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Cited by 1,705Circadian rhythm and melatoninSleep and Work-Related FatigueSleep and Wakefulness Research

The DOI matches its Crossref record; 66 of the 67 references it cites were found in a registry or an index.

Stability, Precision, and Near-24-Hour Period of the Human Circadian Pacemaker

Czeisler, Charles A., Duffy, Jeanne F., Shanahan, Theresa L., Brown, Emery N., Mitchell, Jude F., Rimmer, David W., Ronda, Joseph M., Silva, Edward J., Allan, James S., Emens, Jonathan S., Dijk, Derk-Jan, Kronauer, Richard E.·1999·Science
DOI 10.1126/science.284.5423.2177
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Abstract

Regulation of circadian period in humans was thought to differ from that of other species, with the period of the activity rhythm reported to range from 13 to 65 hours (median 25.2 hours) and the period of the body temperature rhythm reported to average 25 hours in adulthood, and to shorten with age. However, those observations were based on studies of humans exposed to light levels sufficient to confound circadian period estimation. Precise estimation of the periods of the endogenous circadian rhythms of melatonin, core body temperature, and cortisol in healthy young and older individuals living in carefully controlled lighting conditions has now revealed that the intrinsic period of the human circadian pacemaker averages 24.18 hours in both age groups, with a tight distribution consistent with other species. These findings have important implications for understanding the pathophysiology of disrupted sleep in older people.

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Crossref · 10.1126/science.284.5423.2177

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66 of 66 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 24

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Metadata

Authors
Czeisler, C. A., Duffy, J. F., Shanahan, T. L., Brown, E. N., Mitchell, J. F., Rimmer, D. W., Ronda, J. M., Silva, E. J., Allan, J. S., Emens, J. S., Dijk, D.-J., & Kronauer, R. E.
Affiliations
  • Brigham and Women's Hospital (US)
  • Harvard University (US)
Corresponding author
Czeisler, Charles A.
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1999-06-25
Volume
284
Issue
5423
Pages
2177-2181
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.284.5423.2177
OpenAlex
W2104605616
Cited by
1,705
References
67
Citations by year
2026: 45 · 2025: 78 · 2024: 50 · 2023: 76 · 2022: 80 · 2021: 87 · 2020: 94 · 2019: 90 · 2018: 63 · 2017: 60 · 2016: 72 · 2015: 60 · 2014: 57 · 2013: 82 · 2012: 87
FWCI
17.29
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Open Research (University of Surrey) (submittedVersion)
  • Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
Funders
  • National Institute on Aging (P01AG009975, P01 AG-09975)
  • National Institute of General Medical Sciences (R01-GM53559, R01GM053559)
  • National Center for Research Resources (M01RR002635, MO1 RR 02635)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
circadian period, melatonin rhythm, cortisol rhythm, aging, endogenous rhythms
MeSH terms
Adult, Aged, Aging, Biological Clocks, Body Temperature, Circadian Rhythm, Darkness, Female, Humans, Hydrocortisone, Light, Male, Melatonin, Middle Aged, Sleep

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