Cited by 56Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on BehaviorEating Disorders and Behaviors

Persistent effects of obesity: A neuroplasticity hypothesis

Open access
Matikainen‐Ankney, Bridget A., Kravitz, Alexxai V.·2018·Annals of the New York Academy of Sciences

Abstract

The obesity epidemic is a leading cause of health problems in the United States, increasing the risk of cardiovascular, endocrine, and psychiatric diseases. Although many people lose weight through changes in diet and lifestyle, keeping the weight off remains a challenge. Here, we discuss a hypothesis that seeks to explain why obesity is so persistent. There is a great degree of overlap in the circuits implicated in substance use disorder and obesity, and neural plasticity of these circuits in response to drugs of abuse is well documented. We hypothesize that obesity is also associated with neural plasticity in these circuits, and this may underlie persistent changes in behavior, energy balance, and body weight. Here, we discuss how obesity-associated reductions in motivation and physical activity may be rooted in neurophysiological alterations in these circuits. Such plasticity may alter how humans and animals use, expend, and store energy, even after weight loss.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/nyas.13665

Cites

246 of 246 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Matikainen‐Ankney, B. A., & Kravitz, A. V.
Affiliations
National Institutes of Health (US)
Corresponding author
Kravitz, Alexxai V.
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2018-05-09
Volume
1428
Issue
1
Pages
221-239
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
OpenAlex
W2799288713
Cited by
56
References
246
Citations by year
2026: 2 · 2025: 7 · 2024: 8 · 2023: 6 · 2022: 10 · 2021: 10 · 2020: 9 · 2019: 4
FWCI
0.80
Type
journal article
Language
en
Open access
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Keywords
obesity, neuroplasticity, energy balance, drug addiction, motivation, physical activity, weight loss, energy expenditure, energy storage, psychiatric comorbidity
MeSH terms
Analgesics, Opioid, Animals, Corpus Striatum, Dopamine, Energy Metabolism, Feeding Behavior, Glutamates, Humans, Hypothalamus, Inflammation, Motivation, Nerve Net, Neural Pathways, Neuronal Plasticity, Obesity, Receptors, Opioid, Recurrence, Weight Loss, Exercise, Comorbidity, Receptors, Dopamine D2, Ventral Tegmental Area, Substance-Related Disorders, Rats, Diet, High-Fat

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review