The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction
Abstract
To elucidate mechanisms that control and execute activity-dependent synaptic plasticity, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptors (AMPA-Rs) with an electrophysiological tag were expressed in rat hippocampal neurons. Long-term potentiation (LTP) or increased activity of the calcium/calmodulin-dependent protein kinase II (CaMKII) induced delivery of tagged AMPA-Rs into synapses. This effect was not diminished by mutating the CaMKII phosphorylation site on the GluR1 AMPA-R subunit, but was blocked by mutating a predicted PDZ domain interaction site. These results show that LTP and CaMKII activity drive AMPA-Rs to synapses by a mechanism that requires the association between GluR1 and a PDZ domain protein.
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“The prevailing model posits that LTP-mediated covalent modification of the intracellular CTD of GluA1 results in the capture of these modified GluA1-containing receptors by preexisting “slots” in the postsynaptic density (PSD) (17, 18, 212).”
From Synaptic memory and CaMKII (2023) · cites this paper as [212]
In the citing paper
“Earlier studies suggest that long-tailed AMPARs are recruited to synapses in an activity-dependent manner, while short-tailed AMPARs undergo constitutive cycling in and out of synapses (Shi et al., 2001, Hayashi et al., 2000).”
From The AMPA Receptor Code of Synaptic Plasticity (2018) · cites this paper as Hayashi et al., 2000
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Metadata
- Authors
- Hayashi, Y., Shi, S.-H., Esteban, J. A., Piccini, A., Poncer, J.-C., & Malinow, R.
- Affiliations
- Cold Spring Harbor Laboratory (US)
- Corresponding author
- Hayashi, Yasunori
- Shi, Song-Hai
- Poncer, Jean-Christophe
- Malinow, Roberto
- Venue
- Science
- Published
- 2000-03-24
- Volume
- 287
- Issue
- 5461
- Pages
- 2262-2267
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1979586675
- Cited by
- 1,524
- References
- 5
- Citations by year
- 2026: 17 · 2025: 24 · 2024: 31 · 2023: 26 · 2022: 30 · 2021: 54 · 2020: 35 · 2019: 47 · 2018: 61 · 2017: 45 · 2016: 49 · 2015: 54 · 2014: 83 · 2013: 68 · 2012: 70
- FWCI
- 31.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- AMPA receptors, GluR1, PDZ domain, CaMKII, long-term potentiation, synaptic plasticity, CaMKII phosphorylation, hippocampal neurons
- MeSH terms
- Animals, Cell Line, Hippocampus, Humans, Membrane Potentials, Mutation, Synaptic Transmission, Organ Culture Techniques, Phosphorylation, Proteins, Recombinant Fusion Proteins, Synapses, Protein Structure, Tertiary, Long-Term Potentiation, Calcium-Calmodulin-Dependent Protein Kinases, Pyramidal Cells, Receptors, AMPA, Patch-Clamp Techniques, Catalytic Domain, Rats, Calcium-Calmodulin-Dependent Protein Kinase Type 2
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