Baroreflex control of heart rate by oxytocin in the solitary-vagal complex
Abstract
Previous work demonstrated that oxytocinergic projections to the solitary vagal complex are involved in the restraint of exercise-induced tachycardia (2). In the present study, we tested the idea that oxytocin (OT) terminals in the solitary vagal complex [nucleus of the solitary tract (NTS)/dorsal motor nucleus of the vagus (DMV)] are involved in baroreceptor reflex control of heart rate (HR). Studies were conducted in male rats instrumented for chronic cardiovascular monitoring with a cannula in the NTS/DMV for brain injections. Basal mean arterial pressure and HR and reflex HR responses during loading and unloading of the baroreceptors (phenylephrine/sodium nitroprusside intravenously) were recorded after administration of a selective OT antagonist (OT ant) or OT into the NTS/DMV. The NTS/DMV was selected for study because this region contains such a specific and dense concentration of OT-immunoreactive terminals. Vehicle injections served as a control. OT and OT ant changed baroreflex control of HR in opposite directions. OT (20 pmol) increased the maximal bradycardic response (from −56 ± 9 to −75 ± 11 beats/min), whereas receptor blockade decreased the bradycardia (from −61 ± 13 to −35 ± 2 beats/min). OT ant also reduced the operating range of the reflex, thus decreasing baroreflex gain (from −5.68 ± 1.62 to −2.83 ± 1.05 beats · min−1· mmHg−1). OT injected into the NTS/DMV of atenolol-treated rats still potentiated the bradycardic responses to pressor challenges, whereas OT injections had no effect in atropine-treated rats. The brain stem effect was specific because neither vehicle administration nor injection of OT or OT ant into the fourth cerebral ventricle had any effect. Our data suggest that OT terminals in the solitary vagal complex modulate reflex control of the heart, acting to facilitate vagal outflow and the slowdown of the heart.
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The vagus is densely populated with oxytocin receptors in rodents.
“The vagus is densely populated with oxytocin receptors in rodents19,21–26”
From Voluntary upregulation of heart rate variability through biofeedback is improved by mental contemplative training (2019) · cites this paper as [23]
The vagus nerve is densely populated by oxytocin receptors.
“The vagus nerve is densely populated by oxytocin receptors19,21–26”
From Voluntary upregulation of heart rate variability through biofeedback is improved by mental contemplative training (2019) · cites this paper as [23]
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- Authors
- Higa, K. T., Mori, E., Viana, F. F., Morris, M., & Michelini, L. C.
- Affiliations
- Department of Physiology and Biophysics, Biomedical Sciences Institute, University of Sao Paulo, 05508-900 Sao Paulo, Brazil; and
- Universidade de São Paulo (BR)
- Wright State University (US)
- ORCID
- Michelini, Lisete C.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2002-02-01
- Volume
- 282
- Issue
- 2
- Pages
- R537-R545
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2064531921
- Cited by
- 157
- References
- 41
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 8 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 8 · 2017: 8 · 2016: 13 · 2015: 11 · 2014: 9 · 2013: 10 · 2012: 10
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- NSUWorks (Nova Southeastern University) (submittedVersion)
- Funders
- National Institutes of Health (5r01hl043178-09)
- National Heart, Lung, and Blood Institute (HL-43178)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- oxytocin, baroreflex, heart rate, nucleus tractus solitarius, dorsal motor nucleus of the vagus, vagal outflow, bradycardia, baroreflex gain, atenolol, atropine, oxytocin antagonist, brainstem
- MeSH terms
- Animals, Blood Pressure, Bradycardia, Heart Rate, Immunohistochemistry, Male, Motor Neurons, Nitroprusside, Oxytocin, Phenylephrine, Rats, Inbred WKY, Sympathomimetics, Tachycardia, Vagus Nerve, Vasodilator Agents, Solitary Nucleus, Baroreflex, Receptors, Oxytocin, Fourth Ventricle, Rats
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