Cited by 105Neuroendocrine regulation and behaviorHypothalamic control of reproductive hormonesNeuropeptides and Animal Physiology

Oxytocin, vasopressin, and estrogen-stimulated neurophysin: Daily patterns of concentration in cerebrospinal fluid

Perlow, M. J., Reppert, S. M., Artman, H. A., Fisher, D. A., Self, S. M., Robinson, A. G.·1982·Science

Abstract

The concentrations of oxytocin, arginine vasopressin, and estrogen stimulated neurophysin in cerebrospinal fluid of monkeys showed a daily fluctuation with high concentrations occurring during the light period. The patterns of oxytocin and estrogen-stimulated neurophysin in the cerebrospinal fluid were not observed in the plasma nor were they altered after the administration of a dose of estradiol that increased concentrations of estrogen-stimulated neurophysin in plasma. The disassociation between these cerebrospinal fluid and plasma patterns and values suggests that the secretory activity of neurons that release estrogen-stimulated neurophysin and oxytocin into the cerebrospinal fluid is controlled by mechanisms different from those that control their release into the plasma.

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Crossref · 10.1126/science.7201163

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  • In lactating rhesus monkeys, Amico et al. found that CSF oxytocin variations were independent of the suckling stimulus and plasma oxytocin concentrations, and noted that CSF but not plasma levels show a circadian variation; they concluded that oxytocin release into CSF is disassociated from release into the peripheral circulation.

    “In lactating rhesus monkeys, Amico et al. (86) found that”

    From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [87]

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Authors
Perlow, M. J., Reppert, S. M., Artman, H. A., Fisher, D. A., Self, S. M., & Robinson, A. G.
Affiliations
  • Icahn School of Medicine at Mount Sinai (US)
  • Massachusetts General Hospital (US)
  • University of California, Los Angeles (US)
  • University of Pittsburgh (US)
Venue
Science
Published
1982-06-25
Volume
216
Issue
4553
Pages
1416-1418
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2051313430
Cited by
105
References
41
Citations by year
2026: 1 · 2025: 3 · 2024: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 1 · 2013: 1
FWCI
24.81
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
oxytocin, vasopressin, cerebrospinal fluid, diurnal variation, light period, estradiol, plasma hormone levels, neurosecretion
MeSH terms
Animals, Arginine Vasopressin, Circadian Rhythm, Estradiol, Macaca mulatta, Male, Neurons, Efferent, Neurophysins, Oxytocin

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