Specific Inhibition of Stat3 Signal Transduction by PIAS3

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NF-κB (p65) negatively regulates myocardin-induced cardiomyocyte hypertrophy through multiple mechanisms

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Development of a STAT3 reporter prostate cancer cell line for high throughput screening of STAT3 activators and inhibitors

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Cooperative interaction between protein inhibitor of activated signal transducer and activator of transcription‐3 with epidermal growth factor receptor blockade in lung cancer

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Spatial Interplay between PIASy and FIP200 in the Regulation of Signal Transduction and Transcriptional Activity

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Functional characterization of a protein inhibitor of activated STAT (PIAS) gene in Litopenaeus vannamei

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Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction

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Potentiation of Tbx5-mediated transactivation by SUMO conjugation and protein inhibitor of activated STAT 1 (PIAS1)

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Structure-Activity Relationship Analysis of Benzotriazine Analogues as HIV-1 Latency-Reversing Agents

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Heparin Synergistically Enhances Interleukin-11 Signaling through Up-regulation of the MAPK Pathway*

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Janus Tyrosine Kinases and Signal Transducers and Activators of Transcription Regulate Critical Functions of T Cells in Allograft Rejection and Transplantation Tolerance

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The Role of Signal Transducers and Activators of Transcription in T Inflammatory Bowel Diseases

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Protein–DNA Interactions in Interferon-γ Signaling

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Inhibition of JAK2/STAT3 and activation of caspase‑9/3 are involved in KYS05090S‑induced apoptosis in ovarian cancer cells

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Strawberry notch homolog 2 regulates the response to interleukin-6 in the central nervous system

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The role of miRNAs in T helper cell development, activation, fate decisions and tumor immunity

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Cyclosporin A inhibits hepatitis C virus replication and restores interferon‐alpha expression in hepatocytes

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Role of a LIF antagonist in LIF and OSM induced MMP-1, MMP-3, and TIMP-1 expression by primary articular chondrocytes

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MUC1 Expression Is Repressed by Protein Inhibitor of Activated Signal Transducer and Activator of Transcription-y

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Regulation of c-Met Expression in Rats with Acute Hepatic Failure

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Phosphorylation of signal transducer and activator of transcription 3 in soft tissue leiomyosarcoma is associated with a better prognosis

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Initiation and maintenance of CNTF–Jak/STAT signaling in neurons is blocked by protein tyrosine phosphatase inhibitors

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A peek at PIAS

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PIAS family in cancer: from basic mechanisms to clinical applications

Li, X., Rasul, A., Sharif, F., & Hassan, M. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1376633 · Cited by 19

Oncogenic STAT Transcription Factors as Targets for Cancer Therapy: Innovative Strategies and Clinical Translation

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PIAS3 expression in human gastric carcinoma and its adjacent non-tumor tissues

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Could Signal Transducer and Activator of Transcription 3 be a Therapeutic Target in Obesity-Related Gastrointestinal Malignancy?

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OsBP-73, a rice gene, encodes a novel DNA-binding protein with a SAP-like domain and its genetic interference by double-stranded RNA inhibits rice growth

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Expression and DNA-Binding Activity of Signal Transducer and Activator of Transcription 3 in Alcoholic Cirrhosis Compared to Normal Liver and Primary Biliary Cirrhosis in Humans

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FLI-1 Functionally Interacts with PIASxα, a Member of the PIAS E3 SUMO Ligase Family

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Hormonal levels of leptin, insulin, ghrelin, and neuropeptide Y in lean, overweight, and obese Saudi females

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Transcriptional crosstalk between nuclear receptors and cytokine signal transduction pathways in immunity.

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JAK-STAT signaling as an ARDS therapeutic target: Status and future trends

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PIAS3 suppresses acute graft- versus -host disease by modulating effector T and B cell subsets through inhibition of STAT3 activation

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Suppression of STAT3 NH2‐terminal domain chemosensitizes medulloblastoma cells by activation of protein inhibitor of activated STAT3 via de‐repression by microRNA‐21

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A positive feedback loop between miR‐181b and STAT 3 that affects Warburg effect in colon cancer via regulating PIAS 3 expression

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Target Virus or Target Ourselves for COVID-19 Drugs Discovery?―Lessons learned from anti-influenza virus therapies

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Lymphotropic Viruses: Chronic Inflammation and Induction of Cancers

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Interferon-γ

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Role of signal transducer and activator of transcription 3 in liver fibrosis progression in chronic hepatitis C-infected patients

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Role of STAT3 and NRF2 in Tumors: Potential Targets for Antitumor Therapy

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The Role of MicroRNAs in Pancreatitis Development and Progression

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Effect of suppressor of cytokine signaling on hepcidin production in hepatitis C virus replicon cells

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Prognostic value of protein inhibitor of activated STAT3 in breast cancer patients receiving hormone therapy

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Identification, biogenesis and function prediction of novel circRNA during the chicken ALV-J infection

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Loss of adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22

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PIASy inhibits LRH-1-dependent CYP11A1 expression by competing for SRC-1 binding

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Cloning and Analysis of a Murine PIAS Family Member, PIASγ, in Developing Skin and Neurons

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The research development of STAT3 in hepatic ischemia-reperfusion injury

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PIAS3 may represent a potential biomarker for diagnosis and therapeutic of human colorectal cancer

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Isoliquiritigenin attenuates MiR-21 expression via induction of PIAS3 in breast cancer cells

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The conserved ancient role of chordate PIAS as a multilevel repressor of the NF-κB pathway

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Post‐transcriptional regulation of PIAS 3 expression by miR‐18a in malignant mesothelioma

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SUMO Proteomics Analyses Identify Protein Inhibitor of Activated STAT-Mediated Regulatory Networks Involved in Cell Cycle and Cell Proliferation

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Enhancement of placenta growth factor expression by oncostatin M in human rheumatoid arthritis synovial fibroblasts

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Activation of STAT3 signaling in human stomach adenocarcinoma drug-resistant cell line and its relationship with expression of vascular endothelial growth factor

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QUIESCENCE OF CD34-NEGATIVE HAEMATOPOIETIC STEM CELLS IS MEDIATED BY DOWNREGULATION OF CYCLIN B AND NO STAT ACTIVATION

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Introduction: STATs as essential intracellular mediators of cytokine responses

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Not just another meeting: the coming of age of JAKs and STATs

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Hepatocyte Turnover in Chronic HCV-Induced Liver Injury and Cirrhosis

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STAT1: A many-sided transcription factor

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High-throughput virtual screening, identification and in vitro biological evaluation of novel inhibitors of signal transducer and activator of transcription 3

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PASD1 promotes STAT3 activity and tumor growth by inhibiting TC45-mediated dephosphorylation of STAT3 in the nucleus

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UBX Domain Protein 6 Positively Regulates JAK-STAT1/2 Signaling

Ketkar, H., Harrison, A. G., Graziano, V. R., Geng, T., Yang, L., Vella, A. T., & Wang, P. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.1901337 · Cited by 15

PIASy interacts with p73α and regulates cell cycle in HEK293 cells

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ECHS1 interacts with STAT3 and negatively regulates STAT3 signaling

Chang, Y., Wang, S., Wang, Y., Zhou, J., Li, W., Wang, N., Fang, D., Li, H., Li, A., Zhang, X., et al. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.02.005 · Cited by 15

Immunological Trigger of Mast Cells by Monomeric IgE: Effect on Microphthalmia Transcription Factor, STAT3 Network of Interactions

Sonnenblick, A., Levy, C., & Razin, E. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.3.1450 · Cited by 15

PIAS1 regulates CP2c localization and active promoter complex formation in erythroid cell-specific α-globin expression

Kang, H. C., Chae, J. H., Jeon, J., Kim, W. K., Ha, D. H., Shin, J. H., Kim, C. G., & Kim, C. G. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq286 · Cited by 15

A STAT3 of Addiction: Adipose Tissue, Adipocytokine Signalling and STAT3 as Mediators of Metabolic Remodelling in the Tumour Microenvironment

Kadye, R., Stoffels, M., Fanucci, S., Mbanxa, S., & Prinsloo, E. (2020) · Cells · doi:10.3390/cells9041043 · Cited by 15

Erythroblast Transformation by the Friend Spleen Focus-Forming Virus Is Associated with a Block in Erythropoietin-Induced STAT1 Phosphorylation and DNA Binding and Correlates with High Expression of the Hematopoietic Phosphatase SHP-1

Nishigaki, K., Hanson, C. A., Ohashi, T., Spadaccini, A., & Ruscetti, S. K. (2006) · Journal of Virology · doi:10.1128/jvi.02651-05 · Cited by 16

3,3′-Diindolylmethane improves antitumor immune responses of PD-1 blockade via inhibiting myeloid-derived suppressor cells

Sun, Q., Xiao, L., Cui, Z., Yang, Y.-P., Ma, J., Huang, Z., Zhang, J.-F., & Chen, J.-N. (2022) · Chinese Medicine · doi:10.1186/s13020-022-00638-z · Cited by 13

Expression of STAT5, COX-2 and PIAS3 in Correlation with NSCLC Histhopathological Features

Pastuszak‐Lewandoska, D., Domańska, D., Czarnecka, K. H., Kordiak, J., Migdalska‐Sęk, M., Nawrot, E., Kiszałkiewicz, J., Antczak, A. J., Górski, P., & Brzeziańska‐Lasota, E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104265 · Cited by 14

Dissecting multiple roles of SUMOylation in prostate cancer

Wang, Y., & Yu, J. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.08.034 · Cited by 14

Regulation of early Xenopus development by the PIAS genes

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Protein inhibitor of activated signal transducer and activator of transcription (STAT)-1 (PIAS-1) regulates the IFN-γ response in macrophage cell lines

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Mechanisms by Which Interleukin-6 Regulates Prostate-Specific Antigen Gene Expression in Prostate LNCaP Carcinoma Cells

Tsui, K., Lin, Y.-F., Chen, Y.-H., Chang, P. L., & Juang, H. (2010) · Journal of Andrology · doi:10.2164/jandrol.109.009878 · Cited by 14

Regulation of ALS-Associated SOD1 Mutant SUMOylation and Aggregation by SENP and PIAS Family Proteins

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Interplay of the SUMO and MAP Kinase Pathways

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Hydrophobic Residues Phe751 and Leu753Are Essential for STAT5 Transcriptional Activity

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Advances in cytokine signaling: the role of Jaks and STATs

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STAT3 promotes CD1d‐mediated lipid antigen presentation by regulating a critical gene in glycosphingolipid biosynthesis

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S ignal T ransducers and A ctivators of T ranscription: I nsights into the M olecular B asis of O ral C ancer

Siavash, H., Nikitakis, N. G., & Sauk, J. J. (2004) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130401500505 · Cited by 14

Interleukin-6 (IL-6)

Kishimoto, T. (2003) · Elsevier eBooks · doi:10.1016/b978-012689663-3/50016-8 · Cited by 14

Identification of a short PIASx gene promoter that directs male germ cell-specific transcription in vivo

Santti, H., Mikkonen, L., Hirvonen-Santti, S. J., Toppari, J., Jänne, O. A., & Palvimo, J. J. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01339-1 · Cited by 14

Natural bioactive compounds and STAT3 against hepatocellular carcinoma: An update

Manoharan, S., Saha, S., Murugesan, K., Santhakumar, A., & Perumal, E. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122351 · Cited by 14

Genome-Wide STAT3 Binding Analysis after Histone Deacetylase Inhibition Reveals Novel Target Genes in Dendritic Cells

Sun, Y., Iyer, M. K., McEachin, R. C., Zhao, M., Wu, Y.-M., Cao, X., Oravecz-Wilson, K. I., Zajac, C. K., Mathewson, N. D., Wu, S.-R. J., et al. (2016) · Journal of Innate Immunity · doi:10.1159/000450681 · Cited by 13

Identification of a Structural Motif in the Tumor-Suppressive Protein GRIM-19 Required for Its Antitumor Activity

Nallar, S. C., Kalakonda, S., Sun, P., Ohmori, Y., Hiroi, M., Mori, K., Lindner, D. J., & Kalvakolanu, D. V. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.091280 · Cited by 13

PIAS3 enhances the transcriptional activity of HIF-1α by increasing its protein stability

Nakagawa, K., Kohara, T., Uehata, Y., Miyakawa, Y., Sato‐Ueshima, M., Okubo, N., Asaka, M., Takeda, H., & Kobayashi, M. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.12.047 · Cited by 13

Inhibitory Mechanism of the Outer Membrane Growth of Chronic Subdural Hematomas

Osuka, K., Watanabe, Y., Usuda, N., Aoyama, M., Iwami, K., Takeuchi, M., Watabe, T., & Takayasu, M. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2016.4623 · Cited by 13

Approaching non-canonical STAT3 signaling to redefine cancer therapeutic strategy

Dimri, S., Sukanya, S., & De, A. (2017) · Integrative Molecular Medicine · doi:10.15761/imm.1000268 · Cited by 12

The Role of Adipokines in the Establishment and Progression of Head and Neck Neoplasms

Tzanavari, T., Tasoulas, J., Vakaki, C., Mihailidou, C., Tsourouflis, G. S., & Theocharis, S. E. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867325666180713154505 · Cited by 13

Expression and function of IL‐10R in mononuclear cells from patients with systemic lupus erythematosus

Pacheco, G. V., Layseca‐Espinosa, E., Niño-Moreno, P., Portales‐Pérez, D. P., Baranda, L., Rosenstein, Y., Abud‐Mendoza, C., & González‐Amaro, R. (2006) · Scandinavian Journal of Rheumatology · doi:10.1080/03009740600709840 · Cited by 13

Lineage-specific negative regulation of STAT-mediated signaling by proteolytic processing

Nakajima, H., Suzuki, K., & Iwamoto, I. (2003) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(03)00048-0 · Cited by 14

Evidence of balanced diversity at the chicken interleukin 4 receptor alpha chain locus

Downing, T., Lynn, D. J., Connell, S., Lloyd, A. T., Bhuiyan, A., Silva, P., Naqvi, A. N., Sanfo, R., Sow, R. S., Podisi, B., et al. (2009) · BMC Evolutionary Biology · doi:10.1186/1471-2148-9-136 · Cited by 13

B Cell–Activating Transcription Factor Plays a Critical Role in the Pathogenesis of Anti–Major Histocompatibility Complex–Induced Obliterative Airway Disease

Xu, Z., Ramachandran, S., Gunasekaran, M., Nayak, D. K., Benshoff, N. D., Hachem, R. R., Gelman, A. E., & Mohanakumar, T. (2016) · American Journal of Transplantation · doi:10.1111/ajt.13595 · Cited by 13

The role of interleukin-6 in intracellular signal transduction after chronic β-adrenergic stimulation in mouse myocardium

Dziemidowicz, M., Bonda, T. A., Литвинович, С. Н., Taranta, A., Winnicka, M. M., & Kamiński, K. A. (2019) · Archives of Medical Science · doi:10.5114/aoms.2019.89452 · Cited by 13

Identifying a common molecular mechanism for inhibition of MITF and STAT3 by PIAS3

Levy, C., Lee, Y. N., Nechushtan, H., Schueler‐Furman, O., Sonnenblick, A., Hacohen, S., & Razin, E. (2005) · Blood · doi:10.1182/blood-2005-08-3325 · Cited by 36

The enigma of the role of Protein inhibitor of Activated STAT3 (PIAS3) in the immune response

Yagil, Z., Nechushtan, H., Kay, G., Yang, C. M., Kemeny, D. M., & Razin, E. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.01.005 · Cited by 52

PIAS

(2008) · Springer eBooks · doi:10.1007/978-3-540-47648-1_4566

Molecular interactions between STAT3 and protein inhibitor of activated STAT3, and androgen receptor

Yamamoto, T., Sato, N., Sekine, Y., Yumioka, T., Imoto, S., Junicho, A., Fuse, H., & Matsuda, T. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01026-x · Cited by 24

A New Role for the STAT3 Inhibitor, PIAS3

Levy, C., Nechushtan, H., & Razin, E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109236200 · Cited by 92