The effect of a serotonin-induced dissociation between spiking and perisynaptic activity on BOLD functional MRI
Open accessAbstract
The relationship of the blood oxygen-level-dependent (BOLD) signal to its underlying neuronal activity is still poorly understood. Combined physiology and functional MRI experiments suggested that local field potential (LFP) is a better predictor of the BOLD signal than multiunit activity (MUA). To further explore this relationship, we simultaneously recorded BOLD and electrophysiological activity while inducing a dissociation of MUA from LFP activity with injections of the neuromodulator BP554 into the primary visual cortex of anesthetized monkeys. BP554 is a 5-HT1A agonist acting primarily on the membrane of efferent neurons by potassium-induced hyperpolarization. Its infusion in visual cortex reliably reduced MUA without affecting either LFP or BOLD activity. This finding suggests that the efferents of a neuronal network pose relatively little metabolic burden compared with the overall presynaptic and postsynaptic processing of incoming afferents. We discuss implications of this finding for the interpretation of BOLD activity.
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After neuronal input and output are dissociated, the BOLD response remains correlated with LFP but not MUA.
“After dissociating neuronal input and output, the BOLD response is still correlated with LFP but not with MUA (133, 134).”
From Electrophysiological source imaging: A noninvasive window to brain dynamics (2018) · cites this paper as [134]
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- Authors
- Rauch, A., Rainer, G., & Logothetis, N. K.
- Affiliations
- Max Planck Society (DE)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2008-05-06
- Volume
- 105
- Issue
- 18
- Pages
- 6759-6764
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2373337
- OpenAlex
- W1982156343
- Cited by
- 146
- References
- 31
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 4 · 2022: 5 · 2021: 3 · 2020: 7 · 2019: 3 · 2018: 8 · 2017: 7 · 2016: 8 · 2015: 8 · 2014: 11 · 2013: 16 · 2012: 9
- FWCI
- 14.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (106816)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- BOLD signal, serotonin, 5-HT1A receptor agonist, primary visual cortex, multi-unit activity, local field potentials, neuronal activity, efferent neurons, presynaptic activity, postsynaptic activity, neuronal energy metabolism, blood oxygenation, neuromodulation
- MeSH terms
- Animals, Macaca mulatta, Magnetic Resonance Imaging, Male, Oxygen, Photic Stimulation, Piperazines, Serotonin, Synapses
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