The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Systemic administration of epothilone B promotes axon regeneration after spinal cord injury
Open accessAbstract
Progress toward fixing a broken back?: Axon regeneration after a spinal cord injury requires interference with neuronal mechanisms to promote axon extension and early suppression of scar formation. Microtubule stabilization could provide, in principle, a basis for such intervention. Ruschel et al. used animal models of spinal cord injury, time-lapse imaging in vivo, primary neuronal cultures, and behavioral studies to tackle this challenge (see the Perspective by Tran and Silver). They showed that epothilone B, a U.S. Food and Drug Administration–approved microtubule-stabilizing drug that can cross the blood-brain barrier, does promote functional axon regeneration, even after injury. Science , this issue p. 347 ; see also p. 285
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Citations
Cites
Chondroitinase ABC promotes functional recovery after spinal cord injury
Bradbury, E. J., Moon, L. D. F., Popat, R. J., King, V. R., Bennett, G. S., Patel, P. N., Fawcett, J. W., & McMahon, S. B. (2002) · Nature · doi:10.1038/416636a · Cited by 2,357
Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway
Park, K. K., Liu, K., Hu, Y., Smith, P. D., Wang, C., Cai, B., Xu, B., Connolly, L., Kramvis, I., Sahin, M., et al. (2008) · Science · doi:10.1126/science.1161566 · Cited by 1,686
Tracking the ends: a dynamic protein network controls the fate of microtubule tips
Akhmanova, A., & Steinmetz, M. O. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2369 · Cited by 1,047
Fitch, M. T., & Silver, J. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2007.05.014 · Cited by 1,007
A Pericyte Origin of Spinal Cord Scar Tissue
Göritz, C., Dias, D. O., Tomilin, N., Barbacid, M., Shupliakov, O., & Frisén, J. (2011) · Science · doi:10.1126/science.1203165 · Cited by 858
Krendel, M., Zenke, F. T., & Bokoch, G. M. (2002) · Nature Cell Biology · doi:10.1038/ncb773 · Cited by 669
Microtubule stabilization specifies initial neuronal polarization
Witte, H., Neukirchen, D., & Bradke, F. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200707042 · Cited by 564
Self-citationNgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans
Dickendesher, T. L., Baldwin, K. T., Mironova, Y. A., Koriyama, Y., Raiker, S. J., Askew, K. L., Wood, A., Geoffroy, C. G., Zheng, B., Liepmann, C. D., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3070 · Cited by 449
Brunden, K. R., Zhang, B., Carroll, J., Yao, Y., Potuzak, J. S., Hogan, A.-M. L., Iba, M., James, M. J., Xie, S. X., Ballatore, C., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3059-10.2010 · Cited by 320
Zempel, H., Luedtke, J., Kumar, Y., Biernat, J., Dawson, H., Mandelkow, E., & Mandelkow, E. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.207 · Cited by 283
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Astrocyte scar formation aids central nervous system axon regeneration
Anderson, M. A., Burda, J. E., Ren, Y., Ao, Y., O’Shea, T. M., Kawaguchi, R., Coppola, G., Khakh, B. S., Deming, T. J., & Sofroniew, M. V. (2016) · Nature · doi:10.1038/nature17623 · Cited by 1,851
Axonal transport: Driving synaptic function
Guedes-Dias, P., & Holzbaur, E. L. F. (2019) · Science · doi:10.1126/science.aaw9997 · Cited by 355
Regulation of axonal regeneration after mammalian spinal cord injury
Zheng, B., & Tuszynski, M. H. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00562-y · Cited by 328
Cytoskeleton dynamics in axon regeneration
Blanquie, O., & Bradke, F. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.02.024 · Cited by 189
Self-citationLatremoliere, A., Cheng, L., DeLisle, M., Wu, C., Chew, S., Hutchinson, E. B., Sheridan, A., Alexandre, C., Latremoliere, F., Sheu, S.-H., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.029 · Cited by 183
Strategies and prospects of effective neural circuits reconstruction after spinal cord injury
Yang, B., Zhang, F., Cheng, F., Ying, L., Wang, C., Shi, K., Wang, J., Xia, K., Gong, Z., Huang, X., et al. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-2620-z · Cited by 128
Pericytes: Problems and Promises for CNS Repair
Laredo, F., Plebanski, J., & Tedeschi, A. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00546 · Cited by 44
“Both laminin deposition and expression of NG2 proteoglycan diminish at the lesion site in rats administered with Epothilone B (Ruschel et al., 2015).”
BackgroundSelf-citationMicrotubule-stabilizer epothilone B delays anesthetic-induced unconsciousness in rats
Khan, S., Huang, Y., Timuçin, D., Bailey, S., Lee, S., Lopes, J., Gaunce, E., Mosberger, J., Zhan, M., Abdelrahman, B., et al. (2024) · eneuro · doi:10.1523/eneuro.0291-24.2024 · Cited by 30
Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions.
Dias, D. O., Kalkitsas, J., Kelahmetoglu, Y., Estrada, C. P., Tatarishvili, J., Ernst, A., Huttner, H. B., Kokaia, Z., Lindvall, O., Brundin, L., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.30.068965
Rehabilitation enhances epothilone-induced locomotor recovery after spinal cord injury
Griffin, J. M., Hingorani Jai Prakash, S., Bockemühl, T., Benner, J. M., Schaffran, B., Moreno-Manzano, V., Büschges, A., & Bradke, F. (2022) · Brain Communications · doi:10.1093/braincomms/fcad005 · Cited by 19
Self-citationIn situ structural mechanism of epothilone-B-induced CNS axon regeneration
Bodakuntla, S., Taira, K., Yamada, Y., Alvarez-Brecht, P., Cada, A. K., Basnet, N., Zhang, R., Martinez-Sanchez, A., Biertümpfel, C., & Mizuno, N. (2025) · Nature · doi:10.1038/s41586-025-09654-z · Cited by 9
Metadata
- Authors
- Ruschel, J., Hellal, F., Flynn, K. C., Dupraz, S., Elliott, D. A., Tedeschi, A., Bates, M., Sliwinski, C., Brook, G., Dobrindt, K., Peitz, M., Brüstle, O., Norenberg, M. D., Blesch, A., Weidner, N., Bunge, M. B., Bixby, J. L., & Bradke, F.
- Venue
- Science
- Published
- 2015-04-17
- Volume
- 348
- Issue
- 6232
- Pages
- 347-352
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2017856054
- Cited by
- 432
- References
- 11
- FWCI
- 21.58
- Type
- journal article
- Language
- en
- Open access
- green
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