The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Bone marrow derived elements and resident microglia in brain inflammation
Abstract
Infection of the central nervous (CNS) system by the human immunodeficiency virus (HIV) depends on the migration of infected hematogenous cells into the brain. We thus used quantitative light and electron microscopic immunocytochemistry to study the homing and turnover of bone marrow derived cells in the CNS in radiation bone marrow chimeras under normal conditions and in experimental autoimmune encephalomyelitis (EAE) as an experimental model of brain inflammation. Our studies suggest the following conclusions. First, the central nervous system is continuously patrolled by a small number of T‐lymphocytes and monocytes. Meningeal and perivascular monocytes are slowly replaced by hematogenous cells under normal conditions, and this turnover is accelerated in the course of inflammation. In contrast, resident microglia represent a very stable cell pool, which in adult animals is only exceptionally replaced by hematogenous cells, even after recovery from severe brain inflammation. Second, although in bone‐marrow‐chimeric animals resident microglia, astrocytes, and ependymal cells are not able to present antigen to Lewis T‐lymphocytes, the inflammatory reaction in EAE is qualitatively and quantitatively similar in these animals compared to fully histocompatible Lewis rats. Finally, resident microglia express the macrophage activation antigen ED1. Thus, microglia cells appear to function as effector cells in EAE lesions.
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“Host microglia are relatively radio-resistant”
From Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge (2018) · cites this paper as [30]
In the citing paper
“unless combined with conditioning, engraftment of the brain macrophage pool was therefore reported to be limited27,29–31.”
From Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge (2018) · cites this paper as [30]
Citations
Cites
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Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo
Hickey, W. F., & Kimura, H. (1988) · Science · doi:10.1126/science.3276004 · Cited by 1,466
Self-citationT‐lymphocyte entry into the central nervous system
Hickey, W. F., Hsu, B. L., & Kimura, H. (1991) · Journal of Neuroscience Research · doi:10.1002/jnr.490280213 · Cited by 1,177
Self-citationCytology & cellular pathology of the nervous system
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Macrophages and microglia in the nervous system
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Macrophages and the Nervous System
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Self-citation
Research works printed but not linked: 1
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Cited by
The immunology of stroke: from mechanisms to translation
Iadecola, C., & Anrather, J. (2011) · Nature Medicine · doi:10.1038/nm.2399 · Cited by 2,596
New tools for studying microglia in the mouse and human CNS
Bennett, M. L., Bennett, F. C., Liddelow, S. A., Ajami, B., Zamanian, J. L., Fernhoff, N. B., Mulinyawe, S. B., Bohlen, C. J., Adil, A., Tucker, A., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525528113 · Cited by 1,804
MCGEER, P., & MCGEER, E. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(95)00011-9 · Cited by 1,287
Streit, W. J., Walter, S. A., & Pennell, N. A. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00069-0 · Cited by 1,096
Three or more routes for leukocyte migration into the central nervous system
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Metadata
- Authors
- Lassmann, H., Schmied, M., Vass, K., & Hickey, W. F.
- Venue
- Glia
- Publisher
- Wiley
- Published
- 1993-01
- Volume
- 7
- Issue
- 1
- Pages
- 19-24
- ISSN
- 0894-1491
- 1098-1136
- Cited by
- 280
- References
- 38
- Language
- en
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- CoChat. (2026). Citation check: Bone marrow derived elements and resident microglia in brain inflammation. https://app.cochat.ai/papers/10.1002/glia.440070106
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- Lassmann, H., Schmied, M., Vass, K., & Hickey, W. F. (1993). Bone marrow derived elements and resident microglia in brain inflammation. Glia. https://doi.org/10.1002/glia.440070106
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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