Cited by 454Neuroendocrine regulation and behaviorNeuroscience and Neuropharmacology ResearchRegulation of Appetite and Obesity

Metabolic Mapping of Functional Activity in the Hypothalamo-Neurohypophysial System of the Rat

Schwartz, William J., Smith, Carolyn B., Davidsen, Leslie, Savaki, Helen, Sokoloff, Louis, Mata, Marina, Fink, David J., Gainer, Harold·1979·Science

Abstract

Physiological stimulation of the hypothalamo-neurohypophysial system by salt loading of rats resulted in a dramatically increased glucose utilization in the posterior pituitary but not in the paraventricular or supraoptic nuclei. The good correlation between glucose utilization and neural activity in the posterior pituitary (that is, nerve terminals) contrasted with the lack of correlation in the paraventricular and supraoptic nuclei (that is, the sites of the cell bodies of the same neurons). This difference in the metabolic response to functional activity between the two regions of these neurons can be explained by the differences in surface-to-volume ratios of these regions.

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Crossref · 10.1126/science.462184

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20 of 20 references verified0 citation errors · 0 not checkable

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  • The reductions in regional glucose metabolism could reflect decreased activity of terminal neuronal fields, decreased density of terminal neuronal fields, atrophy, or some combination of these factors.

    “Although the reductions in regional glucose metabolism could reflect decreased activity of terminal neuronal fields, 36 decreased density of terminal neuronal fields, atrophy, or some combination of these factors”

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Authors
Schwartz, W. J., Smith, C. B., Davidsen, L., Savaki, H., Sokoloff, L., Mata, M., Fink, D. J., & Gainer, H.
Affiliations
National Institutes of Health (US)
Venue
Science
Published
1979-08-17
Volume
205
Issue
4407
Pages
723-725
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2135248098
Cited by
454
References
20
Citations by year
2024: 2 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 7 · 2019: 4 · 2018: 1 · 2016: 5 · 2015: 3 · 2014: 8 · 2013: 16 · 2012: 9
FWCI
26.43
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
hypothalamo-neurohypophysial system, glucose utilization, metabolic mapping, neurohypophysis, paraventricular nucleus, supraoptic nucleus, salt loading, neuronal activity, surface-to-volume ratio
MeSH terms
Animals, Axons, Deoxyglucose, Energy Metabolism, Hypothalamo-Hypophyseal System, Male, Nerve Endings, Paraventricular Hypothalamic Nucleus, Phenoxybenzamine, Pituitary Gland, Posterior, Supraoptic Nucleus, Water Deprivation, Water-Electrolyte Balance, Rats

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