Regulation of the Human hsp70 Promoter by p53

Agoff, S. Nicholas; Hou, Jeannie; Linzer, Daniel I.; Wu, Barbara

doi:10.1126/science.8418500

Cited by 292Heat shock proteins researchCancer-related Molecular PathwaysGenomics and Chromatin Dynamics

Regulation of the Human hsp70 Promoter by p53

Agoff, S. Nicholas, Hou, Jeannie, Linzer, Daniel I., Wu, Barbara·1993·Science

DOI 10.1126/science.8418500

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Abstract

The tumor suppressor p53 is a nuclear phosphoprotein with characteristics of a transcription factor. It displays sequence-specific DNA binding, contains a potent transactivation domain, and has been implicated as both a transcriptional activator and a repressor. Transcription of the human hsp70 gene is stimulated by adenovirus E1a protein. This E1a transactivation of the hsp70 promoter is mediated by CCAAT binding factor (CBF). It is demonstrated here that p53 both represses transcription from the human hsp70 promoter and also interacts with CBF. Thus, the repression of the hsp70 promoter by p53 may be mediated by direct protein-protein interaction with CBF. These results suggest that protein-protein interaction between p53 and specific transcription factors may be an additional mechanism by which p53 regulates gene expression.

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p53 was first reported to bind to coactivators including TATA-box binding protein, NF-Y, and Sp1, and to interfere with their transactivator function.
“In 1993, p53 was first reported to bind to coactivators, including the TATA-box binding protein,73, 74 the CCAAT-box binding factor (NF-Y)75 and specificity protein 1 (Sp1) that binds to GC-boxes,76 and to interfere with their transactivator function.”
From Census and evaluation of p53 target genes (2017) · cites this paper as [75]

p53 Mutations in Human Cancers
Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018 · see citing works
Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells
Gorman, C., Moffat, L. F., & Howard, B. H. (1982) · Molecular and Cellular Biology · doi:10.1128/mcb.2.9.1044 · Cited by 7,673 · see citing works
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
Scheffner, M., Werness, B. A., Huibregtse, J. M., Levine, A. J., & Howley, P. M. (1990) · Cell · doi:10.1016/0092-8674(90)90409-8 · Cited by 3,995 · see citing works
The p53 tumour suppressor gene
Levine, A. J., Momand, J. A., & Finlay, C. A. (1991) · Nature · doi:10.1038/351453a0 · Cited by 3,785 · see citing works
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
Momand, J., Zambetti, G. P., Olson, D. C., George, D., & Levine, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90644-r · Cited by 3,113 · see citing works
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
Land, H., Parada, L. F., & Weinberg, R. A. (1983) · Nature · doi:10.1038/304596a0 · Cited by 2,804 · see citing works
Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53
Werness, B. A., Levine, A. J., & Howley, P. M. (1990) · Science · doi:10.1126/science.2157286 · Cited by 2,562 · see citing works
T antigen is bound to a host protein in SY40-transformed cells
Lane, D. P., & Crawford, L. V. (1979) · Nature · doi:10.1038/278261a0 · Cited by 2,443 · see citing works
The p53 proto-oncogene can act as a suppressor of transformation
Finlay, C. A., Hinds, P. W., & Levine, A. J. (1989) · Cell · doi:10.1016/0092-8674(89)90045-7 · Cited by 1,987 · see citing works
Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
Linzer, D. I. H., & Levine, A. J. (1979) · Cell · doi:10.1016/0092-8674(79)90293-9 · Cited by 1,814 · see citing works
Self-citation
Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction
Yang-Yen, H.-F., Chambard, J.-C., Sun, Y.-L., Smeal, T., Schmidt, T. J., Drouin, J., & Karin, M. (1990) · Cell · doi:10.1016/0092-8674(90)90396-v · Cited by 1,553 · see citing works
Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone
Jonat, C., Rahmsdorf, H. J., Park, K.-K., Cato, A. C. B., Gebel, S., Ponta, H., & Herrlich, P. (1990) · Cell · doi:10.1016/0092-8674(90)90395-u · Cited by 1,544 · see citing works
Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element
Diamond, M. I., Miner, J. N., Yoshinaga, S. K., & Yamamoto, K. R. (1990) · Science · doi:10.1126/science.2119054 · Cited by 1,274 · see citing works
Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor
Schüle, R., Rangarajan, P. N., Kliewer, S. A., Ransone, L. J., Bolado, J., Yang, N., Verma, I. M., & Evans, R. M. (1990) · Cell · doi:10.1016/0092-8674(90)90397-w · Cited by 1,204 · see citing works
Activating Mutations for Transformation by p53 Produce a Gene Product That Forms an hsc70-p53 Complex with an Altered Half-Life
Finlay, C. A., Hinds, P. W., Tan, T., Eliyahu, D., Oren, M., & Levine, A. J. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.2.531 · Cited by 1,144 · see citing works
Identification of p53 as a Sequence-Specific DNA-Binding Protein
Kern, S. E., Kinzler, K. W., Bruskin, A. M., Jarosz, D., Friedman, P. N., Prives, C. L., & Vogelstein, B. (1991) · Science · doi:10.1126/science.2047879 · Cited by 1,085 · see citing works
Monoclonal antibodies specific for simian virus 40 tumor antigens
Harlow, E., Crawford, L. V., Pim, D. C., & Williamson, N. M. (1981) · Journal of Virology · doi:10.1128/jvi.39.3.861-869.1981 · Cited by 1,038 · see citing works
A cellular DNA-binding protein that activates eukaryotic transcription and DNA replication
Jones, K. A., Kadonaga, J. T., Rosenfeld, P. J., Kelly, T. J., & Tjian, R. (1987) · Cell · doi:10.1016/0092-8674(87)90358-8 · Cited by 1,002 · see citing works
Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells
Sarnow, P., Ho, Y.-S., Williams, J., & Levine, A. J. (1982) · Cell · doi:10.1016/0092-8674(82)90356-7 · Cited by 836 · see citing works
p53: oncogene or anti-oncogene?Preprint
Lane, D. P., & Benchimol, S. (1990) · Genes & Development · doi:10.1101/gad.4.1.1 · Cited by 796 · see citing works
Presence of a Potent Transcription Activating Sequence in the p53 Protein
Fields, S., & Jang, S. K. (1990) · Science · doi:10.1126/science.2144363 · Cited by 790 · see citing works
p53 Functions as a Cell Cycle Control Protein in Osteosarcomas
Diller, L., Kassel, J., Nelson, C. E., Gryka, M. A., Litwak, G., Gebhardt, M. C., Bressac, B., Öztürk, M., Baker, S. J., Vogelstein, B., et al. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.11.5772 · Cited by 775 · see citing works
Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53
Michalovitz, D., Halevy, O., & Oren, M. (1990) · Cell · doi:10.1016/0092-8674(90)90113-s · Cited by 769 · see citing works
Modulation of Activity of the Promoter of the Human MDR 1 Gene by Ras and p53
Chin, K., Ueda, K., Pastan, I. H., & Gottesman, M. M. (1992) · Science · doi:10.1126/science.1346476 · Cited by 726 · see citing works
Wild-type p53 can inhibit oncogene-mediated focus formation.
Eliyahu, D., Michalovitz, D., Eliyahu, S., Pinhasi-Kimhi, O., & Oren, M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.22.8763 · Cited by 681 · see citing works
Transcription activation by the adenovirus E1a protein
Lillie, J. W., & Green, M. R. (1989) · Nature · doi:10.1038/338039a0 · Cited by 668 · see citing works
Transcriptional Activation by Wild-Type but Not Transforming Mutants of the p53 Anti-Oncogene
Raycroft, L., Wu, H., & Lozano, G. (1990) · Science · doi:10.1126/science.2144364 · Cited by 620 · see citing works
Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation
Milner, J., & Medcalf, E. (1991) · Cell · doi:10.1016/0092-8674(91)90384-b · Cited by 612 · see citing works
Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein
Yew, P. R., & Berk, A. J. (1992) · Nature · doi:10.1038/357082a0 · Cited by 570 · see citing works
Post-translational regulation of the 54K cellular tumor antigen in normal and transformed cells.
Oren, M., Maltzman, W., & Levine, A. J. (1981) · Molecular and Cellular Biology · doi:10.1128/mcb.1.2.101 · Cited by 489 · see citing works
Wild-type p53 can down-modulate the activity of various promoters.
Ginsberg, D., Mechta‐Grigoriou, F., Yaniv, M., & Oren, M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.22.9979 · Cited by 434 · see citing works
Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.
Hinds, P. W., Finlay, C. A., Quartin, R. S., Baker, S. J., Fearon, E. R., Vogelstein, B., & Levine, A. J. (1990) · PubMed · Cited by 408 · see citing works
Functional antagonism between c-Jun and MyoD proteins: A direct physical association
Bengal, E., Ransone, L. J., Scharfmann, R., Dwarki, V., Tapscott, S. J., Weintraub, H. M., & Verma, I. M. (1992) · Cell · doi:10.1016/0092-8674(92)90187-h · Cited by 385 · see citing works
GAL4 activates gene expression in mammalian cells
Kakidani, H., & Ptashne, M. (1988) · Cell · doi:10.1016/0092-8674(88)90504-1 · Cited by 360 · see citing works
Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2.
Bischoff, J. R., Friedman, P. N., Marshak, D. R., Prives, C. L., & Beach, D. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4766 · Cited by 342 · see citing works
Heterodimer formation between CREB and JUN proteins.
Benbrook, D. M., & Jones, N. C. (1990) · PubMed · Cited by 334 · see citing works
Human HSP70 promoter contains at least two distinct regulatory domains.
Wu, B. J., Kingston, R. E., & Morimoto, R. I. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.3.629 · Cited by 322 · see citing works
Self-citation
Two distinct mechanisms regulate the levels of a cellular tumor antigen, p53.
Reich, N. C., Oren, M., & Levine, A. J. (1983) · Molecular and Cellular Biology · doi:10.1128/mcb.3.12.2143 · Cited by 310 · see citing works
Expression of human HSP70 during the synthetic phase of the cell cycle.
Milarski, K. L., & Morimoto, R. I. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.24.9517 · Cited by 304 · see citing works
Microinjection of monoclonal antibody to protein p53 inhibits serum-induced DNA synthesis in 3T3 cells.
Mercer, W. E., Nelson, D., DeLeo, A. B., Old, L. J., & Baserga, R. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.20.6309 · Cited by 255 · see citing works
Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression.Preprint
Li, L., Chambard, J., Karin, M., & Olson, E. N. (1992) · Genes & Development · doi:10.1101/gad.6.4.676 · Cited by 229 · see citing works
The murine p53 protein blocks replication of SV40 DNA in vitro by inhibiting the initiation functions of SV40 large T antigen
Wang, E. H., Friedman, P. N., & Prives, C. L. (1989) · Cell · doi:10.1016/0092-8674(89)90913-6 · Cited by 215 · see citing works
Transcription of the human hsp70 gene is induced by serum stimulation.
Wu, B. J., & Morimoto, R. I. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.18.6070 · Cited by 211 · see citing works
Self-citation
Mouse p53 inhibits SV40 origin-dependent DNA replication
Braithwaite, A. W., Stürzbecher, H.-W., Addison, C. M., Palmer, C., Rudge, K., & Jenkins, J. R. (1987) · Nature · doi:10.1038/329458a0 · Cited by 206 · see citing works
Structure of pre-pro-von Willebrand factor and its expression in heterologous cells
Bonthron, D. T., Handin, R. I., Kaufman, R. J., Wasley, L. C., Orr, E. C., Mitsock, L. M., Ewenstein, B. M., Loscalzo, J., Ginsburg, D., & Orkin, S. H. (1986) · Nature · doi:10.1038/324270a0 · Cited by 203 · see citing works
Mutational analysis of the human HSP70 protein: distinct domains for nucleolar localization and adenosine triphosphate binding.
Milarski, K. L., & Morimoto, R. I. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.5.1947 · Cited by 185 · see citing works
Mantle-derived helium in two Peruvian hydrothermal ore deposits
Simmons, S. F., Sawkins, F. J., & Schlutter, D. J. (1987) · Nature · doi:10.1038/329429a0 · Cited by 160 · see citing works
The MCK enhancer contains a p53 responsive element.
Weintraub, H. M., Hauschka, S. D., & Tapscott, S. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.11.4570 · Cited by 159 · see citing works
Transformation properties of type 5 adenovirus mutants that differentially express the E1A gene products.
Haley, K. P., Overhauser, J., Babiss, L. E., Ginsberg, H. S., & Jones, N. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.18.5734 · Cited by 135 · see citing works
The E1A 13S Product of Adenovirus 5 Activates Transcription of the Cellular Human HSP70 Gene
Wu, B. J., Hurst, H. C., Jones, N., & Morimoto, R. I. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.8.2994 · Cited by 123 · see citing works
Self-citation
Selective Induction of Human Heat Shock Gene Transcription by the Adenovirus E1A Gene Products, Including the 12S E1A Product
Simon, M. C., Kitchener, K., Kao, H., Hickey, E. D., Weber, L. E., Voellmy, R. W., Heintz, N., & Nevins, J. R. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.8.2884-2890.1987 · Cited by 123 · see citing works
Addition of fresh medium induces cell cycle and conformation changes in p53, a tumour suppressor protein.
Milner, J., & Jv, W. (1990) · PubMed · Cited by 96 · see citing works
A Cloned Human CCAAT-Box-Binding Factor Stimulates Transcription from the Human hsp70 Promoter
Lum, L. S., Sultzman, L. A., Kaufman, R. J., Linzer, D. I. H., & Wu, B. J. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.12.6709 · Cited by 79 · see citing works
Self-citation
The hsp70 Gene CCAAT-Binding Factor Mediates Transcriptional Activation by the Adenovirus E1a Protein
Lum, L. S., Hsu, S., Vaewhongs, M., & Wu, B. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.6.2599 · Cited by 47 · see citing works
Self-citation

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p53: puzzle and paradigm.Preprint
Ko, L. J., & Prives, C. L. (1996) · Genes & Development · doi:10.1101/gad.10.9.1054 · Cited by 2,338 · see citing works
Transcriptional control of human p53-regulated genes
Riley, T., Sontag, E., Chen, P., & Levine, A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2395 · Cited by 1,921 · see citing works
The cellular and molecular basis of hyperthermia
Hildebrandt, B. (2002) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(01)00179-2 · Cited by 1,714 · see citing works
Clinical Implications of the p53 Tumor-Suppressor Gene
Harris, C. C., & Hollstein, M. C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199310283291807 · Cited by 1,317 · see citing works
Role of the Heat Shock Response and Molecular Chaperones in Oncogenesis and Cell Death
Jolly, C. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.19.1564 · Cited by 1,049 · see citing works
Census and evaluation of p53 target genes
Fischer, M. (2017) · Oncogene · doi:10.1038/onc.2016.502 · Cited by 971 · see citing works
Heat shock proteins in cancer: chaperones of tumorigenesis
Calderwood, S. K., Khaleque, A., Sawyer, D. B., & Ciocca, D. R. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.01.006 · Cited by 954 · see citing works
Regulation ofp53downstream genes
El‐Deiry, W. S. (1998) · Seminars in Cancer Biology · doi:10.1006/scbi.1998.0097 · Cited by 797 · see citing works
Wild-Type Human p53 and a Temperature-Sensitive Mutant Induce Fas/APO-1 Expression
Owen‐Schaub, L. B., Zhang, W. K., Cusack, J. C., Angelo, L. S., Santee, S. M., Fujiwara, T., Roth, J. A., Deisseroth, A., Zhang, W., Kruzel, E., et al. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3032 · Cited by 731 · see citing works
Twenty years of p53 research: structural and functional aspects of the p53 protein
May, P., & May, E. (1999) · Oncogene · doi:10.1038/sj.onc.1203285 · Cited by 663 · see citing works
MDMX: a novel p53‐binding protein with some functional properties of MDM2.
Shvarts, A., Steegenga, W. T., Riteco, N., van Laar, T., Dekker, P., Bazuine, M., van Ham, R. C., van der Houven van Oordt, W., Hateboer, G., van der Eb, A. J., et al. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00919.x · Cited by 648 · see citing works
p53 in growth control and neoplasia
Gottlieb, T. M., & Oren, M. (1996) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(95)00019-c · Cited by 481 · see citing works
Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53.
Forrester, K., Ambs, S., Lupold, S. E., Kapust, R. B., Spillare, E. A., Weinberg, W. C., Felley‐Bosco, E., Wang, X. W., Geller, D. A., Tzeng, E., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.6.2442 · Cited by 463 · see citing works
Induction of Cellular p53 Activity by DNA-Damaging Agents and Growth Arrest
Zhan, Q., Carrier, F., & Fornace, A. J. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.7.4242 · Cited by 441 · see citing works
p53 regulates a G 2 checkpoint through cyclin B1
Innocente, S. A., Abrahamson, J., Cogswell, J. P., & Lee, J. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2147 · Cited by 435 · see citing works
Heat shock protein expression independently predicts clinical outcome in prostate cancer.
Cornford, P. A., Dodson, A. R., PARSONS, K. F., DESMOND, A. D., Woolfenden, A., Fordham, M., Neoptolemos, J. P., Ke, Y., & Foster, C. S. (2000) · PubMed · Cited by 365 · see citing works
The tumore suppressor p53
Donehower, L. A., & Bradley, A. (1993) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(93)90004-v · Cited by 333 · see citing works
Physical and functional interaction between WT1 and p53 proteins.
Maheswaran, S., Park, S., Bernard, A., Morris, J. F., Rauscher, F. J., HILL, D. E., & Haber, D. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.11.5100 · Cited by 307 · see citing works
Repression of RNA Polymerase I Transcription by the Tumor Suppressor p53
Zhai, W., & Comai, L. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.16.5930-5938.2000 · Cited by 289 · see citing works
Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53.Preprint
Yew, P. R., Liu, X., & Berk, A. J. (1994) · Genes & Development · doi:10.1101/gad.8.2.190 · Cited by 282 · see citing works
Chaperones in cell cycle regulation and mitogenic signal transduction: a review
Helmbrecht, K., Zeise, E., & Rensing, L. (2000) · Cell Proliferation · doi:10.1046/j.1365-2184.2000.00189.x · Cited by 278 · see citing works
Accumulation of p53 in a Mutant Cell Line Defective in the Ubiquitin Pathway
Chowdary, D., Dermody, J. J., Jha, K. K., & Ozer, H. L. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.3.1997 · Cited by 278 · see citing works
p53 induction is associated with neuronal damage in the central nervous system.
Sakhi, S., Bruce, A. J., Sun, N., Tocco, G., Baudry, M., & Schreiber, S. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7525 · Cited by 256 · see citing works
Human Heat Shock Factors 1 and 2 Are Differentially Activated and Can Synergistically Induce hsp70 Gene Transcription
Sistonen, L., Sarge, K. D., & Morimoto, R. I. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.3.2087-2099.1994 · Cited by 257 · see citing works
p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling
Wang, X., Kua, H.-Y., Hu, Y., Guo, K., Zeng, Q., Wu, Q., Ng, H., Karsenty, G., Crombrugghe, B. D., Yeh, J. K., et al. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200507106 · Cited by 250 · see citing works
The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis.Preprint
Maheswaran, S., Englert, C., Bennett, P., Heinrich, G., & Haber, D. A. (1995) · Genes & Development · doi:10.1101/gad.9.17.2143 · Cited by 246 · see citing works
Functional and physical interaction between p53 and BZLF1: implications for Epstein-Barr virus latency.
Zhang, Q., Gutsch, D. E., & Kenney, S. C. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.3.1929 · Cited by 237 · see citing works
Inhibition of p53 DNA binding by human papillomavirus E6 proteins
Lechner, M. S., & Laimins, L. A. (1994) · Journal of Virology · doi:10.1128/jvi.68.7.4262-4273.1994 · Cited by 228 · see citing works
Hepatitis B virus X antigen in the pathogenesis of chronic infections and the development of hepatocellular carcinoma.
Feitelson, M. A., & Duan, L. (1997) · Europe PMC (PubMed Central) · Cited by 225 · see citing works
Complex Transcriptional Effects of p63 Isoforms: Identification of Novel Activation and Repression Domains†
Ghioni, P., Bolognese, F., Duijf, P. H. G., van Bokhoven, H., Mantovani, R., & Guerrini, L. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.24.8659-8668.2002 · Cited by 222 · see citing works
p53 Signaling and Cell Cycle Checkpoints
Stewart, Z. A., & Pietenpol, J. A. (2001) · Chemical Research in Toxicology · doi:10.1021/tx000199t · Cited by 200 · see citing works
Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progression
Mirza, A., Wu, Q. J., Wang, L., McClanahan, T., Bishop, W. R., Gheyas, F., Ding, W., Hutchins, B., Hockenberry, T., Kirschmeier, P. T., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1206477 · Cited by 183 · see citing works
Transcriptional Activation of the Human Epidermal Growth Factor Receptor Promoter by Human p53
Ludes-Meyers, J. H., Subler, M. A., Shivakumar, C. V., Muñoz, R. M., Jiang, P., Bigger, J. E., Brown, D. R., Deb, S. P., & Deb, S. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6009 · Cited by 181 · see citing works
p53-Mediated Repression of Alpha-Fetoprotein Gene Expression by Specific DNA Binding
Lee, K. C., Crowe, A. J., & Barton, M. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1279 · Cited by 176 · see citing works
Up-regulation of inducible nitric oxide synthase expression in cancer-prone p53 knockout mice
Ambs, S., Ogunfusika, M. O., Merriam, W. G., Bennett, W. P., Billiar, T. R., & Harris, C. C. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8823 · Cited by 170 · see citing works
Over‐expression of hsp70 confers tumorigenicity to mouse fibrosarcoma cells
Jäättelä, M. (1995) · International Journal of Cancer · doi:10.1002/ijc.2910600520 · Cited by 170 · see citing works
The tumour suppressor protein p53 can repress transcription of cyclin B
Krause, K. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.22.4410 · Cited by 170 · see citing works
Heat shock proteins and Drosophila aging
Tower, J. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.09.002 · Cited by 167 · see citing works
The Transcriptional regulation of heat shock genes: A plethora of heat shock factors and regulatory conditions
Morimoto, R. I., Kroeger, P. E., & Cotto, J. J. (1996) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-9088-5_10 · Cited by 167 · see citing works
KRIBB11 Inhibits HSP70 Synthesis through Inhibition of Heat Shock Factor 1 Function by Impairing the Recruitment of Positive Transcription Elongation Factor b to the hsp70 Promoter
Yoon, Y. J., Kim, J. A., Shin, K. D., Shin, D., Han, Y. M., Lee, Y. J., Lee, J. S., Kwon, B., & Han, D. C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.179440 · Cited by 163 · see citing works
p53 mutation spectrum and load: the generation of hypotheses linking the exposure of endogenous or exogenous carcinogens to human cancer
Hussain, S. P., & Harris, C. C. (1999) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s1383-5742(99)00028-9 · Cited by 162 · see citing works
The transcription factor p53: Not a repressor, solely an activator.
Fischer, M., Steiner, L., & Engeland, K. (2014) · Cell Cycle · doi:10.4161/15384101.2014.949083 · Cited by 153 · see citing works
p53 Negatively Regulates cdc2 Transcription via the CCAAT-binding NF-Y Transcription Factor
Yun, J., Chae, H., Choy, H. E., Chung, J., Yoo, H., Han, M.-H., & Shin, D. Y. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.29677 · Cited by 155 · see citing works
p53 Regulates Insulin-Like Growth Factor-I (IGF-I) Receptor Expression and IGF-I-Induced Tyrosine Phosphorylation in an Osteosarcoma Cell Line: Interaction between p53 and Sp1
Ohlsson, C., Kley, N., Werner, H., & LeRoith, D. (1998) · Endocrinology · doi:10.1210/endo.139.3.5832 · Cited by 157 · see citing works
Heat shock proteins: Stress proteins with Janus-like properties in cancer
Calderwood, S. K., & Ciocca, D. R. (2008) · International Journal of Hyperthermia · doi:10.1080/02656730701858305 · Cited by 152 · see citing works
Apoptosis, cancer and the p53 tumour suppressor gene
Lee, J. M., & Bernstein, A. (1995) · Cancer and Metastasis Reviews · doi:10.1007/bf00665797 · Cited by 149 · see citing works
Inhibition of DNA Topoisomerase IIα Gene Expression by the p53 Tumor Suppressor
Wang, Q., Zambetti, G. P., & Suttle, D. P. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.1.389 · Cited by 149 · see citing works
Repression of the insulin receptor promoter by the tumor suppressor gene product p53: a possible mechanism for receptor overexpression in breast cancer.
Webster, N. J. G., Resnik, J. L., Reichart, D. B., Strauss, B. E., Haas, M., & Seely, B. L. (1996) · PubMed · Cited by 150 · see citing works
Increased levels of hsp70 transcripts induced when cells are exposed to low frequency electromagnetic fields
Goodman, R., Blank, M., Lin, H., Dai, R., Khorkova, O., Soo, L., Weisbrot, D., & Henderson, A. (1994) · Bioelectrochemistry and Bioenergetics · doi:10.1016/0302-4598(94)85002-x · Cited by 145 · see citing works
p53 Down-regulates Human Matrix Metalloproteinase-1 (Collagenase-1) Gene Expression
Sun, Y., Sun, Y., Wenger, L., Rutter, J. L., Brinckerhoff, C., & Cheung, H. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.17.11535 · Cited by 143 · see citing works
Differential regulation of plasminogen activator and inhibitor gene transcription by the tumor suppressor p53
Kunz, C., Pebler, S., Otte, J., & von der Ahe, D. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.18.3710 · Cited by 144 · see citing works
Transcriptional regulation of basic fibroblast growth factor gene by p53 in human glioblastoma and hepatocellular carcinoma cells.
Ueba, T., Nosaka, T., Takahashi, J. A., Shibata, F., Florkiewicz, R. Z., Vogelstein, B., Oda, Y., Kikuchi, H., & Hatanaka, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.9009 · Cited by 142 · see citing works
Low-Dose Irradiation Alters the Transcript Profiles of Human Lymphoblastoid Cells Including Genes Associated with Cytogenetic Radioadaptive Response
Coleman, M. A., Yin, E., Peterson, L. E., Nelson, D. O., Sorensen, K. J., Tucker, J. D., & Wyrobek, A. J. (2005) · Radiation Research · doi:10.1667/rr3356.1 · Cited by 139 · see citing works
The dynamic range of protein expression: A challenge for proteomic research
Corthals, G. L., Wasinger, V. C., Hochstrasser, D. F., & Sanchez, J. (2000) · Electrophoresis · doi:10.1002/(sici)1522-2683(20000401)21:6 · Cited by 615 · see citing works
Deregulated manganese superoxide dismutase expression and resistance to oxidative injury in p53-deficient cells.
Pani, G., Bedogni, B., Anzevino, R., Colavitti, R., Palazzotti, B., Borrello, S., & Galeotti, T. (2000) · PubMed · Cited by 134 · see citing works
Cancer and the heat shock response
Fuller, K., Issels, R. D., Slosman, D. O., Guillet, J., Soussi, T., & Polla, B. S. (1994) · European Journal of Cancer · doi:10.1016/0959-8049(94)00362-9 · Cited by 132 · see citing works
Transcriptional activation of the human proliferating-cell nuclear antigen promoter by p53.
Morris, G. F., Bischoff, J. R., & Mathews, M. B. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.2.895 · Cited by 130 · see citing works
A temperature‐sensitive mutant of human p53.
Zhang, W., Guo, X. Y., Hu, G., Liu, W. B., Shay, J. W., & Deisseroth, A. B. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06543.x · Cited by 127 · see citing works
Cytokine control of developmental programs in normal hematopoiesis and leukemia
Lotem, J., & Sachs, L. (2002) · Oncogene · doi:10.1038/sj.onc.1205319 · Cited by 125 · see citing works
Functional Domains of Wild-Type and Mutant p53 Proteins Involved in Transcriptional Regulation, Transdominant Inhibition, and Transformation Suppression
Unger, T., Mietz, J. A., Scheffner, M., Yee, C., & Howley, P. M. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.9.5186 · Cited by 123 · see citing works
Cooperative DNA binding of p53 with TFIID (TBP): a possible mechanism for transcriptional activation.Preprint
Chen, X., Farmer, G., Zhu, H., Prywes, R., & Prives, C. L. (1993) · Genes & Development · doi:10.1101/gad.7.10.1837 · Cited by 123 · see citing works
Tyrosinase Gene Expression is Regulated by p53
Khlgatian, M. K., Hadshiew, I., Asawanonda, P., Yaar, M., Eller, M. S., Gilchrest, B. A., Fujita, M., & Norris, D. A. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01667.x · Cited by 122 · see citing works
Roles of the functional loss of p53 and other genes in astrocytoma tumorigenesis and progression
Nozaki, M., Tada, M., Kobayashi, H., Zhang, C. L., Sawamura, Y., Abe, H., Ishii, N., & Meir, E. G. V. (1999) · Neuro-Oncology · doi:10.1093/neuonc/1.2.124 · Cited by 126 · see citing works
Wild-type p53 transgenic mice exhibit altered differentiation of the ureteric bud and possess small kidneys.Preprint
Godley, L. A., Kopp, J. B., Eckhaus, M., Paglino, J. J., Owens, J., & VARMUS, H. E. (1996) · Genes & Development · doi:10.1101/gad.10.7.836 · Cited by 119 · see citing works
Wild-Type Human p53 Transactivates the Human Proliferating Cell Nuclear Antigen Promoter
Shivakumar, C. V., Brown, D. R., Deb, S., & Deb, S. P. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.12.6785 · Cited by 120 · see citing works
Molecular epidemiology and carcinogenesis: endogenous and exogenous carcinogens
Hussain, S. P., & Harris, C. C. (2000) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(00)00015-6 · Cited by 120 · see citing works
Radiation-induced G1 arrest is selectively mediated by the p53-WAF1/Cip1 pathway in human thyroid cells.
Namba, H., Hara, T., Tukazaki, T., Migita, K., Ishikawa, N., Ito, K., Nagataki, S., & Yamashita, S. (1995) · PubMed · Cited by 119 · see citing works
p53: A Cell Cycle Regulator Activated by DNA Damage
Selivanova, G., & Wiman, K. G. (1995) · Advances in cancer research · doi:10.1016/s0065-230x(08)60253-5 · Cited by 118 · see citing works
DeltaNp63alpha up-regulates the Hsp70 gene in human cancer.
Wu, G., Osada, M., Guo, Z., Fomenkov, A. I., Begum, S., Zhao, M., Upadhyay, S. K., Xing, M., Wu, F., Moon, C., et al. (2005) · PubMed · Cited by 117 · see citing works
Human Cytomegalovirus Immediate-Early Protein IE2 Tethers a Transcriptional Repression Domain to p53
Tsai, H.-L., Kou, G. H., Chen, S.-C., Wu, C., & Lin, Y.-S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.7.3534 · Cited by 112 · see citing works
Repression of Glucocorticoid Receptor Transactivation and DNA Binding of a Glucocorticoid Response Element within the Serum/Glucocorticoid-Inducible Protein Kinase (sgk) Gene Promoter by the p53 Tumor Suppressor Protein
Maiyar, A. C., Phu, P. T., Huang, A. J. Y., & Firestone, G. L. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.3.9893 · Cited by 104 · see citing works
Hsp70 in cancer: A double agent in the battle between survival and death
Vostakolaei, M. A., Hatami-Baroogh, L., Babaei, G., Molavi, O., Kordi, S., & Abdolalizadeh, J. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30132 · Cited by 104 · see citing works
Functional and Physical Interaction between p53 and BZLF1: Implications for Epstein-Barr Virus Latency
Zhang, Q., Gutsch, D. E., & Kenney, S. C. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.3.1929-1938.1994 · Cited by 104 · see citing works
Functional studies of a germ-line polymorphism at codon 47 within the p53 gene.
Felley‐Bosco, E., Weston, A., Cawley, H., Bennett, W. P., & Harris, C. C. (1993) · Europe PMC (PubMed Central) · Cited by 103 · see citing works
Dependence of efficient adenoviral gene delivery in malignant glioma cells on the expression levels of the Coxsackievirus and adenovirus receptor
Asaoka, K., Tada, M., Sawamura, Y., Ikeda, J., & Abe, H. (2000) · Journal of neurosurgery · doi:10.3171/jns.2000.92.6.1002 · Cited by 103 · see citing works
Regulation of insulin-like growth factor II P3 promotor by p53: a potential mechanism for tumorigenesis.
Zhang, L., Kashanchi, F., Zhan, Q., Zhan, S., Brady, J. N., Fornace, A. J., Seth, P. K., & Helman, L. J. (1996) · PubMed · Cited by 102 · see citing works
p53 and Sp1 Interact and Cooperate in the Tumor Necrosis Factor-induced Transcriptional Activation of the HIV-1 Long Terminal Repeat
Gualberto, A., & Baldwin, A. S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.34.19680 · Cited by 101 · see citing works
Selective neuronal vulnerability in the hippocampus — a role for gene expression?
Schreiber, S. S., & Baudry, M. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)94495-q · Cited by 99 · see citing works
ΔNp63α Up-Regulates the Hsp70 Gene in Human Cancer
Wu, G., Osada, M., Guo, Z., Fomenkov, A. I., Begum, S., Zhao, M., Upadhyay, S. K., Xing, M., Wu, F., Moon, C., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.758.65.3 · Cited by 98 · see citing works
p53 binds and represses the HBV enhancer: an adjacent enhancer element can reverse the transcription effect of p53
Ori, A., Zauberman, A., Doitsh, G., Paran, N., Oren, M., & Shaul, Y. (1998) · The EMBO Journal · doi:10.1093/emboj/17.2.544 · Cited by 97 · see citing works
Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70Preprint
Maheswaran, S., Englert, C., Zheng, G., Lee, S. B., Wong, J. C., Harkin, D. P., Bean, J. M., Ezzell, R. M., Garvin, A. J., McCluskey, R. T., et al. (1998) · Genes & Development · doi:10.1101/gad.12.8.1108 · Cited by 97 · see citing works
Wild Type and Mutant p53 Differentially Regulate the Gene Expression of Human Collagenase-3 (hMMP-13)
Sun, Y., Cheung, J. M., Martel‐Pelletier, J., Pelletier, J. P., Wenger, L., Altman, R. D., Howell, D. S., & Cheung, H. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.15.11327 · Cited by 95 · see citing works
p53 and its homologues, p63 and p73, induce a replicative senescence through inactivation of NF-Y transcription factor
Jung, M.-S., Yun, J., Chae, H., Kim, J., Kim, S., Choi, T.-S., & Shin, D. Y. (2001) · Oncogene · doi:10.1038/sj.onc.1204748 · Cited by 93 · see citing works
Sp1-Mediated Transcription of the Werner Helicase Gene Is Modulated by Rb and p53
Yamabe, Y., Shimamoto, A., Goto, M., Yokota, J., Sugawara, M., & Furuichi, Y. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6191 · Cited by 91 · see citing works
p53 Regulates the Minimal Promoter of the Human Topoisomerase II Gene
Sandri, M., Isaacs, R., Ongkeko, W. M., Harris, A. L., Hickson, I. D., Broggini, M., & Vikhanskaya, F. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.22.4464 · Cited by 91 · see citing works
DNA Damage-induced Inhibition of Securin Expression Is Mediated by p53
Zhou, Y., Mehta, K. R., Choi, A., Scolavino, S., & Zhang, X. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203793200 · Cited by 90 · see citing works
Inhibition of protein kinase C and proto-oncogene expression by crocetin in NIH/3T3 cells
Wang, C., Cheng, T., Liu, J.-Y., Chou, F., Kuo, M., & Lin, J.-K. (1996) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199612)17:4 · Cited by 28 · see citing works
Tumor Suppressor p53 Mutations and Breast Cancer: A Critical Analysis
Ozbun, M. A., & Butel, J. S. (1995) · Advances in cancer research · doi:10.1016/s0065-230x(08)60252-3 · Cited by 89 · see citing works
A new approach to identifying genotoxic carcinogens: p53 induction as an indicator of genotoxic damage
Yang, J. J. (1998) · Carcinogenesis · doi:10.1093/carcin/19.6.1117 · Cited by 86 · see citing works
Adenovirus-mediated p53 gene delivery inhibits 9L glioma growth in rats
Badie, B., Drazan, K. E., Krama, M. H., Shaked, A. A., & Black, K. L. (1995) · Neurological Research · doi:10.1080/01616412.1995.11740314 · Cited by 83 · see citing works
The Induction Levels of Heat Shock Protein 70 Differentiate the Vulnerabilities to Mutant Huntingtin among Neuronal Subtypes
Tagawa, K., Marubuchi, S., Qi, M., Enokido, Y., Tamura, T., Inagaki, R., Murata, M., Kanazawa, I., Wanker, E. E., & Okazawa, H. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4522-06.2007 · Cited by 79 · see citing works
Tumor suppressor genes: at the crossroads of molecular carcinogenesis, molecular epidemiology and human risk assessment
Hussain, S. P., Hofseth, L. J., & Harris, C. C. (2001) · Lung Cancer · doi:10.1016/s0169-5002(01)00339-7 · Cited by 78 · see citing works
p53 Stimulates Promoter Activity of the sgk Serum/Glucocorticoid-inducible Serine/Threonine Protein Kinase Gene in Rodent Mammary Epithelial Cells
Maiyar, A. C., Huang, A. J. Y., Phu, P. T., Cha, H. H., & Firestone, G. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.21.12414 · Cited by 74 · see citing works
Cellular transformation by papilomavirus oncorproteins
Mansur, C. P. (1993) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(93)90013-3 · Cited by 76 · see citing works
Negative regulation of transcription in eukaryotes
Clark, A. R., & Docherty, K. (1993) · Biochemical Journal · doi:10.1042/bj2960521 · Cited by 76 · see citing works
Overview of the Biologic Markers of Breast Cancer
Porter-Jordan, K., & Lippman, M. E. (1994) · Hematology/Oncology Clinics of North America · doi:10.1016/s0889-8588(18)30188-6 · Cited by 76 · see citing works
Mitochondrial Liaisons of p53
Galluzzi, L., Morselli, E., Kepp, O., Vitale, I., Pinti, M., & Kroemer, G. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3504 · Cited by 74 · see citing works
Transcriptional repression by p53 involves molecular interactions distinct from those with the TATA box binding protein
Farmer, G. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.21.4281 · Cited by 74 · see citing works
Phosphorylation of p53 at the casein kinase II site selectively regulates p53-dependent transcriptional repression but not transactivation
Hall, S. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.6.1119 · Cited by 74 · see citing works
Adenovirus E1A Proteins Inhibit Activation of Transcription by p53
Steegenga, W. T., van Laar, T., Riteco, N., Mandarino, A., Shvarts, A., van der Eb, A. J., & Jochemsen, A. G. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.5.2101 · Cited by 73 · see citing works

Transcription repression of a CCAAT-binding transcription factor CBF/HSP70 by p53
Chae, H., Yun, J., & Shi, D. Y. (2005) · Experimental & Molecular Medicine · doi:10.1038/emm.2005.60 · Cited by 14 · see citing works
The hsp70 Gene CCAAT-Binding Factor Mediates Transcriptional Activation by the Adenovirus E1a Protein
Lum, L. S., Hsu, S., Vaewhongs, M., & Wu, B. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.6.2599 · Cited by 47 · see citing works
Self-citation
Physical interaction of tumour suppressor p53/p73 with CCAAT-binding transcription factor 2 (CTF2) and differential regulation of human high-mobility group 1 (HMG1) gene expression
Uramoto, H., Izumi, H., Nagatani, G., Ohmori, H., Nagasue, N., Ise, T., Yoshida, T., Yasumoto, K., & Kohno, K. (2003) · Biochemical Journal · doi:10.1042/bj20021646 · Cited by 59 · see citing works
Transcriptional repression of the human p53 gene by hepatitis B viral X protein
Lee, S., & Rho, H. M. (2000) · Oncogene · doi:10.1038/sj.onc.1203312 · Cited by 122 · see citing works
p53 regulates Ki-67 promoter activity through p53- and Sp1-dependent manner in HeLa cells
Wang, M., Pei, D., Qian, G., Yin, X., Cheng, Q., Li, L., Li, H., & Zheng, J. (2011) · Tumor Biology · doi:10.1007/s13277-011-0191-4 · Cited by 18 · see citing works

Authors: Agoff, S. N., Hou, J., Linzer, D. I., & Wu, B.
Affiliations: Northwestern University (US)
ORCID: Agoff, S. Nicholas
Hou, Jeannie
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1993-01
Volume: 259
Issue: 5091
Pages: 84-87
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.8418500
OpenAlex: W2061154169
Cited by: 292
References: 54
Citations by year: 2025: 2 · 2024: 2 · 2023: 6 · 2022: 2 · 2021: 1 · 2020: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 6
FWCI: 13.77
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: p53, HSP70 gene, promoter regulation, transcriptional repression, CCAAT-binding factor, protein-protein interaction, adenovirus E1A, transcriptional activator, tumor suppressor, gene expression regulation
MeSH terms: Base Sequence, Cloning, Molecular, DNA-Binding Proteins, Electrophoresis, Polyacrylamide Gel, Escherichia coli, Gene Expression Regulation, Heat-Shock Proteins, Humans, Promoter Regions, Genetic, Recombinant Fusion Proteins, Transcription Factors, Transcription, Genetic, Chloramphenicol O-Acetyltransferase, Tumor Suppressor Protein p53, TATA Box, Adenovirus E1A Proteins, CCAAT-Enhancer-Binding Proteins

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Regulation of the Human hsp70 Promoter by p53

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