The DOI matches its Crossref record.
Persistence of Memory CD8 T Cells in MHC Class I-Deficient Mice
Abstract
An understanding of how T cell memory is maintained is crucial for the rational design of vaccines. Memory T cells were shown to persist indefinitely in major histocompatibility complex (MHC) class I–deficient mice and retained the ability to make rapid cytokine responses upon reencounter with antigen. In addition, memory CD8 T cells, unlike naı̈ve cells, divided without MHC–T cell receptor interactions. This “homeostatic” proliferation is likely to be important in maintaining memory T cell numbers in the periphery. Thus, after naı̈ve CD8 T cells differentiate into memory cells, they evolve an MHC class I–independent “life-style” and do not require further stimulation with specific or cross-reactive antigen for their maintenance.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue
Masopust, D., Vezys, V., Marzo, A. L., & Lefrançois, L. (2001) · Science · doi:10.1126/science.1058867 · Cited by 1,952
Lineage relationship and protective immunity of memory CD8 T cell subsets
Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864
Self-citationmTOR regulates memory CD8 T-cell differentiation
Araki, K., Turner, A. P., Shaffer, V. O., Gangappa, S., Keller, S. A., Bachmann, M. F., Larsen, C. P., & Ahmed, R. (2009) · Nature · doi:10.1038/nature08155 · Cited by 1,575
Self-citationWnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells
Gattinoni, L., Zhong, X.-S., Palmer, D. C., Ji, Y., Hinrichs, C. S., Yu, Z., Wrzesinski, C., Boni, A., Cassard, L., Garvin, L. M., et al. (2009) · Nature Medicine · doi:10.1038/nm.1982 · Cited by 1,031
Human Effector and Memory CD8+ T Cell Responses to Smallpox and Yellow Fever Vaccines
Miller, J. D., van der Most, R. G., Akondy, R. S., Glidewell, J. T., Albott, S., Masopust, D., Murali-Krishna, K., Mahar, P. L., Edupuganti, S., Lalor, S., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.020 · Cited by 601
Self-citationHomann, D., Teyton, L., & Oldstone, M. B. A. (2001) · Nature Medicine · doi:10.1038/90950 · Cited by 587
CD8 + T‐cell memory in tumor immunology and immunotherapy
Klebanoff, C. A., Gattinoni, L., & Restifo, N. P. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00391.x · Cited by 511
S-2-hydroxyglutarate regulates CD8(+) T-lymphocyte fate
Tyrakis, P. A., Palazon, A., Macias, D., Lee, K. L., Phan, A. T., Veliça, P., You, J., Chia, G. S., Sim, J., Doedens, A., et al. (2016) · Nature · doi:10.1038/nature20165 · Cited by 433
Targeting MHC-I molecules for cancer: function, mechanism, and therapeutic prospects
Wu, X., Li, T., Jiang, R., Yang, X., Guo, H., & Yang, R. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01899-4 · Cited by 223
White, J. T., Cross, E. W., Burchill, M. A., Danhorn, T., McCarter, M. D., Rosen, H. R., O’Connor, B., & Kedl, R. M. (2016) · Nature Communications · doi:10.1038/ncomms11291 · Cited by 219
Tamburini, B. A., Burchill, M. A., & Kedl, R. M. (2014) · Nature Communications · doi:10.1038/ncomms4989 · Cited by 153
Direct measurement of T cell subset kinetics in vivo in elderly men and women
Wallace, D. L., Zhang, Y., Ghattas, H., Worth, A., Irvine, A., Bennett, A. R., Griffin, G. E., Beverley, P. C. L., Tough, D. F., & Macallan, D. C. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.3.1787 · Cited by 115
DOCK8 is essential for T‐cell survival and the maintenance of CD8+ T‐cell memory
Lambe, T., Crawford, G., Johnson, A. L., Crockford, T. L., Bouriez‐Jones, T., Smyth, A. M., Pham, T. H. M., Zhang, Q., Freeman, A. F., Cyster, J. G., et al. (2011) · European Journal of Immunology · doi:10.1002/eji.201141759 · Cited by 115
Masopust, D., Murali-Krishna, K., & Ahmed, R. (2007) · Journal of Virology · doi:10.1128/jvi.01459-06 · Cited by 114
Self-citationGrabert, R. C., Cousens, L. P., Smith, J. A., Olson, S., Gall, J., Young, W. B., Davol, P. A., & Lum, L. G. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2005 · Cited by 79
CXCR3 Identifies Human Naive CD8+ T Cells with Enhanced Effector Differentiation Potential
De Simone, G., Mazza, E. M. C., Cassotta, A., Davydov, A. N., Kuka, M., Zanon, V., De Paoli, F., Scamardella, E., Metsger, M., Roberto, A., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1901072 · Cited by 49
Wells, J. W., Cowled, C. J., Farzaneh, F., & Noble, A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.5.3422 · Cited by 53
van Leeuwen, E. M. M., Koning, J. J., Remmerswaal, E. B. M., van Baarle, D., van Lier, R. A. W., & ten Berge, I. J. M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.8.4998 · Cited by 50
Homeostasis and Durability of T-Cell Memory—The Resting and the Restless T-Cell Memory
Radbruch, A., McGrath, M. A., Siracusa, F., Hoffmann, U., Sercan-Alp, Ö., Hutloff, A., Tokoyoda, K., Chang, H.-D., & Dong, J. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a038083 · Cited by 16
Metadata
- Authors
- Murali-Krishna, K., Lau, L. L., Sambhara, S., Lemonnier, F., Altman, J., & Ahmed, R.
- Venue
- Science
- Published
- 1999-11-12
- Volume
- 286
- Issue
- 5443
- Pages
- 1377-1381
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2008366157
- Cited by
- 725
- References
- 0
- FWCI
- 20.08
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
