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Cited by 638

The DOI matches its Crossref record.

NF-kappa B activation by ultraviolet light not dependent on a nuclear signal

Devary, Y, Rosette, C, DiDonato, J., Karin, M·1993·Science
DOI 10.1126/science.8367725
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Abstract

Exposure of mammalian cells to radiation triggers the ultraviolet (UV) response, which includes activation of activator protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B). This was postulated to occur by induction of a nuclear signaling cascade by damaged DNA. Recently, induction of AP-1 by UV was shown to be mediated by a pathway involving Src tyrosine kinases and the Ha-Ras small guanosine triphosphate-binding protein, proteins located at the plasma membrane. It is demonstrated here that the same pathway mediates induction of NF-kappa B by UV. Because inactive NF-kappa B is stored in the cytosol, analysis of its activation directly tests the involvement of a nuclear-initiated signaling cascade. Enucleated cells are fully responsive to UV both in NF-kappa B induction and in activation of another key signaling event. Therefore, the UV response does not require a signal generated in the nucleus and is likely to be initiated at or near the plasma membrane.

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Metadata

Authors
Devary, Y., Rosette, C., DiDonato, J., & Karin, M.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1993-09-10
Volume
261
Issue
5127
Pages
1442-1445
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.8367725
OpenAlex
W2037915962
Cited by
638
References
0
FWCI
29.85
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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