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Localization of Protein Kinases by Anchoring Proteins: a Theme in Signal Transduction

Mochly-Rosen, Daria·1995·Science
DOI 10.1126/science.7716516
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Abstract

A fundamental question in signal transduction is how stimulation of a specific protein kinase leads to phosphorylation of particular protein substrates throughout the cell. Recent studies indicate that specific anchoring proteins located at various sites in the cell compartmentalize the kinases to their sites of action. Inhibitors of the interactions between kinases and their anchoring proteins inhibit the functions mediated by the kinases. These data indicate that the location of these anchoring proteins provides some of the specificity of the responses mediated by each kinase and suggest that inhibitors of the interaction between the kinases and their anchoring proteins may be useful as therapeutic agents.

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  1. ADAMS, S.R., FLUORESCENCE RATIO IMAGING OF CYCLIC-AMP IN SINGLE CELLS, NATURE 349: 694 (1991). · DOI · Paper page
  2. AITKEN, A, KINASE AND NEUROTRANSMITTERS, NATURE 344: 594 (1990). · DOI
  3. 10.1073/pnas.83.9.2797 · DOI
  4. 10.1016/S0021-9258(17)42306-4 · DOI
  5. BONEH, A, BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 66: 262 (1988). · DOI
  6. BREGMAN, D.B., HIGH-AFFINITY BINDING-PROTEIN FOR THE REGULATORY SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE-II-B - CLONING, CHARACTERIZATION, AND EXPRESSION OF CDNAS FOR RAT-BRAIN P150, JOURNAL OF BIOLOGICAL CHEMISTRY 264: 4648 (1989). · DOI
  7. 10.1038/327629a0 · DOI · Paper page
  8. CARR, D.W., INTERACTION OF THE REGULATORY SUBUNIT (RII) OF CAMP-DEPENDENT PROTEIN-KINASE WITH RII-ANCHORING PROTEINS OCCURS THROUGH AN AMPHIPATHIC HELIX BINDING MOTIF, JOURNAL OF BIOLOGICAL CHEMISTRY 266: 14188 (1991). · DOI
  9. CARR, D.W., LOCALIZATION OF THE CAMP-DEPENDENT PROTEIN-KINASE TO THE POSTSYNAPTIC DENSITIES BY A-KINASE ANCHORING PROTEINS - CHARACTERIZATION OF AKAP-79, JOURNAL OF BIOLOGICAL CHEMISTRY 267: 16816 (1992). · DOI · Paper page
  10. CHAPLINE, C, INTERACTION CLONING OF PROTEIN-KINASE-C SUBSTRATES, JOURNAL OF BIOLOGICAL CHEMISTRY 268: 6858 (1993). · DOI
  11. 10.1126/science.7528941 · DOI
  12. DECAMILLI, P, HETEROGENEOUS DISTRIBUTION OF THE CAMP RECEPTOR PROTEIN RII IN THE NERVOUS-SYSTEM - EVIDENCE FOR ITS INTRACELLULAR ACCUMULATION ON MICROTUBULES, MICROTUBULE-ORGANIZING CENTERS, AND IN THE AREA OF THE GOLGI-COMPLEX, JOURNAL OF CELL BIOLOGY 103: 189 (1986). · DOI
  13. DISATNIK, M.H., DISTINCT RESPONSES OF PROTEIN-KINASE-C ISOZYMES TO C-ERBB-2 ACTIVATION IN SKBR-3 HUMAN BREAST-CARCINOMA CELLS, CELL GROWTH & DIFFERENTIATION 5: 873 (1994).
  14. DISATNIK, M.H., LOCALIZATION OF PROTEIN-KINASE-C ISOZYMES IN CARDIAC MYOCYTES, EXPERIMENTAL CELL RESEARCH 210: 287 (1994). · DOI · Paper page
  15. FABIAN, J.R., A SINGLE AMINO-ACID CHANGE IN RAF-1 INHIBITS RAS BINDING AND ALTERS RAF-1 FUNCTION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91: 5982 (1994).
  16. 10.1038/371612a0 · DOI · Paper page
  17. FANTOZZI, D.A., THERMOSTABLE INHIBITOR OF CAMP-DEPENDENT PROTEIN-KINASE ENHANCES THE RATE OF EXPORT OF THE KINASE CATALYTIC SUBUNIT FROM THE NUCLEUS, JOURNAL OF BIOLOGICAL CHEMISTRY 269: 2676 (1994). · DOI
  18. FORCE, T, ENZYMATIC CHARACTERISTICS OF THE C-RAF-1 PROTEIN-KINASE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91: 1270 (1994).
  19. 10.1126/science.8085158 · DOI · Paper page
  20. GLANTZ, S.B., CAMP SIGNALING IN NEURONS - PATTERNS OF NEURONAL EXPRESSION AND INTRACELLULAR-LOCALIZATION FOR A NOVEL PROTEIN, AKAP-150, THAT ANCHORS THE REGULATORY SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE-II-BETA, MOLECULAR BIOLOGY OF THE CELL 3: 1215 (1992). · DOI
  21. GOPALAKRISHNA, R, FACTORS INFLUENCING CHELATOR-STABLE, DETERGENT-EXTRACTABLE, PHORBOL DIESTER-INDUCED MEMBRANE ASSOCIATION OF PROTEIN-KINASE-C - DIFFERENCES BETWEEN CA-2+-INDUCED AND PHORBOL ESTER-STABILIZED MEMBRANE BINDINGS OF PROTEIN-KINASE-C, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 16438 (1986). · DOI
  22. GOSH, S, J BIOL CHEM 269: 10000 (1994). · DOI
  23. GRAFF, J.M., CHARACTERIZATION OF THE PHOSPHORYLATION SITES IN THE CHICKEN AND BOVINE MYRISTOYLATED ALANINE-RICH C-KINASE SUBSTRATE PROTEIN, A PROMINENT CELLULAR SUBSTRATE FOR PROTEIN KINASE-C, JOURNAL OF BIOLOGICAL CHEMISTRY 264: 11912 (1989). · DOI
  24. HAGIWARA, M, DISCREPANCY OF PROTEIN KINASE-C TRANSLOCATION AND PLATELET-AGGREGATION IMMUNOCYTOBIOCHEMICAL EVIDENCE, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 280: 201 (1990). · DOI
  25. HIRSCH, A.H., CLONING AND EXPRESSION OF AN INTRON-LESS GENE FOR AKAP-75, AN ANCHOR PROTEIN FOR THE REGULATORY SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE-II-BETA, JOURNAL OF BIOLOGICAL CHEMISTRY 267: 2131 (1992). · DOI
  26. HOCEVAR, B.A., SELECTIVE TRANSLOCATION OF BETA-II-PROTEIN KINASE-C TO THE NUCLEUS OF HUMAN PROMYELOCYTIC (HL60) LEUKEMIA-CELLS, JOURNAL OF BIOLOGICAL CHEMISTRY 266: 28 (1991). · DOI
  27. HOCEVAR, B.A., PROTEIN-KINASE-C ISOTYPES IN HUMAN ERYTHROLEUKEMIA CELL-PROLIFERATION AND DIFFERENTIATION, JOURNAL OF CELL SCIENCE 101: 671 (1992). · DOI
  28. HYATT, S.L., IDENTIFICATION AND CHARACTERIZATION OF ALPHA-PROTEIN KINASE-C BINDING-PROTEINS IN NORMAL AND TRANSFORMED REF52 CELLS, BIOCHEMISTRY 33: 1223 (1994). · DOI
  29. HYATT, S.L., PROTEIN KINASE-C IS LOCALIZED IN FOCAL CONTACTS OF NORMAL BUT NOT TRANSFORMED FIBROBLASTS, MOLECULAR CARCINOGENESIS 3: 45 (1990). · DOI
  30. 10.1016/S0021-9258(20)80439-6 · DOI · Paper page
  31. 10.1016/S0021-9258(20)80439-6 · DOI · Paper page
  32. 10.1126/science.8085159 · DOI
  33. Jaken, S., Protein Kinase C, Current Concepts and Future Perspectives: 237 (1992).
  34. KAMEYAMA, K, ACTIVATION BY G-PROTEIN BETA-GAMMA-SUBUNITS OF BETA-ADRENERGIC AND MUSCARINIC RECEPTOR KINASE, JOURNAL OF BIOLOGICAL CHEMISTRY 268: 7753 (1993). · DOI
  35. KILEY, S.C., ACTIVATION OF ALPHA-PROTEIN KINASE-C LEADS TO ASSOCIATION WITH DETERGENT-INSOLUBLE COMPONENTS OF GH4C1 CELLS, MOLECULAR ENDOCRINOLOGY 4: 59 (1990). · DOI
  36. KIM, C.M., MECHANISM OF BETA-ADRENERGIC-RECEPTOR KINASE ACTIVATION BY G-PROTEINS, JOURNAL OF BIOLOGICAL CHEMISTRY 268: 15412 (1993). · DOI
  37. KRAFT, A.S., PHORBOL ESTERS INCREASE THE AMOUNT OF CA-2+, PHOSPHOLIPID-DEPENDENT PROTEIN-KINASE ASSOCIATED WITH PLASMA-MEMBRANE, NATURE 301: 621 (1983). · DOI · Paper page
  38. LEEVERS, S.J., REQUIREMENT FOR RAS IN RAF ACTIVATION IS OVERCOME BY TARGETING RAF TO THE PLASMA-MEMBRANE, NATURE 369: 411 (1994). · DOI · Paper page
  39. Lohmann, S. M., Advances in Cyclic Nucleotide and Protein Phosphorylation Research: 63 (1984).
  40. MISRA, U.K., PROTEIN-KINASE-C BINDING TO ISOLATED-NUCLEI AND ITS ACTIVATION BY A CA-2+ PHOSPHOLIPID-INDEPENDENT MECHANISM, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 145: 760 (1987). · DOI
  41. MOCHLYROSEN, D, A PROTEIN-KINASE-C ISOZYME IS TRANSLOCATED TO CYTOSKELETAL ELEMENTS ON ACTIVATION, CELL REGULATION 1: 693 (1990). · DOI
  42. 10.1016/S0021-9258(18)98554-6 · DOI
  43. 10.1073/pnas.88.9.3997 · DOI · Paper page
  44. MURRAY, N.R., PRESENCE OF A BETA(II) PROTEIN-KINASE C-SELECTIVE NUCLEAR-MEMBRANE ACTIVATION FACTOR IN HUMAN LEUKEMIA-CELLS, JOURNAL OF BIOLOGICAL CHEMISTRY 269: 21385 (1994). · DOI
  45. MURTHY, ASN, THE SITES AT WHICH BRAIN MICROTUBULE-ASSOCIATED PROTEIN-2 IS PHOSPHORYLATED INVIVO DIFFER FROM THOSE ACCESSIBLE TO CAMP-DEPENDENT KINASE INVITRO, JOURNAL OF BIOLOGICAL CHEMISTRY 260: 4364 (1985). · DOI
  46. NDUBUKA, C, EXPRESSION OF A KINASE ANCHOR PROTEIN-75 DEPLETES TYPE-II CAMP-DEPENDENT PROTEIN-KINASES FROM THE CYTOPLASM AND SEQUESTERS THE KINASES IN A PARTICULATE POOL, JOURNAL OF BIOLOGICAL CHEMISTRY 268: 7621 (1993). · DOI
  47. NIGG, E.A., RAPID AND REVERSIBLE TRANSLOCATION OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN-KINASE TYPE-II FROM THE GOLGI-COMPLEX TO THE NUCLEUS, EMBO JOURNAL 4: 2801 (1985). · DOI · Paper page
  48. 10.1126/science.1411571 · DOI · Paper page
  49. Obar, R. A., Neuron 3: 639 (1989). · DOI
  50. 10.1126/science.8036498 · DOI
  51. PAPADOPOULOS, V, ISOLATION AND CHARACTERIZATION OF PROTEIN KINASE-C FROM Y-1 ADRENAL-CELL CYTOSKELETON, JOURNAL OF CELL BIOLOGY 108: 553 (1989). · DOI
  52. PARKER, P.J., PROTEIN KINASE-C - A FAMILY AFFAIR, MOLECULAR AND CELLULAR ENDOCRINOLOGY 65: 1 (1989). · DOI · Paper page
  53. 10.1126/science.1325672 · DOI · Paper page
  54. 10.1126/science.7939633 · DOI
  55. RON, D, AGONISTS AND ANTAGONISTS OF PROTEIN-KINASE-C FUNCTION, DERIVED FROM ITS BINDING-PROTEINS, JOURNAL OF BIOLOGICAL CHEMISTRY 269: 21395 (1994). · DOI
  56. RON, D, CLONING OF AN INTRACELLULAR RECEPTOR FOR PROTEIN-KINASE-C - A HOMOLOG OF THE BETA-SUBUNIT OF G-PROTEINS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91: 839 (1994).
  57. RON, D, AN AUTOREGULATORY REGION IN PROTEIN-KINASE-C - THE PSEUDOANCHORING SITE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 92: 492 (1995).
  58. ROSEN, A, ACTIVATION OF PROTEIN-KINASE-C RESULTS IN THE DISPLACEMENT OF ITS MYRISTOYLATED, ALANINE-RICH SUBSTRATE FROM PUNCTATE STRUCTURES IN MACROPHAGE FILOPODIA, JOURNAL OF EXPERIMENTAL MEDICINE 172: 1211 (1990). · DOI
  59. ROTEM, R, PROTEIN-KINASE-C IS PRESENT IN HUMAN SPERM - POSSIBLE ROLE IN FLAGELLAR MOTILITY, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87: 7305 (1990).
  60. SCOTT, J.D., TYPE-II REGULATORY SUBUNIT DIMERIZATION DETERMINES THE SUBCELLULAR-LOCALIZATION OF THE CAMP-DEPENDENT PROTEIN-KINASE, JOURNAL OF BIOLOGICAL CHEMISTRY 265: 21561 (1990). · DOI
  61. SCOTT, J.D., SUBCELLULAR-LOCALIZATION OF THE TYPE-II CAMP-DEPENDENT PROTEIN-KINASE, NEWS IN PHYSIOLOGICAL SCIENCES 7: 143 (1992).
  62. SHOJI, M, IMMUNOCYTOCHEMICAL EVIDENCE FOR PHORBOL ESTER-INDUCED PROTEIN-KINASE-C TRANSLOCATION IN HL60 CELLS, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 135: 1144 (1986). · DOI
  63. SMITH, B.L., INHIBITION OF PROTEIN-KINASE-C FUNCTION BY INJECTION OF INTRACELLULAR RECEPTORS FOR THE ENZYME, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 188: 1235 (1992). · DOI
  64. SPUDICH, A, ASSOCIATION OF THE BETA ISOFORM OF PROTEIN-KINASE-C WITH VIMENTIN FILAMENTS, CELL MOTILITY AND THE CYTOSKELETON 22: 250 (1992). · DOI
  65. STAUDINGER, J, PICK1 - A PERINUCLEAR BINDING-PROTEIN AND SUBSTRATE FOR PROTEIN-KINASE-C ISOLATED BY THE YEAST 2-HYBRID SYSTEM, JOURNAL OF CELL BIOLOGY 128: 263 (1995). · DOI
  66. 10.1126/science.7811320 · DOI · Paper page
  67. STRASSER, R.H., A NOVEL CATECHOLAMINE-ACTIVATED ADENOSINE CYCLIC 3',5'-PHOSPHATE INDEPENDENT PATHWAY FOR BETA-ADRENERGIC-RECEPTOR PHOSPHORYLATION IN WILD-TYPE AND MUTANT S49-LYMPHOMA CELLS - MECHANISM OF HOMOLOGOUS DESENSITIZATION OF ADENYLATE-CYCLASE, BIOCHEMISTRY 25: 1371 (1986). · DOI
  68. STRASSER, R.H., BETA-AGONIST AND PROSTAGLANDIN-E1-INDUCED TRANSLOCATION OF THE BETA-ADRENERGIC-RECEPTOR KINASE - EVIDENCE THAT THE KINASE MAY ACT ON MULTIPLE ADENYLATE CYCLASE-COUPLED RECEPTORS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 6362 (1986).
  69. THEURKAUF, W.E., MOLECULAR CHARACTERIZATION OF THE CAMP-DEPENDENT PROTEIN-KINASE BOUND TO MICROTUBULE-ASSOCIATED PROTEIN-2, JOURNAL OF BIOLOGICAL CHEMISTRY 257: 3284 (1982). · DOI · Paper page
  70. TRAVERSE, S, SPECIFIC ASSOCIATION OF ACTIVATED MAP KINASE KINASE KINASE (RAF) WITH THE PLASMA-MEMBRANES OF RAS-TRANSFORMED RETINAL CELLS, ONCOGENE 8: 3175 (1993).
  71. WARTMANN, M, THE NATIVE STRUCTURE OF THE ACTIVATED RAF PROTEIN-KINASE IS A MEMBRANE-BOUND MULTISUBUNIT COMPLEX, JOURNAL OF BIOLOGICAL CHEMISTRY 269: 6695 (1994). · DOI
  72. WOLF, M, PROTEIN-KINASE-C AND PHOSPHATIDYLSERINE BIND TO MR 110,000/115,000 POLYPEPTIDES ENRICHED IN CYTOSKELETAL AND POSTSYNAPTIC DENSITY PREPARATIONS, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 13327 (1986). · DOI
  73. ZALEWSKI, P.D., TRANSLOCATION OF PROTEIN KINASE-C TO A TRITON-INSOLUBLE SUB-CELLULAR COMPARTMENT INDUCED BY THE LIPOPHILIC GOLD COMPOUND AURANOFIN, BIOCHEMICAL PHARMACOLOGY 37: 1415 (1988). · DOI

Cited by

Metadata

Authors
Mochly-Rosen, D.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1995-04-14
Volume
268
Issue
5208
Pages
247-251
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.7716516
OpenAlex
W2089330962
Cited by
906
References
2
FWCI
28.42
Type
journal article
Language
en
Open access
closed

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