Specific Inhibition of Stat3 Signal Transduction by PIAS3

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Cytokine receptor signalling

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Structure and function of a new STAT-induced STAT inhibitor

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Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

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Sumoylation Delimits KLF8 Transcriptional Activity Associated with the Cell Cycle Regulation

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Altered expression and activation of signal transducers and activators of transcription (STATs) in hepatitis C virus infection: in vivo and in vitro studies

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Protein-tyrosine Phosphatase PTPεC Inhibits Jak-STAT Signaling and Differentiation Induced by Interleukin-6 and Leukemia Inhibitory Factor in M1 Leukemia Cells

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Therapeutic Implication of SOCS1 Modulation in the Treatment of Autoimmunity and Cancer

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STAT transcription factors in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention

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The novel PIAS-like protein hZimp10 is a transcriptional co-activator of the p53 tumor suppressor

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The SUMO‐E3 ligase PIAS3 targets pyruvate kinase M2

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JAK/STAT signalling pathway in colorectal cancer: A new biological target with therapeutic implications

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SOCS1, SOCS3, and PIAS1 Promote Myogenic Differentiation by Inhibiting the Leukemia Inhibitory Factor-Induced JAK1/STAT1/STAT3 Pathway

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Regulation of Signal Transducer and Activator of Transcription and Suppressor of Cytokine-Signaling Gene Expression in the Brain of Mice with Astrocyte-Targeted Production of Interleukin-12 or Experimental Autoimmune Encephalomyelitis

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Repression of IL-4-Induced Gene Expression by IFN-γ Requires Stat1 Activation

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Loss and Dysregulation of Th17 Cells during HIV Infection

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PIASx Is a MEF2 SUMO E3 Ligase That Promotes Postsynaptic Dendritic Morphogenesis

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Hypoxia Inactivates the VHL Tumor Suppressor through PIASy-Mediated SUMO Modification

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Clinical Implications of Apoptosis in Ischemic Myocardium

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Modification of GATA-2 Transcriptional Activity in Endothelial Cells by the SUMO E3 Ligase PIASy

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Bruton’s tyrosine kinase (BTK) as a dual-function regulator of apoptosis

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Innate Immunity in Pluripotent Human Cells

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Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors

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Morin inhibits STAT3 tyrosine 705 phosphorylation in tumor cells through activation of protein tyrosine phosphatase SHP1

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Stat5B Shuttles Between Cytoplasm and Nucleus in a Cytokine-Dependent and -Independent Manner

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The Novel PIAS-like Protein hZimp10 Enhances Smad Transcriptional Activity

Li, X., Thyssen, G. N., Beliakoff, J., & Sun, Z. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508365200 · Cited by 75

Suppressors of cytokine signaling: Relevance to gastrointestinal function and disease

Greenhalgh, C. J., Miller, M. E., Hilton, D. J., & Lund, P. K. (2002) · Gastroenterology · doi:10.1053/gast.2002.37068 · Cited by 75

Targeting oncogenic transcription factors: therapeutic implications of endogenous STAT inhibitors

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Analysis of the Life Cycle of Stat6

Andrews, R. P., Ericksen, M. B., Cunningham, C. M., Daines, M., & Hershey, G. K. K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200986200 · Cited by 76

Nucleus, mitochondrion, or reticulum? STAT3 à La Carte

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Differentiation-Dependent Prolactin Responsiveness and Stat (Signal Transducers and Activators of Transcription) Signaling in Rat Ovarian Cells

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The Inhibition of Interleukin-6-dependent STAT Activation by Mitogen-activated Protein Kinases Depends on Tyrosine 759 in the Cytoplasmic Tail of Glycoprotein 130

Terstegen, L., Gatsios, P., Bode, J. G., Schaper, F., Heinrich, P. C., & Graeve, L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m904148199 · Cited by 73

PIASx acts as an Elk‐1 coactivator by facilitating derepression

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Tumor necrosis factor α attenuates interferon‐α signaling in the liver: involvement of SOCS3 and SHP2 and implication in resistance to interferon therapy

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STAT3 silencing inhibits glioma single cell infiltration and tumor growth

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Inhibition of Interleukin 2 Signaling and Signal Transducer and Activator of Transcription (Stat)5 Activation during T Cell Receptor–Mediated Feedback Inhibition of T Cell Expansion

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Hepatitis C virus core protein exerts an inhibitory effect on suppressor of cytokine signaling (SOCS)-1 gene expression

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Janus kinases and their role in growth and disease

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Cross-Talk between Signal Transducer and Activator of Transcription 3 and Androgen Receptor Signaling in Prostate Carcinoma Cells

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STAT Signaling in Glioma Cells

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The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling

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Role of the JAK-STAT Pathway in Bovine Mastitis and Milk Production

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IL-6: From Laboratory to Bedside

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Regulation of Signal Transducer and Activator of Transcription Signaling by the Tyrosine Phosphatase PTP-BL

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Kinases as Potential Therapeutic Targets for Anti-coronaviral Therapy

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Identification of Novel miR-21 Target Proteins in Multiple Myeloma Cells by Quantitative Proteomics

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Design strategies, structure activity relationship and mechanistic insights for purines as kinase inhibitors

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Regulation of expression of the rat SOCS‐3 gene in hepatocytes by growth hormone, interleukin‐6 and glucocorticoids

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UBC9 deficiency enhances immunostimulatory macrophage activation and subsequent antitumor T cell response in prostate cancer

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Interleukin-6 and new strategies for the treatment of cancer, hyperproliferative diseases and paraneoplastic syndromes

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Regulation of SOCS-1 Expression by Translational Repression

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LIF signal in mouse embryonic stem cells

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STAT3 activation in response to growth factors or cytokines participates in retina precursor proliferation

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FAM64A positively regulates STAT3 activity to promote Th17 differentiation and colitis-associated carcinogenesis

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Epstein–Barr virus-encoded miR-BART5-5p upregulates PD-L1 through PIAS3/pSTAT3 modulation, worsening clinical outcomes of PD-L1-positive gastric carcinomas

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STAT3 and metabolism: How many ways to use a single molecule?

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Role of miRNAs in CD4 T cell plasticity during inflammation and tolerance

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Methylation of STAT6 Modulates STAT6 Phosphorylation, Nuclear Translocation, and DNA-Binding Activity

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Crif1 is a novel transcriptional coactivator of STAT3

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Regulation of a lymphocyte–endothelial–IL-6 trans-signaling axis by fever-range thermal stress: Hot spot of immune surveillance

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Antiproliferative Mechanisms of a Transcription Factor Decoy Targeting Signal Transducer and Activator of Transcription (STAT) 3: The Role of STAT1

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Altered expression of prolactin receptor-associated signaling proteins in human breast carcinoma

McHale, K., Tomaszewski, J. E., Puthiyaveettil, R., LiVolsi, V. A., & Clevenger, C. V. (2008) · Modern Pathology · doi:10.1038/modpathol.2008.7 · Cited by 66

TRIM 8 regulates stemness in glioblastoma through PIAS 3‐ STAT 3

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STAT proteins: Signal tranducers and activators of transcription

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Increased K+ Efflux and Apoptosis Induced by the Potassium Channel Modulatory Protein KChAP/PIAS3β in Prostate Cancer Cells

Wible, B. A., Wang, L., Kuryshev, Y. A., Basu, A., Haldar, S., & Brown, A. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201689200 · Cited by 66

Identification of Critical Residues Required for Suppressor of Cytokine Signaling-specific Regulation of Interleukin-4 Signaling

Haque, S. J., Harbor, P. C., & Williams, B. R. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.34.26500 · Cited by 66

The role of prolactin in central nervous system inflammation

Ramos-Martínez, E. G., Ramos-Martínez, I. E., Molina-Salinas, G., Zepeda-Ruiz, W. A., & Cerbón, M. A. (2021) · Reviews in the Neurosciences · doi:10.1515/revneuro-2020-0082 · Cited by 68

ERp57 is present in STAT3–DNA complexes

Eufemi, M., Coppari, S., Fabio Altieri, F., Grillo, C., Ferraro, A., & Turano, C. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.09.009 · Cited by 64

New strategies for immunosuppression: interfering with cytokines by targeting the Jak/Stat pathway

O’Shea, J. J., Park, H., Pesu, M., Borie, D. C., & Changelian, P. S. (2005) · Current Opinion in Rheumatology · doi:10.1097/01.bor.0000160781.07174.db · Cited by 63

KChAP/Kvβ1.2 interactions and their effects on cardiac Kv channel expression

Kuryshev, Y. A., Wible, B. A., Gudz, T. I., Ramirez, A. N., & Brown, A. M. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.281.1.c290 · Cited by 65

PIASy-Mediated Sumoylation of SREBP1c Regulates Hepatic Lipid Metabolism upon Fasting Signaling

Lee, G. Y., Jang, H., Lee, J. H., Huh, J. Y., Choi, S., Chung, J., & Kim, J. B. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01166-13 · Cited by 66

Negative regulators of STAT3 signaling pathway in cancers

Wu, M., Song, D., Li, H. Z., Yang, Y., Ma, X., Deng, S., Ren, C., & Shu, X. H. (2019) · Cancer Management and Research · doi:10.2147/cmar.s206175 · Cited by 67

Turning off signal transducer and activator of transcription (STAT): The negative regulation of STAT signaling

Chen, W., Daines, M., & Hershey, G. K. K. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.06.042 · Cited by 66

Perspectives Regarding the Intersections between STAT3 and Oxidative Metabolism in Cancer

Chun, K., Jang, J., & Kim, D. (2020) · Cells · doi:10.3390/cells9102202 · Cited by 62

The Ubiquitin Ligase TRAF6 Negatively Regulates the JAK-STAT Signaling Pathway by Binding to STAT3 and Mediating Its Ubiquitination

Wei, J., Yuan, Y., Jin, C., Chen, H., Leng, L., He, F., & Wang, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049567 · Cited by 65

Malignant JAK-signaling: at the interface of inflammation and malignant transformation

Perner, F., Pahl, H. L., Zeiser, R., & Heidel, F. H. (2025) · Leukemia · doi:10.1038/s41375-025-02569-8 · Cited by 71

Cytokine signalling via gp130 in gastric cancer

Howlett, M., Menheniott, T. R., Judd, L. M., & Giraud, A. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2009.07.009 · Cited by 65

Nuclear Smad6 promotes gliomagenesis by negatively regulating PIAS3-mediated STAT3 inhibition

Jiao, J., Zhang, R., Li, Z., Yin, Y., Fang, X., Ding, X., Cai, Y., Yang, S., Mu, H., Zong, D., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04936-9 · Cited by 62

Androgen Receptor-interacting Protein 3 and Other PIAS Proteins Cooperate with Glucocorticoid Receptor-interacting Protein 1 in Steroid Receptor-dependent Signaling

Kotaja, N., Vihinen, M. K., Palvimo, J. J., & Jänne, O. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m106354200 · Cited by 62

Interleukin-7 (IL-7) and IL-7 receptor (IL-7R) signalling complex in human solid tumours.

Al-Rawi, M. A. A., Mansel, R. E., & Jiang, W. G. (2003) · PubMed · doi:10.14670/hh-18.911 · Cited by 61

Role of STAT3 in Genesis and Progression of Human Malignant Gliomas

Ouedraogo, Z. G., Biau, J., Kémény, J., Morel, L., Verrelle, P., & Chautard, E. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0103-0 · Cited by 63

TRIM59 Promotes Gliomagenesis by Inhibiting TC45 Dephosphorylation of STAT3

Sang, Y., Li, Y., Song, L., Alvarez, A. A., Zhang, W., Lv, D., Tang, J., Liu, F., Chang, Z., Hatakeyama, S., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-2774 · Cited by 60

Overexpression of PIAS3 Suppresses Cell Growth, Restores the Drug Sensitivity of Human Lung Cancer Cells in Association with PI3-K/Akt Inactivation

Ogata, Y., Osaki, T., Naka, T., Iwahori, K., Furukawa, M., Nagatomo, I., Kijima, T., Kumagai, T., Yoshida, M., Tachibana, I., et al. (2006) · Neoplasia · doi:10.1593/neo.06409 · Cited by 61

Signaling mechanisms of cytokine receptors and their perturbances in disease

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Genetic profiles of subcutaneous panniculitis-like T-cell lymphoma and clinicopathological impact of HAVCR2 mutations

Koh, J., Jang, I., Mun, S., Lee, C., Cha, H. J., Oh, Y., Kim, J., Han, J. H., Paik, J. H., Cho, J., et al. (2021) · Blood Advances · doi:10.1182/bloodadvances.2021004562 · Cited by 59

A STAT inhibitor patent review: progress since 2011

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Adiponectin inhibits leptin-induced oncogenic signalling in oesophageal cancer cells by activation of PTP1B

Beales, I., García‐Morales, C., Ogunwobi, O. O., & Mutungi, G. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.08.013 · Cited by 58

Nuclear localization of pyruvate dehydrogenase complex-E2 (PDC-E2), a mitochondrial enzyme, and its role in signal transducer and activator of transcription 5 (STAT5)-dependent gene transcription

Chueh, F., Leong, K.-F., Cronk, R. J., Venkitachalam, S., Pabich, S., & Yu, C. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.03.004 · Cited by 58

Analysis of the expression of mir-34a, mir-199a, mir-30c and mir-19a in peripheral blood CD4+T lymphocytes of relapsing-remitting multiple sclerosis patients

Ghadiri, N., Emamnia, N., Ganjalıkhani-Hakemi, M., Ghaedi, K., Etemadifar, M., Salehi, M., Shirzad, H., & Nasr‐Esfahani, M. H. (2018) · Gene · doi:10.1016/j.gene.2018.03.035 · Cited by 56

Protein Inhibitor of Activated STAT 1 (PIAS1) Is Identified as the SUMO E3 Ligase of CCAAT/Enhancer-Binding Protein β (C/EBPβ) during Adipogenesis

Liu, Y., Zhang, Y.-D., Guo, L., Huang, H.-Y., Zhu, H., Huang, J.-X., Liu, Y., Zhou, S.-R., Dang, Y., Li, X., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00723-13 · Cited by 59

Protein Inhibitor of Activated STAT 3 Modulates Osteoclastogenesis by Down-Regulation of NFATc1 and Osteoclast-Associated Receptor

Kim, K., Lee, J., Kim, J. H., Jin, H. M., Zhou, B., Lee, S. Y., & Kim, N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.9.5588 · Cited by 57

STAT3 Regulates the Type I IFN-Mediated Antiviral Response by Interfering with the Nuclear Entry of STAT1

Wang, H., Yuan, M., Wang, S., Zhang, L., Zhang, R., Zou, X., Wang, X., Chen, D., & Wu, Z. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194870 · Cited by 56

Grb2 regulates Stat3 activation negatively in epidermal growth factor signalling

Zhang, T., Ma, J., & Cao, X. (2003) · Biochemical Journal · doi:10.1042/bj20030668 · Cited by 56

The GRIMs: a new interface between cell death regulation and interferon/retinoid induced growth suppression

Kalvakolanu, D. V. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2004.01.002 · Cited by 56

Signal transducers and activators of transcription—from cytokine signalling to cancer biology

Santos, C. I., & Costa‐Pereira, A. P. (2011) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2011.03.003 · Cited by 59

Role of STAT3 in Transformation and Drug Resistance in CML

Nair, R. R., Tolentino, J. H. G., & Hazlehurst, L. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00030 · Cited by 57

hZimp7, a Novel PIAS-Like Protein, Enhances Androgen Receptor-Mediated Transcription and Interacts with SWI/SNF-Like BAF Complexes

Huang, C., Beliakoff, J., Li, X., Lee, J., Li, X., Sharma, M., Lim, B., & Sun, Z. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0097 · Cited by 55

PTP1B Suppresses Prolactin Activation of Stat5 in Breast Cancer Cells

Johnson, K. J., Peck, A. R., Liu, C., Tran, T. H., Utama, F. E., Sjolund, A. B., Schaber, J. D., Witkiewicz, A. K., & Rui, H. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090399 · Cited by 55

STAT3 in tissue fibrosis: Is there a role in the lung?

Knight, D. A., Mutsaers, S. E., & Prêle, C. M. (2010) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2010.10.005 · Cited by 55

ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3

Nojiri, S., Joh, T., Miura, Y., Sakata, N., Nomura, T., Nakao, H., Sobue, S., Ohara, H., Asai, K., & Itō, M. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.12.054 · Cited by 56

Interaction of Moloney Murine Leukemia Virus Capsid with Ubc9 and PIASy Mediates SUMO-1 Addition Required Early in Infection

Yueh, A., Leung, J., Bhattacharyya, S., Perrone, L. A., Santos, K. D. L., Pu, S., & Goff, S. P. (2005) · Journal of Virology · doi:10.1128/jvi.80.1.342-352.2006 · Cited by 55

Stress-induced Inactivation of the c-Myb Transcription Factor through Conjugation of SUMO-2/3 Proteins

Šramko, M., Markus, J., Kabát, J., Wolff, L., & Bies, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m609404200 · Cited by 56

TheDrosophilatrithorax group genetonalli(tna) interacts genetically with the Brahma remodeling complex and encodes an SP-RING finger protein

Gutiérrez, L., Zurita, M., Kennison, J. A., & Vâzquez, M. (2002) · Development · doi:10.1242/dev.00222 · Cited by 55

Reverse MAPPIT: screening for protein-protein interaction modifiers in mammalian cells

Eyckerman, S., Lemmens, I. H., Catteeuw, D., Verhee, A., Vandekerckhove, J. S., Lievens, S., & Tavernier, J. H. (2005) · Nature Methods · doi:10.1038/nmeth760 · Cited by 55

Identifying a common molecular mechanism for inhibition of MITF and STAT3 by PIAS3

Levy, C., Lee, Y. N., Nechushtan, H., Schueler‐Furman, O., Sonnenblick, A., Hacohen, S., & Razin, E. (2005) · Blood · doi:10.1182/blood-2005-08-3325 · Cited by 36

The enigma of the role of Protein inhibitor of Activated STAT3 (PIAS3) in the immune response

Yagil, Z., Nechushtan, H., Kay, G., Yang, C. M., Kemeny, D. M., & Razin, E. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.01.005 · Cited by 52

PIAS

(2008) · Springer eBooks · doi:10.1007/978-3-540-47648-1_4566

Molecular interactions between STAT3 and protein inhibitor of activated STAT3, and androgen receptor

Yamamoto, T., Sato, N., Sekine, Y., Yumioka, T., Imoto, S., Junicho, A., Fuse, H., & Matsuda, T. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01026-x · Cited by 24

A New Role for the STAT3 Inhibitor, PIAS3

Levy, C., Nechushtan, H., & Razin, E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109236200 · Cited by 92