Metabolic Mapping of Functional Activity in the Hypothalamo-Neurohypophysial System of the Rat
Abstract
Physiological stimulation of the hypothalamo-neurohypophysial system by salt loading of rats resulted in a dramatically increased glucose utilization in the posterior pituitary but not in the paraventricular or supraoptic nuclei. The good correlation between glucose utilization and neural activity in the posterior pituitary (that is, nerve terminals) contrasted with the lack of correlation in the paraventricular and supraoptic nuclei (that is, the sites of the cell bodies of the same neurons). This difference in the metabolic response to functional activity between the two regions of these neurons can be explained by the differences in surface-to-volume ratios of these regions.
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The reductions in regional glucose metabolism could reflect decreased activity of terminal neuronal fields, decreased density of terminal neuronal fields, atrophy, or some combination of these factors.
“Although the reductions in regional glucose metabolism could reflect decreased activity of terminal neuronal fields, 36 decreased density of terminal neuronal fields, atrophy, or some combination of these factors”
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Cites
Sokoloff, L., Reivich, M., Kennedy, C., Rosiers, M. H. D., Patlak, C. S., Pettigrew, K. D., Sakurada, O., & Shinohara, M. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb10649.x · Cited by 6,000 · see citing works
Self-citationRELATION BETWEEN PHYSIOLOGICAL FUNCTION AND ENERGY METABOLISM IN THE CENTRAL NERVOUS SYSTEM
Sokoloff, L. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb03919.x · Cited by 807 · see citing works
Self-citationMata, M. M., Fink, D. J., Gainer, H., Smith, C. B., Davidsen, L., Savaki, H. E., Schwartz, W. J., & Sokoloff, L. (1980) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1980.tb04643.x · Cited by 616 · see citing works
Self-citationVandesande, F., & Dierickx, K. (1975) · Cell and Tissue Research · doi:10.1007/bf00218970 · Cited by 496 · see citing works
Kennedy, C., Rosiers, M. H. D., Jehle, J. W., Reivich, M., Sharpe, F., & Sokoloff, L. (1975) · Science · doi:10.1126/science.1114332 · Cited by 436 · see citing works
Self-citationWAKERLEY, J. B., & LINCOLN, D. W. (1973) · Journal of Endocrinology · doi:10.1677/joe.0.0570477 · Cited by 327 · see citing works
Kennedy, C., Rosiers, M. H. D., Sakurada, O., Shinohara, M., Reivich, M., Jehle, J. W., & Sokoloff, L. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.11.4230 · Cited by 306 · see citing works
Self-citationBrimble, M. J., & Dyball, R. E. J. (1977) · The Journal of Physiology · doi:10.1113/jphysiol.1977.sp011999 · Cited by 283 · see citing works
Sharp, F. R., Kauer, J. S., & Shepherd, G. M. (1975) · Brain Research · doi:10.1016/0006-8993(75)90377-7 · Cited by 275 · see citing works
Biosynthesis and axonal transport of rat neurohypophysial proteins and peptides.
Gainer, H., Sarne, Y., & Brownstein, M. J. (1977) · The Journal of Cell Biology · doi:10.1083/jcb.73.2.366 · Cited by 267 · see citing works
Self-citationLINCOLN, D. W., & Wakerley, J. B. (1974) · The Journal of Physiology · doi:10.1113/jphysiol.1974.sp010722 · Cited by 252 · see citing works
Electrophysiological differentiation of oxytocin-and vasopressin-secreting neurones
Poulain, D. A., Wakerley, J. B., & Dyball, R. E. J. (1977) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1977.0046 · Cited by 243 · see citing works
The oxygen consumption of mammalian non‐myelinated nerve fibres at rest and during activity
Ritchie, J. M. (1967) · The Journal of Physiology · doi:10.1113/jphysiol.1967.sp008141 · Cited by 120 · see citing works
Ultrastructural morphometry of the rat neurohypophysis.
Jj, N. (1977) · PubMed · Cited by 113 · see citing works
Activity of phasic neurosecretory cells during haemorrhage
Wakerley, J. B., POULAIN, D. A., Dyball, R. E. J., & Cross, B. (1975) · Nature · doi:10.1038/258082a0 · Cited by 105 · see citing works
The role of central adrenergic receptors in the reflex release of oxytocin
Tribollet, E., Clarke, G., Dreifuss, J.-J., & LINCOLN, D. W. (1978) · Brain Research · doi:10.1016/0006-8993(78)90177-4 · Cited by 85 · see citing works
Dyball, R. E. J., & POUNTNEY, P. S. (1973) · Journal of Endocrinology · doi:10.1677/joe.0.0560091 · Cited by 72 · see citing works
Supraoptic neuronal activity in rats during five days of water deprivation
Walters, J. K., & Hatton, G. I. (1974) · Physiology & Behavior · doi:10.1016/0031-9384(74)90237-6 · Cited by 64 · see citing works
Bridges, T. E., & Thorn, N. A. (1970) · Journal of Endocrinology · doi:10.1677/joe.0.0480265 · Cited by 62 · see citing works
Zimmerman, E. A., ROBINSON, A. G., Husain, M., et al. (1974) · Endocrinology · doi:10.1210/endo-95-4-931 · Cited by 55 · see citing works
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Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
Jack, C. R., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., Petersen, R. C., & Trojanowski, J. Q. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70299-6 · Cited by 4,806 · see citing works
Searching for a baseline: Functional imaging and the resting human brain
Gusnard, D. A., & Raichle, M. E. (2001) · Nature Reviews Neuroscience · doi:10.1038/35094500 · Cited by 3,371 · see citing works
Expression of c- <i>fos</i> Protein in Brain: Metabolic Mapping at the Cellular Level
Sagar, S. M., Sharp, F. R., & Curran, T. (1988) · Science · doi:10.1126/science.3131879 · Cited by 1,925 · see citing works
Raichle, M. E., & Mintun, M. A. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112819 · Cited by 1,630 · see citing works
Reiman, E. M., Caselli, R. J., Yun, L. S., Chen, K., Bandy, D., Minoshima, S., Thibodeau, S. N., & Osborne, D. (1996) · New England Journal of Medicine · doi:10.1056/nejm199603213341202 · Cited by 1,366 · see citing works
Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia
Reiman, E. M., Chen, K., Alexander, G. E., Caselli, R. J., Bandy, D., Osborne, D., Saunders, A. M., & Hardy, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2635903100 · Cited by 977 · see citing works
Volkow, N. D., Fowler, J. S., Wang, G., Hitzemann, R., Logan, J., Schlyer, D. J., Dewey, S. L., & Wolf, A. P. (1993) · Synapse · doi:10.1002/syn.890140210 · Cited by 924 · see citing works
Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity.
Sibson, N. R., Dhankhar, A., Mason, G. F., Rothman, D. L., Behar, K. L., & Shulman, R. G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.316 · Cited by 897 · see citing works
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Johnson, K. A., Fox, N. C., Sperling, R. A., & Klunk, W. E. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006213 · Cited by 875 · see citing works
Neuroanatomical correlates of externally and internally generated human emotion
(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.7.918 · Cited by 711 · see citing works
Drevets, W. C., & Raichle, M. E. (1998) · Cognition & Emotion · doi:10.1080/026999398379646 · Cited by 702 · see citing works
Liang, W. S., Reiman, E. M., Valla, J., Dunckley, T., Beach, T. G., Grover, A., Niedzielko, T. L., Schneider, L. E., Mastroeni, D., Caselli, R., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709259105 · Cited by 585 · see citing works
Volkow, N. D., Wang, G.-J., Fowler, J. S., Hitzemann, R., Angrist, B., Gatley, S. J., Logan, J., Ding, Y.-S., & Pappas, N. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.1.19 · Cited by 405 · see citing works
Volkow, N. D., Wang, G.-J., Ma, Y., Fowler, J. S., Zhu, W., Maynard, L., Telang, F., Vaska, P., Ding, Y.-S., Wong, C., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-36-11461.2003 · Cited by 302 · see citing works
Cognitive control of drug craving inhibits brain reward regions in cocaine abusers
Volkow, N. D., Fowler, J. S., Wang, G.-J., Telang, F., Logan, J., Jayne, M., Ma, Y., Pradhan, K., Wong, C., & Swanson, J. M. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.10.088 · Cited by 283 · see citing works
Levy, R., Friedman, H. R., Davachi, L., & Goldman-Rakic, P. S. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-10-03870.1997 · Cited by 279 · see citing works
Sekar, S., McDonald, J., Cuyugan, L., Aldrich, J., Kurdoglu, A., Adkins, J., Serrano, G., Beach, T. G., Craig, D. W., Valla, J., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.09.027 · Cited by 199 · see citing works
Patel, A. B., Lai, J. C. K., Chowdhury, G. M. I., Hyder, F., Rothman, D. L., Shulman, R. G., & Behar, K. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1403576111 · Cited by 186 · see citing works
Adler, L. J., Gyulai, F. E., Diehl, D. J., Mintun, M. A., Winter, P. M., & Firestone, L. L. (1997) · Anesthesia & Analgesia · doi:10.1097/00000539-199701000-00023 · Cited by 174 · see citing works
Rauch, A., Rainer, G., & Logothetis, N. K. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800312105 · Cited by 146 · see citing works
Activation of human medial prefrontal cortex during autonomic responses to hypoglycemia
Teves, D., Videen, T. O., Cryer, P. E., & Powers, W. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307048101 · Cited by 138 · see citing works
When Does Alzheimer′s Disease Really Start? The Role of Biomarkers
Lloret, A., Esteve, D., Lloret, M.-A., Cervera-Ferri, A., Lopez, B., Nepomuceno, M., & Monllor, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225536 · Cited by 131 · see citing works
Adler, L. J., Gyulai, F. E., Diehl, D. J., Mintun, M. A., Winter, P. M., & Firestone, L. L. (1997) · Anesthesia & Analgesia · doi:10.1213/00000539-199701000-00023 · Cited by 174 · see citing works
Attenuation of Counterregulatory Responses to Recurrent Hypoglycemia by Active Thalamic Inhibition
Arbelaez, A. M., Powers, W. J., Videen, T. O., Price, J. L., & Cryer, P. E. (2008) · Diabetes · doi:10.2337/db07-1329 · Cited by 92 · see citing works
Kaliszewska, A., Bijata, M., Kaczmarek, L., & Kossut, M. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr303 · Cited by 55 · see citing works
- Authors
- Schwartz, W. J., Smith, C. B., Davidsen, L., Savaki, H., Sokoloff, L., Mata, M., Fink, D. J., & Gainer, H.
- Affiliations
- National Institutes of Health (US)
- Venue
- Science
- Published
- 1979-08-17
- Volume
- 205
- Issue
- 4407
- Pages
- 723-725
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2135248098
- Cited by
- 454
- References
- 20
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 7 · 2019: 4 · 2018: 1 · 2016: 5 · 2015: 3 · 2014: 8 · 2013: 16 · 2012: 9
- FWCI
- 26.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- hypothalamo-neurohypophysial system, glucose utilization, metabolic mapping, neurohypophysis, paraventricular nucleus, supraoptic nucleus, salt loading, neuronal activity, surface-to-volume ratio
- MeSH terms
- Animals, Axons, Deoxyglucose, Energy Metabolism, Hypothalamo-Hypophyseal System, Male, Nerve Endings, Paraventricular Hypothalamic Nucleus, Phenoxybenzamine, Pituitary Gland, Posterior, Supraoptic Nucleus, Water Deprivation, Water-Electrolyte Balance, Rats
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