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Cited by 1,753

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Inhibition of NF-κB by Sodium Salicylate and Aspirin

Kopp, Elizabeth, Ghosh, Sankar·1994·Science

Abstract

The transcription factor nuclear factor-κB (NF-κB) is critical for the inducible expression of multiple cellular and viral genes involved in inflammation and infection including interleukin-1 (IL-1), IL-6, and adhesion molecules. The anti-inflammatory drugs sodium salicylate and aspirin inhibited the activation of NF-κB, which further explains the mechanism of action of these drugs. This inhibition prevented the degradation of the NF-κB inhibitor, IκB, and therefore NF-κB was retained in the cytosol. Sodium salicylate and aspirin also inhibited NF-κB-dependent transcription from the Igκ enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells.

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Metadata

Authors
Kopp, E., & Ghosh, S.
Venue
Science
Published
1994-08-12
Volume
265
Issue
5174
Pages
956-959
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2010237936
Cited by
1,753
References
0
FWCI
24.74
Type
journal article
Language
en
Open access
closed

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