Experience-dependent plasticity of the barrel cortex in mice observed with 2-DG brain mapping and c-Fos: effects of MMP-9 KO
Abstract
Modifications of properties of the adult sensory cortex by elimination of sensory input (deprivation) serves as a model for studying plasticity in the adult brain. We studied the effects of short- and long-term deprivation (sparing one row of vibrissae) upon the barrel cortex. The response to stimulation (exploration of a new environment) of the spared row was examined with [14C]-2-deoxyglucose autoradiography and c-Fos immunohistochemistry. Both methods found large increases of the functional cortical representation of the spared row of vibrissae, extending into parts of the barrel cortex previously activated by the deprived vibrissae. With both methods, the greatest expansion of spared input was observed in cortical layer IV. In this way, we established a model, which was applied for examining involvement of matrix metalloproteinase 9 (MMP-9), upon experience-dependent cortical plasticity. MMP-9 is an enzyme implicated in plastic modification of the neuronal connections. We found that MMP-9 activity was increased in response to stimulation, and furthermore, MMP-9 knockout mice showed a modest but significant decrease of plasticity in layer IV with 2-DG mapping and in layers II/III with c-Fos mapping. Thus, in adult mouse brain experience-dependent plasticity is in part supported by the activity of MMP-9.
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MMP-9 regulates normal sensory cortex development (Kaliszewska et al., 2012).
“MMP-9 regulates normal development of sensory cortex (Kaliszewska et al., 2012)”
From Matrix metalloproteinase-9 deletion rescues auditory evoked potential habituation deficit in a mouse model of Fragile X Syndrome (2016) · cites this paper as Kaliszewska et al., 2012
The weakening of thalamic inputs to FS INs is a novel role for MMP-9.
“The weakening of thalamic inputs to FS INs is a novel role for MMP-9, which is typically associated with the growth and strengthening of excitatory synapses onto excitatory neurons (Kaliszewska et al., 2012; Lebida and Mozrzymas, 2016; Michaluk et al., 2011; Ganguly et al., 2013), but see (Romberg et al., 2013).”
From Light reintroduction after dark exposure reactivates plasticity in adults via perisynaptic activation of MMP-9 (2017) · cites this paper as Kaliszewska et al., 2012
Cites
An Energy Budget for Signaling in the Grey Matter of the Brain
Attwell, D., & Laughlin, S. B. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200110000-00001 · Cited by 3,543 · see citing works
Pellerin, L., & Magistretti, P. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10625 · Cited by 2,927 · see citing works
Herdegen, T., & Leah, J. D. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00018-6 · Cited by 1,352 · see citing works
Transient and persistent dendritic spines in the neocortex in vivo
Holtmaat, A. J. G. D., Trachtenberg, J. T., Wilbrecht, L., Shepherd, G. M., Zhang, X., Knott, G. W., & Svoboda, K. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.003 · Cited by 1,131 · see citing works
Herrera, D., & Robertson, H. A. (1996) · Progress in Neurobiology · doi:10.1016/s0301-0082(96)00021-4 · Cited by 713 · see citing works
Axon Guidance and the Patterning of Neuronal Projections in Vertebrates
Dodd, J., & Jessell, T. M. (1988) · Science · doi:10.1126/science.3055291 · Cited by 699 · see citing works
Experience-dependent and cell-type-specific spine growth in the neocortex
Holtmaat, A., Wilbrecht, L., Knott, G. W., Welker, E., & Svoboda, K. (2006) · Nature · doi:10.1038/nature04783 · Cited by 631 · see citing works
Spine growth precedes synapse formation in the adult neocortex in vivo
Knott, G. W., Holtmaat, A., Wilbrecht, L., Welker, E., & Svoboda, K. (2006) · Nature Neuroscience · doi:10.1038/nn1747 · Cited by 563 · see citing works
Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memory
Nagy, V., Bozdagi, O., Matynia, A., Balcerzyk, M., Okulski, P., Dzwonek, J., Costa, R. M., Silva, A. J., Kaczmarek, L., & Huntley, G. W. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4359-05.2006 · Cited by 499 · see citing works
Self-citationMetabolic Mapping of Functional Activity in the Hypothalamo-Neurohypophysial System of the Rat
Schwartz, W. J., Smith, C. B., Davidsen, L., Savaki, H., Sokoloff, L., Mata, M., Fink, D. J., & Gainer, H. (1979) · Science · doi:10.1126/science.462184 · Cited by 454 · see citing works
Formation of Dendritic Spines with GABAergic Synapses Induced by Whisker Stimulation in Adult Mice
Knott, G. W., Quairiaux, C., Genoud, C., & Welker, E. (2002) · Neuron · doi:10.1016/s0896-6273(02)00663-3 · Cited by 438 · see citing works
A critical period for experience-dependent synaptic plasticity in rat barrel cortex
Fox, K. D. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-05-01826.1992 · Cited by 420 · see citing works
Cell type-specific structural plasticity of axonal branches and boutons in the adult neocortex
De Paola, V., Holtmaat, A., Knott, G., Song, S., Wilbrecht, L., Caroni, P., & Svoboda, K. (2006) · Neuron · doi:10.1016/j.neuron.2006.02.017 · Cited by 419 · see citing works
Nishijima, T., Piriz, J., Duflot, S., Fernandez, A. M., Gaitán, G., Gómez‐Pinedo, U., García‐Verdugo, J. M., Leroy, F., Soya, H., Núñez, Á., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.007 · Cited by 335 · see citing works
An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke
Li, S., Overman, J. J., Katsman, D., Kozlov, S. V., Donnelly, C. J., Twiss, J. L., Giger, R. J., Coppola, G., Geschwind, D. H., & Carmichael, S. T. (2010) · Nature Neuroscience · doi:10.1038/nn.2674 · Cited by 329 · see citing works
Wang, X.-B., Bozdagi, O., Nikitczuk, J. S., Zhai, Z. W., Zhou, Q., & Huntley, G. W. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807248105 · Cited by 316 · see citing works
Anatomical pathways and molecular mechanisms for plasticity in the barrel cortex
Fox, K. D. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00027-1 · Cited by 307 · see citing works
Important role of matrix metalloproteinase 9 in epileptogenesis
Wilczynski, G. M., Konopacki, F. A., Wilczek, E., Lasiecka, Z., Gorlewicz, A., Michaluk, P., Wawrzyniak, M., Malinowska, M., Okulski, P., Kolodziej, L. R., et al. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200708213 · Cited by 292 · see citing works
Self-citationLaminar Comparison of Somatosensory Cortical Plasticity
Diamond, M. E., Huang, W. M., & Ebner, F. F. (1994) · Science · doi:10.1126/science.8091215 · Cited by 289 · see citing works
Meighan, S. E., Meighan, P. C., Choudhury, P., Davis, C. J., Olson, M. L., Zornes, P. A., Wright, J. W., & Harding, J. W. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03565.x · Cited by 285 · see citing works
Interdigitated Paralemniscal and Lemniscal Pathways in the Mouse Barrel Cortex
Bureau, I., Paul, F. V. S., & Svoboda, K. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040382 · Cited by 274 · see citing works
Glazewski, S., & Fox, K. D. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.75.4.1714 · Cited by 236 · see citing works
Duncan, G. E., Johnson, K., & Breese, G. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-09-03932.1993 · Cited by 223 · see citing works
Stimulation‐induced [14C]2‐deoxyglucose labeling of synaptic activity in the central auditory system
Nudo, R. J., & Masterton, R. B. (1986) · The Journal of Comparative Neurology · doi:10.1002/cne.902450410 · Cited by 222 · see citing works
Influence of matrix metalloproteinase MMP-9 on dendritic spine morphology
Michaluk, P., Wawrzyniak, M., Alot, P., Szczot, M., Wyrembek, P., Mercik, K., Medvedev, N., Wilczek, E., De Roo, M., Zuschratter, W., et al. (2011) · Journal of Cell Science · doi:10.1242/jcs.090852 · Cited by 214 · see citing works
Self-citationExtracellular Matrix‐Degrading Proteinases in the Nervous System
Romanic, A. M., & Madri, J. A. (1994) · Brain Pathology · doi:10.1111/j.1750-3639.1994.tb00825.x · Cited by 209 · see citing works
Cell Type-Specific Circuits of Cortical Layer IV Spiny Neurons
Schubert, D., Kötter, R., Zilles, K., Luhmann, H. J., & Staiger, J. F. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02961.2003 · Cited by 207 · see citing works
Matrix Metalloproteinase-9 Controls NMDA Receptor Surface Diffusion through Integrin β1 Signaling
Michaluk, P., Mikasová, L., Groc, L., Frischknecht, R., Choquet, D., & Kaczmarek, L. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5346-08.2009 · Cited by 204 · see citing works
Self-citationLübke, J. H. R. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.10.1051 · Cited by 202 · see citing works
Neurotrophins, synaptic plasticity and dementia
Arancio, O., & Chao, M. V. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.03.013 · Cited by 193 · see citing works
Vaillant, C., Didier‐Bazès, M., Hutter, A., Belin, M., & Thomasset, N. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-12-04994.1999 · Cited by 188 · see citing works
Insulin-Like Growth Factor I Stimulates Dendritic Growth in Primary Somatosensory Cortex
Niblock, M. M., Brunso‐Bechtold, J. K., & Riddle, D. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04165.2000 · Cited by 184 · see citing works
Bozdagi, O., Nagy, V., Kwei, K. T., & Huntley, G. W. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00202.2007 · Cited by 182 · see citing works
Meyer, H. S., Wimmer, V. C., Oberlaender, M., de Kock, C. P. J., Sakmann, B., & Helmstaedter, M. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq067 · Cited by 170 · see citing works
Kaczmarek, L., Dzwonek, J., & Szymczak, S. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf676 · Cited by 154 · see citing works
Self-citationTIMP-1 Abolishes MMP-9-Dependent Long-lasting Long-term Potentiation in the Prefrontal Cortex
Okulski, P., Jay, T. M., Jaworski, J., Duniec, K., Dzwonek, J., Konopacki, F. A., Wilczynski, G. M., Sánchez‐Capelo, A., Mallet, J. J., & Kaczmarek, L. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.012 · Cited by 154 · see citing works
Self-citationOngoing in Vivo Experience Triggers Synaptic Metaplasticity in the Neocortex
Clem, R. L., Celikel, T., & Barth, A. L. (2008) · Science · doi:10.1126/science.1143808 · Cited by 151 · see citing works
Kossut, M. M., Hand, P. J., Greenberg, J. H., & Hand, C. L. (1988) · Journal of Neurophysiology · doi:10.1152/jn.1988.60.2.829 · Cited by 129 · see citing works
Self-citationAxonal dynamics of excitatory and inhibitory neurons in somatosensory cortex
Marik, S. A., Yamahachi, H., McManus, J. N. J., Szabo, G., & Gilbert, C. D. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000395 · Cited by 124 · see citing works
Duncan, G. E., Moy, S. S., Knapp, D. J., Mueller, R. A., & Breese, G. R. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01390-5 · Cited by 117 · see citing works
Siucińska, E., & Kossut, M. M. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.3.506 · Cited by 109 · see citing works
Self-citationBender, K. J., Rangel, J., & Feldman, D. E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-25-08759.2003 · Cited by 108 · see citing works
Bisler, S., Schleicher, A., Gass, P., Stehle, J. H., Zilles, K., & Staiger, J. F. (2002) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(01)00155-7 · Cited by 106 · see citing works
Activity-dependent maintenance and growth of dendrites in adult cortex
Tailby, C., Wright, L. L., Metha, A. B., & Calford, M. B. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402747102 · Cited by 98 · see citing works
Experience-Dependent Plasticity of Adult Rat S1 Cortex Requires Local NMDA Receptor Activation
Rema, V., Armstrong‐James, M., & Ebner, F. F. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-23-10196.1998 · Cited by 94 · see citing works
Staiger, J. F., Bisler, S., Schleicher, A., Gass, P., Stehle, J., & Zilles, K. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00166-4 · Cited by 92 · see citing works
Large-Scale Organization of Rat Sensorimotor Cortex Based on a Motif of Large Activation Spreads
Frostig, R. D., Xiong, Y., Chen‐Bee, C. H., Kvašňák, E., & Stehberg, J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4074-08.2008 · Cited by 90 · see citing works
Lebedev, M. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.1.23 · Cited by 86 · see citing works
Sensory Experience Alters Cortical Connectivity and Synaptic Function Site Specifically
Cheetham, C. E. J., Hammond, M. S. L., Edwards, C. E. J., & Finnerty, G. T. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5143-06.2007 · Cited by 83 · see citing works
Large-scale changes in dendritic structure during reorganization of adult somatosensory cortex
Hickmott, P. W., & Steen, P. A. (2005) · Nature Neuroscience · doi:10.1038/nn1384 · Cited by 80 · see citing works
Neuronal extracellular proteases facilitate cell migration, axonal growth, and pathfinding
Seeds, N. W., Siconolfi, L. B., & Haffke, S. P. (1997) · Cell and Tissue Research · doi:10.1007/s004410050942 · Cited by 79 · see citing works
Local axonal trajectories in mouse barrel cortex
Bernardo, K. L., McCasland, J. S., & Woolsey, T. A. (1990) · Experimental Brain Research · doi:10.1007/bf00231244 · Cited by 75 · see citing works
Templates for locating the whisker area in fresh flattened mouse and rat cortex
Strominger, R. N., & Woolsey, T. A. (1987) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(87)90004-5 · Cited by 75 · see citing works
Functional reorganization of adult cat somatosensory cortex is dependent on NMDA receptors
Kano, M., lino, K., & Kano, M. (1991) · Neuroreport · doi:10.1097/00001756-199102000-00003 · Cited by 74 · see citing works
Shubayev, V. I., & Myers, R. R. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20160 · Cited by 71 · see citing works
Rapid, Learning-Induced Inhibitory Synaptogenesis in Murine Barrel Field
Jasińska, M., Siucińska, E., Cybulska-Kłosowicz, A., Pyza, E., Furness, D. N., Kossut, M. M., & Glazewski, S. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2970-09.2010 · Cited by 70 · see citing works
Self-citationThe effect of vibrissa deprivation pattern on the form of plasticity induced in rat barrel cortex
Fox, K. D., & WALLACE, H. (1999) · Somatosensory & Motor Research · doi:10.1080/08990229970564 · Cited by 67 · see citing works
Single vibrissal cortical column in the mouse labeled with 2-deoxyglucose
Chmielowska, J., Kossut, M., & Chmielowski, M. (1986) · Experimental Brain Research · doi:10.1007/bf00237483 · Cited by 64 · see citing works
Self-citationCortical local circuit axons do not mature after early deafferentation.
McCasland, J. S., Bernardo, K. L., Probst, K. L., & Woolsey, T. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1832 · Cited by 60 · see citing works
Experience‐induced plasticity of thalamocortical axons in both juveniles and adults
Wimmer, V. C., Broser, P. J., Kuner, T., & Bruno, R. M. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22483 · Cited by 60 · see citing works
Kossut, M., & Juliano, S. L. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00722-2 · Cited by 59 · see citing works
Self-citationSkangiel-Kramska, J., Glazewski, S., Jabłońska, B., Siucińska, E., & Kossut, M. M. (1994) · Experimental Brain Research · doi:10.1007/bf00227277 · Cited by 59 · see citing works
Self-citationSpolidoro, M., Putignano, E., Munafò, C., Maffei, L., & Pizzorusso, T. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr158 · Cited by 58 · see citing works
McCown, T. J., Duncan, G. E., Johnson, K. B., & Breese, G. R. (1995) · Brain Research · doi:10.1016/0006-8993(95)00970-x · Cited by 58 · see citing works
Imaging of experience-dependent structural plasticity in the mouse neocortex in vivo
Holtmaat, A. J. D. G., Paola, V. D., Wilbrecht, L., & Knott, G. W. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.04.005 · Cited by 55 · see citing works
Deafferentation induced changes in GAD67 and GluR2 mRNA expression in mouse somatosensory cortex
Gierdalski, M., Jablonska, B., Smith, A., Skangiel-Kramska, J., & Kossut, M. M. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00153-9 · Cited by 47 · see citing works
Self-citationPartial blocking of NMDA receptors restricts plastic changes in adult mouse barrel cortex
Jabłońska, B., Gierdalski, M., Siucińska, E., Skangiel-Kramska, J., & Kossut, M. M. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(94)00141-2 · Cited by 46 · see citing works
Self-citationCheetham, C. E. J., Hammond, M. S. L., McFarlane, R., & Finnerty, G. T. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2974-08.2008 · Cited by 44 · see citing works
Sallaz, M., Hamm-Baarke, A., & Montag, D. (2003) · Journal of Neurobiology · doi:10.1002/neu.10254 · Cited by 42 · see citing works
Benedetti, B. L., Glazewski, S., & Barth, A. L. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3431-09.2009 · Cited by 37 · see citing works
Ipsilateral Whiskers Suppress Experience-Dependent Plasticity in the Barrel Cortex
Glazewski, S., Benedetti, B. L., & Barth, A. L. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0181-07.2007 · Cited by 35 · see citing works
Wirtshafter, D. (2005) · Brain Research · doi:10.1016/j.brainres.2005.05.052 · Cited by 33 · see citing works
The development of the vibrissal cortical column: A 2-deoxyglucose study in the rat
Kossut, M., & Hand, P. J. (1984) · Neuroscience Letters · doi:10.1016/0304-3940(84)90189-7 · Cited by 33 · see citing works
Self-citationFox, K. D., Glazewski, S., Chen, C., Silva, A. J., & Li, X. (1996) · Journal of Physiology-Paris · doi:10.1016/s0928-4257(97)81436-2 · Cited by 29 · see citing works
Large-scale plasticity in barrel cortex following repeated whisker trimming in young adult hamsters
Maier, D. L., Grieb, G., Stelzner, D. J., & McCasland, J. S. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00335-2 · Cited by 23 · see citing works
Eells, J. B., Clough, R. W., Miller, J. W., et al. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00276-8 · Cited by 22 · see citing works
Impairment of experience-dependent cortical plasticity in aged mice
Liguz‐Lecznar, M., Siucińska, E., Zakrzewska, R., et al. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.11.009 · Cited by 14 · see citing works
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Wang, D., & Fawcett, J. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1375-y · Cited by 373 · see citing works
Reinhard, S. M., Razak, K., & Ethell, I. M. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00280 · Cited by 219 · see citing works
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- Authors
- Kaliszewska, A., Bijata, M., Kaczmarek, L., & Kossut, M.
- Affiliations
- Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-10-20
- Volume
- 22
- Issue
- 9
- Pages
- 2160-2170
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2137059302
- Cited by
- 55
- References
- 77
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 5 · 2016: 6 · 2015: 9 · 2014: 5 · 2013: 2 · 2012: 2
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- experience-dependent plasticity, barrel cortex, sensory deprivation, whiskers, MMP-9, MMP-9 knockout mice, c-fos, 2-deoxyglucose autoradiography, layer 4, cortical reorganization
- MeSH terms
- Animals, Autoradiography, Brain Mapping, Deoxyglucose, Immunohistochemistry, Mice, Inbred C57BL, Neuronal Plasticity, Sensory Deprivation, Somatosensory Cortex, Vibrissae, Proto-Oncogene Proteins c-fos, Mice, Knockout, Matrix Metalloproteinase 9, Mice
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