Cited by 146Advanced MRI Techniques and ApplicationsAdvanced Neuroimaging Techniques and ApplicationsFunctional Brain Connectivity Studies

The effect of a serotonin-induced dissociation between spiking and perisynaptic activity on BOLD functional MRI

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Rauch, Alexander, Rainer, Gregor, Logothetis, Nikos K.·2008·Proceedings of the National Academy of Sciences

Abstract

The relationship of the blood oxygen-level-dependent (BOLD) signal to its underlying neuronal activity is still poorly understood. Combined physiology and functional MRI experiments suggested that local field potential (LFP) is a better predictor of the BOLD signal than multiunit activity (MUA). To further explore this relationship, we simultaneously recorded BOLD and electrophysiological activity while inducing a dissociation of MUA from LFP activity with injections of the neuromodulator BP554 into the primary visual cortex of anesthetized monkeys. BP554 is a 5-HT1A agonist acting primarily on the membrane of efferent neurons by potassium-induced hyperpolarization. Its infusion in visual cortex reliably reduced MUA without affecting either LFP or BOLD activity. This finding suggests that the efferents of a neuronal network pose relatively little metabolic burden compared with the overall presynaptic and postsynaptic processing of incoming afferents. We discuss implications of this finding for the interpretation of BOLD activity.

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Authors
Rauch, A., Rainer, G., & Logothetis, N. K.
Affiliations
Max Planck Society (DE)
Venue
Proceedings of the National Academy of Sciences
Published
2008-05-06
Volume
105
Issue
18
Pages
6759-6764
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W1982156343
Cited by
146
References
31
Citations by year
2026: 1 · 2024: 1 · 2023: 4 · 2022: 5 · 2021: 3 · 2020: 7 · 2019: 3 · 2018: 8 · 2017: 7 · 2016: 8 · 2015: 8 · 2014: 11 · 2013: 16 · 2012: 9
FWCI
14.07
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (submittedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Funders
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (106816)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
BOLD signal, serotonin, 5-HT1A receptor agonist, primary visual cortex, multi-unit activity, local field potentials, neuronal activity, efferent neurons, presynaptic activity, postsynaptic activity, neuronal energy metabolism, blood oxygenation, neuromodulation
MeSH terms
Animals, Macaca mulatta, Magnetic Resonance Imaging, Male, Oxygen, Photic Stimulation, Piperazines, Serotonin, Synapses

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