Cited by 597Axon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanismsVisual perception and processing mechanisms

Growth and Reshaping of Axons in the Establishment of Visual Callosal Connections

Innocenti, G. M.·1981·Science

Abstract

The visual cortical areas in the two hemispheres are interconnected by axons running through the corpus callosum. In adult cats, these axons originate from, and terminate in, tangentially restricted portions of each area. In young kittens, however, callosal axons originate from the entire extent of each area, although they apparently enter the gray matter only in the restricted regions where they will also be found in adults. In kittens, but not in adults, callosal axons also reach other regions, but there they appear to be confined to the lowest part of layer VI. During the first two postnatal months, the callosal efferent zones become progressively restricted to their adult locations. During this process, many neurons eliminate the axons (or axon collaterals) that they had formerly sent through the corpus callosum and form permanent connections ipsilaterally.

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Crossref · 10.1126/science.7221566

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15 of 15 references verified0 citation errors · 0 not checkable

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  • A second pervasive form of degeneration in the developing brain is degeneration limited to axonal connections leaving the neurons of origin intact.

    “A second, pervasive form of degeneration in the developing brain is degeneration limited to axonal connections leaving the neurons of origin intact.”

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Authors
Innocenti, G. M.
Affiliations
University of Lausanne (CH)
Corresponding author
Innocenti, G. M.
Venue
Science
Published
1981-05-15
Volume
212
Issue
4496
Pages
824-827
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1978268702
Cited by
597
References
15
Citations by year
2026: 3 · 2025: 4 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 3 · 2013: 8 · 2012: 6
FWCI
14.12
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Keywords
corpus callosum, callosal axons, visual cortex, axon growth, axon pruning, postnatal development, kittens, cats, axon collaterals, layer 6
MeSH terms
Age Factors, Animals, Axons, Cats, Corpus Callosum, Visual Pathways

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