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Localization of Protein Kinases by Anchoring Proteins: a Theme in Signal Transduction

Mochly-Rosen, Daria·1995·Science
DOI 10.1126/science.7716516
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Abstract

A fundamental question in signal transduction is how stimulation of a specific protein kinase leads to phosphorylation of particular protein substrates throughout the cell. Recent studies indicate that specific anchoring proteins located at various sites in the cell compartmentalize the kinases to their sites of action. Inhibitors of the interactions between kinases and their anchoring proteins inhibit the functions mediated by the kinases. These data indicate that the location of these anchoring proteins provides some of the specificity of the responses mediated by each kinase and suggest that inhibitors of the interaction between the kinases and their anchoring proteins may be useful as therapeutic agents.

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Metadata

Authors
Mochly-Rosen, D.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1995-04-14
Volume
268
Issue
5208
Pages
247-251
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.7716516
OpenAlex
W2089330962
Cited by
906
References
2
FWCI
28.42
Type
journal article
Language
en
Open access
closed

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