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Inhibition of NF-κB by Sodium Salicylate and Aspirin
Abstract
The transcription factor nuclear factor-κB (NF-κB) is critical for the inducible expression of multiple cellular and viral genes involved in inflammation and infection including interleukin-1 (IL-1), IL-6, and adhesion molecules. The anti-inflammatory drugs sodium salicylate and aspirin inhibited the activation of NF-κB, which further explains the mechanism of action of these drugs. This inhibition prevented the degradation of the NF-κB inhibitor, IκB, and therefore NF-κB was retained in the cytosol. Sodium salicylate and aspirin also inhibited NF-κB-dependent transcription from the Igκ enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells.
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Metadata
- Authors
- Kopp, E., & Ghosh, S.
- Venue
- Science
- Published
- 1994-08-12
- Volume
- 265
- Issue
- 5174
- Pages
- 956-959
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2010237936
- Cited by
- 1,753
- References
- 0
- FWCI
- 24.74
- Type
- journal article
- Language
- en
- Open access
- closed
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