Oxytocin, vasopressin, and estrogen-stimulated neurophysin: Daily patterns of concentration in cerebrospinal fluid
Abstract
The concentrations of oxytocin, arginine vasopressin, and estrogen stimulated neurophysin in cerebrospinal fluid of monkeys showed a daily fluctuation with high concentrations occurring during the light period. The patterns of oxytocin and estrogen-stimulated neurophysin in the cerebrospinal fluid were not observed in the plasma nor were they altered after the administration of a dose of estradiol that increased concentrations of estrogen-stimulated neurophysin in plasma. The disassociation between these cerebrospinal fluid and plasma patterns and values suggests that the secretory activity of neurons that release estrogen-stimulated neurophysin and oxytocin into the cerebrospinal fluid is controlled by mechanisms different from those that control their release into the plasma.
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In lactating rhesus monkeys, Amico et al. found that CSF oxytocin variations were independent of the suckling stimulus and plasma oxytocin concentrations, and noted that CSF but not plasma levels show a circadian variation; they concluded that oxytocin release into CSF is disassociated from release into the peripheral circulation.
“In lactating rhesus monkeys, Amico et al. (86) found that”
From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [87]
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- Authors
- Perlow, M. J., Reppert, S. M., Artman, H. A., Fisher, D. A., Self, S. M., & Robinson, A. G.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Massachusetts General Hospital (US)
- University of California, Los Angeles (US)
- University of Pittsburgh (US)
- ORCID
- Reppert, S. M.
- Venue
- Science
- Published
- 1982-06-25
- Volume
- 216
- Issue
- 4553
- Pages
- 1416-1418
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2051313430
- Cited by
- 105
- References
- 41
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 1 · 2013: 1
- FWCI
- 24.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, vasopressin, cerebrospinal fluid, diurnal variation, light period, estradiol, plasma hormone levels, neurosecretion
- MeSH terms
- Animals, Arginine Vasopressin, Circadian Rhythm, Estradiol, Macaca mulatta, Male, Neurons, Efferent, Neurophysins, Oxytocin
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