Cited by 1,705Circadian rhythm and melatoninSleep and Work-Related FatigueSleep and Wakefulness Research

The DOI matches its Crossref record; 66 of the 67 references it cites were found in a registry or an index.

Stability, Precision, and Near-24-Hour Period of the Human Circadian Pacemaker

Czeisler, Charles A., Duffy, Jeanne F., Shanahan, Theresa L., Brown, Emery N., Mitchell, Jude F., Rimmer, David W., Ronda, Joseph M., Silva, Edward J., Allan, James S., Emens, Jonathan S., Dijk, Derk-Jan, Kronauer, Richard E.·1999·Science

DOI 10.1126/science.284.5423.2177

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Abstract

Regulation of circadian period in humans was thought to differ from that of other species, with the period of the activity rhythm reported to range from 13 to 65 hours (median 25.2 hours) and the period of the body temperature rhythm reported to average 25 hours in adulthood, and to shorten with age. However, those observations were based on studies of humans exposed to light levels sufficient to confound circadian period estimation. Precise estimation of the periods of the endogenous circadian rhythms of melatonin, core body temperature, and cortisol in healthy young and older individuals living in carefully controlled lighting conditions has now revealed that the intrinsic period of the human circadian pacemaker averages 24.18 hours in both age groups, with a tight distribution consistent with other species. These findings have important implications for understanding the pathophysiology of disrupted sleep in older people.

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Clock Mutants of Drosophila melanogaster
Konopka, R. J., & Benzer, S. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.9.2112 · Cited by 2,287
Role of the CLOCK Protein in the Mammalian Circadian Mechanism
Gekakis, N., Staknis, D., Nguyen, H. B., Davis, F. C., Wilsbacher, L. D., King, D. P., Takahashi, J. S., & Weitz, C. J. (1998) · Science · doi:10.1126/science.280.5369.1564 · Cited by 2,035
Mutagenesis and Mapping of a Mouse Gene, Clock , Essential for Circadian Behavior
Vitaterna, M. H., King, D. P., Chang, A.-M., Kornhauser, J. M., Lowrey, P. L., McDonald, J. D., Dove, W. F., Pinto, L. H., Turek, F. W., & Takahashi, J. S. (1994) · Science · doi:10.1126/science.8171325 · Cited by 1,632
Positional Cloning of the Mouse Circadian Gene
King, D. P., Zhao, Y., Sangoram, A. M., Wilsbacher, L. D., Tanaka, M., Antoch, M. P., Steeves, T. D. L., Vitaterna, M. H., Kornhauser, J. M., Lowrey, P. L., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80245-7 · Cited by 1,382
Sleep and Wakefulness
Kleitman, N., & Eckenhoff, J. E. (1964) · Anesthesiology · doi:10.1097/00000441-196502000-00024 · Cited by 1,131
Bright Light Induction of Strong (Type 0) Resetting of the Human Circadian Pacemaker
Czeisler, C. A., Kronauer, R. E., Allan, J. S., Duffy, J. F., Jewett, M. E., Brown, E. N., & Ronda, J. M. (1989) · Science · doi:10.1126/science.2734611 · Cited by 946
Human Sleep: Its Duration and Organization Depend on Its Circadian Phase
Czeisler, C. A., Weitzman, E. D., Moore-Ede, M. C., Zimmerman, J. C., & Knauer, R. S. (1980) · Science · doi:10.1126/science.7434029 · Cited by 903
Three period Homologs in Mammals: Differential Light Responses in the Suprachiasmatic Circadian Clock and Oscillating Transcripts Outside of Brain
Zylka, M. J., Shearman, L. P., Weaver, D. R., & Reppert, S. M. (1998) · Neuron · doi:10.1016/s0896-6273(00)80492-4 · Cited by 865
Closing the Circadian Loop: CLOCK-Induced Transcription of Its Own Inhibitors per and tim
Darlington, T. K., Wager‐Smith, K., Ceriani, M. F., Staknis, D., Gekakis, N., Steeves, T. D. L., Weitz, C. J., Takahashi, J. S., & Kay, S. A. (1998) · Science · doi:10.1126/science.280.5369.1599 · Cited by 826
Circadian oscillation of a mammalian homologue of the Drosophila period gene
Tei, H., Okamura, H., Shigeyoshi, Y., Fukuhara, C., Ozawa, R., Hirose, M., & Sakaki, Y. (1997) · Nature · doi:10.1038/39086 · Cited by 792

Show all 67 references

Research works printed but not linked: 24

Millar A. J., Carré I. A., Strayer C. A., Chua N.-H., Kay S. A., ibid. 267, 1161 (1995).
Pittendrigh C. S., Daan S., ibid. 186, 548 (1974);
W. C. Dement et al. in The Biology of Aging C. E. Finch and E. L. Schneider Eds. (Van Nostrand Reinhold New York 1985) pp. 692–717;
Campbell S. S., Dawson D., Zulley J., Sleep 16, 638 (1993).
Czeisler C. A., Allan J. S., Kronauer R. E., Sleep Res. 15, 266 (1986);
; in Sleep and Biological Rhythms: Basic Mechanisms and Applications to Psychiatry J. Montplaisir and R. Godbout Eds. (Oxford Univ. Press New York 1990) pp. 87–98.
Duffy J. F., Dijk D.-J., Klerman E. B., Czeisler C. A., Am. J. Physiol. 275, R1478 (1998);
Kronauer R. E., Fookson J. E., Strogatz S. H., Sleep Res. 15, 274 (1986).
Klerman E. B., Dijk D.-J., Kronauer R. E., Czeisler C. A., Am. J. Physiol. 270, R271 (1996).
Gander P. H., Kronauer R. E., Czeisler C. A., Moore-Ede M. C., Am. J. Physiol. 247, R427 (1984).
Shanahan T. L., Czeisler C. A., Sleep Res. 20A, 557 (1991);
; T. L. Shanahan thesis Harvard Medical School (1995).
Wyatt J. K., et al., Sleep Res. 26, 759 (1997);
Rimmer D. W., Dijk D. J., Wyatt J. K., Dinges D. F., Czeisler C. A., Med. Sci. Sports Exercise 30, 5 (1997).
Emens J. S., Brotman D. J., Czeisler C. A., Sleep Res. 23, 256 (1994);
C. A. Czeisler thesis Stanford University (1978).
Edgar D. M., Dement W. C., Am. J. Physiol. 261, R928 (1991) ;
Kronauer R. E., Czeisler C. A., Pilato S. F., Moore-Ede M. C., Am. J. Physiol. 242, R3 (1982);
Zulley J., Campbell S. S., Hum. Neurobiol. 4, 123 (1985);
Sack R. L., Lewy A. J., Blood M. L., Keith L. D., Nakagawa H., J. Clin. Endocrinol. Metab. 75, 127 (1992);
Lockley S. W., et al., J. Clin. Endocrinol. Metab. 82, 3763 (1997).
A. Eskin in Biochronometry M. Menaker Ed. (National Academy of Sciences Washington DC 1971) pp. 55–80.
Davis F. C., Viswanathan N., Am. J. Physiol. 275, R960 (1998);
; J. F. Duffy thesis Northeastern University (1998).

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Non-photic entrainment of human rest-activity cycle independent of circadian pacemaker
Hashimoto, S., Nakamura, K., Honma, S., & Honma, K. (2004) · Sleep and Biological Rhythms · doi:10.1111/j.1479-8425.2003.00078.x · Cited by 27
Circadian entrainment and its role in depression: a mechanistic review
Lall, G. S., Atkinson, L., Corlett, S. A., Broadbridge, P., & Bonsall, D. R. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-012-0858-z · Cited by 28
Diagnosis, Cause, and Treatment Approaches for Delayed Sleep-Wake Phase Disorder
Magee, M., Marbas, E. M., Wright, K. P., Rajaratnam, S. M. W., & Broussard, J. L. (2016) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2016.05.004 · Cited by 28
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Brito, L. C., Marin, T. C., Azevêdo, L. M., Rosa‐Silva, J. M., Shea, S. A., & Thosar, S. S. (2022) · Comprehensive physiology · doi:10.1002/cphy.c210036 · Cited by 45
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Diurnal fluctuations in musical preference
Heggli, O. A., Stupacher, J., & Vuust, P. (2021) · Royal Society Open Science · doi:10.1098/rsos.210885 · Cited by 27
Proof‐of‐principle demonstration of endogenous circadian system and circadian misalignment effects on human oral microbiota
Chellappa, S. L., Engen, P. A., Naqib, A. D., Qian, J., Vujovic, N., Rahman, N., Green, S. J., Garaulet, M., Keshavarzian, A., & Scheer, F. A. J. L. (2021) · The FASEB Journal · doi:10.1096/fj.202101153r · Cited by 28
Feeding and circadian clocks
Pardini, L., & Kaeffer, B. (2006) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:2006032 · Cited by 28
Circadian rhythms on hypothalamic–pituitary–adrenal axis hormones and cytokines of collagen induced arthritis in rats
Li, S., Lü, A., Li, B., & Wang, Y. (2004) · Journal of Autoimmunity · doi:10.1016/j.jaut.2004.03.001 · Cited by 27
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Keller, L. K., Zöschg, S., Grünewald, B., Roenneberg, T., & Schulte‐Körne, G. (2016) · Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie · doi:10.1024/1422-4917/a000406 · Cited by 27
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Lovato, N., Micic, G., Gradisar, M., Ferguson, S. A., Burgess, H. J., Kennaway, D. J., & Lack, L. C. (2016) · Chronobiology International · doi:10.1080/07420528.2016.1220386 · Cited by 27
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Hida, A., Ohsawa, Y., Kitamura, S., Nakazaki, K., Ayabe, N., Motomura, Y., Matsui, K., Kobayashi, M., Usui, A., Inoue, Y., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.75 · Cited by 27
Normative values for sleep parameters in pre-schoolers using actigraphy
Sahlberg, L., Lapinleimu, H., Elovainio, M. J., Rönnlund, H., & Virtanen, I. (2018) · Clinical Neurophysiology · doi:10.1016/j.clinph.2018.06.027 · Cited by 26
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Hou, D., He, S., Dai, C., Chen, S., Chen, H., & Lin, Y. (2021) · Building and Environment · doi:10.1016/j.buildenv.2021.107913 · Cited by 26
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Swope, C. B., Rong, S., Campanella, C., Vaicekonyte, R., Phillips, A. J. K., Cain, S. W., & McGlashan, E. M. (2023) · Chronobiology International · doi:10.1080/07420528.2023.2188091 · Cited by 31
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Sollars, P. J., Weiser, M. J., Kudwa, A. E., Bramley, J. R., Ogilvie, M. D., Spencer, R. L., Handa, R. J., & Pickard, G. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111944 · Cited by 26
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Authors: Czeisler, C. A., Duffy, J. F., Shanahan, T. L., Brown, E. N., Mitchell, J. F., Rimmer, D. W., Ronda, J. M., Silva, E. J., Allan, J. S., Emens, J. S., Dijk, D.-J., & Kronauer, R. E.
Affiliations: Brigham and Women's Hospital (US)
Harvard University (US)
Corresponding author: Czeisler, Charles A.
ORCID: Czeisler, Charles A.
Duffy, Jeanne F.
Brown, Emery N.
Mitchell, Jude F.
Ronda, Joseph M.
Allan, James S.
Emens, Jonathan S.
Dijk, Derk-Jan
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1999-06-25
Volume: 284
Issue: 5423
Pages: 2177-2181
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.284.5423.2177
OpenAlex: W2104605616
Cited by: 1,705
References: 67
Citations by year: 2026: 45 · 2025: 78 · 2024: 50 · 2023: 76 · 2022: 80 · 2021: 87 · 2020: 94 · 2019: 90 · 2018: 63 · 2017: 60 · 2016: 72 · 2015: 60 · 2014: 57 · 2013: 82 · 2012: 87
FWCI: 17.29
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Open Research (University of Surrey) (submittedVersion)
Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
Funders: National Institute on Aging (P01AG009975, P01 AG-09975)
National Institute of General Medical Sciences (R01-GM53559, R01GM053559)
National Center for Research Resources (M01RR002635, MO1 RR 02635)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords: circadian period, melatonin rhythm, cortisol rhythm, aging, endogenous rhythms
MeSH terms: Adult, Aged, Aging, Biological Clocks, Body Temperature, Circadian Rhythm, Darkness, Female, Humans, Hydrocortisone, Light, Male, Melatonin, Middle Aged, Sleep

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Stability, Precision, and Near-24-Hour Period of the Human Circadian Pacemaker

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