

Contrôle de la signalisation oncogénique du mutant L858R de l'EGFR par la protéine

Ozenne, P. (2011)

Regulation of Stat1 Through Post-translational Modifications

Vanhatupa, S. (2008) · Tampere University Institutional Repository (Tampere University)

Charakterisierung der Funktion des Transkriptionsfaktors Gfi1 während der T-Zell-vermittelten Immunantwort in Gfi1-defizienten Mäusen

Pargmann, D. (2006) · DuEPublico (University of Duisburg-Essen)

Regulation of telomerase by genistein in human prostate cancer cells

Chau, M. N. (2008) · DigitalGeorgetown (Georgetown University Library)

Das Tyrosin 759 des Signaltransduktors gp130 in der IL-6-abhängigen Proliferation von Prä-B-Zellen

Friederichs, K., & Heinrich, P. C. (2004) · RWTH Publications (RWTH Aachen)

Functional studies of Tyk2 in IFNalpha signaling : a new interactor and an activating mutationPreprint

Gakovic, M. (2007)

Development of Secretion System for Heterologous Recombinant Protein Expression in E.coli Bacteria and Pichia pastoris Yeast

Qu, H. (2013) · eScholarship (California Digital Library)

Modulation der hepatischen Akut-Phase-Reaktion und der antiviralen Antwort durch pro-apoptotische Stimuli

Mathematisch-naturwissenschaftlichen Fakultät, I. (2009)

Cytokines and Signaling

David, M. (2005) · CRC Press eBooks · doi:10.1201/9781420039849.ch4

Developmental Biology of the Hematopoietic Growth Factors

Yöder, M. C., & Schibler, K. R. (2004) · Elsevier eBooks · doi:10.1016/b978-0-7216-9654-6.50147-8

REGULAÇÃO DA ATIVIDADE DE STAT3 E O PAPEL DA PROTEÍNA STI1/HOP SECRETADA EM GLIOBLASTOMA

Rodrigues, B. R. (2014)

Alterations in JAK/STAT signaling pathway and blood-brain barrier function: Mechanisms underlying worsened outcome following stroke in the aged rat.

DiNapoli, V. A. (2008) · doi:10.33915/etd.8760

Étude de la SUMOylation dans l’immunité innée et l’oncogenèse

Decque, A. (2014) · theses.fr (ABES) · doi:10.70675/9c751457z588az4210za1bbz3b5d58fb2087

Design and Synthesis of New Scaffolds for Stat5 Inhibition

Brown, C. E. (2013) · TSpace (University of Toronto)

Analyse génotypique et fonctionnelle des cardiomyocytes issus de la différenciation précoce des cellules souches embryonnaires murines

Dagouassat, M. (2006)

Effects of gp130 cytokines on adipocytes

Zvonic, S. (2004) · Louisiana State University · doi:10.31390/gradschool_dissertations.3173

Modulation of adipocyte genes by signal transducers and activators of transcription

Hogan, J. C. (2004) · Louisiana State University · doi:10.31390/gradschool_dissertations.1670

Die Rolle der STAT3 N-terminale Domäne und GAS-Sequenzerkennung bei der Signaltransduktion und der Wechselwirkung mit STAT1 und NF-κB

Martincuks, A. (2017) · RWTH Publications (RWTH Aachen) · doi:10.18154/rwth-2017-01944

Novel interaction partners of the chromatin remodeler CHD7, a protein mutated in CHARGE syndrome

Tserendulam, B. (2012) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-1453

The Role of STAT3 in the Pathogenesis of Chronic Lymphocytic Leukaemia

Brophy, S. (2018) · Trinity's Access to Research Output (TARA) (Trinity College Dublin)

Inhibition of liver and bone marrow derived dendritic cell maturation and function by Interleukin-6 activation of Signal Transducer and Activator of Transcription-3

Lunz, & George, J. E. (2007) · D-Scholarship@Pitt (University of Pittsburgh)

Intracellular Signaling Defects Contribute to TH17 Dysregulation during HIV Infection

Bixler, S. L. (2014)

Signal Transducer and Activator of Transcription 6 (STAT6) as a regulator of pancreatic beta cell health

Leslie, K. A. (2019) · Figshare

Der Einfluss einer Aktivierung des STAT3-Signalweges auf das Ansprechen kolorektaler Karzinomzellen auf eine Radiochemotherapie

Herzberg, C. (2019) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-7706

STAT3 inhibits Myocardin induced cardiac hypertrophyPreprint

Liao, X., Xiang, Y., Li, J., Li, H., Huang, Y., Shen, C., Zhang, H., & Zhang, T. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.21.392902

Роль транскрипционного фактора STAT3 в патогенезе бронхиальной астмы

Никольский, А. А., Шиловский, И. П., Barvinskaia, E. D., Викторович, К. А., Sundukova, M. S., & Khaitov, M. R. (2021) · Biochemistry (Moscow) · doi:10.31857/s032097252111004x

Deletion of Smooth Muscle Lethal Giant Larvae 1 Promotes Neointimal Hyperplasia in Mice

Zhang, Y. P., Yuan, P., Ma, X., Deng, Q., Gao, J., Yang, J., Zhang, T., Zhang, C., & Zhang, W. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.834296

Developmental Biology of the Hematopoietic Growth Factors

Schibler, K. R. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-3479-7.10142-9

Cell Signaling Mechanisms Underlying the Cardiac Actions of Adipokines

Karmazyn, M., & Rajapurohitam, V. (2011) · Royal Society of Chemistry eBooks · doi:10.1039/9781849733434-00057

HP1 and Noncanonical Functions of STAT

Li, W. X., & Silver-Morse, L. (2023) · SpringerBriefs in biochemistry and molecular biology · doi:10.1007/978-3-031-29029-9_1

Funktionelle Charakterisierung von Substitutionsmutationen in Position 566 der Linker-Domäne des onkogenen Transkriptionsfaktors STAT3

Bohne, N. M. (2023) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-9923

gp130-Related Cytokines

Auernhammer, C. J., & Melmed, S. K. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-032-2_7 · Cited by 1

Decreased Levels of PIAS Genes in Periodontitis: A Pilot Study for Finding Possible Contribution of Immune-Related Pathways in Periodontitis

Sayad, A., Gholami, L., Badrlou, E., Nazer, N., Khalilian, S., & Ghafouri‐Fard, S. (2025) · Shiraz E-Medical Journal · doi:10.5812/semj-148039

Determine Protein Interaction Affinity without Purification Reveals a Two-enzyme Co-recognition of SUMOylation Substrate using Quantitative FRET (qFRET) TechnologyPreprint

Jiang, L., Xiong, Z., Liu, Y., Dang, R., Li, J., & Liao, J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.29.667540

Feedback inhibition of the Janus kinase/signal transducer and activator of transcription signaling pathway by CG5953 through Ptp61F

Hu, W., Liu, H., Lin, L., Li, M., Fan, Z., Zhang, Y., Lin, X., & Qi, Y. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.147875

Host-specific bacterial modulation of airway gene expression and alternative splicing

Horvath, M., Kang, H. G., Wu, T.-C., Aiken, E. S., Castaneda, D. C., Akkurt, S., Marches, F., Anczuków, O., Palucka, K., & Oh, J. (2025) · mSphere · doi:10.1128/msphere.00577-25

Functional and cellular analysis of autoimmune regulator (AIRE) protein

Ilmarinen, T. (2007) · Työväentutkimus Vuosikirja

Role of Cell-cell Interactions and Palmitate on β-cells Function

Chowdhury, A. I. (2014) · Uppsala University Publications (Uppsala University)

Oncogene functions in human cancer

Tang, J. (2010) · ResearchSpace (University of Auckland)

Additional file 1 of 3,3′-Diindolylmethane improves antitumor immune responses of PD-1 blockade via inhibiting myeloid-derived suppressor cells

Sun, Q., Xiao, L., Cui, Z., Yang, Y., Ma, J., Huang, Z., Zhang, J., & Chen, J. (2022) · Figshare · doi:10.6084/m9.figshare.20208254

Additional file 2 of 3,3′-Diindolylmethane improves antitumor immune responses of PD-1 blockade via inhibiting myeloid-derived suppressor cells

Sun, Q., Xiao, L., Cui, Z., Yang, Y., Ma, J., Huang, Z., Zhang, J., & Chen, J. (2022) · Figshare · doi:10.6084/m9.figshare.20208257

Breast cancer: JAK/STAT signaling dysregulation, potential proteomic techniques, therapeutic strategies, and future perspectives

Altaf, I., Jan, A., Ahmad, S. N., Mir, A. W., Thakur, N., & Mir, M. A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-23908-3.00001-0

Zinc transporters and cardiac pathophysiology

Cheng, X., Zhao, H., Zhang, Q., & Xu, Z. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.02.045

Etude comparative de la réponse immune innée à une souche porcine d'influenza de sous-type H3N2 et implication potentielle des protéïnes SOCS

Delgado-Ortega, M. (2014) · theses.fr (ABES) · doi:10.70675/2660560dzc8a8z4eadz9cecz6d056220ad06

Fonctions oncogéniques de STAT5 : rôle dans la régulation du métabolisme oxydatif

Bourgeais, J. (2015) · theses.fr (ABES) · doi:10.70675/642a7bdcz3eb5z47fcza4fez4dd048c937e2

Etudes de nouveaux paramètres environnementaux sur la plasticité des cellules souches embryonnaires murines (mESC)

Hammoud, A. A. (2015) · theses.fr (ABES) · doi:10.70675/69fcb3faz5934z4940zbfe4z6caed8b6b168

Coopération de la phosphoprotéine et de la protéine de matrice du virus de la rage dans la modulation des voies de signalisation Jak/Stat et NF-!B et développement d’une approche thérapeutique

Sonthonnax, F. (2017) · theses.fr (ABES) · doi:10.70675/93be8d4dzc4b9z4f85za9c0z8bfbda61e63a

Étude mécanistique de la fibrose interstitielle rénale et essai de preuve de concept thérapeutique

Gaillard, F. (2018) · theses.fr (ABES) · doi:10.70675/72e11c14zcc9fz4acdzbb83z2368f5351848

Les astrocytes réactifs, des partenaires anti-agrégants dans la maladie de Huntington : identification des mécanismes impliqués dans le dialogue neurone-astrocyte

Abjean, L. (2019) · theses.fr (ABES) · doi:10.70675/f664e003zf93fz467eza6a3z3d953eaffe4e

Effet pléiotrope de la mutation R96C dans le gène SOCS2 chez la brebis laitière

Oget, C. (2019) · theses.fr (ABES) · doi:10.70675/eb729d82z5b2fz44a4z8462z6fde7b3822db

Rôle des signalisations STAT3 et Hippo dans les gliomes : Identification de nouveaux biomarqueurs pronostiques et cibles thérapeutiques

Masliantsev, K. (2018) · theses.fr (ABES) · doi:10.70675/ade51a77zd032z4962z8279zcdcfd25488ae

Rôle chromatinien de SUMO dans l’immunité innée et ses implications dans l’immunothérapie des cancers

Morel, V. (2021) · theses.fr (ABES) · doi:10.70675/31e506dazce13z4d4cz8c40z9823077c170b

Multifaceted role of SUMOylation in maintaining centromere biology and regulation of replication fork restart in Schizosaccharomyces pombe

Chakraborty, S. (2024) · theses.fr (ABES) · doi:10.70675/f23c02c9z088bz4837z842fzce289b4be545

PDLIM4 promotes dephosphorylation of STAT transcription factors by recruiting PTP-BL and inhibits Th1, Th2, and Th17 cell differentiation

Jodo, A. I., Nakahira, M., Kochi, Y., Sugimoto-Ishige, A., Kaisho, T., & Tanaka, T. (2026) · International Immunology · doi:10.1093/intimm/dxag019

Targeting BCL9/BCL9L enhances CD4+ T cell-mediated Th1 antitumor immunity through activation of STAT1/STAT4 signaling

Zhu, Y.-Y., Li, A., Yang, F., Dong, Y.-X., Huang, Y.-S., Meng, X.-J., Zhang, D.-Z., Li, Y., Xian, Y., Zhu, D., et al. (2026) · Acta Pharmacologica Sinica · doi:10.1038/s41401-026-01845-2

Interleukin-11 Signaling in Liver Disease: Mechanisms, Cellular Crosstalk, and Therapeutic Potential

Chen, Z., Fan, Y., Qiu, Y., Lin, J., Yu, M., Yan, J., & Liu, X. (2026) · Biomolecules · doi:10.3390/biom16091309 · Cited by 1

Discovery of novel dual STAT3/TrxR1 inhibitors via pharmacophore fusion as potent lead compounds for colorectal cancer

Li, Y., Xu, R., Xie, X., Zhao, W., He, L., Zheng, T., Zhang, W., Sun, P., Xu, J., & Chen, X. (2026) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2026.130777

Cellular signaling meets bacterial infection: the integrative role of STAT3

McCoy, J. R., Weinstein, K. H., Warwick, P. A., & McBride, J. W. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1826683

BindingDB Entry 50015680: Discovery of a Highly Potent and Orally Bioavailable STAT3 Dual Phosphorylation Inhibitor for Pancreatic Cancer Treatment.

BindingDB (2023) · UC San Diego · doi:10.7270/q2rb78j1

BindingDB Entry 50018879: Design strategies, structure activity relationship and mechanistic insights for purines as kinase inhibitors.

BindingDB (2024) · UC San Diego · doi:10.7270/q21v5k7m

BindingDB Entry 50016597: Kinases as Potential Therapeutic Targets for Anti-coronaviral Therapy.

BindingDB (2023) · UC San Diego · doi:10.7270/q2rf601n

BindingDB Entry 50043924: A 2,6,9-hetero-trisubstituted purine inhibitor exhibits potent biological effects against multiple myeloma cells.

BindingDB (2014) · UC San Diego · doi:10.7270/q2125v53

Twist1 and Etv5 are part of a transcription factor network defining T helper cell identity

Pham, D. (2014) · doi:10.7912/c2/1727

Inhibition of the IL-6/STAT3 signaling pathway for therapeutic intervention in prostate carcinogenesis and cancer cell differentiation

Schröder, A., & Jove, R. (2013) · RWTH Publications (RWTH Aachen)

Der Beitrag der SH2-Domäne von STAT1 zur Regulation transkriptioneller Antworten im IFN-Gamma-abhängigen Signalweg

Zadeh, T. G. C. (2014) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-4775

PTPRT/D MUTATION OR PROMOTER METHYLATION: IMPLICATIONS FOR STAT3 INHIBITION

Peyser, N. D. (2015) · D-Scholarship@Pitt (University of Pittsburgh)

Biological Roles of the STAT Family in Cytokine Signaling

Takeda, K., & Akira, S. (2004) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-18932-6_4

The role of immunoproteasome subunit LMP7 in modulating T-helper cell differentiation and progression of autoimmune diseases

Kalim, K. W. (2013) · KOPS (University of Konstanz)

The Regulation of Vascular Wall Cells by a TLR Ligand and Gp130 Cytokines

Schnittker, D. L. K. (2012) · MacSphere (McMaster University) · doi:10.71548/16578

Cytokine resistance in melanoma

Komyod, W., & Behrmann, I. (2007) · RWTH Publications (RWTH Aachen)

The Senescent Cell Induced Bystander Effect

Wordsworth, J. (2014)

Rational Design of DNA Anticancer Agent That Targets Signal Transducer and Activator of Transcription 3 (Stat3) for Cancer Therapy

Jing, N. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0730-0_8

Estudos funcionais e estruturais da proteina reguladora humana Ki-1/57

Nery, F. C. (2005) · doi:10.47749/t/unicamp.2005.345721

Untitled work

Zujovic (2000) · doi:10.1002/(sici)1098-1136(20000215)29:4

Identifying a common molecular mechanism for inhibition of MITF and STAT3 by PIAS3

Levy, C., Lee, Y. N., Nechushtan, H., Schueler‐Furman, O., Sonnenblick, A., Hacohen, S., & Razin, E. (2005) · Blood · doi:10.1182/blood-2005-08-3325 · Cited by 36

The enigma of the role of Protein inhibitor of Activated STAT3 (PIAS3) in the immune response

Yagil, Z., Nechushtan, H., Kay, G., Yang, C. M., Kemeny, D. M., & Razin, E. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.01.005 · Cited by 52

PIAS

(2008) · Springer eBooks · doi:10.1007/978-3-540-47648-1_4566

Molecular interactions between STAT3 and protein inhibitor of activated STAT3, and androgen receptor

Yamamoto, T., Sato, N., Sekine, Y., Yumioka, T., Imoto, S., Junicho, A., Fuse, H., & Matsuda, T. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01026-x · Cited by 24

A New Role for the STAT3 Inhibitor, PIAS3

Levy, C., Nechushtan, H., & Razin, E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109236200 · Cited by 92