Specific Inhibition of Stat3 Signal Transduction by PIAS3

Positional cloning of the mouse obese gene and its human homologue

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Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

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Cytokine receptor signalling

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Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice.

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Structure and function of a new STAT-induced STAT inhibitor

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Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

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Signal Transducer and Activator of Transcription-3: A Molecular Hub for Signaling Pathways in Gliomas

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JAK/STAT signaling by cytokine receptors

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Anaplastic lymphoma kinase proteins in growth control and cancer

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The Role of Interleukin-6 in Nociception and Pain

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Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases

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Post-translational modification by the small ubiquitin-related modifier SUMO has big effects on transcription factor activity

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The regulation of JAKs in cytokine signaling and its breakdown in disease

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STAT3 as a therapeutic target in head and neck cancer

Leeman‐Neill, R. J., Lui, V. W. Y., & Grandis, J. R. (2006) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.6.3.231 · Cited by 225

Regulation of cytokine signaling pathways by PIAS proteins

Shuai, K. (2006) · Cell Research · doi:10.1038/sj.cr.7310027 · Cited by 228

Cytokine receptor signaling pathways

Leonard, W. J., & Lin, J. (2000) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2000.106899 · Cited by 221

Negative regulators of cytokine signal transduction

Hilton, D. J. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050396 · Cited by 221

GRIM‐19, a death‐regulatory gene product, suppresses Stat3 activity via functional interaction

Lufei, C., Ma, J., Huang, G., Zhang, T., Novotny‐Diermayr, V., Ong, C. T., & Cao, X. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg135 · Cited by 220

Regulation of Proliferation, Differentiation and Survival by the IL-3/IL-5/GM-CSF Receptor Family

de Groot, R. P., Coffer, P. J., & Koenderman, L. (1998) · Cellular Signalling · doi:10.1016/s0898-6568(98)00023-0 · Cited by 215

STAT3 is constitutively activated in Hodgkin cell lines

Kube, D., Holtick, U., Vockerodt, M., Ahmadi, T., Haier, B., Behrmann, I., Heinrich, P. C., Diehl, V., & Tesch, H. (2001) · Blood · doi:10.1182/blood.v98.3.762 · Cited by 218

PIAS1 and PIASxα Function as SUMO-E3 Ligases toward Androgen Receptor and Repress Androgen Receptor-dependent Transcription

Nishida, T., & Yasuda, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206741200 · Cited by 217

Amyloid-β causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons

Chiba, T., Yamada, M., Sasabe, J., Terashita, K., Shimoda, M., Matsuoka, M., & Aiso, S. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.105 · Cited by 194

A transcriptional corepressor of Stat1 with an essential LXXLL signature motif

Liu, B., Gross, M. E., ten Hoeve, J., & Shuai, K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051489598 · Cited by 207

Interleukins in Atherosclerosis: Molecular Pathways and Therapeutic Potential

von der Thüsen, J. H., Kuiper, J., van Berkel, T. J. C., & Biessen, E. A. L. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.1.5 · Cited by 212

The SH2 domain: versatile signaling module and pharmaceutical target

Kazuya, M., & Mayer, B. J. (2004) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2004.10.005 · Cited by 213

The Physiology of Cellular Liporegulation

Unger, R. H. (2003) · Annual Review of Physiology · doi:10.1146/annurev.physiol.65.092101.142622 · Cited by 208

JAK/STAT Pathway in Drosophila Immunity

Myllymäki, H., & Rämet, M. (2014) · Scandinavian Journal of Immunology · doi:10.1111/sji.12170 · Cited by 205

Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells

Li, F., Fernandez, P. P., Rajendran, P., Hui, K. M., & Sethi, G. (2010) · Cancer Letters · doi:10.1016/j.canlet.2009.12.003 · Cited by 207

DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex.

Niki, T., Takahashi-Niki, K., Taira, T., Iguchi‐Ariga, S. M. M., & Ariga, H. (2003) · PubMed · Cited by 197

Roles and Regulation of Stat Family Transcription Factors in Human Breast Cancer

Clevenger, C. V. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63403-7 · Cited by 199

Yeast Ull1/Siz1 Is a Novel SUMO1/Smt3 Ligase for Septin Components and Functions as an Adaptor between Conjugating Enzyme and Substrates

Takahashi, Y., Kahyo, T., Toh‐e, A., Yasuda, H., & Kikuchi, Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m109295200 · Cited by 193

Multiple transcription factor families regulate axon growth and regeneration

Moore, D. L., & Goldberg, J. L. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20934 · Cited by 195

microRNA-301a regulation of a T-helper 17 immune response controls autoimmune demyelination

Mycko, M. P., Cichalewska, M., Machlańska, A., Ćwiklińska, H., Mariasiewicz, M., & Selmaj, K. W. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114325109 · Cited by 190

Stats: Multifaceted Regulators of Transcription

Brierley, M. M., & Fish, E. N. (2005) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2005.25.733 · Cited by 197

STAT 3 the oncogene – still eluding therapy?

Wake, M., & Watson, C. J. (2015) · FEBS Journal · doi:10.1111/febs.13285 · Cited by 188

The Drosophila Su(var)2-10 locus regulates chromosome structure and function and encodes a member of the PIAS protein familyPreprint

Hari, K. L., Cook, K. R., & Karpen, G. H. (2001) · Genes & Development · doi:10.1101/gad.877901 · Cited by 187

The complex STATes of astrocyte reactivity: How are they controlled by the JAK-STAT3 pathway?

Ceyzériat, K., Abjean, L., Carrillo-de Sauvage, M.-A., Ben Haim, L., & Escartin, C. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.043 · Cited by 185

A Janus Kinase Inhibitor, JAB, Is an Interferon-γ–Inducible Gene and Confers Resistance to Interferons

Sakamoto, H., Yasukawa, H., Masuhara, M., Tanimura, S., Sasaki, A. T., Yuge, K., Ohtsubo, M., Ohtsuka, A., Fujita, T., Ohta, T., et al. (1998) · Blood · doi:10.1182/blood.v92.5.1668.417k09_1668_1676 · Cited by 177

Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway

Li, F., Rajendran, P., & Sethi, G. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00874.x · Cited by 176

ARIP3 (Androgen Receptor-Interacting Protein 3) and Other PIAS (Protein Inhibitor of Activated STAT) Proteins Differ in Their Ability to Modulate Steroid Receptor-Dependent Transcriptional Activation

Kotaja, N., Aittomäki, S., Silvennoinen, O., Palvimo, J. J., & Jänne, O. A. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.12.0569 · Cited by 175

SUMO Modification of STAT1 and Its Role in PIAS-mediated Inhibition of Gene Activation

Rogers, R. S., Horvath, C. M., & Matunis, M. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301344200 · Cited by 182

Dysregulation of JAK-STAT pathway in hematological malignancies and JAK inhibitors for clinical application

Furqan, M., Mukhi, N., Lee, B., & Liu, D. (2013) · Biomarker Research · doi:10.1186/2050-7771-1-5 · Cited by 178

Maintenance of cancer stemness by miR-196b-5p contributes to chemoresistance of colorectal cancer cells via activating STAT3 signaling pathway

Ren, D., Lin, B., Zhang, X., Peng, Y., Ye, Z., Ma, Y., Liang, Y., Cao, L., Li, X., Li, R., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.17971 · Cited by 173

The roles of the Drosophila JAK/STAT pathway

Zeidler, M. P., Bach, E. A., & Perrimon, N. (2000) · Oncogene · doi:10.1038/sj.onc.1203482 · Cited by 172

Lipocalin-2 Is a Chemokine Inducer in the Central Nervous System

Lee, S., Kim, J., Kim, J., Seo, J.-W., Han, H. S., Lee, W., Mori, K., Nakao, K., Barasch, J. M., & Suk, K. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.299248 · Cited by 175

Therapeutic uses of anti-interleukin-6 receptor antibody

Kang, S., Tanaka, T., & Kishimoto, T. (2014) · International Immunology · doi:10.1093/intimm/dxu081 · Cited by 174

Cellular Physiology of STAT3: Where's the Cytoplasmic Monomer?

Ndubuisi, M. I., Guo, G. G., Fried, V. A., Etlinger, J. D., & Sehgal, P. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.36.25499 · Cited by 173

SHP-2 Is a Dual-specificity Phosphatase Involved in Stat1 Dephosphorylation at Both Tyrosine and Serine Residues in Nuclei

Wu, T., Hong, Y. K., Wang, X., Ling, M. Y., Dragoi, A. M., Chung, A. S., Campbell, A. G., Han, Z.-Y., Feng, G., & Chin, Y. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207536200 · Cited by 170

Leukaemia inhibitory factor in implantation and uterine biology

Kimber, S. J. (2005) · Reproduction · doi:10.1530/rep.1.00304 · Cited by 167

The Transcriptional Repressor Gfi1 Affects Development of Early, Uncommitted c-Kit+ T Cell Progenitors and CD4/CD8 Lineage Decision in the Thymus

Yücel, R., Karsunky, H., Klein‐Hitpaß, L., & Möröy, T. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021417 · Cited by 165

Stat1 as a Component of Tumor Necrosis Factor Alpha Receptor 1-TRADD Signaling Complex To Inhibit NF-κB Activation

Wang, Y., Wu, T., Cai, S., Welte, T., & Chin, Y. E. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.13.4505-4512.2000 · Cited by 167

Anti-androgen receptor ASC-J9 versus anti-androgens MDV3100 (Enzalutamide) or Casodex (Bicalutamide) leads to opposite effects on prostate cancer metastasis via differential modulation of macrophage infiltration and STAT3-CCL2 signaling

Lin, T., Izumi, K., Lee, S. O., Lin, W.-J., Yeh, S.-D., & Chang, C. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.270 · Cited by 166

The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3

Zhang, J., Yang, J., Roy, S. K., Tininini, S., Hu, J., Bromberg, J., Poli, V., Stark, G. R., & Kalvakolanu, D. V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1633516100 · Cited by 167

Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells

Gross, M. E., Liu, B., Tan, J.-A., French, F. S., Carey, M., & Shuai, K. (2001) · Oncogene · doi:10.1038/sj.onc.1204489 · Cited by 165

Signal transducer and activator of transcription (STAT) signalling and T‐cell lymphomas

Mitchell, T. J., & John, S. (2005) · Immunology · doi:10.1111/j.1365-2567.2005.02091.x · Cited by 172

Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel

Lee, J. H., Kim, C., Sethi, G., & Ahn, K. S. (2015) · Oncotarget · doi:10.18632/oncotarget.3443 · Cited by 162

The intranuclear prolactin/cyclophilin B complex as a transcriptional inducer

Rycyzyn, M. A., & Clevenger, C. V. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092160699 · Cited by 160

PIAS proteins promote SUMO-1 conjugation to STAT1

Ungureanu, D., Vanhatupa, S., Kotaja, N., Yang, J., Aittomäki, S., Jänne, O. A., Palvimo, J. J., & Silvennoinen, O. (2003) · Blood · doi:10.1182/blood-2002-12-3816 · Cited by 167

Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma

Tai, W., Cheng, A., Shiau, C., Huang, H., Huang, J., Chen, P., & Chen, K. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.01.047 · Cited by 158

Targeting STAT3 signaling pathway in cancer by agents derived from Mother Nature

Mohan, C. D., Rangappa, S., Preetham, H. D., Nayaka, S. C., Gupta, V. K., Basappa, B., Sethi, G., & Rangappa, K. S. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.03.016 · Cited by 162

Proinflammatory Stimuli Induce IKKα-Mediated Phosphorylation of PIAS1 to Restrict Inflammation and Immunity

Liu, B., Yang, Y., Chernishof, V., Loo, R. R. O., Jang, H., Tahk, S., Yang, R., Mink, S. R., Shultz, D. B., Bellone, C. J., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.056 · Cited by 156

STAT3 in cancer: A double edged sword

Avalle, L., Camporeale, A., Camperi, A., & Poli, V. (2017) · Cytokine · doi:10.1016/j.cyto.2017.03.018 · Cited by 160

Cardiac-specific Activation of Signal Transducer and Activator of Transcription 3 Promotes Vascular Formation in the Heart

Osugi, T., Oshima, Y., Fujio, Y., Funamoto, M., Yamashita, A., Negoro, S., Kunisada, K., Izumi, M., Nakaoka, Y., Hirota, H., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108246200 · Cited by 152

A Testis-specific Androgen Receptor Coregulator That Belongs to a Novel Family of Nuclear Proteins

Moilanen, A., Karvonen, U., Poukka, H., Yan, W., Toppari, J., Jänne, O. A., & Palvimo, J. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.6.3700 · Cited by 154

Neutropenia with impaired host defense against microbial infection in mice lacking androgen receptor

Chuang, K., Altuwaijri, S., Li, G., Lai, J., Chu, C., Lai, K., Lin, H., Hsu, J., Keng, P., Wu, M., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082521 · Cited by 160

STAT‐1: a novel regulator of apoptosis

Stephanou, A., & Latchman, D. S. (2003) · International Journal of Experimental Pathology · doi:10.1111/j.0959-9673.2003.00363.x · Cited by 152

Signaling by STATs.

Ivashkiv, L. B., & Hu, X. (2004) · Arthritis Research · doi:10.1186/ar1197 · Cited by 160

Functional Interaction of STAT3 Transcription Factor with the Cell Cycle Inhibitor p21 WAF1/CIP1/SDI1 *

Coqueret, O., & Gascan, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001601200 · Cited by 169

Suppressors of Cytokine Signaling (SOCS): Inhibitors of the JAK/STAT Pathway

Cooney, R. N. (2002) · Shock · doi:10.1097/00024382-200202000-00001 · Cited by 153

Opposing actions of STAT-1 and STAT-3

Stephanou, A., & Latchman, D. S. (2005) · Growth Factors · doi:10.1080/08977190500178745 · Cited by 154

Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring

Mirabella, F., Desiato, G., Mancinelli, S., Fossati, G., Rasile, M., Morini, R., Markicevic, M., Grimm, C., Amegandjin, C. A., Termanini, A., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.10.006 · Cited by 152

Negative Regulation of NF-κB Signaling by PIAS1

Liu, B., Yang, R., Wong, K. A., Getman, C., Stein, N., Teitell, M. A., Cheng, G., Wu, H., & Shuai, K. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.3.1113-1123.2005 · Cited by 150

Immunoproteasome Subunit LMP7 Deficiency and Inhibition Suppresses Th1 and Th17 but Enhances Regulatory T Cell Differentiation

Kalim, K. W., Basler, M., Kirk, C. J., & Groettrup, M. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201183 · Cited by 153

PIAS proteins as regulators of small ubiquitin-related modifier (SUMO) modifications and transcription

Palvimo, J. J. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351405 · Cited by 146

IFN-α Induces the Human IL-10 Gene by Recruiting Both IFN Regulatory Factor 1 and Stat3

Ziegler-Heitbrock, L., Lötzerich, M., Schaefer, A. E., Werner, T., Frankenberger, M., & Benkhart, E. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.1.285 · Cited by 146

Tissue-Specific Autoregulation of the stat3 Gene and Its Role in Interleukin-6-Induced Survival Signals in T Cells

Narimatsu, M., Maeda, H., Itoh, S., Atsumi, T., Ohtani, T., Nishida, K., Itoh, M., Kamimura, D., Park, S., Mizuno, K., et al. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.19.6615-6625.2001 · Cited by 145

PIAS proteins and transcriptional regulation—more than just SUMO E3 ligases?Preprint

Sharrocks, A. D. (2006) · Genes & Development · doi:10.1101/gad.1421006 · Cited by 145

STATs as critical mediators of signal transduction and transcription: lessons learned from STAT5

Paukku, K., & Silvennoinen, O. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2004.09.001 · Cited by 147

The role of the interleukin‐6 family of cytokines in inflammatory arthritis and bone turnover

Wong, P. K. K., Campbell, I. K., Egan, P. J., Ernst, M., & Wicks, I. P. (2003) · Arthritis & Rheumatism · doi:10.1002/art.10943 · Cited by 139

JAB/SOCS1/SSI-1 is an interleukin-2–induced inhibitor of IL-2 signaling

Spörri, B., Kovanen, P. E., Sasaki, A. T., Yoshimura, A., & Leonard, W. J. (2001) · Blood · doi:10.1182/blood.v97.1.221 · Cited by 140

Curcumin suppresses constitutive activation of STAT‐3 by up‐regulating protein inhibitor of activated STAT‐3 (PIAS‐3) in ovarian and endometrial cancer cells

Saydmohammed, M., Joseph, D., & Syed, V. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22558 · Cited by 142

Phosphorylation of Signal Transducer and Activator of Transcription-3 (Stat3) after Focal Cerebral Ischemia in Rats

Suzuki, S., Tanaka, K., Nogawa, S., Dembo, T., Kosakai, A., & Fukuuchi, Y. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7701 · Cited by 136

A Sensitized Genetic Screen to Identify Novel Regulators and Components of the Drosophila Janus Kinase/Signal Transducer and Activator of Transcription Pathway

Bach, E. A., Vincent, S., Zeidler, M. P., & Perrimon, N. (2003) · Genetics · doi:10.1093/genetics/165.3.1149 · Cited by 141

ERK and PI3K negatively regulate STAT-transcriptional activities in human melanoma cells: implications towards sensitization to apoptosis

Ma, K., Ivanov, V. N., Dong, J., & Ronai, Z. A. (2003) · Oncogene · doi:10.1038/sj.onc.1206598 · Cited by 132

The use of antibodies against the IL-2 receptor in transplantation

Waldmann, T. A., & O’Shea, J. J. (1998) · Current Opinion in Immunology · doi:10.1016/s0952-7915(98)80215-x · Cited by 135

The Role and Therapeutic Targeting of JAK/STAT Signaling in Glioblastoma

Ou, A. C., Ott, M., Fang, D., & Heimberger, A. B. (2021) · Cancers · doi:10.3390/cancers13030437 · Cited by 132

A Drosophila PIAS homologue negatively regulates stat92E

Betz, A., Lampen, N., Martinek, S., Young, M. W., & Darnell, J. E., Jr. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171302098 · Cited by 132

STAT3 mediates IL-6-induced growth inhibition in the human prostate cancer cell line LNCaP

Spiotto, M. T., & Chung, T. D. (2000) · The Prostate · doi:10.1002/(sici)1097-0045(20000201)42:2 · Cited by 133

γ‐Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro‐apoptotic and chemosensitizing agent

Rajendran, P., Li, F., Manu, K. A., Shanmugam, M. K., Loo, S. Y., Kumar, A. P., & Sethi, G. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01187.x · Cited by 131

Regulation of granulopoiesis by transcription factors and cytokine signals

Ward, A. C., Loeb, D., Soede-Bobok, A. A., Touw, I., & Friedman, A. (2000) · Leukemia · doi:10.1038/sj.leu.2401808 · Cited by 134

PIASx Is a Transcriptional Co-repressor of Signal Transducer and Activator of Transcription 4

Arora, T., Liu, B., He, H., Kim, J. J., Murphy, T. L., MURPHY, K. M. M., Modlin, R. L., & Shuai, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300119200 · Cited by 139

hZimp10 is an androgen receptor co‐activator and forms a complex with SUMO‐1 at replication foci

Sharma, M., Li, X., Wang, Y., Zarnegar, M. A., Huang, C., Palvimo, J. J., Lim, B., & Sun, Z. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg585 · Cited by 129

Cytokines and STAT Signaling

Schindler, C., & Strehlow, I. (1999) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60111-8 · Cited by 130

Cross-talk between KLF4 and STAT3 regulates axon regeneration

Qin, S., Zou, Y., & Zhang, C. (2013) · Nature Communications · doi:10.1038/ncomms3633 · Cited by 132

The zinc finger protein Gfi‐1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3

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