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Adenosine Inhibition of Mesopontine Cholinergic Neurons: Implications for EEG Arousal
Open accessAbstract
Increased discharge activity of mesopontine cholinergic neurons participates in the production of electroencephalographic (EEG) arousal; such arousal diminishes as a function of the duration of prior wakefulness or of brain hyperthermia. Whole-cell and extracellular recordings in a brainstem slice show that mesopontine cholinergic neurons are under the tonic inhibitory control of endogenous adenosine, a neuromodulator released during brain metabolism. This inhibitory tone is mediated postsynaptically by an inwardly rectifying potassium conductance and by an inhibition of the hyperpolarization-activated current. These data provide a coupling mechanism linking neuronal control of EEG arousal with the effects of prior wakefulness, brain hyperthermia, and the use of the adenosine receptor blockers caffeine and theophylline.
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Metadata
- Authors
- Rainnie, D. G., Grunze, H. C. R., McCarley, R. W., & Greene, R. W.
- Venue
- Science
- Published
- 1994-02-04
- Volume
- 263
- Issue
- 5147
- Pages
- 689-692
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2032121387
- Cited by
- 340
- References
- 1
- FWCI
- 9.92
- Type
- journal article
- Language
- en
- Open access
- green
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