The Testicular Feminized Rat: A Naturally Occurring Model of Androgen Independent Brain Masculinization

The Formation of Estrogens by Central Neuroendocrine Tissues

NAFTOLIN, F., RYAN, K. J., DAVIES, I. J., REDDY, V. V., FLORES, F., PETRO, Z., KUHN, M., WHITE, R. J., TAKAOKA, Y., & WOLIN, L. (1975) · Proceedings of the 1974 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571131-9.50012-8 · Cited by 793 · see citing works

The syndrome of testicular feminization in male pseudohermaphrodites

Morris, J. M. (1953) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(53)90359-7 · Cited by 617 · see citing works

Sexual differences of the hypophyses and their determination by the gonads

Pfeiffer, C. A. (1936) · American Journal of Anatomy · doi:10.1002/aja.1000580112 · Cited by 383 · see citing works

Hormonal determinants of the development of masculine and feminine behavior in male and female rats

Whalen, R. E., & Edwards, D. A. (1967) · The Anatomical Record · doi:10.1002/ar.1091570208 · Cited by 220 · see citing works

Part II. Androgen Metabolism and Mechanism of Action in Male Pseudohermaphroditism: A Study of Testicular Feminization

Bardin, C. W., BULLOCK, L. P., Sherins, R. J., Mowszowicz, I., & Blackburn, W. R. (1973) · Elsevier eBooks · doi:10.1016/b978-0-12-571129-6.50006-3 · Cited by 179 · see citing works

Lordosis Reflex Intensity in Rats in Relation to the Estrous Cycle, Ovariectomy, Estrogen Administration and Mating Behavior

Komisaruk, B. R., & Diakow, C. A. (1973) · Endocrinology · doi:10.1210/endo-93-3-548 · Cited by 153 · see citing works

Male and Female Sexual Responses in Male Rats Given Estradiol Benzoate and 5α-Androstan-17β-ol-3-one Propionate

Feder, H. H., Naftolin, F. N., & Ryan, K. J. (1974) · Endocrinology · doi:10.1210/endo-94-1-136 · Cited by 127 · see citing works

Androgen and Estrogen Receptors in Brain Cytosol from Male, Female, and Testicular Feminized (tfm/y ♂) Mice

Attardi, B., Geller, P. J., TABOR, L. N., & Ohno, S. (1976) · Endocrinology · doi:10.1210/endo-98-4-864 · Cited by 91 · see citing works

Part I. Male Pseudohermaphroditism in the Laboratory Norway Rat

STANLEY, A. J., GUMBRECK, L. G., ALLISON, J. E., & EASLEY, R. B. (1973) · Proceedings of the 1972 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571129-6.50005-1 · Cited by 80 · see citing works

FAILURE OF POSITIVE FEEDBACK IN NORMAL MEN AND SUBJECTS WITH TESTICULAR FEMINIZATION

Look, P. F. A. V., HUNTER, W. M., Corker, C. S., & Baird, D. T. (1977) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1977.tb03344.x · Cited by 71 · see citing works

The “Puberty” of the Rat Liver. Feminine Pattern of Cortisol Metabolism in Male Rats Castrated at Birth1

MOOR, P. D., & Denef, C. (1968) · Endocrinology · doi:10.1210/endo-82-3-480 · Cited by 70 · see citing works

Male Rats With Inherited Insensitivity to Androgen Show Reduced Sexual Behavior

Beach, F. A., & BUEHLER, M. G. (1977) · Endocrinology · doi:10.1210/endo-100-1-197 · Cited by 62 · see citing works

Anti-estrogen inhibition of androgen induced sexual receptivity in rats

Whalen, R. E., Battie, C. A., & Luttge, W. G. (1972) · Behavioral Biology · doi:10.1016/s0091-6773(72)80103-2 · Cited by 59 · see citing works

Expression of H–Y (male) antigen in phenotypically female Tfm/Y mice

Bennett, D., Boyse, E. A., Lyon, M. F., Mathieson, B. J., Scheid, M. P., & Yanagisawa, K. (1975) · Nature · doi:10.1038/257236a0 · Cited by 58 · see citing works

Hormonal control of female sexual behavior in the rat

Zemlan, F. P., & Adler, N. T. (1977) · Hormones and Behavior · doi:10.1016/0018-506x(77)90069-1 · Cited by 57 · see citing works

Induction of male mating behavior in androgen-insensitive (tfm) and normal (King-Holtzman) male rats: Effect of testosterone propionate, estradiol benzoate, and dihydrotestosterone

Olsen, K. L. (1979) · Hormones and Behavior · doi:10.1016/0018-506x(79)90035-7 · Cited by 55 · see citing works

Androgen-insensitive rats are defeminised by their testes

OLSEN, K. L. (1979) · Nature · doi:10.1038/279238a0 · Cited by 52 · see citing works

Is feminine differentiation of the brain hormonally determined?

Shapiro, B., Goldman, A. S., Steinbeck, H., & Neumann, F. (1976) · Cellular and Molecular Life Sciences · doi:10.1007/bf01990214 · Cited by 40 · see citing works

Metabolism of Steroid Hormones, Sterols, and Bile Acids in Liver Microsomes from Male, Female, and Male‐Pseudohermaphroditic Rats

Einarsson, K., Gustafsson, J.-Α., & Goldman, A. S. (1972) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1972.tb02539.x · Cited by 31 · see citing works

Hormonal Control of Sexual Differentiation of the Hypothalamus in the Neonatal Female Rat

Doughty, C., & McDonald, P. G. (1974) · Differentiation · doi:10.1111/j.1432-0436.1974.tb00362.x · Cited by 25 · see citing works

Central aromatization of testosterone in testicular feminized mice

Rosenfeld, J. M., Daley, J. D., Ohno, S., & Younglai, E. V. (1977) · Cellular and Molecular Life Sciences · doi:10.1007/bf01920200 · Cited by 25 · see citing works

The Y-linked H-Y antigen locus and the X-linked Tfm locus as major regulatory genes of the mammalian sex determining mechanism

Ohno, S. (1977) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(77)90266-7 · Cited by 23 · see citing works

Masculine-like Hypothalamic-Pituitary Axis in the Androgen-Insensitive Genetically Male Rat Pseudohermaphrodite

Shapiro, B. H., Goldman, A. S., & Gustafsson, J.-Α. (1975) · Endocrinology · doi:10.1210/endo-97-2-487 · Cited by 14 · see citing works

Testicular Maintenance and Masculinized Development of the Vagina of the Androgen-Insensitive Male Rat Pseudohermaphrodite

Shapiro, B. H., & GOLDMAN, A. S. (1975) · Endocrinology · doi:10.1210/endo-96-6-1392 · Cited by 5 · see citing works

Correction of developmental defects in adrenal steroid metabolizing enzymes of the genetically male rat pseudohermaphrodite by prolactin

Goluman, A. S., & Shapiro, B. H. (1977) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(77)90213-8 · Cited by 2 · see citing works

Gonadal Hormones Induce Dendritic Growth in the Adult Avian Brain

DeVoogd, T. J., & Nottebohm, F. (1981) · Science · doi:10.1126/science.7280692 · Cited by 386 · see citing works

Prenatal gonadal hormones and sex differences in human behavior.

Hines, M. (1982) · Psychological Bulletin · doi:10.1037/0033-2909.92.1.56 · Cited by 241 · see citing works

Prenatal exposure to diethylstilbestrol (DES) and the development of sexually dimorphic cognitive abilities and cerebral lateralization.

Hines, M., & Shipley, C. (1984) · Developmental Psychology · doi:10.1037/0012-1649.20.1.81 · Cited by 194 · see citing works

Steroid Hormones: Humoral Signals Which Alter Brain Cell Properties and Functions

McEwen, B. S., Biegon, A. R., Davis, P. G., Krey, L. C., Luine, V. N., McGinnis, M. Y., Paden, C. M., Parsons, B., & Rainbow, T. C. (1982) · Elsevier eBooks · doi:10.1016/b978-0-12-571138-8.50007-x · Cited by 178 · see citing works

Androgen receptor is essential for sexual differentiation of responses to olfactory cues in mice

Bodo, C., & Rissman, E. F. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05484.x · Cited by 109 · see citing works

The endocrinology of transsexualism: A review and commentary

Gooren, L. J. (1990) · Psychoneuroendocrinology · doi:10.1016/0306-4530(90)90041-7 · Cited by 78 · see citing works

Ontogeny of 5 alpha-reductase (type 1) messenger ribonucleic acid expression in rat brain: early presence in germinal zones

Lauber, M., & LICHTENSTEIGER, W. (1996) · Endocrinology · doi:10.1210/endo.137.7.8770891 · Cited by 72 · see citing works

Genetic Influences on Sexual Behavior Differentiation

Olsen, K. L. (1992) · Handbooks of Behavioral Neurobiology · doi:10.1007/978-1-4899-2453-7_1 · Cited by 52 · see citing works

Development of male gender identity/role and a sexual orientation towards women in a 46,XY subject with an incomplete form of the androgen insensitivity syndrome

Gooren, L. J., & Cohen‐Kettenis, P. T. (1991) · Archives of Sexual Behavior · doi:10.1007/bf01542408 · Cited by 41 · see citing works

Sexual Differentiation of Behavior in the Context of Developmental Psychobiology

Yahr, P. (1988) · Handbook of behavioral neurobiology · doi:10.1007/978-1-4684-5421-5_6 · Cited by 38 · see citing works

Systemic hypotensive effects of testosterone are androgen structure-specific and neuronal nitric oxide synthase-dependent

Perusquı́a, M., Greenway, C. D., Perkins, L. M., & Stallone, J. N. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00110.2015 · Cited by 31 · see citing works

Play fighting in androgen-insensitivetfm rats: Evidence that androgen receptors are necessary for the development of adult playful attack and defense

Field, E. F., Whishaw, I. Q., Pellis, S. M., & Watson, N. V. (2006) · Developmental Psychobiology · doi:10.1002/dev.20121 · Cited by 30 · see citing works

Genetic Determinants of Sexual Differentiation

Olsen, K. L. (1983) · Proceedings in life sciences · doi:10.1007/978-3-642-69216-1_10 · Cited by 24 · see citing works

Genetics of Steroid Receptors and Their Disorders

Pinsky, L., & Kaufman, M. (1987) · Springer eBooks · doi:10.1007/978-1-4757-0620-8_5 · Cited by 24 · see citing works

Steroids induce hypothalamic progestin receptors and facilitate female sexual behavior in neonatal rats

Williams, C. L., & Blaustein, J. D. (1988) · Brain Research · doi:10.1016/0006-8993(88)91064-5 · Cited by 24 · see citing works

Albumin is a secret factor involved in multidirectional interactions among the serotoninergic, immune and endocrine systems that supervises the mechanism of CYP1A and CYP3A regulation in the liver

Daujat‐Chavanieu, M., & Kot, M. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107616 · Cited by 22 · see citing works

Developmental androgen fluctuations and the five dimensions of mammalian sex (with emphasis upon the behavioral dimension and the human species)

Ellis, L. M. (1982) · Ethology and Sociobiology · doi:10.1016/0162-3095(82)90048-6 · Cited by 19 · see citing works

Androgen-receptor defect abolishes sex differences in nitric oxide and reactivity to vasopressin in rat aorta

Stallone, J. N., Salisbury, R. L., & Fulton, C. T. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.6.2602 · Cited by 18 · see citing works

Sex differences in the brain–an interplay of sex steroid hormones and sex chromosomes

Grgurevič, N., & Majdič, G. (2016) · Clinical Science · doi:10.1042/cs20160299 · Cited by 17 · see citing works

Biological Determinants of Sexual Orientation

Gooren, L. J., Fliers, E., & Courtney, K. (1990) · Annual Review of Sex Research · doi:10.1080/10532528.1990.10559860 · Cited by 17 · see citing works

Hypogonadal hypertension in male Sprague-Dawley rats is renin-angiotensin system-dependent: role of endogenous androgens

Hanson, A. E., Perusquı́a, M., & Stallone, J. N. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00324-5 · Cited by 16 · see citing works

A role for the androgen receptor in the sexual differentiation of the olfactory system in mice

Bodo, C. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.08.008 · Cited by 16 · see citing works

Genetics, Hormones, and Aggression

Maxson, S. C., Shrenker, P., & Vigue, L. C. (1983) · Springer eBooks · doi:10.1007/978-1-4613-3521-4_8 · Cited by 16 · see citing works

Gonadal steroids regulate immunoreactive tachykinin in the ventromedial nucleus of the rat hypothalamus

Akesson, T. R. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903410306 · Cited by 15 · see citing works

Sexually dimorphic postural adjustments are used in a skilled reaching task in the rat

Field, E. F., & Whishaw, I. Q. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.05.008 · Cited by 14 · see citing works

The genetics of hormonal influences on male sexual behavior of mice and rats

Shrenker, P., & Maxson, S. C. (1983) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(83)90037-4 · Cited by 14 · see citing works

Irreversible perinatal imprinting of adult expression of the principal sex‐dependent drug‐metabolizing enzyme CYP2C11

Das, R. K., Banerjee, S., & Shapiro, B. H. (2014) · The FASEB Journal · doi:10.1096/fj.13-248864 · Cited by 13 · see citing works

Consequences of Mutations in Androgen Receptor Genes

McGinnis, M. Y., Marcelli, M., & Lamb, D. J. (2002) · Hormones, Brain and Behavior · doi:10.1016/b978-012532104-4/50095-0 · Cited by 13 · see citing works

SEXUAL DIFFERENTIATION OF THE BRAIN: GONADAL HORMONE ACTION AND CURRENT CONCEPTS OF NEURONAL DIFFERENTIATION

McEwen, B. S. (1982) · Elsevier eBooks · doi:10.1016/b978-0-12-137020-6.50013-4 · Cited by 13 · see citing works

A masculinized skeletomusculature is not necessary for male-typical patterns of food-protective movement

Field, E. F., Watson, N. V., Whishaw, I. Q., & Pellis, S. M. (2005) · Hormones and Behavior · doi:10.1016/j.yhbeh.2004.08.007 · Cited by 10 · see citing works

Heterotypical Sexual Behaviour in Female Mammals

Goy, R. W., & Roy, M. M. (1991) · Springer eBooks · doi:10.1007/978-94-011-3078-3_4 · Cited by 10 · see citing works

Evolutionary Insights from Reptilian Sexual Differentiation

Crews, D. P., & Bull, J. J. (1987) · Springer eBooks · doi:10.1007/978-1-4899-1965-6_2 · Cited by 10 · see citing works

Growth hormone: a newly identified developmental organizer

Das, R. K., Banerjee, S., & Shapiro, B. H. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0471 · Cited by 8 · see citing works

The social interactions of adult conspecifics with an adult XY gonadal dysgenetic chacma baboon (Papio ursinus)

Bielert, C. F. (1984) · Hormones and Behavior · doi:10.1016/0018-506x(84)90049-7 · Cited by 8 · see citing works

Sex Differences in Righting From Supine to Prone in Rats (Rattus norvegicus): A Masculinized Skeletomusculature Is Not Required.

Field, E. F., Martens, D. J., Watson, N. V., & Pellis, S. M. (2005) · Journal of Comparative Psychology · doi:10.1037/0735-7036.119.2.238 · Cited by 7 · see citing works

Pattern in Behavior

Pellis, S. M., Pellis, V. C., & Iwaniuk, A. N. (2014) · Advances in the study of behavior · doi:10.1016/b978-0-12-800286-5.00004-3 · Cited by 7 · see citing works

The Timing of Hormone Signals in the Orchestration of Brain Development

Timiras, P. S. (1982) · Springer eBooks · doi:10.1007/978-1-4684-4076-8_5 · Cited by 5 · see citing works

Feminization imprinted by developmental growth hormone

Banerjee, S., Das, R. K., & Shapiro, B. H. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.08.011 · Cited by 4 · see citing works

Early expression of requisite developmental growth hormone imprinted cytochromes P450 and dependent transcription factors

Banerjee, S., Hayes, A. M., & Shapiro, B. H. (2021) · Endocrine Connections · doi:10.1530/ec-21-0143 · Cited by 1 · see citing works

Sex Differentiation and Fetal Endocrinology

Pasqualini, J. R., Kincl, F. A., & SUMIDA, C. (1991) · Elsevier eBooks · doi:10.1016/b978-0-08-035720-1.50007-4 · Cited by 1 · see citing works

The androgen-response system in developmental health and disease

Pinsky, L., & Kaufman, M. (1985) · Elsevier eBooks · doi:10.1016/b978-0-407-02312-3.50017-x · Cited by 1 · see citing works

Masculinization of female rats by intracranial implantation of androgen in infancy.

Nadler, R. D. (1968) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0025955 · Cited by 46 · see citing works

Is feminine differentiation of the brain hormonally determined?

Shapiro, B., Goldman, A. S., Steinbeck, H., & Neumann, F. (1976) · Cellular and Molecular Life Sciences · doi:10.1007/bf01990214 · Cited by 40 · see citing works

The role of androgen receptors in the masculinization of brain and behavior: What we've learned from the testicular feminization mutation

Zuloaga, D. G., Puts, D. A., Jordan, C. L., & Breedlove, S. M. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.01.013 · Cited by 236 · see citing works

Brain masculinization requires androgen receptor function

Sato, T., Matsumoto, T., Kawano, H., Watanabe, T., Uematsu, Y., Sekine, K., Fukuda, T., Aihara, K.-I., Krust, A., Yamada, T., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305303101 · Cited by 303 · see citing works

Partial demasculinization of several brain regions in adult male (XY) rats with a dysfunctional androgen receptor gene

Morris, J. A., Jordan, C. L., Dugger, B. N., & Breedlove, S. M. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20558 · Cited by 65 · see citing works