Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53

WAF1, a potential mediator of p53 tumor suppression

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p53, the cellular gatekeeper for growth and division

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Surfing the p53 network

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Empirical Predictions of Protein Conformation

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p53: puzzle and paradigm.Preprint

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PUMA, a Novel Proapoptotic Gene, Is Induced by p53

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Conformational parameters for amino acids in helical, β-sheet, and random coil regions calculated from proteins

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Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

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TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis

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Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis

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Definition of a consensus binding site for p53

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Impact of mutant p53 functional properties on <i>TP53</i> mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

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Transcriptional Activation of miR-34a Contributes to p53-Mediated Apoptosis

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PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells

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A Global Map of p53 Transcription-Factor Binding Sites in the Human Genome

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Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs

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Post‐translational modifications and activation of p53 by genotoxic stresses

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FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements) isolates active regulatory elements from human chromatinPreprint

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Oncogenic Forms of p53 Inhibit p53-Regulated Gene Expression

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TP53 mutations in human cancers: Functional selection and impact on cancer prognosis and outcomes

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Understanding the function–structure and function–mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis

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A Transcriptionally Active DNA-Binding Site for Human p53 Protein Complexes

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Ensembl 2007

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Expression of the <i>p48</i> xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair

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Crystal Structure of the Tetramerization Domain of the p53 Tumor Suppressor at 1.7 Angstroms

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An inherited <i>p53</i> mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma

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The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots.Preprint

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Transcriptional regulation by p53: one protein, many possibilities

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Transcriptional Regulation by p53 through Intrinsic DNA/Chromatin Binding and Site-Directed Cofactor Recruitment

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Structural Basis of DNA Recognition by p53 Tetramers

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Sequence-specific transcriptional activation is essential for growth suppression by p53.

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Ensembl 2008

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Pidd, a new death-domain–containing protein, is induced by p53 and promotes apoptosis

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Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo

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In vivo site-directed mutagenesis using oligonucleotides

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Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential.

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Expression profiling in primates reveals a rapid evolution of human transcription factors

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The Delitto Perfetto Approach to In Vivo Site‐Directed Mutagenesis and Chromosome Rearrangements with Synthetic Oligonucleotides in Yeast

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The p53MH algorithm and its application in detecting p53-responsive genes

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A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer

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A functional p53-responsive intronic promoter is contained within the human<i>mdm2</i>gene

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The role of tetramerization in p53 function

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Solution structure of the tetrameric minimum transforming domain of p53

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The p53 protein is an unusually shaped tetramer that binds directly to DNA.

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How p53 binds DNA as a tetramer

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p53 Functions through Stress- and Promoter-Specific Recruitment of Transcription Initiation Components before and after DNA Damage

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p53 and Metabolism: Inside the TIGAR

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Comparative Binding of p53 to its Promoter and DNA Recognition Elements

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Cell signaling can direct either binary or graded transcriptional responses

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Differential Transactivation by the p53 Transcription Factor Is Highly Dependent on p53 Level and Promoter Target Sequence

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Wild‐type p53 adopts a ‘mutant’‐like conformation when bound to DNA.

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Chromosomal site-specific double-strand breaks are efficiently targeted for repair by oligonucleotides in yeast

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Kinetics of p53 Binding to Promoter Sites In Vivo

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p53 tagged sites from human genomic DNA

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Promoter-associated Pausing in Promoter Architecture and Postinitiation Transcriptional RegulationPreprint

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The proto-oncogene c-myc and apoptosis

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p53 Domains: Structure, Oligomerization, and Transformation

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8. Stress-induced activation of the heat-shock response: cell and molecular biology of heat-shock factors

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Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activity

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Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversity

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Interaction of p53 with Its Consensus DNA-Binding Site

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Nine hydrophobic side chains are key determinants of the thermodynamic stability and oligomerization status of tumour suppressor p53 tetramerization domain

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p53 oligomerization and DNA looping are linked with transcriptional activation.

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The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding.

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Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA.

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The structure of p53 tumour suppressor protein reveals the basis for its functional plasticity

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Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53Preprint

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Characterization of the oligomerization defects of two p53 mutants found in families with Li–Fraumeni and Li–Fraumeni-like syndrome

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The relationship among p53 oligomer formation, structure and transcriptional activity using a comprehensive missense mutation library

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Cell Cycle–Specified Fluctuation of Nucleosome Occupancy at Gene Promoters

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Characterization of p53 oligomerization domain mutations isolated from Li–Fraumeni and Li–Fraumeni like family members

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Dual feedback loops in the GAL regulon suppress cellular heterogeneity in yeast

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p53FamTaG: a database resource of human p53, p63 and p73 direct target genes combining in silico prediction and microarray data

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Functionally distinct polymorphic sequences in the human genome that are targets for p53 transactivation

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A SNP in the flt-1 promoter integrates the VEGF system into the p53 transcriptional network

Menéndez, D., Krysiak, O., Inga, A., Krysiak, B., Resnick, M. A., & Schönfelder, G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508103103 · Cited by 82 · see citing works

The biological impact of the human master regulator p53 can be altered by mutations that change the spectrum and expression of its target genes

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Reversible Amyloid Formation by the p53 Tetramerization Domain and a Cancer-associated Mutant

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Meta-analysis of the p53 Mutation Database for Mutant p53 Biological Activity Reveals a Methodologic Bias in Mutation Detection

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Crystallization and structure solution of p53 (residues 326–356) by molecular replacement using an NMR model as template

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Functional evolution of the p53 regulatory network through its target response elements

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Architectural Accommodation in the Complex of Four p53 DNA Binding Domain Peptides with the p21/waf1/cip1 DNA Response Element

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A Single-Nucleotide Polymorphism in a Half-Binding Site Creates p53 and Estrogen Receptor Control of Vascular Endothelial Growth Factor Receptor 1

Menéndez, D., Inga, A., Snipe, J. R., Krysiak, O., Schönfelder, G., & Resnick, M. A. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01742-06 · Cited by 66 · see citing works

Two functional assays employed to detect an unusual mutation in the oligomerisation domain of p53 in a Li-Fraumeni like family

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One Mechanism for Cell Type-specific Regulation of thebax Promoter by the Tumor Suppressor p53 Is Dictated by the p53 Response Element

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Binary and Graded Responses in Gene Networks

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Transcriptional functionality of germ line p53 mutants influences cancer phenotype

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Chromatin Immunoprecipitation-Based Screen To Identify Functional Genomic Binding Sites for Sequence-Specific Transactivators

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The regulation of energy generating metabolic pathways by p53

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Sequence analysis of p53 response-elements suggests multiple binding modes of the p53 tetramer to DNA targets

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Delitto PerfettoTargeted Mutagenesis in Yeast with Oligonucleotides

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A novel p53 mutational hotspot in skin tumors from UV-irradiated Xpc mutant mice alters transactivation functions

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Functional Analysis of the Human p53 Tumor Suppressor and its Mutants Using Yeast

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The expanding universe of p53 targets

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The Tumor Suppressor p53: From Structures to Drug DiscoveryPreprint

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ROS-Mediated p53 Induction of Lpin1 Regulates Fatty Acid Oxidation in Response to Nutritional Stress

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An Active Role of the ΔN Isoform of p63 in Regulating Basal Keratin Genes K5 and K14 and Directing Epidermal Cell Fate

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Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells

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Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop

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The Toll-like receptor gene family is integrated into human DNA damage and p53 networks

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Autophagy and cardiac diseases: Therapeutic potential of natural products

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How theTP53Family ProteinsTP63andTP73Contribute to Tumorigenesis: Regulators and Effectors

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The Human <i>TLR</i> Innate Immune Gene Family Is Differentially Influenced by DNA Stress and <i>p53</i> Status in Cancer Cells

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Redefining the p53 response element

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Interactions between the tumor suppressor p53 and immune responses

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p53 responsive elements in human retrotransposons

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Sequence-dependent sliding kinetics of p53

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Characterization of the p53 Cistrome – DNA Binding Cooperativity Dissects p53's Tumor Suppressor Functions

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Distinct p53 genomic binding patterns in normal and cancer-derived human cells

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Altered-Function p53 Missense Mutations Identified in Breast Cancers Can Have Subtle Effects on Transactivation

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Whole-genome cartography of p53 response elements ranked on transactivation potential

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Conservation of DNA-binding specificity and oligomerisation properties within the p53 family

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Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides

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A Comprehensive and High-Resolution Genome-wide Response of p53 to Stress

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Methylation and deamination of CpGs generate p53-binding sites on a genomic scale

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Structural and Drug Targeting Insights on Mutant p53

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More targets, more pathways and more clues for mutant p53

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To repress or not to repress: This is the guardian's question

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Identification of new p53 target microRNAs by bioinformatics and functional analysis

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Interactions of Chromatin Context, Binding Site Sequence Content, and Sequence Evolution in Stress-Induced p53 Occupancy and Transactivation

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Sequence-dependent cooperative binding of p53 to DNA targets and its relationship to the structural properties of the DNA targets

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Determinants of p53 DNA binding, gene regulation, and cell fate decisions

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Structure of p73 DNA-binding domain tetramer modulates p73 transactivation

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Gain-of-function p53 mutants have widespread genomic locations partially overlapping with p63

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p53 Binding to Nucleosomal DNA Depends on the Rotational Positioning of DNA Response Element

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Estrogen receptor acting in cis enhances WT and mutant p53 transactivation at canonical and noncanonical p53 target sequences

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Probing the Functional Impact of Sequence Variation on p53-DNA Interactions Using a Novel Microsphere Assay for Protein-DNA Binding with Human Cell Extracts

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TP53 Mutants in the Tower of Babel of Cancer Progression

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Diverse p53/DNA binding modes expand the repertoire of p53 response elements

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Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code

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p53 Transactivation and the Impact of Mutations, Cofactors and Small Molecules Using a Simplified Yeast-Based Screening System

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Two p53 tetramers bind one consensus DNA response element

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Recognition of Local DNA Structures by p53 Protein

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Low-level p53 expression changes transactivation rules and reveals superactivating sequences

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P53 Family Members Modulate the Expression of PRODH, but Not PRODH2, via Intronic p53 Response Elements

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Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation

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TP53-inducible putative long noncoding RNAs encode functional polypeptides that suppress cell proliferationPreprint

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Human single-nucleotide polymorphisms alter p53 sequence-specific binding at gene regulatory elements

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Preferential binding of p53 tumor suppressor to p21 promoter sites that contain inverted repeats capable of forming cruciform structure

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Modulation of immune responses by the tumor suppressor p53

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New Therapeutic Strategies for Cancer and Neurodegeneration Emerging from Yeast Cell-based Systems

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The Coordinated P53 and Estrogen Receptor Cis-Regulation at an FLT1 Promoter SNP Is Specific to Genotoxic Stress and Estrogenic Compound

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Functional four-base A/T gap core sequence CATTAG of P53 response elements specifically bound tetrameric P53 differently than two-base A/T gap core sequence CATG bound both dimeric and tetrameric P53

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ΔN-P63α and TA-P63α exhibit intrinsic differences in transactivation specificities that depend on distinct features of DNA target sites

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The complex architecture of p53 binding sites

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A p53-dependent promoter associated with polymorphic tandem repeats controls the expression of a viral transcript encoding clustered microRNAs

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Interferon regulatory factor 4 binding protein is a novel p53 target gene and suppresses cisplatin-induced apoptosis of breast cancer cells

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Cooperativity Dominates the Genomic Organization of p53-Response Elements: A Mechanistic View

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Roles of p53 Family Structure and Function in Non-Canonical Response Element Binding and Activation

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Lysine120 Interactions with p53 Response Elements can Allosterically Direct p53 Organization

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The structure formed by inverted repeats in p53 response elements determines the transactivation activity of p53 protein

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Single-Molecule Studies of Unlabeled Full-Length p53 Protein Binding to DNA

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Making Connections: p53 and the Cathepsin Proteases as Co-Regulators of Cancer and Apoptosis

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P53 protein and the diseases in central nervous system

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A Regulatory Loop Composed of RAP80-HDM2-p53 Provides RAP80-enhanced p53 Degradation by HDM2 in Response to DNA Damage

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Formation of stress-specific p53 binding patterns is influenced by chromatin but not by modulation of p53 binding affinity to response elements †

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OPINION Interactions between the tumor suppressor p53 and immune responses

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Data from Altered-Function p53 Missense Mutations Identified in Breast Cancers Can Have Subtle Effects on Transactivation

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Data from Altered-Function p53 Missense Mutations Identified in Breast Cancers Can Have Subtle Effects on Transactivation

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Optimisation of TP53 reporters by systematic dissection of synthetic TP53 response elementsPreprint

Trauernicht, M., Rastogi, C., Manzo, S. G., Bussemaker, H. J., & van Steensel, B. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.24.549988

Molecular characterization of FOX factors and Wnt signalling interplay in human cancers

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Novel therapeutic interventions to overcome drug resistance in cancer: targeting key regulators of the apoptotic pathway

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Diversity Within the Master Regulatory p53 Transcriptional Network: Impact of Sequence, Binding Motifs and Mutations

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Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code

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60 Binding and transactivation by the tumor suppression protein p53 are encoded in the differential structural properties of its response elements

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