Intra-synapse-type and inter-synapse-type relationships between synaptic size and AMPAR expression

Fukazawa, Yugo; Shigemoto, Ryuichi

doi:10.1016/j.conb.2012.01.006

Cited by 38Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersNicotinic Acetylcholine Receptors Study

Intra-synapse-type and inter-synapse-type relationships between synaptic size and AMPAR expression

Fukazawa, Yugo, Shigemoto, Ryuichi·2012·Current Opinion in Neurobiology

DOI 10.1016/j.conb.2012.01.006

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Abstract

To gain insights into structure-function relationship of excitatory synapses, we revisit our quantitative analysis of synaptic AMPAR by highly sensitive freeze-fracture replica labeling in eight different connections. All of these connections showed linear correlation between synapse size and AMPAR number indicating a common intra-synapse-type relationship in CNS synapses. On the contrary, inter-synapse-type relationship is unexpected indicating no correlation between averages of synapse size and AMPAR number. Interestingly, connections with large average synapse size and low AMPAR density showed high variability of AMPAR number and mosaic distribution within the postsynaptic membrane. We propose an idea that these connections may quickly exhibit synaptic plasticity by modifying AMPAR density/number whereas those with high AMPAR density change their efficacy by modifying synapse size.

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The number of AMPARs at dendritic spine synapses is highly variable but averages roughly 50, and this number strongly correlates with the size of the PSD.
“The number of AMPARs at dendritic spine synapses is highly variable but averages roughly 50 (143, 438, 439), and this number strongly correlates with the size of the PSD.”
From Synaptic memory and CaMKII (2023) · cites this paper as [438]
The number of NMDARs at spine synapses and perhaps filopodia synapses is much less variable, averaging roughly 20, and this number is largely independent of PSD size.
“The number of NMDARs at spine synapses and perhaps filopodia synapses is much less variable, averaging roughly 20, and this number is largely independent of PSD size (143, 438, 439).”
From Synaptic memory and CaMKII (2023) · cites this paper as [438]

Structural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,500 · see citing works
Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study.
Eg, G. (1959) · PubMed · Cited by 1,768 · see citing works
Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons
Matsuzaki, M., Ellis-Davies, G. C. R., Nemoto, T., Miyashita, Y., Iino, M., & Kasai, H. (2001) · Nature Neuroscience · doi:10.1038/nn736 · Cited by 1,563 · cited 1× · see citing works
“This result is in accordance with theoretical predictions [15] and previous experiments showing the positive correlation of the AMPAR-mediated response at single spines with their volume in CA1 pyramidal cells [16] considering the positive correlation with PSD size and spine volume in these cells [17].”
Result
Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction
Hayashi, Y., Shi, S.-H., Esteban, J. A., Piccini, A., Poncer, J.-C., & Malinow, R. (2000) · Science · doi:10.1126/science.287.5461.2262 · Cited by 1,524 · see citing works
Rapid Spine Delivery and Redistribution of AMPA Receptors After Synaptic NMDA Receptor Activation
Shi, S.-H., Hayashi, Y., Petralia, R. S., Zaman, S. H., Wenthold, R. J., Svoboda, K., & Malinow, R. (1999) · Science · doi:10.1126/science.284.5421.1811 · Cited by 1,276 · see citing works
Evidence for silent synapses: Implications for the expression of LTP
Isaac, J. T. R., Nicoll, R. A., & Malenka, R. C. (1995) · Neuron · doi:10.1016/0896-6273(95)90046-2 · Cited by 1,233 · see citing works
Dendritic spines of CA 1 pyramidal cells in the rat hippocampus: serial electron microscopy with reference to their biophysical characteristics
Harris, K., & Stevens, J. (1989) · The Journal of Neuroscience · doi:10.1523/jneurosci.09-08-02982.1989 · Cited by 1,073 · see citing works
Quantitative ultrastructural analysis of hippocampal excitatory synapses
Schikorski, T., & Stevens, C. F. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-15-05858.1997 · Cited by 997 · see citing works
Cell Type and Pathway Dependence of Synaptic AMPA Receptor Number and Variability in the Hippocampus
Nusser, Z., Lujan, R., Laube, G., Roberts, J. D. B., Molnar, E., & Somogyi, P. (1998) · Neuron · doi:10.1016/s0896-6273(00)80565-6 · Cited by 804 · see citing works
Different modes of expression of AMPA and NMDA receptors in hippocampal synapses
Takumi, Y., Ramírez-León, V., Laake, P., Rinvik, E., & Ottersen, O. P. (1999) · Nature Neuroscience · doi:10.1038/10172 · Cited by 675 · see citing works
Silent synapses and the emergence of a postsynaptic mechanism for LTP
Kerchner, G. A., & Nicoll, R. A. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2501 · Cited by 602 · see citing works
Regulation of AMPA receptor lateral movements
Borgdorff, A. J., & Choquet, D. (2002) · Nature · doi:10.1038/nature00780 · Cited by 542 · see citing works
Long-lasting morphological changes in dendritic spines of dentate granular cells following stimulation of the entorhinal area
Fifkova´, E., & Harreveld, A. V. (1977) · Journal of Neurocytology · doi:10.1007/bf01261506 · Cited by 452 · see citing works
Freeze-fracture replica electron microscopy combined with sds digestion for cytochemical labeling of integral membrane proteins: Application to the immunogold labeling of intercellular junctional complexes
Fujimoto, K. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.11.3443 · Cited by 431 · see citing works
Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors
Groc, L., Heine, M., Cognet, L., Brickley, K., Stephenson, F. A., Lounis, B., & Choquet, D. (2004) · Nature Neuroscience · doi:10.1038/nn1270 · Cited by 429 · see citing works
Organization of AMPA Receptor Subunits at a Glutamate Synapse: A Quantitative Immunogold Analysis of Hair Cell Synapses in the Rat Organ of Corti
Matsubara, A., Laake, J. H., Davanger, S., Usami, S., & Ottersen, O. P. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-14-04457.1996 · Cited by 424 · see citing works
Subsynaptic segregation of metabotropic and ionotropic glutamate receptors as revealed by immunogold localization
Nusser, Z., Mulvihill, E. R., Streit, P., & Somogyi, P. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90421-9 · Cited by 416 · see citing works
Variability of Neurotransmitter Concentration and Nonsaturation of Postsynaptic AMPA Receptors at Synapses in Hippocampal Cultures and Slices
Liu, G., Choi, S., & Tsien, R. W. (1999) · Neuron · doi:10.1016/s0896-6273(00)81099-5 · Cited by 356 · see citing works
Diffusional trapping of GluR1 AMPA receptors by input-specific synaptic activity
Ehlers, M. D., Heine, M., Groc, L., Lee, M.-C., & Choquet, D. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.010 · Cited by 300 · see citing works
High-resolution immunogold localization of AMPA type glutamate receptor subunits at synaptic and non-synaptic sites in rat hippocampus
Baude, A., Nusser, Z., Molnár, E., McIlhinney, R. A. J., & Somogyi, P. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00350-r · Cited by 291 · see citing works
Differential Localization of δ Glutamate Receptors in the Rat Cerebellum: Coexpression with AMPA Receptors in Parallel Fiber–Spine Synapses and Absence from Climbing Fiber–Spine Synapses
Landsend, A. S., Amiry-Moghaddam, M. R., Matsubara, A., Bergersen, L. H., Usami, S., Wenthold, R. J., & Ottersen, O. P. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-02-00834.1997 · Cited by 281 · see citing works
Amplitude fluctuations of
Kullmann, D. (1994) · Neuron · doi:10.1016/0896-6273(94)90318-2 · Cited by 277 · see citing works
A Monte Carlo Model Reveals Independent Signaling at Central Glutamatergic Synapses
Franks, K. M., Bartol, T. M., & B, T. J. S. A. (2002) · Biophysical Journal · doi:10.1016/s0006-3495(02)75248-x · Cited by 175 · see citing works
Number and Density of AMPA Receptors in Single Synapses in Immature Cerebellum
Tanaka, J., Matsuzaki, M., Tarusawa, E., Momiyama, A., Molnár, E., Kasai, H., & Shigemoto, R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4256-04.2005 · Cited by 171 · see citing works
Self-citation
Number and Density of AMPA Receptors in Individual Synapses in the Rat Cerebellum as Revealed by SDS-Digested Freeze-Fracture Replica Labeling
Masugi-Tokita, M., Tarusawa, E., Watanabe, M., Molnár, E., Fujimoto, K., & Shigemoto, R. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2861-06.2007 · Cited by 168 · see citing works
Self-citation
Membrane structure at synaptic junctions in area CA1 of the rat hippocampus
Harris, K. M., & Landis, D. M. D. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90304-0 · Cited by 121 · see citing works
Synaptic interface surface area increases with long-term potentiation in the hippocampal dentate gyrus
Desmond, N. L., & Levy, W. B. (1988) · Brain Research · doi:10.1016/0006-8993(88)90171-0 · Cited by 118 · see citing works
Input-Specific Intrasynaptic Arrangements of Ionotropic Glutamate Receptors and Their Impact on Postsynaptic Responses
Tarusawa, E., Matsui, K., Budisantoso, T., Molnár, E., Watanabe, M., Matsui, M., Fukazawa, Y., & Shigemoto, R. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.6160-08.2009 · Cited by 118 · see citing works
Self-citation
High-resolution quantitative visualization of glutamate and GABA receptors at central synapses.
Masugi-Tokita, M., & Shigemoto, R. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.04.012 · Cited by 109 · see citing works
Self-citation
Long-term potentiation at single fiber inputs to hippocampal CA1 pyramidal cells.
Isaac, J. T. R., Hjelmstad, G. O., Nicoll, R. A., & Malenka, R. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8710 · Cited by 105 · see citing works
Tangential synaptic distribution of NMDA and AMPA receptors in rat neocortex
Kharazia, V. N., & Weinberg, R. J. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00846-x · Cited by 104 · see citing works
Particle aggregations at specialized sites in freeze-etched postsynaptic membranes
Sandri, C., Akert, K., Livingston, R. B., & Moor, H. (1972) · Brain Research · doi:10.1016/0006-8993(72)90612-9 · Cited by 91 · see citing works
Glutamate Receptor δ2 Is Essential for Input Pathway-Dependent Regulation of Synaptic AMPAR Contents in Cerebellar Purkinje Cells
Yamasaki, M., Miyazaki, T., Azechi, H., Abe, M., Natsume, R., Hagiwara, T., Aiba, A., Mishina, M., Sakimura, K., & Watanabe, M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5601-10.2011 · Cited by 80 · see citing works
Numbers, Densities, and Colocalization of AMPA- and NMDA-Type Glutamate Receptors at Individual Synapses in the Superficial Spinal Dorsal Horn of Rats
Antal, M., Fukazawa, Y., Eördögh, M., Muszil, D., Molnár, E., Itakura, M., Takahashi, M., & Shigemoto, R. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1551-08.2008 · Cited by 80 · see citing works
Self-citation
The high variance of AMPA receptor- and NMDA receptor-mediated responses at single hippocampal synapses: Evidence for multiquantal release
Conti, R., & Lisman, J. (2003) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0630290100 · Cited by 77 · see citing works
δ‐Glutamate Receptors Are Differentially Distributed at Parallel and Climbing Fiber Synapses on Purkinje Cells
Zhao, H., Wenthold, R. J., Wang, Y., & Petralia, R. S. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68031041.x · Cited by 76 · see citing works

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Goncalves, J., Bartol, T. M., Camus, C., Levet, F., Menegolla, A. P., Sejnowski, T. J., Sibarita, J.-B., Vivaudou, M., Choquet, D., & Hosy, E. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922563117 · Cited by 112 · see citing works
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Patriarchi, T., Buonarati, O. R., & Hell, J. W. (2018) · The EMBO Journal · doi:10.15252/embj.201899771 · Cited by 65 · see citing works
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Authors: Fukazawa, Y., & Shigemoto, R.
Affiliations: The Graduate University for Advanced Studies, SOKENDAI (JP)
Corresponding author: Shigemoto, Ryuichi
ORCID: Fukazawa, Yugo
Shigemoto, Ryuichi
Venue: Current Opinion in Neurobiology
Publisher: Elsevier BV
Published: 2012-06
Volume: 22
Issue: 3
Pages: 446-452
ISSN: 0959-4388 (ISSN-L)
DOI: 10.1016/j.conb.2012.01.006
OpenAlex: W2030664089
Cited by: 38
References: 36
Citations by year: 2025: 3 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 8 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 2
FWCI: 0.24
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Funders: SORST
CREST
Japan Science and Technology Agency (JST)
Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT) (20019031, 18022043)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords: excitatory synapses, structure-function relationship, postsynaptic membrane, synaptic plasticity, synaptic efficacy
MeSH terms: Animals, Central Nervous System, Freeze Fracturing, Synaptic Transmission, Neuronal Plasticity, Synapses, Receptors, AMPA

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Intra-synapse-type and inter-synapse-type relationships between synaptic size and AMPAR expression

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