Specific Inhibition of Stat3 Signal Transduction by PIAS3

Positional cloning of the mouse obese gene and its human homologue

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Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080

Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6

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Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

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TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

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Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

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Cytokine receptor signalling

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Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice.

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Structure and function of a new STAT-induced STAT inhibitor

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Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

Akira, S., Nishio, Y., Inoue, M., Wang, X.-J., We, S., Matsusaka, T., Yoshida, K., Sudo, T., Naruto, M., & Kishimoto, T. (1994) · Cell · doi:10.1016/0092-8674(94)90235-6 · Cited by 1,019

Emerging role of signal transducer and activator of transcription 3 (STAT3) in pituitary adenomas

Liu, C., Nakano-Tateno, T., Satou, M., Chik, C. L., & Tateno, T. (2021) · Endocrine Journal · doi:10.1507/endocrj.ej21-0106 · Cited by 12

Adenovirus E1B-55K controls SUMO-dependent degradation of antiviral cellular restriction factors

Ip, W.-H., Tatham, M. H., Krohne, S., Gruhne, J., Melling, M., Meyer, T., Gornott, B., Bertzbach, L. D., Hay, R. T., Rodríguez, E., et al. (2023) · Journal of Virology · doi:10.1128/jvi.00791-23 · Cited by 12

Investigating the Potential Therapeutic Targeting of the JAK-STAT Pathway in Cerebrovascular Diseases: Opportunities and Challenges

Wu, J., Wang, B., Shen, L.-P., Chen, Y.-L., Du, Z., Du, S., Lu, X.-J., & Zhao, X. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04834-4 · Cited by 11

Screening of Stat3 inhibitory effects of Korean herbal medicines in the A549 human lung cancer cell line

Park, J.-S., Bang, O., & Kim, J. (2013) · Integrative Medicine Research · doi:10.1016/j.imr.2013.10.004 · Cited by 12

Augmenter of liver regeneration (ALR) exhibits a dual signaling impact on hepatic acute-phase response

Dayoub, R., Buerger, L., Ibrahim, S., Melter, M., & Weiß, T. S. (2017) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2017.05.011 · Cited by 12

Modulation of STAT3 phosphorylation by PTPN2 inhibits naïve pluripotency of embryonic stem cells

Zhang, Y., Ding, H., Wang, X., & Ye, S. (2018) · FEBS Letters · doi:10.1002/1873-3468.13112 · Cited by 13

The E3 SUMO ligase PIASγ is a novel interaction partner regulating the activity of diabetes associated hepatocyte nuclear factor-1α

Kaci, A., Keindl, M., Solheim, M. H., Njølstad, P. R., Bjørkhaug, L., & Aukrust, I. (2018) · Scientific Reports · doi:10.1038/s41598-018-29448-w · Cited by 12

The Negative Regulation of JAK/STAT Signaling

Murphy, J. M., Tannahill, G. M., Hilton, D. J., & Greenhalgh, C. J. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00064-4 · Cited by 12

The RING domain of PIASy is involved in the suppression of bone morphogenetic protein-signaling pathway

Imoto, S., Sugiyama, K., Yamamoto, T., & Matsuda, T. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.04.161 · Cited by 12

LFA-1 co-stimulation inhibits Th2 differentiation by down-modulating IL-4 responsiveness

Jenks, S. A. (2005) · International Immunology · doi:10.1093/intimm/dxh211 · Cited by 12

Cytokine signal transduction in P19 embryonal carcinoma cells: regulation of Stat3-mediated transactivation occurs independently of p21ras-Erk signaling.

van Puijenbroek, A. V., van der Saag, P. T., & Coffer, P. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4576 · Cited by 15

Jak2 Tyrosine Kinase: A Mediator of Both Housekeeping and Ligand-Dependent Gene Expression?

Wallace, T. A., & Sayeski, P. P. (2006) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:44:2:213 · Cited by 12

Regulation Of Rod Photoreceptor Differentiation By STAT3 Is Controlled By A Tyrosine Phosphatase

Pinzon-Guzman, C., Xing, T.-S., Zhang, S. S., & Barnstable, C. (2014) · Journal of Molecular Neuroscience · doi:10.1007/s12031-014-0397-1 · Cited by 14

Interplay between epigenetic and genetic alterations in inborn errors of immunity

Rodríguez‐Ubreva, J., Calvillo, C. L., Satter, L. F., & Ballestar, E. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.09.005 · Cited by 11

In vitro evaluation of the biological effect of SOFAT on osteoblasts

Napimoga, M. H., Demasi, A. P. D., Jarry, C. R., Ortega, M. C., de Araújo, V. C., & Martinez, E. F. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.04.033 · Cited by 11

Protein Inhibitors of Activated STAT (Pias1 and Piasy) Differentially Regulate Pituitary Homeobox 2 (PITX2) Transcriptional Activity

Wang, J., Sun, Z. Q., Zhang, Z., Saadi, I., Wang, J., Li, X., Gao, S., Engle, J. J., Kuburas, A., Fu, X., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.374561 · Cited by 11

Expression of JAKs/STATs pathway molecules in rat model of rapid focal segmental glomerulosclerosis

Liang, Y., Yu, J. H., & Yu-ning, L. (2009) · Pediatric Nephrology · doi:10.1007/s00467-009-1163-4 · Cited by 12

Determination of SUMO1 and ATP affinity for the SUMO E1by quantitative FRET technology

Wiryawan, H., Dan, K., Etuale, M., Shen, Y., & Liao, J. (2014) · Biotechnology and Bioengineering · doi:10.1002/bit.25480 · Cited by 11

Interaction of protein inhibitor of activated STAT 2 (PIAS2) with receptor of activated C kinase 1, RACK1

Zheng, Y., Zhang, L., Jia, X., Wang, H., & Hu, Y. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.12.013 · Cited by 11

A functional SUMO-motif in the active site of PIM1 promotes its degradation via RNF4, and stimulates protein kinase activity

Iyer, R. S., Chatham, L. R., Sleigh, R., & Meek, D. W. (2017) · Scientific Reports · doi:10.1038/s41598-017-03775-w · Cited by 11

Increased expression of mir-301a in PBMCs of patients with relapsing-remitting multiple sclerosis is associated with reduced NKRF and PIAS3 expression levels and disease activity

Tavakolpour, V., Shokri, G., Moghadasi, A. N., Nahavandi, P. M., Hashemi, M., & Kouhkan, F. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.10.002 · Cited by 11

Suppressors of Cytokine Signaling and Protein Inhibitors of Activated Signal Transducer and Activator of Transcriptions As Therapeutic Targets in Flavivirus Infections

Yakass, M. B., Franco, D., & Quaye, O. (2019) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2019.0097 · Cited by 11

DNA Binding Activity of Cytoplasmic Phosphorylated Stat6 Is Masked by an Interaction with a Detergent-sensitive Factor

Daines, M., Andrews, R. P., Chen, W., El-Zayaty, S. A., & Hershey, G. K. K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301094200 · Cited by 11

PIASγ expression in relation to clinicopathological, tumour factors and survival in indigenous black breast cancer women

Agboola, A., Musa, A. A., Banjo, A. A. F., Ayoade, B., Deji-Agboola, A. M., Nolan, C. C., Rakha, E. A., Ellis, I. O., & Green, A. R. (2013) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2013-201658 · Cited by 11

PIAS1 Negatively Regulates Ubiquitination of Msx1 Homeoprotein Independent of Its SUMO Ligase Activity

Song, Y. J., & Lee, H. (2011) · Molecules and Cells · doi:10.1007/s10059-011-1020-8 · Cited by 11

STAT and SMAD signaling in cancer.

Iwamoto, T., Oshima, K., Seng, T. J., Feng, X., Oo, M. L., Hamaguchi, M., & Matsuda, S. (2002) · PubMed · doi:10.14670/hh-17.887 · Cited by 11

STAT module can function as a biphasic amplitude filter

Mayya, V., & Loew, L. M. (2005) · Systems Biology · doi:10.1049/sb:20045037 · Cited by 11

The PIAS Protein Family and TC-PTP

Liu, B., & Shuai, K. (2003) · Springer eBooks · doi:10.1007/978-94-017-3000-6_6 · Cited by 10

Tomosyn Interacts with the SUMO E3 Ligase PIASγ

Geerts, C. J., Jacobsen, L., van de Bospoort, R., Verhage, M., & Groffen, A. J. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091697 · Cited by 10

Site-specific SUMOylation of viral polymerase processivity factor: a way of localizingtoND10 subnuclear domains for restricted and self-controlled reproduction of herpesvirus

Lai, S., Xu, M., Wang, Y., Li, R., Xia, C., Xia, S., & Chen, J. (2021) · Virulence · doi:10.1080/21505594.2021.2000689 · Cited by 10

The Role of Jak/STAT Pathways in Osteoclast Differentiation

Lee, Y., & Kim, H. H. (2011) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2011.19.2.141 · Cited by 10

SC‐1, a sorafenib derivative, shows anti‐tumor effects in osteogenic sarcoma cells

Wang, C., Lin, C., Shiau, C., Chu, P., Hsiao, C.-C., Chiang, Y.-L., Tai, W., & Chen, K. (2012) · Journal of Orthopaedic Research® · doi:10.1002/jor.22218 · Cited by 10

SHD1 is a novel cytokine-inducible, negative feedback regulator of STAT5-dependent transcription

Nakajima, H., Tamura, T., Ito, M., Shibata, F., Kuroda, K., Fukuchi, Y., Watanabe, N., Kitamura, T., Ikeda, Y., & Handa, M. (2008) · Blood · doi:10.1182/blood-2008-01-133405 · Cited by 10

Interruption of nuclear localization of ATBF1 during the histopathologic progression of head and neck squamous cell carcinoma

Sun, X., Li, J., Sica, G., Fan, S., Wang, Y., Chen, Z., Müller, S., Chen, Z., Fu, X., Dong, X., et al. (2012) · Head & Neck · doi:10.1002/hed.23077 · Cited by 10

A 2,6,9-hetero-trisubstituted purine inhibitor exhibits potent biological effects against multiple myeloma cells

Shahani, V. M., Ball, D. P., Ramos, A. V., Li, Z., Spagnuolo, P. A., Haftchenary, S., Schimmer, A. D., Trudel, S., & Gunning, P. T. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.04.080 · Cited by 10

Anti-inflammatory effect of insulin in the human hepatoma cell line HepG2 involves decreased transcription of IL-6 target genes and nuclear exclusion of FOXO1

Wallerstedt, E., Sandqvist, M., Smith, U., & Andersson, C. X. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-0738-0 · Cited by 11

STAT3 Protein–Protein Interaction Analysis Finds P300 as a Regulator of STAT3 and Histone 3 Lysine 27 Acetylation in Pericytes

Kundu, G., Ghasemi, M., Yim, S., Rohil, A., Xin, C., Ren, L. B., Srivastava, S., Akinfolarin, A. A., Kumar, S., Srivastava, G. P., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12092102 · Cited by 9

STAT signaling in the pathogenesis and therapy of acute myeloid leukemia and myelodysplastic syndromes

King, Z., Desai, S. R., Frank, D. A., & Shastri, A. (2025) · Neoplasia · doi:10.1016/j.neo.2025.101137 · Cited by 11

Identification of STAT3-independent regulatory effects for protein inhibitor of activated STAT3 by binding to novel transcription factors

Dabir, S., Kluge, A., Aziz, M. A., Houghton, J. A., & Dowlati, A. (2011) · Cancer Biology & Therapy · doi:10.4161/cbt.12.2.15732 · Cited by 9

Ubiquitously expressed transcript is a novel interacting protein of protein inhibitor of activated signal transducer and activator of transcription 2

KONG, X., Ma, S., Guo, J., Ma, Y., Hu, Y., Wang, J., & Zheng, Y. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.3023 · Cited by 9

Protein Inhibitor of Activated STAT Y (PIASy) Regulates Insulin Secretion by Interacting with LIM Homeodomain Transcription Factor Isl1

Yan, C., Yu, C., Zhang, D., Cui, Y., Zhou, J., & Cui, S. (2016) · Scientific Reports · doi:10.1038/srep39308 · Cited by 9

In and out: Traffic and dynamics of thrombopoietin receptor

Roy, A., Shrivastva, S., & Naseer, S. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16878 · Cited by 9

Transcriptional Activity of Erythroid Kruppel-like Factor (EKLF/KLF1) Modulated by PIAS3 (Protein Inhibitor of Activated STAT3)

Siatecka, M., Soni, S., Planutis, A., & Bieker, J. J. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.610246 · Cited by 9

Immune deficiency vs. immune excess in inflammatory bowel diseases—STAT3 as a rheo-STAT of intestinal homeostasis

Leppkes, M., Neurath, M. F., i, M. H., & Becker, C. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.5mr0515-221r · Cited by 10

Thrombocytopenia Absent Radius (TAR)-Syndrome: From Current Genetics to Patient Self-Empowerment

Strauß, G., Mott, K., Klopocki, E., & Schulze, H. (2023) · Hämostaseologie · doi:10.1055/a-2088-1801 · Cited by 8

3-Formylchromone inhibits proliferation and induces apoptosis of multiple myeloma cells by abrogating STAT3 signaling through the induction of PIAS3

Ko, J., Baek, S. H., Nam, D., Chung, W., Lee, S., Lee, J., Yang, W. M., Um, J., & Ahn, K. S. (2016) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2016.1203928 · Cited by 8

Expression Analysis of Protein Inhibitor of Activated STAT in Inflammatory Demyelinating Polyradiculoneuropathy

Ghafouri‐Fard, S., Hussen, B. M., Nicknafs, F., Nazer, N., Sayad, A., & Taheri, M. N. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.659038 · Cited by 8

The converging path of protein SUMOylation in phytohormone signalling: highlights and new frontiers

Srivastava, M., Verma, V. C., & Srivastava, A. K. (2021) · Plant Cell Reports · doi:10.1007/s00299-021-02732-2 · Cited by 8

Inhibition of STAT3 signaling as critical molecular event in HUC-MSCs suppressed Glioblastoma Cells

Wang, M., Zhang, Y., Liu, M., Jia, Y., He, J., Xu, X., Shi, H., Zhang, Y., Zhang, J., & Liu, Y. (2023) · Journal of Cancer · doi:10.7150/jca.77905 · Cited by 8

STAT5 activity in pancreatic β-cells

Dalgaard, L. T., Billestrup, N., & Nielsen, J. H. (2008) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.3.4.423 · Cited by 9

A Meta-Analysis of the Effects of Interleukin-6 −174 G>C Genetic Polymorphism on Acute Graft-Versus-Host Disease Susceptibility

Choi, B., Lee, D.-E., Park, H. Y., Jeong, S., Lee, S., Ji, E., Park, S., & Oh, J. M. (2012) · Clinical Therapeutics · doi:10.1016/j.clinthera.2012.01.010 · Cited by 8

Correlative analyses of the expression levels of PIAS3, p-SHP2, SOCS1 and SOCS3 with STAT3 activation in human astrocytomas

Liu, L., Li, H., Cheng, X., Kong, Q., Chen, X.-Y., Wu, M., Li, Y., Liu, J., & Li, C. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.6079 · Cited by 8

Transcription Factor Activation in Human Neutrophils

Cloutier, A., & McDonald, P. P. (2003) · KARGER eBooks · doi:10.1159/000071553 · Cited by 11

Proinflammatory Stem Cell Signaling in Cardiac Ischemia

Herrmann, J. L., Markel, T. A., Abarbanell, A. M., Weil, B. R., Wang, M., Wang, Y., Tan, J., & Meldrum, D. R. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2434 · Cited by 8

Novel Interaction Between Nuclear Coactivator CBP and the Protein Inhibitor of Activated Stat1 (PIAS1)

Yin, X., Warner, D. R., Roberts, E. A., Pisano, M. M., & Greene, R. M. (2005) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2005.25.321 · Cited by 8

La vía JAK-STAT de señalización intracelular y su repercusión en oncogénesis, inmunomodulación y desarrollo

Duarte, R., & Frank, D. (2000) · Medicina Clínica · doi:10.1016/s0025-7753(00)71252-8 · Cited by 7

Isolation and chromosomal assignment of a human gene encoding protein inhibitor of activated STAT3 (PIAS3)

Ueki, N., Seki, N., Yano, K., Saito, T., Masuho, Y., & Muramatsu, M. (1999) · Journal of Human Genetics · doi:10.1007/s100380050141 · Cited by 8

Termination and modulation of IL-6-type cytokine signaling.

Heinrich, P. C., Bode, J. G., Decker, M., Graeve, L., Martens, A. S., Müller-Newen, G., Pflanz, S., Schaper, F., & Schmitz, J. (2001) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4615-0685-0_20 · Cited by 10

PIAS3 acts as a zinc sensor under zinc deficiency and plays an important role in myocardial ischemia/reperfusion injury

Zhao, H., Liu, D., Sun, S., Yu, J., Bian, X., Cheng, X., Yang, Q., Yu, Y., & Xu, Z. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.05.025 · Cited by 7

Crosstalk between PKA and PIAS3 regulates cardiac Kv4 channel SUMOylation

Jansen, L. R., Welch, M. A., Plant, L. D., & Baro, D. J. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01795-4 · Cited by 7

SUMO1 modification of 0N4R-tau is regulated by PIASx, SENP1, SENP2, and TRIM11

Wada, H., Maruyama, T., & Niikura, T. (2024) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2024.101800 · Cited by 7

Role of STAT3 in Colorectal Cancer Development

Lakkim, V., Reddy, M. C., Prasad, D. V. R., & Lomada, D. (2017) · Springer eBooks · doi:10.1007/978-981-10-6728-0_19 · Cited by 8

Antimigratory effect of pyrazole derivatives through the induction of STAT1 phosphorylation in A549 cancer cells

Demir, Y. D. Ş., Özdemir, A., Özdemir, R. G., Cevher, S. C., Çalışkan, B., & Ark, M. (2021) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgab022 · Cited by 7

PIAS Factors from Rainbow Trout Control NF-κB- and STAT-Dependent Gene Expression

Sarais, F., Kummerow, S., Montero, R., Rebl, H., Köllner, B., Goldammer, T., Collet, B., & Rebl, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312815 · Cited by 7

Protein inhibitor of activated STAT3 (PIAS3) attenuates psoriasis and associated inflammation

Zhou, J., Bian, H., & Wu, N. (2023) · The Journal of Dermatology · doi:10.1111/1346-8138.16874 · Cited by 7

A systems approach identifies co-signaling molecules of early growth response 1 transcription factor in immobilization stress

Papanikolaou, N. A., Tillinger, A., Liu, X., Papavassiliou, A. G., & Sabban, E. L. (2014) · BMC Systems Biology · doi:10.1186/s12918-014-0100-8 · Cited by 7

Cellular, Molecular, and Biological Perspective of Polyphenols in Chemoprevention and Therapeutic Adjunct in Cancer

Banerjee, S., & Rajamani, P. (2013) · Springer eBooks · doi:10.1007/978-3-642-22144-6_72 · Cited by 7

Hepatitis B virus surface protein-induced hPIAS1 transcription requires TAL1, E47, MYOG, NFI, and MAPK signal pathways

Wang, H., Wu, D., Wang, X., Chen, G., Zhang, Y., Yan, W., Luo, X., Han, M., & Ning, Q. (2016) · Biological Chemistry · doi:10.1515/hsz-2015-0290 · Cited by 7

MEK is a negative regulator of Stat5b in PDGF‐stimulated cells

Valgeirsdóttir, S., Ruusala, A., & Heldin, C. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00459-7 · Cited by 7

Prime Time for the Drosophila JAK/STAT Pathway

Bach, E. A., & Perrimon, N. (2003) · Springer eBooks · doi:10.1007/978-94-017-3000-6_7 · Cited by 7

TNF deficiency dysregulates inflammatory cytokine production leading to lung pathology and death during respiratory poxvirus infectionPreprint

Kels, M. J. T., Ng, E., Rumaih, Z. A., Pandey, P., Ruuls, S. R., Körner, H., Newsome, T. P., Chaudhri, G., & Karupiah, G. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2019.12.22.883728 · Cited by 7

Towards a quantitative understanding of the MITF-PIAS3-STAT3 connection

Thingnes, J., Lavelle, T. J., Gjuvsland, A. B., Omholt, S. W., & Hovig, E. J. (2012) · BMC Systems Biology · doi:10.1186/1752-0509-6-11 · Cited by 6

Molecular mechanisms of versatile biological activity of interleukin-7

Slyvka, A., & Okunev, O. V. (2014) · Biopolymers and Cell · doi:10.7124/bc.0008b1 · Cited by 6

Complex regulation of orphan nuclear receptor Nur77 (Nr4a1) transcriptional activity by SUMO2 and PIASγ

Dodat, F., Cotnoir‐White, D., Dianati, E., Vallet, A., Mader, S., & Lévesque, D. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118908 · Cited by 6

Super-resolution study of PIAS SUMO E3-ligases in hippocampal and cortical neurons

Conz, A., Musi, C. A., Russo, L., Borsello, T., & Colnaghi, L. (2021) · European Journal of Histochemistry · doi:10.4081/ejh.2021.3241 · Cited by 6

Progress in basic and clinical research on molecular targeted therapy for primary hepatic carcinoma

Li, J., Yang, Z., & Huang, Z.-S. (2019) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v27.i10.643 · Cited by 6

Generation of a Quantitative Luciferase Reporter for Sox9 SUMOylation

Saotome, H., Ito, A., Kubo, A., & Inui, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041274 · Cited by 6

cDNA cloning and expression pattern analysis of protein inhibitor of activated STAT (PIAS) of the mud crab, Scylla paramamosain

Huang, A. M., Geng, Y., Fang, W. H., Wang, K., Chen, D. F., Huang, X., Ou, Y., Chen, Z. L., & Lai, W. (2015) · Aquaculture · doi:10.1016/j.aquaculture.2015.03.023 · Cited by 6

Evidence for a functional link between Dd-STATa and Dd-PIAS, a Dictyostelium PIAS homologue

Kawata, T., Hirano, T., Ogasawara, S., Aoshima, R., & Yachi, A. (2011) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2011.01296.x · Cited by 6

Unraveling the critical role of SUMOylation in the governing of tumor immunity

Liu, X., Ding, W., Jiang, L., Chen, Q., & Luo, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1654167 · Cited by 5

Upregulation of tumor suppressor PIAS3 by Honokiol promotes tumor cell apoptosis via selective inhibition of STAT3 tyrosine 705 phosphorylation

Fei, Y., Zhang, X., Wang, X., Sun, Y., He, J. W., Liu, X., Song, Z., Qiu, L., Qiu, L., Qian, Z., et al. (2023) · Journal of Natural Medicines · doi:10.1007/s11418-023-01757-z · Cited by 5

Identification of Pold2 as a novel interaction partner of protein inhibitor of activated STAT2

Zheng, Y., Sheng, S., Wang, H., Jia, X., Hu, Y., Qian, Y., Zhu, Y., & Wang, J. (2012) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2012.1065 · Cited by 5

Grass carp (Ctenopharyngodon idellus) PIAS1 inhibits innate immune response via interacting with STAT1

Lu, S., Peng, X., Zeng, S., Deng, H., Feng, Z., Zeng, Q., Cheng, X., Hu, J., Ye, Z., Li, M., et al. (2021) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2021.104216 · Cited by 5

Disrupting PIAS3-mediated SUMOylation of MLK3 ameliorates poststroke neuronal damage and deficits in cognitive and sensorimotor behaviors

Jiang, Y., Hu, L., Wang, B., Zhang, B., Shao, M., Li, M., Xu, Y., Chen, R., Li, M., & Du, C. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05166-7 · Cited by 5

Effects of miR-214-5p and miR-21-5p in hypoxic endometrial epithelial-cell-derived exosomes on human umbilical cord mesenchymal stem cells

Zhang, W., Wang, H.-B., & Deng, C. (2024) · World Journal of Stem Cells · doi:10.4252/wjsc.v16.i11.906 · Cited by 5

Oncogenic ALKF1174L drives tumorigenesis in cutaneous squamous cell carcinoma

Gualandi, M., Iorio, M. C., Engeler, O., Serra‐Roma, A., Gasparre, G., Schulte, J. H., Hohl, D., & Shakhova, O. (2020) · Life Science Alliance · doi:10.26508/lsa.201900601 · Cited by 5

The PINIT domain of PIAS3: structure‐function analysis of its interaction with STAT3

Mautsa, N., Prinsloo, E., Bishop, Ö. T., & Blatch, G. L. (2011) · Journal of Molecular Recognition · doi:10.1002/jmr.1111 · Cited by 5

The role played by key transcription factors in activated mast cells

Carmi-Levy, I., & Razin, E. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00508.x · Cited by 5

Progress in research on correlation among STAT3, CyclinD1, P21 genes and tumors

Xinhua, B., & Li, R. (2012) · Journal of Otology · doi:10.1016/s1672-2930(12)50005-x · Cited by 5

Crosstalk between signaling pathways of adrenoreceptors and signal transducers and activators of transcription 3 (STAT3) in heart

Gong, K., ZHANG, H., Du, J., & Zhang, Y. (2007) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2007.00525.x · Cited by 5

Les protéines de la famille CIS-SOCS : des modulateurs des effets biologiques des cytokines.

Gisselbrecht, S. (1999) · médecine/sciences · doi:10.4267/10608/1253 · Cited by 5

STAT3 in medulloblastoma: a key transcriptional regulator and potential therapeutic target

Zaiter, A., Audi, Z. F., Shawraba, F., Saker, Z., Bahmad, H. F., Nabha, R. H., Harati, H., & Nabha, S. M. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07694-6 · Cited by 6

Leptin in Teleost Fish

Vissers, M. E. P., Gorissen, M., Flik, G., & Huising, M. O. (2010) · Radboud Repository (Radboud University) · Cited by 4

Alcohol attenuates anti‐HCV function of IFN‐λ1 through up‐regulation of PLASy expression in human hepatic cells

Ran, M., Huang, J., Liang, H., Jiang, J., Liang, B., Ning, C., Zang, N., Liao, W., Liu, H., Qin, F., et al. (2018) · Journal of Medical Virology · doi:10.1002/jmv.25053 · Cited by 4

Human SUMOylation Pathway Is Critical for Influenza B Virus

Dang, R., Rodgers, V. G. J., García‐Sastre, A., & Liao, J. (2022) · Viruses · doi:10.3390/v14020314 · Cited by 6

Signaling Molecules Affecting Immune Response

Hertzog, P. J., Fenner, J. E., & Mansell, A. S. (2005) · Elsevier eBooks · doi:10.1016/b978-012455900-4/50267-1 · Cited by 4

Gene Activation by the Cytokine-Driven Transcription Factor STAT1

Nast, R., Staab, J., & Meyer, T. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.82699 · Cited by 4

Transcription Factors That Regulate Macrophage Development and Function

Hume, D., & Himes, S. R. (2003) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-55742-2_2 · Cited by 5

Molecular mechanisms of hormonal and hormonal-cytokine control of immune tolerance in pregnancy

Ширшев, С. В. (2015) · Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology · doi:10.1134/s1990747814050079 · Cited by 6

Emerging therapeutic targets in allergy: IL-4Rα and Stat6

Izuhara, K., Shirakawa, T., Adra, C. N., Hamasaki, N., & Hopkin, J. M. (1999) · Emerging Therapeutic Targets · doi:10.1517/14728222.3.3.381 · Cited by 4

Identifying a common molecular mechanism for inhibition of MITF and STAT3 by PIAS3

Levy, C., Lee, Y. N., Nechushtan, H., Schueler‐Furman, O., Sonnenblick, A., Hacohen, S., & Razin, E. (2005) · Blood · doi:10.1182/blood-2005-08-3325 · Cited by 36

The enigma of the role of Protein inhibitor of Activated STAT3 (PIAS3) in the immune response

Yagil, Z., Nechushtan, H., Kay, G., Yang, C. M., Kemeny, D. M., & Razin, E. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.01.005 · Cited by 52

PIAS

(2008) · Springer eBooks · doi:10.1007/978-3-540-47648-1_4566

Molecular interactions between STAT3 and protein inhibitor of activated STAT3, and androgen receptor

Yamamoto, T., Sato, N., Sekine, Y., Yumioka, T., Imoto, S., Junicho, A., Fuse, H., & Matsuda, T. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01026-x · Cited by 24

A New Role for the STAT3 Inhibitor, PIAS3

Levy, C., Nechushtan, H., & Razin, E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109236200 · Cited by 92